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The map label for this gene is degP [H]

Identifier: 116621594

GI number: 116621594

Start: 3145535

End: 3147163

Strand: Direct

Name: degP [H]

Synonym: Acid_2476

Alternate gene names: 116621594

Gene position: 3145535-3147163 (Clockwise)

Preceding gene: 116621593

Following gene: 116621595

Centisome position: 31.56

GC content: 61.39

Gene sequence:

>1629_bases
ATGAGTTTCTTCGACAAAATGCGAACACAGAAATTTCTTTCGTTCACGCTGATCCTGTTCACACTGAGCACCGGTATTGT
TATCGGTACGCTGGTTAACCAAGGTGTCAAGGCGGCGAAGAACGAGGGCACGGTGGCGCCAGGTGCGACGCCGCTCGTGA
TTCCCAACCCCGTCGAATTGTCCAACACGTTTAGTCAGATTGCGAAGCAGGTGGAACCCTCGGTCGTCAATATCTCGACC
ACATACCTGCCGAAAGCCACATCCTCCCGCGTGCCCCGCAACGGACGCCGGCAGGCTATCCCGCAGCCTGACGAGGATCA
GGGTGACAACGGCGGTATGGACGATTTCATTTACCGTTTCTTCGGCAACCCCTTCGGCGGCCAGGGAATGGGACCGGATA
TGCCGAACCGTAAGAGCCAGGCGCTCGGTTCGGGCGTGGTCGTGGACCGCGCCGGCTATATCCTGACCAACAACCACGTG
GTCGATAAAGCCGACCGCATCCAGGTGAAGTTCAACGGCGACCCCGTGGAATACGACGCCAAAGTGGTCGGCGTGGATTC
CGCAACCGATCTGGCCGTGATCCGCGTGGAAGGCAAGAAGGACCTGACGGTCGCCAAGATCGGCAACTCCGACGCCGTGC
AGGTGGGCGATTGGGCGATCGCGATCGGTTCTCCGTTCGGGTACCAGGCGACCATGACCGCGGGCATCATCAGCGCGAAA
GAGCGCGATGTGGATCCGACGATGCAGTTCCAGCACTTCCTGCAGACAGATGCAGCCATCAACCCAGGGAACAGCGGTGG
ACCGCTGCTCAACATCCGCGGCGAAGTGATCGGCATCAACACCGCCATCGCCACCCACTCGGGCGGCAATCAGGGCGTAG
GCTTTGCGCTGCCGGTGAACACCGCGGCGCAGGTCTATAACGACATCATCAAGAATGGCAAGGTGACCCGCGGCTCCATC
GGCATCAGCTTCACGCCGAGCGAAACCGACCGCGCCCGCGCCAACCTGAAGGTGGCCGGAGCCAAGGAAGGCGTCTTCGT
GGAGCAGGTCACTCCCGGCGGACCCAGCGAAAAGGCCGGCATGAAAGATGGCGACGTGATCGTCGCGATCAACGGCAAGC
CGGTGCACGATGGTAACCAGCTGATCGGCACCGTGACCGCCACTCCGCTCGGCAATGCGCTCAACATCACAGTGGATCGC
GAAGGCAAGCGCCACGAGCTCAAGGTCGTGGTGGCCGACCTGGCCCAGGTCTTCCCGGAACGCTACGGCAACGGCCGTGA
GAACCCGCTGAAGAACGAAGAACCGACCGCGGTCAGCTTCGGCATGCAGATCCAGAACCTCACGGATCAGCAGGCCGACC
GGCTCGGCGTCAAGCAGAAGGGCGGAGTGCAGGTGGTTTCGGTGGAGCCCAACAGCTTCGCCGAAGACATCGGCCTGGCC
CCCGGCGACATCATCGTTTCGATCAACCGTCAAACCGTCAACACGACCGAAGACATCGCCAAGATCCGCGGCGGCCTGCA
TTCAGGTGACGCGGTGCAGTTCAAGGTGATGCGCAAGACCGGCGGCCGTAACAGCTCCGAATGGGGTTCCAGCTTCGTCG
CCGGAACTCTTCCCAGCAATGCCCGTTAA

Upstream 100 bases:

>100_bases
ATGAAACCGTTAAAGCCGCGAGAACATCAATCAAGGTAGCAGCCAATTGAGGCAGAAATAAGAATTTCGCTGCGAAGCGT
ATTGAGGAGCAAGTAGGCCA

Downstream 100 bases:

