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The map label for this gene is hsaD [H]

Identifier: 116621662

GI number: 116621662

Start: 3221430

End: 3222365

Strand: Direct

Name: hsaD [H]

Synonym: Acid_2544

Alternate gene names: 116621662

Gene position: 3221430-3222365 (Clockwise)

Preceding gene: 116621661

Following gene: 116621664

Centisome position: 32.33

GC content: 61.86

Gene sequence:

>936_bases
ATGAAGAAATGGTGGTTCGTGGTGGCCGCTGTGGCCATGCTGGCACTGGTTGTAGTGCCGCGCATCATCCGCTATCGGAA
CGCGAACCTGGAAACCCGGCAGCTGAATTCCGTGGTGCGGGAGAAGCTCCCGGGCAGTTTTGTGCAGCTTCCGGACGGCG
TGATGCACTACGAGGTGGCGGGTCCAGTGGACGGACGGCTGGTGGTGCTGGTCGCGGGTTTTTCAGCGCCGTACGCGGTT
TGGGATGCTACGTTCGCGGGGTTGACGCAGGCCGGATTTCGGGTGCTGCGCTACGATCATTTCGGCCGCGGGTACTCGGA
CCGGCCGGACGCGCGGTACGACCCCGAGTTCTTCGACAAGCAGCTTCAGGATCTTCTGGACGCACTGAAGGTGACGGGCA
AGGTGGACCTGGTCGGCGAGGATATGGGCGGCGCGATCGCCGCCGCGTTCGCCAACCGGCATCCGGCGCGGGCCAACCGG
CTGGTGATGATCGACCCCGGATATCGGACCGGGTATGAGGTGCCGATCCGCCTGCGCATGCCGCTCTCGCGCGATTACGG
GATCATGCTTCGCGCCTCCACGATGGCGGATGCGCAGATGAACGACTTCGTGCACCCGGAGCGTTTTTCGAGTTACCTCG
CTACGTACCGCGAGCAGATGCGGTATCGGGGATTTCGCAAGGCGATCCTCTCCACCATGCTGAACTACTGGGTGGAAGAT
TCCACGGCGGAATACAGGCAGTTGGGCAAGATCGGGCGGCCCGTGCTGTTGTTGTGGGGCGTGGCGGATGAATCGAGCCG
GATCGAACTGAGCGCGAAGGTGCGGGAAGATATTCCGCAGGCGGAATTCCACGTGATCAAAGACGCGGGCCATCGTCCGG
CTTTGGAGCGGCCGGAGATTGTGAATCCAATACTGATTGAGTTTTTGAAAAAGTGA

Upstream 100 bases:

>100_bases
CGAGTTACTGGCCGGCGCCGGCGGAGTTGCGGCGGTGCTGCGCTGGCGCAACTGAGCGGCGCGCCACCGTTCGGGGAACC
TGCTAACATCGCAGTGGCCT

Downstream 100 bases:

>100_bases
GAATGTTAGTTCTGCCGTAGGGCTTGGAGCGGGTCGATGCGGGTGGCGCGCCAGGCGGGGATGGCGCAGGCCAGGATCGC
GATTAAGCCGACCGATGCAG

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; Meta-cleavage product hydrolase; MCP hydrolase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKKWWFVVAAVAMLALVVVPRIIRYRNANLETRQLNSVVREKLPGSFVQLPDGVMHYEVAGPVDGRLVVLVAGFSAPYAV
WDATFAGLTQAGFRVLRYDHFGRGYSDRPDARYDPEFFDKQLQDLLDALKVTGKVDLVGEDMGGAIAAAFANRHPARANR
LVMIDPGYRTGYEVPIRLRMPLSRDYGIMLRASTMADAQMNDFVHPERFSSYLATYREQMRYRGFRKAILSTMLNYWVED
STAEYRQLGKIGRPVLLLWGVADESSRIELSAKVREDIPQAEFHVIKDAGHRPALERPEIVNPILIEFLKK

Sequences:

>Translated_311_residues
MKKWWFVVAAVAMLALVVVPRIIRYRNANLETRQLNSVVREKLPGSFVQLPDGVMHYEVAGPVDGRLVVLVAGFSAPYAV
WDATFAGLTQAGFRVLRYDHFGRGYSDRPDARYDPEFFDKQLQDLLDALKVTGKVDLVGEDMGGAIAAAFANRHPARANR
LVMIDPGYRTGYEVPIRLRMPLSRDYGIMLRASTMADAQMNDFVHPERFSSYLATYREQMRYRGFRKAILSTMLNYWVED
STAEYRQLGKIGRPVLLLWGVADESSRIELSAKVREDIPQAEFHVIKDAGHRPALERPEIVNPILIEFLKK
>Mature_311_residues
MKKWWFVVAAVAMLALVVVPRIIRYRNANLETRQLNSVVREKLPGSFVQLPDGVMHYEVAGPVDGRLVVLVAGFSAPYAV
WDATFAGLTQAGFRVLRYDHFGRGYSDRPDARYDPEFFDKQLQDLLDALKVTGKVDLVGEDMGGAIAAAFANRHPARANR
LVMIDPGYRTGYEVPIRLRMPLSRDYGIMLRASTMADAQMNDFVHPERFSSYLATYREQMRYRGFRKAILSTMLNYWVED
STAEYRQLGKIGRPVLLLWGVADESSRIELSAKVREDIPQAEFHVIKDAGHRPALERPEIVNPILIEFLKK

Specific function: Catalyzes the hydrolysis of a carbon-carbon bond in 4,5- 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19- hexanorandrostan-5-oic acid (DOHNAA) and 2-hydroxy-hexa-2,4- dienoic acid (HHD). Al

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. HsaD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.7.1.8 [H]

Molecular weight: Translated: 35366; Mature: 35366

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKWWFVVAAVAMLALVVVPRIIRYRNANLETRQLNSVVREKLPGSFVQLPDGVMHYEVA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCEEEEEEC
GPVDGRLVVLVAGFSAPYAVWDATFAGLTQAGFRVLRYDHFGRGYSDRPDARYDPEFFDK
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
QLQDLLDALKVTGKVDLVGEDMGGAIAAAFANRHPARANRLVMIDPGYRTGYEVPIRLRM
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEEC
PLSRDYGIMLRASTMADAQMNDFVHPERFSSYLATYREQMRYRGFRKAILSTMLNYWVED
CCCCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
STAEYRQLGKIGRPVLLLWGVADESSRIELSAKVREDIPQAEFHVIKDAGHRPALERPEI
CHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHCCCHHHHHHHHCCCCCCCCCCCCC
VNPILIEFLKK
CCHHHHHHHCC
>Mature Secondary Structure
MKKWWFVVAAVAMLALVVVPRIIRYRNANLETRQLNSVVREKLPGSFVQLPDGVMHYEVA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCEEEEEEC
GPVDGRLVVLVAGFSAPYAVWDATFAGLTQAGFRVLRYDHFGRGYSDRPDARYDPEFFDK
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
QLQDLLDALKVTGKVDLVGEDMGGAIAAAFANRHPARANRLVMIDPGYRTGYEVPIRLRM
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEEC
PLSRDYGIMLRASTMADAQMNDFVHPERFSSYLATYREQMRYRGFRKAILSTMLNYWVED
CCCCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
STAEYRQLGKIGRPVLLLWGVADESSRIELSAKVREDIPQAEFHVIKDAGHRPALERPEI
CHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHCCCHHHHHHHHCCCCCCCCCCCCC
VNPILIEFLKK
CCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA