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The map label for this gene is gabT [C]

Identifier: 116621553

GI number: 116621553

Start: 3097410

End: 3098771

Strand: Reverse

Name: gabT [C]

Synonym: Acid_2435

Alternate gene names: 116621553

Gene position: 3098771-3097410 (Counterclockwise)

Preceding gene: 116621555

Following gene: 116621552

Centisome position: 31.09

GC content: 64.24

Gene sequence:

>1362_bases
ATGGGAAACACCCTGGAACGAGTCCGCACGGACCTTCCGAGCCTGACCGGCTCAGTCCCCGGCCCGCGCGCGCGTGCCGT
TATCGAACGTGATGAGAAAGTGGTATCGCCGTCGTATACCCGCTGCTATCCGCTGGTGGTAGAAAAGGGCGAGGGCGCGA
TGATCGAGGACGTGGATGGAAATCGCTTCCTCGATTTCAACGCCGGCATCGCGGTGGTGGCCACAGGCCACTGCCATCCG
CGGGTGGTCGAGGCGATCCAGAAGCAGGCCGCGCGCCTGATCCACATGTCGGGCACGGATTTCTACTATGAAGAACTGAC
CGCGCTCGCGGAGAAGCTCAACGAGATCGCGCCCGGCGACGTGGCGCGTCGCGTCTCGTTCGGTAACTCCGGCGCGGAGG
CGATGGAAGGCGCCATCAAACTCGCGCGCTATGCCACGAAGCGCGATAAGATCATCGCGTTCTTCGGCAGCTTCCATGGG
CGCACGATGGGAGCGCTCTCGCTGACCTCGCGCCGCGCGGTGCAGCGCGCGGGCTTCGGTCCGCTGATCCCGGGCGTGGT
GCATGCACCTTACCCCTATTGCTATCGCTGCCCCTACGGTCAGAAGCCCGAGAGCTGCGCGGTGGAGTGCGTGAAGCACA
TCGAAGATACGCTGCTGAAGACCATCTGCCCCGCCGAAGAAACGGCGGCGATTGTGGTGGAACCGGTGCAGGGCGAAGGC
GGCTATATCGTGCCGCCGCGCAAGTTCATCGATGAACTGACGCGGGTCGCCAAAGAGAATGGCATCCTGCTGGTGTTCGA
CGAAGTGCAGAGCGGAATGGGGCGCACCGGAAAGATGTTCGCCGCGGATCACTTCGACGCGGTGCCGGATATCCTGAGCG
TGGCTAAGGGAATCGCCAGCGGAATGCCGATAGGCGCCACGGTGGCGCGCGCGGACCTGATGACGTGGCCTCCGGGGGCG
CACGCCTCCACGTTCGGCGGCAATCCGGTGGCATGCGCGGCGGCGCTGGTGACCATCGAACTGCTGCAGCGCGAGTTGGT
GGACAACGCGGCGCGCATGGGCGCCTACCTGATGGAGCGGCTGCGCCAGTGGCCGTCGCGTTTCCCGATCGTGGGCGACG
TGCGCGGGCTTGGCCTGATGATCGGCATCGAACTGGTGCTCGATCAGGCGACCAAAGAGAAAGCGCCCTCCGGCTTGCGC
GATCGGGTGGTGGAGTTGGCTTTCCGCCGAGGGCTGTTGATTCTCGGCGCGGGCGACAATGTGTTGCGTTTATGTCCGCC
CCTGATCATCACGCGCGACCAGTGCGATTTCGCACTTGATACTCTGGAAGCGTGCCTCCAACAGGTGATCGAAAAAGCCT
GA

Upstream 100 bases:

>100_bases
CCTCTTCGGCGACTAACTCTTCTTCCGCATCCTCTCGGCGCGCGCTCACGAGTGCGCAGGTTCTCACCTTAAAACCGAAG
TGAAGAAGAGGAGTAATGCC

Downstream 100 bases:

