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The map label for this gene is accD [C]

Identifier: 116621380

GI number: 116621380

Start: 2888244

End: 2889779

Strand: Direct

Name: accD [C]

Synonym: Acid_2261

Alternate gene names: 116621380

Gene position: 2888244-2889779 (Clockwise)

Preceding gene: 116621379

Following gene: 116621381

Centisome position: 28.98

GC content: 63.09

Gene sequence:

>1536_bases
TTGTCCAACACAGAAAAGCTCGAGCTCAAGAGGGAGCATCTGAAGCTGGGGGGCGGCGCCCAGCGCATTGAGAAGCAGCA
CCAATCCGGCAAGCTGACGGCGCGCGAGCGCGTCACATTGCTCGCCGATCGCGATTCCTTCCAGGAGGCCGGGCTGTTTG
CCAGGCACAACGGCAAGCATTTCGGCATGAACGACAAGGTCCTGCCCGCCGATGGCGTGGTTACCGGACGCGCGCGCGTT
CACGGCCGCCCCGTACATCTCGCGAGCCAGGATTTCACGGTGGCCGGGGGCTCGGCCGGCGAAGTCCACGCCAACAAGAT
CGCCGACACCATGAAGGCGTCCATGAAGACCGGCACGCCTTTCATCTTCATCAACGATTCCGGCGGCGCGCGCGTGCAGG
AGGGCGTCAGCAGCCTCTCCGGGTACGCCAAGATCTTCCACCAGAACGTGATGCTCTCCGGCGTAGTCCCGCAAATCTCG
CTCATCTGCGGACCCTGCGCCGGGGGAGCCGCGTACAGCCCCGCGCTCACGGATTTCATCATCCAGACGCGCGATGGCCT
GATCTTCATCACCGGCCCCACCGTGATCAAACAGGTCACGGGGGAAATGGTCACCGCGCAGGAACTCGGCGGCGCGCGCG
CCCAGATGAACAAATCCGGCGTGGTTCACTTCGTCGCCGAAAACGATGTGGAGGCGATGCAGATCTGCAAACGCCTGCTC
TCCTTCCTGCCCTCCAACAATATGGAGGATCCGCCGCGCATCGAATCGAGCGACGACCGCACCTACGAACACCGCCTCAA
CCACGTCGTGCCGCCCGAGCCCAAATGCGGCTACGACGTGCGCGATGTCATCAACCTGGTGGTGGACTACGGCGATTTCC
TCGAAGTTCAAAGCGAGTTCGCGCGCAATCTGGTAGTTGGCTTTGGACGGATGCGCGGCGCTACGGTCGGCATCGTCGCC
AATCAGCCCTCCGTACTGGCCGGCGCGCTCGATATCGACGCTTCGGATAAGGGCGCGGGCTTCGTGCGCTTCTGCAACGC
TTTCAACATTCCGCTGATCACCTTCGTCGATATCCCGGGCTTCCTCCCCGGTGTAGATCAGGAATACGGCGGAATTATCC
GCCACGGCGCCAAACTGCTCTTCGCCTATTCGGCGGCCACGGTGCCTAAGATCACCGTGATCCTGCGCAAAGCTTATGGC
GGCGGCTACATCGCCATGTGCGCCAAGGATCTTGGCGCCGATTGCACGCTTGCCTGGCCCGGCTCGGAGATCGCCGTCAT
GGGCGCGGAGGCCGCGGTGGAGATCGTATTCCACCGCGAGTTGGTCGAGGCGCGAGACCCAGCGGCGGCCCGCCAGGAAC
TGATACAGGAGTACCGCGAGACCTTTTATACTCCCTACGAAGCCGCAGCGCTGCGCCTGGTGGACGACATCATCGAGCCC
GCCCGCACCCGCGGCTATCTTGCCGACGCGCTGGAAACCCTTTCCACCAAGCGCGATTGGCGTCCGCAGAAAAAACACGG
GTTGATCCCACTGTGA

Upstream 100 bases:

>100_bases
CCACGGATGAACACGGATGAACGCGGATAAGAAAAAGAGCCTGCGTTTGTTACGTTTTTCACCGTTCGTATTTCGGCAAT
TAAGTTACAATACTCCTTAA

Downstream 100 bases:

>100_bases
GCACGTTATGAGCCCCCAAGAATCCATTCCGGAAATCCATCGCGCGATGCTGGCCGCGGCGGTCAACGCCATACCCAGCG
GTTGGACCCGGCGCGGGCAC

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSNTEKLELKREHLKLGGGAQRIEKQHQSGKLTARERVTLLADRDSFQEAGLFARHNGKHFGMNDKVLPADGVVTGRARV
HGRPVHLASQDFTVAGGSAGEVHANKIADTMKASMKTGTPFIFINDSGGARVQEGVSSLSGYAKIFHQNVMLSGVVPQIS
LICGPCAGGAAYSPALTDFIIQTRDGLIFITGPTVIKQVTGEMVTAQELGGARAQMNKSGVVHFVAENDVEAMQICKRLL
SFLPSNNMEDPPRIESSDDRTYEHRLNHVVPPEPKCGYDVRDVINLVVDYGDFLEVQSEFARNLVVGFGRMRGATVGIVA
NQPSVLAGALDIDASDKGAGFVRFCNAFNIPLITFVDIPGFLPGVDQEYGGIIRHGAKLLFAYSAATVPKITVILRKAYG
GGYIAMCAKDLGADCTLAWPGSEIAVMGAEAAVEIVFHRELVEARDPAAARQELIQEYRETFYTPYEAAALRLVDDIIEP
ARTRGYLADALETLSTKRDWRPQKKHGLIPL

Sequences:

>Translated_511_residues
MSNTEKLELKREHLKLGGGAQRIEKQHQSGKLTARERVTLLADRDSFQEAGLFARHNGKHFGMNDKVLPADGVVTGRARV
HGRPVHLASQDFTVAGGSAGEVHANKIADTMKASMKTGTPFIFINDSGGARVQEGVSSLSGYAKIFHQNVMLSGVVPQIS
LICGPCAGGAAYSPALTDFIIQTRDGLIFITGPTVIKQVTGEMVTAQELGGARAQMNKSGVVHFVAENDVEAMQICKRLL
SFLPSNNMEDPPRIESSDDRTYEHRLNHVVPPEPKCGYDVRDVINLVVDYGDFLEVQSEFARNLVVGFGRMRGATVGIVA
NQPSVLAGALDIDASDKGAGFVRFCNAFNIPLITFVDIPGFLPGVDQEYGGIIRHGAKLLFAYSAATVPKITVILRKAYG
GGYIAMCAKDLGADCTLAWPGSEIAVMGAEAAVEIVFHRELVEARDPAAARQELIQEYRETFYTPYEAAALRLVDDIIEP
ARTRGYLADALETLSTKRDWRPQKKHGLIPL
>Mature_510_residues
SNTEKLELKREHLKLGGGAQRIEKQHQSGKLTARERVTLLADRDSFQEAGLFARHNGKHFGMNDKVLPADGVVTGRARVH
GRPVHLASQDFTVAGGSAGEVHANKIADTMKASMKTGTPFIFINDSGGARVQEGVSSLSGYAKIFHQNVMLSGVVPQISL
ICGPCAGGAAYSPALTDFIIQTRDGLIFITGPTVIKQVTGEMVTAQELGGARAQMNKSGVVHFVAENDVEAMQICKRLLS
FLPSNNMEDPPRIESSDDRTYEHRLNHVVPPEPKCGYDVRDVINLVVDYGDFLEVQSEFARNLVVGFGRMRGATVGIVAN
QPSVLAGALDIDASDKGAGFVRFCNAFNIPLITFVDIPGFLPGVDQEYGGIIRHGAKLLFAYSAATVPKITVILRKAYGG
GYIAMCAKDLGADCTLAWPGSEIAVMGAEAAVEIVFHRELVEARDPAAARQELIQEYRETFYTPYEAAALRLVDDIIEPA
RTRGYLADALETLSTKRDWRPQKKHGLIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=516, Percent_Identity=53.2945736434108, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI295821216, Length=536, Percent_Identity=51.3059701492537, Blast_Score=510, Evalue=1e-144,
Organism=Homo sapiens, GI11545863, Length=497, Percent_Identity=34.6076458752515, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI134142062, Length=407, Percent_Identity=25.0614250614251, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI38679974, Length=492, Percent_Identity=25.2032520325203, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI38679971, Length=492, Percent_Identity=25.2032520325203, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI38679960, Length=485, Percent_Identity=25.1546391752577, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI38679977, Length=492, Percent_Identity=25.2032520325203, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI38679967, Length=492, Percent_Identity=25.2032520325203, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1788655, Length=265, Percent_Identity=28.6792452830189, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=509, Percent_Identity=53.2416502946955, Blast_Score=533, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25147359, Length=509, Percent_Identity=53.2416502946955, Blast_Score=533, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17552936, Length=524, Percent_Identity=32.4427480916031, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71997163, Length=402, Percent_Identity=25.3731343283582, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323863, Length=280, Percent_Identity=25.3571428571429, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586065, Length=511, Percent_Identity=34.0508806262231, Blast_Score=241, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 55405; Mature: 55274

