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The map label for this gene is vraR [H]

Identifier: 116621801

GI number: 116621801

Start: 3398102

End: 3398779

Strand: Reverse

Name: vraR [H]

Synonym: Acid_2683

Alternate gene names: 116621801

Gene position: 3398779-3398102 (Counterclockwise)

Preceding gene: 116621806

Following gene: 116621800

Centisome position: 34.1

GC content: 63.42

Gene sequence:

>678_bases
ATGCTAGTTCCCAGTCCGAGCGCGCATCGCTCCGCTACCGCTGCCAGGAGTCCGGAACCGGGTGTCATCCGCGTACTGAT
CGCGGACGATCACCCCGTTGTGTGCCTGGGACTGCTGGGCATCATCAACGGACAACCGGACATGACTGTGGTGGGCCAGG
CCAAGACCGGCACCGAAGCCGTGGCCCTGGCGCGCAAGCATTCGCCGGATGTGATCCTGATGGACCTGCGCATGCCGGGG
ATGAGCGGCGTGGAAGCGACGGAAGTGATCCGCGCCGAGCGTCCGGAGAGCGCGGTGATCGTGCTCACGACGTACCAGGG
CGATGAGGACATTCGCAAGGCGCTGGCCGCGGGTGCGCAGTCTTACCTGTTGAAAGGGATGTCGCACCTGAAACTGCTCG
AGGCGATCCGCAGCGTGCGCACCGGGCATACGTATTTTCCACGCGCGATCCGCAACTCGGTGCCGGGGAAATTGAACCGG
GCGGCGTTGAGTCCGCGCGAGATGGACATTCTGCGGCTGATTGTGCGCGGGCTGAGCAATCAGGAAATCGCCGACGCCTT
GAATATTACGCGGGGCACGGTGAAGTGGCACGTGAACATCATTCTGCGACGGCTGGATGTGAATGACCGGACGCAGGCTG
TGGTGGTGGCGGTGCAGCGCGGCATCGTCGTGATTTAG

Upstream 100 bases:

>100_bases
CGATCGCGAACAGCAACAGGGCTGCGCGAATTCCGGAATGGAGCGAGTTGCCAGGCAAGAGATCTGCGCCTACCGGCCTT
TTAGTGTACAATCCTTCCGG

Downstream 100 bases:

>100_bases
AGTTATTTCGGCTATACTTATCTCAAATCGTGCATCCTATACGGAAGGCCATTGTGACCGACTACGACTCGGTGGAACTG
CGCGGAGGACGGCTGCACAA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MLVPSPSAHRSATAARSPEPGVIRVLIADDHPVVCLGLLGIINGQPDMTVVGQAKTGTEAVALARKHSPDVILMDLRMPG
MSGVEATEVIRAERPESAVIVLTTYQGDEDIRKALAAGAQSYLLKGMSHLKLLEAIRSVRTGHTYFPRAIRNSVPGKLNR
AALSPREMDILRLIVRGLSNQEIADALNITRGTVKWHVNIILRRLDVNDRTQAVVVAVQRGIVVI

Sequences:

>Translated_225_residues
MLVPSPSAHRSATAARSPEPGVIRVLIADDHPVVCLGLLGIINGQPDMTVVGQAKTGTEAVALARKHSPDVILMDLRMPG
MSGVEATEVIRAERPESAVIVLTTYQGDEDIRKALAAGAQSYLLKGMSHLKLLEAIRSVRTGHTYFPRAIRNSVPGKLNR
AALSPREMDILRLIVRGLSNQEIADALNITRGTVKWHVNIILRRLDVNDRTQAVVVAVQRGIVVI
>Mature_225_residues
MLVPSPSAHRSATAARSPEPGVIRVLIADDHPVVCLGLLGIINGQPDMTVVGQAKTGTEAVALARKHSPDVILMDLRMPG
MSGVEATEVIRAERPESAVIVLTTYQGDEDIRKALAAGAQSYLLKGMSHLKLLEAIRSVRTGHTYFPRAIRNSVPGKLNR
AALSPREMDILRLIVRGLSNQEIADALNITRGTVKWHVNIILRRLDVNDRTQAVVVAVQRGIVVI

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=35.2380952380952, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1787473, Length=214, Percent_Identity=38.3177570093458, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=32.3809523809524, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788712, Length=191, Percent_Identity=25.6544502617801, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1786747, Length=191, Percent_Identity=29.3193717277487, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790102, Length=193, Percent_Identity=28.4974093264249, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788546, Length=179, Percent_Identity=27.9329608938547, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082052, Length=120, Percent_Identity=32.5, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24363; Mature: 24363

Theoretical pI: Translated: 10.56; Mature: 10.56

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVPSPSAHRSATAARSPEPGVIRVLIADDHPVVCLGLLGIINGQPDMTVVGQAKTGTEA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCHHH
VALARKHSPDVILMDLRMPGMSGVEATEVIRAERPESAVIVLTTYQGDEDIRKALAAGAQ
HHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCHH
SYLLKGMSHLKLLEAIRSVRTGHTYFPRAIRNSVPGKLNRAALSPREMDILRLIVRGLSN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCC
QEIADALNITRGTVKWHVNIILRRLDVNDRTQAVVVAVQRGIVVI
HHHHHHHHCCCCEEEEEEEEEEEECCCCCCHHEEEEEEECCEEEC
>Mature Secondary Structure
MLVPSPSAHRSATAARSPEPGVIRVLIADDHPVVCLGLLGIINGQPDMTVVGQAKTGTEA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCHHH
VALARKHSPDVILMDLRMPGMSGVEATEVIRAERPESAVIVLTTYQGDEDIRKALAAGAQ
HHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCHH
SYLLKGMSHLKLLEAIRSVRTGHTYFPRAIRNSVPGKLNRAALSPREMDILRLIVRGLSN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCC
QEIADALNITRGTVKWHVNIILRRLDVNDRTQAVVVAVQRGIVVI
HHHHHHHHCCCCEEEEEEEEEEEECCCCCCHHEEEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]