>100_bases
TGACTCTCGACGTCGGCTGCGGGATTCACAAGCAGCCCGGTTCCATAGGAATCGACCGGAATCCCGCCAGCCGCGCCGAC
GTGCTGGCGGATCTCGACCG

Product: 4-aminobutyrate aminotransferase

Products: succinate semialdehyde; L-glutamate

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MGNTLERVRTDLPSLTGSVPGPRARAVIERDEKVVSPSYTRCYPLVVEKGEGAMIEDVDGNRFLDFNAGIAVVATGHCHP
RVVEAIQKQAARLIHMSGTDFYYEELTALAEKLNEIAPGDVARRVSFGNSGAEAMEGAIKLARYATKRDKIIAFFGSFHG
RTMGALSLTSRRAVQRAGFGPLIPGVVHAPYPYCYRCPYGQKPESCAVECVKHIEDTLLKTICPAEETAAIVVEPVQGEG
GYIVPPRKFIDELTRVAKENGILLVFDEVQSGMGRTGKMFAADHFDAVPDILSVAKGIASGMPIGATVARADLMTWPPGA
HASTFGGNPVACAAALVTIELLQRELVDNAARMGAYLMERLRQWPSRFPIVGDVRGLGLMIGIELVLDQATKEKAPSGLR
DRVVELAFRRGLLILGAGDNVLRLCPPLIITRDQCDFALDTLEACLQQVIEKA

Sequences:

>Translated_453_residues
MGNTLERVRTDLPSLTGSVPGPRARAVIERDEKVVSPSYTRCYPLVVEKGEGAMIEDVDGNRFLDFNAGIAVVATGHCHP
RVVEAIQKQAARLIHMSGTDFYYEELTALAEKLNEIAPGDVARRVSFGNSGAEAMEGAIKLARYATKRDKIIAFFGSFHG
RTMGALSLTSRRAVQRAGFGPLIPGVVHAPYPYCYRCPYGQKPESCAVECVKHIEDTLLKTICPAEETAAIVVEPVQGEG
GYIVPPRKFIDELTRVAKENGILLVFDEVQSGMGRTGKMFAADHFDAVPDILSVAKGIASGMPIGATVARADLMTWPPGA
HASTFGGNPVACAAALVTIELLQRELVDNAARMGAYLMERLRQWPSRFPIVGDVRGLGLMIGIELVLDQATKEKAPSGLR
DRVVELAFRRGLLILGAGDNVLRLCPPLIITRDQCDFALDTLEACLQQVIEKA
>Mature_452_residues
GNTLERVRTDLPSLTGSVPGPRARAVIERDEKVVSPSYTRCYPLVVEKGEGAMIEDVDGNRFLDFNAGIAVVATGHCHPR
VVEAIQKQAARLIHMSGTDFYYEELTALAEKLNEIAPGDVARRVSFGNSGAEAMEGAIKLARYATKRDKIIAFFGSFHGR
TMGALSLTSRRAVQRAGFGPLIPGVVHAPYPYCYRCPYGQKPESCAVECVKHIEDTLLKTICPAEETAAIVVEPVQGEGG
YIVPPRKFIDELTRVAKENGILLVFDEVQSGMGRTGKMFAADHFDAVPDILSVAKGIASGMPIGATVARADLMTWPPGAH
ASTFGGNPVACAAALVTIELLQRELVDNAARMGAYLMERLRQWPSRFPIVGDVRGLGLMIGIELVLDQATKEKAPSGLRD
RVVELAFRRGLLILGAGDNVLRLCPPLIITRDQCDFALDTLEACLQQVIEKA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=451, Percent_Identity=33.0376940133038, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI4557809, Length=440, Percent_Identity=31.3636363636364, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI24119277, Length=420, Percent_Identity=31.1904761904762, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI37574042, Length=419, Percent_Identity=30.0715990453461, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=30.749354005168, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI226442705, Length=419, Percent_Identity=29.3556085918854, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI188536080, Length=473, Percent_Identity=25.369978858351, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI38679950, Length=473, Percent_Identity=25.369978858351, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI38679946, Length=473, Percent_Identity=25.369978858351, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI284507298, Length=333, Percent_Identity=32.4324324324324, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789016, Length=428, Percent_Identity=37.8504672897196, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1787560, Length=406, Percent_Identity=39.1625615763547, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788044, Length=419, Percent_Identity=34.1288782816229, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI145693181, Length=441, Percent_Identity=35.1473922902494, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1789759, Length=427, Percent_Identity=35.1288056206089, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1786349, Length=346, Percent_Identity=30.9248554913295, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786991, Length=425, Percent_Identity=28, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=449, Percent_Identity=31.8485523385301, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=33.0210772833724, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71992977, Length=427, Percent_Identity=31.1475409836066, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI25144274, Length=290, Percent_Identity=33.1034482758621, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=477, Percent_Identity=27.0440251572327, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71981843, Length=205, Percent_Identity=31.219512195122, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=438, Percent_Identity=32.4200913242009, Blast_Score=222, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6324432, Length=430, Percent_Identity=32.093023255814, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321456, Length=473, Percent_Identity=24.5243128964059, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324386, Length=366, Percent_Identity=25.1366120218579, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI161085790, Length=432, Percent_Identity=32.6388888888889, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI28574759, Length=429, Percent_Identity=32.6340326340326, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI21357415, Length=442, Percent_Identity=32.1266968325792, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=32.1596244131455, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI281366494, Length=471, Percent_Identity=26.3269639065817, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24667139, Length=471, Percent_Identity=26.3269639065817, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24667143, Length=471, Percent_Identity=26.3269639065817, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19