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTEKLELKREHLKLGGGAQRIEKQHQSGKLTARERVTLLADRDSFQEAGLFARHNGKH
CCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHEEEEEECCCCHHHCCCEEECCCCC
FGMNDKVLPADGVVTGRARVHGRPVHLASQDFTVAGGSAGEVHANKIADTMKASMKTGTP
CCCCCCCCCCCCEEECCCEECCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
FIFINDSGGARVQEGVSSLSGYAKIFHQNVMLSGVVPQISLICGPCAGGAAYSPALTDFI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHH
IQTRDGLIFITGPTVIKQVTGEMVTAQELGGARAQMNKSGVVHFVAENDVEAMQICKRLL
HCCCCCEEEEECHHHHHHHHCCHHHHHHHCCHHHHCCCCCEEEEEECCCHHHHHHHHHHH
SFLPSNNMEDPPRIESSDDRTYEHRLNHVVPPEPKCGYDVRDVINLVVDYGDFLEVQSEF
HHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
ARNLVVGFGRMRGATVGIVANQPSVLAGALDIDASDKGAGFVRFCNAFNIPLITFVDIPG
HHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHEECCCCCCCEEEEEECCC
FLPGVDQEYGGIIRHGAKLLFAYSAATVPKITVILRKAYGGGYIAMCAKDLGADCTLAWP
CCCCCCCHHHHHHHHCHHEEEEECCCCCCCEEEEEEHHCCCCEEEEEHHHCCCCEEEECC
GSEIAVMGAEAAVEIVFHRELVEARDPAAARQELIQEYRETFYTPYEAAALRLVDDIIEP
CCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ARTRGYLADALETLSTKRDWRPQKKHGLIPL
HHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
>Mature Secondary Structure 
SNTEKLELKREHLKLGGGAQRIEKQHQSGKLTARERVTLLADRDSFQEAGLFARHNGKH
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHEEEEEECCCCHHHCCCEEECCCCC
FGMNDKVLPADGVVTGRARVHGRPVHLASQDFTVAGGSAGEVHANKIADTMKASMKTGTP
CCCCCCCCCCCCEEECCCEECCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
FIFINDSGGARVQEGVSSLSGYAKIFHQNVMLSGVVPQISLICGPCAGGAAYSPALTDFI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHH
IQTRDGLIFITGPTVIKQVTGEMVTAQELGGARAQMNKSGVVHFVAENDVEAMQICKRLL
HCCCCCEEEEECHHHHHHHHCCHHHHHHHCCHHHHCCCCCEEEEEECCCHHHHHHHHHHH
SFLPSNNMEDPPRIESSDDRTYEHRLNHVVPPEPKCGYDVRDVINLVVDYGDFLEVQSEF
HHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
ARNLVVGFGRMRGATVGIVANQPSVLAGALDIDASDKGAGFVRFCNAFNIPLITFVDIPG
HHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHEECCCCCCCEEEEEECCC
FLPGVDQEYGGIIRHGAKLLFAYSAATVPKITVILRKAYGGGYIAMCAKDLGADCTLAWP
CCCCCCCHHHHHHHHCHHEEEEECCCCCCCEEEEEEHHCCCCEEEEEHHHCCCCEEEECC
GSEIAVMGAEAAVEIVFHRELVEARDPAAARQELIQEYRETFYTPYEAAALRLVDDIIEP
CCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ARTRGYLADALETLSTKRDWRPQKKHGLIPL
HHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]