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The map label for this gene is gmhA [H]

Identifier: 116621356

GI number: 116621356

Start: 2861297

End: 2861878

Strand: Reverse

Name: gmhA [H]

Synonym: Acid_2237

Alternate gene names: 116621356

Gene position: 2861878-2861297 (Counterclockwise)

Preceding gene: 116621357

Following gene: 116621355

Centisome position: 28.72

GC content: 58.59

Gene sequence:

>582_bases
ATGAGCTTTCCCCAAACCTATAAAGCGGACCTTCTTAAAGCCGTTGACACGATCGACCTGGCCCGGGTAGATGAGGCGAT
TCAGATTCTGAGCCAGGCCCGCGACGAGAATCGCCGTATCTTCGTCTGCGGCAACGGCGGCAGCGCTTCCACCGCCTCGC
ATTTCGTCTGCGATATGGTCAAAGGCGCCAGTTTCAACCGCGCCAGCCGCTTTCGCATCATGGCCCTCACGGATTCCCTG
CCCACCATCACCGCCTATTCCAATGACGTGAGCTATGAGTGCGTCTTCGTCGAACAGCTGAAGAACTTCGCCGAACCCGG
CGATGTCCTGATCGCGATCAGCGGATCCGGTAATTCGCCCAACGTTCTGCGCGCGGTCGAATATGCAAATTCCCTGGGAT
GCCGCACCATCGCCCTCTCCGGCCGCGACGGCGGCCGGCTGGCGCCGCTCGCCGGCCTGAACATTCAGGTCGCGCACCCG
CACATGGGCCGCATCGAAGATGGCCACATGGTAGTCATGCACATGATTTGCTACTACTTTATGGATCATGAAAAAGTGAA
TCAGGAAAAACTCGCGGGGTAG

Upstream 100 bases:

>100_bases
TTCTGCTTTACGGCCGCGAGCCCGGCGGCCACCGGGAAGAGCTGGACCCCGTACTTGACACATCGGCCGGCGCGAGTGCA
TCTTTGGAGTAACCACCACC

Downstream 100 bases:

>100_bases
GCTGGTCCCGCATGAGATTCATCAGCGTCGTCAGCGGGTGTTATAACGAGGAAGACAATATCCGCGAACTCTACGATAGG
GTCTGCCGGGTCATGGCCGA

Product: sugar isomerase (SIS)

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSFPQTYKADLLKAVDTIDLARVDEAIQILSQARDENRRIFVCGNGGSASTASHFVCDMVKGASFNRASRFRIMALTDSL
PTITAYSNDVSYECVFVEQLKNFAEPGDVLIAISGSGNSPNVLRAVEYANSLGCRTIALSGRDGGRLAPLAGLNIQVAHP
HMGRIEDGHMVVMHMICYYFMDHEKVNQEKLAG

Sequences:

>Translated_193_residues
MSFPQTYKADLLKAVDTIDLARVDEAIQILSQARDENRRIFVCGNGGSASTASHFVCDMVKGASFNRASRFRIMALTDSL
PTITAYSNDVSYECVFVEQLKNFAEPGDVLIAISGSGNSPNVLRAVEYANSLGCRTIALSGRDGGRLAPLAGLNIQVAHP
HMGRIEDGHMVVMHMICYYFMDHEKVNQEKLAG
>Mature_192_residues
SFPQTYKADLLKAVDTIDLARVDEAIQILSQARDENRRIFVCGNGGSASTASHFVCDMVKGASFNRASRFRIMALTDSLP
TITAYSNDVSYECVFVEQLKNFAEPGDVLIAISGSGNSPNVLRAVEYANSLGCRTIALSGRDGGRLAPLAGLNIQVAHPH
MGRIEDGHMVVMHMICYYFMDHEKVNQEKLAG

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate [H]

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1789539, Length=158, Percent_Identity=34.8101265822785, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786416, Length=171, Percent_Identity=32.7485380116959, Blast_Score=90, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020620
- InterPro:   IPR001347 [H]

Pfam domain/function: PF01380 SIS [H]

EC number: =5.3.1.28 [H]

Molecular weight: Translated: 21075; Mature: 20944

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPQTYKADLLKAVDTIDLARVDEAIQILSQARDENRRIFVCGNGGSASTASHFVCDMV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHH
KGASFNRASRFRIMALTDSLPTITAYSNDVSYECVFVEQLKNFAEPGDVLIAISGSGNSP
CCCCCCCCCEEEEEEEECCCCEEEEECCCCCEEEEEHHHHHHHCCCCCEEEEEECCCCCC
NVLRAVEYANSLGCRTIALSGRDGGRLAPLAGLNIQVAHPHMGRIEDGHMVVMHMICYYF
HHHHHHHHHCCCCCEEEEEECCCCCEECEEECCEEEEECCCCCCCCCCCHHHHHHHHHHH
MDHEKVNQEKLAG
HCCHHCCHHHCCC
>Mature Secondary Structure 
SFPQTYKADLLKAVDTIDLARVDEAIQILSQARDENRRIFVCGNGGSASTASHFVCDMV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHH
KGASFNRASRFRIMALTDSLPTITAYSNDVSYECVFVEQLKNFAEPGDVLIAISGSGNSP
CCCCCCCCCEEEEEEEECCCCEEEEECCCCCEEEEEHHHHHHHCCCCCEEEEEECCCCCC
NVLRAVEYANSLGCRTIALSGRDGGRLAPLAGLNIQVAHPHMGRIEDGHMVVMHMICYYF
HHHHHHHHHCCCCCEEEEEECCCCCEECEEECCEEEEECCCCCCCCCCCHHHHHHHHHHH
MDHEKVNQEKLAG
HCCHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11121031 [H]