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The map label for this gene is 116621365

Identifier: 116621365

GI number: 116621365

Start: 2870308

End: 2871204

Strand: Reverse

Name: 116621365

Synonym: Acid_2246

Alternate gene names: NA

Gene position: 2871204-2870308 (Counterclockwise)

Preceding gene: 116621366

Following gene: 116621364

Centisome position: 28.81

GC content: 58.75

Gene sequence:

>897_bases
ATGTCAAGCCATATGGAAATAACGCCAGTTAAGATTGGTAACAAACTGGTGGGCGATGGTTACCCAAGTTATATCATTGC
CGAGATTGGAATCAATCATAACGGAGATCTCGATTTGGCTCGGCGTCTCATCAGCGTCGCCGTGGCCGCCGGCTGTAATG
CGGTTAAGTTTCAAAAGCGAACTGTTGATATCGTCTATACCCCGGAGGAGCTGGCCAAACCGCGTGAGAATCCCTTCGGC
CCCACCAATGGCGATCTCAAGCGCGGCCTGGAATTCGGTCTGGAGGAATATAGGCTGATCGACCGCTACTGCCGCGAAGT
CAAAATGCCGTGGCTTTCCTCCTGCTGGGATGAGCCCTCGGTCGATTTCATGGAGCAGTTCGACCCTCCGTGTTACAAAA
TCGCCTCCGCCTGCCTGACCGATGACAACCTGCTGCGACATACCCGCTCCAAAGGCCGCTCCATTATCCTGTCAACCGGC
ATGAGCACGCTGGAAGAGATCGATCACGCGGTCGGTGTGATCGGCACGAAGGACCTCATCCTTCTTCACACCTGCGCCTG
CTACCCCGCGAACTATGTCGAACTGAACCTCCGCGCCATCACCACGCTGCGCGAGCGCTACGGCGTGCCGGTGGGTTATT
CCGGCCACGAAACCGGGCTGCCCTCGAGCGTCGCCGCGATCGCCTTGGGCGCCTGCTGCATAGAGCGGCACATCACCCTG
GACCGCGCCATGTGGGGCTCCGACCAGGCGGCGTCCCTGGAACCCAACGGCATCGGACGGCTGGTCAGCTATATCCGGCT
GGTGGAGCAATCGATGGGTGACGGACAAAAGACCGTAATCGAGCGCGAGAGGCCGATCATCCAGAAACTCCGCCGCATTG
GCGCCAAGGCCTCTTGA

Upstream 100 bases:

>100_bases
TAGTGTTACGGCGAAAGCCCTAGCTGTGATTAAATGTACGAATCTAGGCGTGTGACGGCCGTGACGCCGCGGGTCCACCT
GACTGGGGAGAACAATAAGA

Downstream 100 bases:

>100_bases
TGGCCGCGATCAAGGCGATTGCCTTGGATGTGGATGGCGTGCTCACCGACGGCGGAGTGTGGTGGGGACCCGACGGCGCG
GAGTGGAAGCGCTTTTGCTT

Product: N-acetylneuraminate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSSHMEITPVKIGNKLVGDGYPSYIIAEIGINHNGDLDLARRLISVAVAAGCNAVKFQKRTVDIVYTPEELAKPRENPFG
PTNGDLKRGLEFGLEEYRLIDRYCREVKMPWLSSCWDEPSVDFMEQFDPPCYKIASACLTDDNLLRHTRSKGRSIILSTG
MSTLEEIDHAVGVIGTKDLILLHTCACYPANYVELNLRAITTLRERYGVPVGYSGHETGLPSSVAAIALGACCIERHITL
DRAMWGSDQAASLEPNGIGRLVSYIRLVEQSMGDGQKTVIERERPIIQKLRRIGAKAS

Sequences:

>Translated_298_residues
MSSHMEITPVKIGNKLVGDGYPSYIIAEIGINHNGDLDLARRLISVAVAAGCNAVKFQKRTVDIVYTPEELAKPRENPFG
PTNGDLKRGLEFGLEEYRLIDRYCREVKMPWLSSCWDEPSVDFMEQFDPPCYKIASACLTDDNLLRHTRSKGRSIILSTG
MSTLEEIDHAVGVIGTKDLILLHTCACYPANYVELNLRAITTLRERYGVPVGYSGHETGLPSSVAAIALGACCIERHITL
DRAMWGSDQAASLEPNGIGRLVSYIRLVEQSMGDGQKTVIERERPIIQKLRRIGAKAS
>Mature_297_residues
SSHMEITPVKIGNKLVGDGYPSYIIAEIGINHNGDLDLARRLISVAVAAGCNAVKFQKRTVDIVYTPEELAKPRENPFGP
TNGDLKRGLEFGLEEYRLIDRYCREVKMPWLSSCWDEPSVDFMEQFDPPCYKIASACLTDDNLLRHTRSKGRSIILSTGM
STLEEIDHAVGVIGTKDLILLHTCACYPANYVELNLRAITTLRERYGVPVGYSGHETGLPSSVAAIALGACCIERHITLD
RAMWGSDQAASLEPNGIGRLVSYIRLVEQSMGDGQKTVIERERPIIQKLRRIGAKAS

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=295, Percent_Identity=36.9491525423729, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21357081, Length=248, Percent_Identity=36.2903225806452, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 32966; Mature: 32835

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHMEITPVKIGNKLVGDGYPSYIIAEIGINHNGDLDLARRLISVAVAAGCNAVKFQKR
CCCCCEEEEEECCCEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
TVDIVYTPEELAKPRENPFGPTNGDLKRGLEFGLEEYRLIDRYCREVKMPWLSSCWDEPS
EEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
VDFMEQFDPPCYKIASACLTDDNLLRHTRSKGRSIILSTGMSTLEEIDHAVGVIGTKDLI
HHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCHHH
LLHTCACYPANYVELNLRAITTLRERYGVPVGYSGHETGLPSSVAAIALGACCIERHITL
HHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
DRAMWGSDQAASLEPNGIGRLVSYIRLVEQSMGDGQKTVIERERPIIQKLRRIGAKAS
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSHMEITPVKIGNKLVGDGYPSYIIAEIGINHNGDLDLARRLISVAVAAGCNAVKFQKR
CCCCEEEEEECCCEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
TVDIVYTPEELAKPRENPFGPTNGDLKRGLEFGLEEYRLIDRYCREVKMPWLSSCWDEPS
EEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
VDFMEQFDPPCYKIASACLTDDNLLRHTRSKGRSIILSTGMSTLEEIDHAVGVIGTKDLI
HHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCHHH
LLHTCACYPANYVELNLRAITTLRERYGVPVGYSGHETGLPSSVAAIALGACCIERHITL
HHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
DRAMWGSDQAASLEPNGIGRLVSYIRLVEQSMGDGQKTVIERERPIIQKLRRIGAKAS
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]