>100_bases
CAACGCACGTTAAACCTCCCTCCCGCAGCACACAGGGCAGGCCTCCCGCCTGCCCTGTTCTCACGCTAAAATAGATTCTT
ACATTCTGATGAAGATTTTC

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSFFDKMRTQKFLSFTLILFTLSTGIVIGTLVNQGVKAAKNEGTVAPGATPLVIPNPVELSNTFSQIAKQVEPSVVNIST
TYLPKATSSRVPRNGRRQAIPQPDEDQGDNGGMDDFIYRFFGNPFGGQGMGPDMPNRKSQALGSGVVVDRAGYILTNNHV
VDKADRIQVKFNGDPVEYDAKVVGVDSATDLAVIRVEGKKDLTVAKIGNSDAVQVGDWAIAIGSPFGYQATMTAGIISAK
ERDVDPTMQFQHFLQTDAAINPGNSGGPLLNIRGEVIGINTAIATHSGGNQGVGFALPVNTAAQVYNDIIKNGKVTRGSI
GISFTPSETDRARANLKVAGAKEGVFVEQVTPGGPSEKAGMKDGDVIVAINGKPVHDGNQLIGTVTATPLGNALNITVDR
EGKRHELKVVVADLAQVFPERYGNGRENPLKNEEPTAVSFGMQIQNLTDQQADRLGVKQKGGVQVVSVEPNSFAEDIGLA
PGDIIVSINRQTVNTTEDIAKIRGGLHSGDAVQFKVMRKTGGRNSSEWGSSFVAGTLPSNAR

Sequences:

>Translated_542_residues
MSFFDKMRTQKFLSFTLILFTLSTGIVIGTLVNQGVKAAKNEGTVAPGATPLVIPNPVELSNTFSQIAKQVEPSVVNIST
TYLPKATSSRVPRNGRRQAIPQPDEDQGDNGGMDDFIYRFFGNPFGGQGMGPDMPNRKSQALGSGVVVDRAGYILTNNHV
VDKADRIQVKFNGDPVEYDAKVVGVDSATDLAVIRVEGKKDLTVAKIGNSDAVQVGDWAIAIGSPFGYQATMTAGIISAK
ERDVDPTMQFQHFLQTDAAINPGNSGGPLLNIRGEVIGINTAIATHSGGNQGVGFALPVNTAAQVYNDIIKNGKVTRGSI
GISFTPSETDRARANLKVAGAKEGVFVEQVTPGGPSEKAGMKDGDVIVAINGKPVHDGNQLIGTVTATPLGNALNITVDR
EGKRHELKVVVADLAQVFPERYGNGRENPLKNEEPTAVSFGMQIQNLTDQQADRLGVKQKGGVQVVSVEPNSFAEDIGLA
PGDIIVSINRQTVNTTEDIAKIRGGLHSGDAVQFKVMRKTGGRNSSEWGSSFVAGTLPSNAR
>Mature_541_residues
SFFDKMRTQKFLSFTLILFTLSTGIVIGTLVNQGVKAAKNEGTVAPGATPLVIPNPVELSNTFSQIAKQVEPSVVNISTT
YLPKATSSRVPRNGRRQAIPQPDEDQGDNGGMDDFIYRFFGNPFGGQGMGPDMPNRKSQALGSGVVVDRAGYILTNNHVV
DKADRIQVKFNGDPVEYDAKVVGVDSATDLAVIRVEGKKDLTVAKIGNSDAVQVGDWAIAIGSPFGYQATMTAGIISAKE
RDVDPTMQFQHFLQTDAAINPGNSGGPLLNIRGEVIGINTAIATHSGGNQGVGFALPVNTAAQVYNDIIKNGKVTRGSIG
ISFTPSETDRARANLKVAGAKEGVFVEQVTPGGPSEKAGMKDGDVIVAINGKPVHDGNQLIGTVTATPLGNALNITVDRE
GKRHELKVVVADLAQVFPERYGNGRENPLKNEEPTAVSFGMQIQNLTDQQADRLGVKQKGGVQVVSVEPNSFAEDIGLAP
GDIIVSINRQTVNTTEDIAKIRGGLHSGDAVQFKVMRKTGGRNSSEWGSSFVAGTLPSNAR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=270, Percent_Identity=38.8888888888889, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI4506141, Length=276, Percent_Identity=36.5942028985507, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI24308541, Length=291, Percent_Identity=34.020618556701, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI7019477, Length=261, Percent_Identity=35.632183908046, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI1786356, Length=453, Percent_Identity=36.2030905077263, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789629, Length=442, Percent_Identity=35.0678733031674, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI1789630, Length=282, Percent_Identity=37.5886524822695, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24646839, Length=258, Percent_Identity=31.3953488372093, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 57390; Mature: 57259