Molecular weight: Translated: 49030; Mature: 48899

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNTLERVRTDLPSLTGSVPGPRARAVIERDEKVVSPSYTRCYPLVVEKGEGAMIEDVDG
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHCCCCCCEEEEEEEECCCCCEEEECCC
NRFLDFNAGIAVVATGHCHPRVVEAIQKQAARLIHMSGTDFYYEELTALAEKLNEIAPGD
CEEEEECCCEEEEEECCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCH
VARRVSFGNSGAEAMEGAIKLARYATKRDKIIAFFGSFHGRTMGALSLTSRRAVQRAGFG
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
PLIPGVVHAPYPYCYRCPYGQKPESCAVECVKHIEDTLLKTICPAEETAAIVVEPVQGEG
CCCCCHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
GYIVPPRKFIDELTRVAKENGILLVFDEVQSGMGRTGKMFAADHFDAVPDILSVAKGIAS
CEECCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHC
GMPIGATVARADLMTWPPGAHASTFGGNPVACAAALVTIELLQRELVDNAARMGAYLMER
CCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRQWPSRFPIVGDVRGLGLMIGIELVLDQATKEKAPSGLRDRVVELAFRRGLLILGAGDN
HHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCC
VLRLCPPLIITRDQCDFALDTLEACLQQVIEKA
HHHHCCCCEEECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GNTLERVRTDLPSLTGSVPGPRARAVIERDEKVVSPSYTRCYPLVVEKGEGAMIEDVDG
CCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHCCCCCCEEEEEEEECCCCCEEEECCC
NRFLDFNAGIAVVATGHCHPRVVEAIQKQAARLIHMSGTDFYYEELTALAEKLNEIAPGD
CEEEEECCCEEEEEECCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCH
VARRVSFGNSGAEAMEGAIKLARYATKRDKIIAFFGSFHGRTMGALSLTSRRAVQRAGFG
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
PLIPGVVHAPYPYCYRCPYGQKPESCAVECVKHIEDTLLKTICPAEETAAIVVEPVQGEG
CCCCCHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
GYIVPPRKFIDELTRVAKENGILLVFDEVQSGMGRTGKMFAADHFDAVPDILSVAKGIAS
CEECCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHC
GMPIGATVARADLMTWPPGAHASTFGGNPVACAAALVTIELLQRELVDNAARMGAYLMER
CCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRQWPSRFPIVGDVRGLGLMIGIELVLDQATKEKAPSGLRDRVVELAFRRGLLILGAGDN
HHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCC
VLRLCPPLIITRDQCDFALDTLEACLQQVIEKA
HHHHCCCCEEECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-aminobutanoate; 2-oxoglutarate

Specific reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA