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The map label for this gene is mmlH [H]

Identifier: 116621753

GI number: 116621753

Start: 3332315

End: 3333679

Strand: Reverse

Name: mmlH [H]

Synonym: Acid_2635

Alternate gene names: 116621753

Gene position: 3333679-3332315 (Counterclockwise)

Preceding gene: 116621754

Following gene: 116621750

Centisome position: 33.45

GC content: 62.42

Gene sequence:

>1365_bases
ATGTCCCAATCCGGAACAACACCTGGGCTCGCTTCCGGCGGCCAGAATTACGCGTGGTACCGAGAGCTTACCGGCTACCA
TTGGTTCGTGCTGAGCGTGGCCAGCATGGGTTGGATGTTCGATACCATGGCGCAGCAGTTGTTTAACCTGGCGCGCAAGC
CCGCGATCAAGGAACTGCTTGGCGCCGGCGCGAGCAATGCCACGATCGACCAGCAGGCCGCGTGGGCAACCTCGATATTC
ATGATTGGTTGGGCCATCGGCGGCGTCTTCTTCGGCATCCTCGGCGATCGCCTGGGGCGCGCCAAGACGATGACCATCAC
GATCCTGAGCTACACCATCTTCACCGGCCTCAGCGTACTTTCCACCTCCGTGTGGGACTTCAATGTCTATCGGTTCCTTT
GCGGCCTCGGCGTCGGCGGACAGTTCGCGGTGGGCGTGGCGCTGGTGGCGGAGGTGGTGCCGCAGCGGGCGCGGCCGTAC
GCGCTCGGCTTCGTGCAGGCGGCGTCGGCAATCGGCAACATGATGGCCGCGTTCACCGGGATTATTGTCGGGCAGATGGA
AGTCGCCGGCACCATCACAGGCGCGTGGCGCTGGGAATTCCTGGCGGGCGCGATCCCCGCCCCGCTCGCCTTCATCGTAT
TTAAGAAGCTCAAAGAGCCCGAACAGTGGCTCAAGGCGCGGGCGGAAAAGAAGCAGATGGGCTCGTATAGCGAGCTGTTC
AATGACCCGCGGTGGCGCAAGAACGCCATCGTCGGCTTTCTGCTGGCCTTCGCCGGAGTGGTCGGATTGTGGGGTATCGG
CTTCTTCAGCTACGATCTCTTCCGCCCGGTGCTGGAGCGCACGTTCGCCGCAGAAGGTCTGGCGGGCAAAGCACTTTCAG
GCAAAGTGACTACCTGGATCGGCATCACTTCGCTGCTGCAAAACATCGGCTGCTTTTTCGGCATCTACGCGTTCACTTAC
CTGACGCACTACACCGGCCGCAAGAAGGCCTTTGCGATCGCGTTCCTGGCAGCGATGGGAATGACCGCGTACACCTTCTG
GAACCTCAAGCAGATCAGCGACATCTTCTGGATGATCCCGCTGATGGGCTTCGCGCAGCTCTCGCTCTTCGGCGGCTATT
CCATCTATCTCGCGGAGTTGTTCCCCACGCGATTGCGCAGCACCGGCACCAGTTTCTGCTACAACGTGGGGCGGTTCGCC
GCCGCCGCGGGGCCCTTCACGCTCGGGTACCTGACGAAGGACGTCTTCGGCGGGTATGCGGAGCCCATGCGCTATGCGGG
CGTCGCCATGAGCCTGGTCTTTTTGGTTGGATTGGCCGCGCTGCCCTTCGCGCCGGAGACCAAAGGCAAGCCGCTGCCGG
AGTAG

Upstream 100 bases:

>100_bases
TCTGGAAGGAATTAACGATACCGATGCCGTGGCCCTTCCGGCCGACATACCGTTAAAGACCGGCGACCGCGTCAGCGCCA
CGATGTAGAATAGCAACTTA

Downstream 100 bases:

>100_bases
GGCGGGGCTGCTGGTTGAGGCCGATTACCGGACGCTCCCTAACGGTCGCGGCTCGGATGAGGACGATGCGAAAGGCGGGG
ACTCGTTGCGCTGCGTCACG

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSQSGTTPGLASGGQNYAWYRELTGYHWFVLSVASMGWMFDTMAQQLFNLARKPAIKELLGAGASNATIDQQAAWATSIF
MIGWAIGGVFFGILGDRLGRAKTMTITILSYTIFTGLSVLSTSVWDFNVYRFLCGLGVGGQFAVGVALVAEVVPQRARPY
ALGFVQAASAIGNMMAAFTGIIVGQMEVAGTITGAWRWEFLAGAIPAPLAFIVFKKLKEPEQWLKARAEKKQMGSYSELF
NDPRWRKNAIVGFLLAFAGVVGLWGIGFFSYDLFRPVLERTFAAEGLAGKALSGKVTTWIGITSLLQNIGCFFGIYAFTY
LTHYTGRKKAFAIAFLAAMGMTAYTFWNLKQISDIFWMIPLMGFAQLSLFGGYSIYLAELFPTRLRSTGTSFCYNVGRFA
AAAGPFTLGYLTKDVFGGYAEPMRYAGVAMSLVFLVGLAALPFAPETKGKPLPE

Sequences:

>Translated_454_residues
MSQSGTTPGLASGGQNYAWYRELTGYHWFVLSVASMGWMFDTMAQQLFNLARKPAIKELLGAGASNATIDQQAAWATSIF
MIGWAIGGVFFGILGDRLGRAKTMTITILSYTIFTGLSVLSTSVWDFNVYRFLCGLGVGGQFAVGVALVAEVVPQRARPY
ALGFVQAASAIGNMMAAFTGIIVGQMEVAGTITGAWRWEFLAGAIPAPLAFIVFKKLKEPEQWLKARAEKKQMGSYSELF
NDPRWRKNAIVGFLLAFAGVVGLWGIGFFSYDLFRPVLERTFAAEGLAGKALSGKVTTWIGITSLLQNIGCFFGIYAFTY
LTHYTGRKKAFAIAFLAAMGMTAYTFWNLKQISDIFWMIPLMGFAQLSLFGGYSIYLAELFPTRLRSTGTSFCYNVGRFA
AAAGPFTLGYLTKDVFGGYAEPMRYAGVAMSLVFLVGLAALPFAPETKGKPLPE
>Mature_453_residues
SQSGTTPGLASGGQNYAWYRELTGYHWFVLSVASMGWMFDTMAQQLFNLARKPAIKELLGAGASNATIDQQAAWATSIFM
IGWAIGGVFFGILGDRLGRAKTMTITILSYTIFTGLSVLSTSVWDFNVYRFLCGLGVGGQFAVGVALVAEVVPQRARPYA
LGFVQAASAIGNMMAAFTGIIVGQMEVAGTITGAWRWEFLAGAIPAPLAFIVFKKLKEPEQWLKARAEKKQMGSYSELFN
DPRWRKNAIVGFLLAFAGVVGLWGIGFFSYDLFRPVLERTFAAEGLAGKALSGKVTTWIGITSLLQNIGCFFGIYAFTYL
THYTGRKKAFAIAFLAAMGMTAYTFWNLKQISDIFWMIPLMGFAQLSLFGGYSIYLAELFPTRLRSTGTSFCYNVGRFAA
AAGPFTLGYLTKDVFGGYAEPMRYAGVAMSLVFLVGLAALPFAPETKGKPLPE

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=469, Percent_Identity=22.3880597014925, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082404, Length=397, Percent_Identity=26.9521410579345, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786229, Length=399, Percent_Identity=24.5614035087719, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082231, Length=470, Percent_Identity=23.6170212765957, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49435; Mature: 49304

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSGTTPGLASGGQNYAWYRELTGYHWFVLSVASMGWMFDTMAQQLFNLARKPAIKELL
CCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
GAGASNATIDQQAAWATSIFMIGWAIGGVFFGILGDRLGRAKTMTITILSYTIFTGLSVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHH
STSVWDFNVYRFLCGLGVGGQFAVGVALVAEVVPQRARPYALGFVQAASAIGNMMAAFTG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IIVGQMEVAGTITGAWRWEFLAGAIPAPLAFIVFKKLKEPEQWLKARAEKKQMGSYSELF
HHHHHHHHHEEEEHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
NDPRWRKNAIVGFLLAFAGVVGLWGIGFFSYDLFRPVLERTFAAEGLAGKALSGKVTTWI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
GITSLLQNIGCFFGIYAFTYLTHYTGRKKAFAIAFLAAMGMTAYTFWNLKQISDIFWMIP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMGFAQLSLFGGYSIYLAELFPTRLRSTGTSFCYNVGRFAAAAGPFTLGYLTKDVFGGYA
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHH
EPMRYAGVAMSLVFLVGLAALPFAPETKGKPLPE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQSGTTPGLASGGQNYAWYRELTGYHWFVLSVASMGWMFDTMAQQLFNLARKPAIKELL
CCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH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HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]