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFDKMRTQKFLSFTLILFTLSTGIVIGTLVNQGVKAAKNEGTVAPGATPLVIPNPVEL
CCHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHCCCCCCCCCCCCEEECCCCHH
SNTFSQIAKQVEPSVVNISTTYLPKATSSRVPRNGRRQAIPQPDEDQGDNGGMDDFIYRF
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
FGNPFGGQGMGPDMPNRKSQALGSGVVVDRAGYILTNNHVVDKADRIQVKFNGDPVEYDA
HCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEECCEEECCCEEEEEEECCCCEEECC
KVVGVDSATDLAVIRVEGKKDLTVAKIGNSDAVQVGDWAIAIGSPFGYQATMTAGIISAK
EEEECCCCCCEEEEEECCCCCEEEEEECCCCCEEECCEEEEECCCCCCEEEHHHHHEECC
ERDVDPTMQFQHFLQTDAAINPGNSGGPLLNIRGEVIGINTAIATHSGGNQGVGFALPVN
CCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEEEEEEECCCCCCCCEEEECCC
TAAQVYNDIIKNGKVTRGSIGISFTPSETDRARANLKVAGAKEGVFVEQVTPGGPSEKAG
HHHHHHHHHHHCCCEEECEEEEEECCCCCCHHHCEEEEECCCCCEEEEEECCCCCCCCCC
MKDGDVIVAINGKPVHDGNQLIGTVTATPLGNALNITVDREGKRHELKVVVADLAQVFPE
CCCCCEEEEECCEECCCCCEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
RYGNGRENPLKNEEPTAVSFGMQIQNLTDQQADRLGVKQKGGVQVVSVEPNSFAEDIGLA
HHCCCCCCCCCCCCCCEEEECCEEECCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHCCC
PGDIIVSINRQTVNTTEDIAKIRGGLHSGDAVQFKVMRKTGGRNSSEWGSSFVAGTLPSN
CCCEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHCCCEEEECCCCC
AR
CC
>Mature Secondary Structure 
SFFDKMRTQKFLSFTLILFTLSTGIVIGTLVNQGVKAAKNEGTVAPGATPLVIPNPVEL
CHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHCCCCCCCCCCCCEEECCCCHH
SNTFSQIAKQVEPSVVNISTTYLPKATSSRVPRNGRRQAIPQPDEDQGDNGGMDDFIYRF
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
FGNPFGGQGMGPDMPNRKSQALGSGVVVDRAGYILTNNHVVDKADRIQVKFNGDPVEYDA
HCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEECCEEECCCEEEEEEECCCCEEECC
KVVGVDSATDLAVIRVEGKKDLTVAKIGNSDAVQVGDWAIAIGSPFGYQATMTAGIISAK
EEEECCCCCCEEEEEECCCCCEEEEEECCCCCEEECCEEEEECCCCCCEEEHHHHHEECC
ERDVDPTMQFQHFLQTDAAINPGNSGGPLLNIRGEVIGINTAIATHSGGNQGVGFALPVN
CCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEEEEEEECCCCCCCCEEEECCC
TAAQVYNDIIKNGKVTRGSIGISFTPSETDRARANLKVAGAKEGVFVEQVTPGGPSEKAG
HHHHHHHHHHHCCCEEECEEEEEECCCCCCHHHCEEEEECCCCCEEEEEECCCCCCCCCC
MKDGDVIVAINGKPVHDGNQLIGTVTATPLGNALNITVDREGKRHELKVVVADLAQVFPE
CCCCCEEEEECCEECCCCCEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
RYGNGRENPLKNEEPTAVSFGMQIQNLTDQQADRLGVKQKGGVQVVSVEPNSFAEDIGLA
HHCCCCCCCCCCCCCCEEEECCEEECCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHCCC
PGDIIVSINRQTVNTTEDIAKIRGGLHSGDAVQFKVMRKTGGRNSSEWGSSFVAGTLPSN
CCCEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHCCCEEEECCCCC
AR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]