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The map label for this gene is lytS [H]

Identifier: 116621300

GI number: 116621300

Start: 2793580

End: 2794890

Strand: Reverse

Name: lytS [H]

Synonym: Acid_2181

Alternate gene names: 116621300

Gene position: 2794890-2793580 (Counterclockwise)

Preceding gene: 116621302

Following gene: 116621299

Centisome position: 28.05

GC content: 59.12

Gene sequence:

>1311_bases
ATGCTCGAAAGCTATTTTCCGCTGCTGGTCAAACTCGGTGCGATGGCCTCCATCGCGAGCGTGCTGGCACGGTCGAACAG
CTTCAAGAGCCTCTTGATGCAGGAGACGCGCACGCTCAATCAGCGGGTGGCGCTGTCGCTCTGGCTTTCCAGCGCGTTCG
CCGCGAGCGTTGCGGTCCGGGTCTTCAGCAAGAGCTATCCGGCGGCGGATCTCGGACTGGAAGGCGCGCTGATCGCCGGG
ATTCTGGGCGGGTATGTCACCGGGCTTTTCTCCGGGGTGCTGATTTCCGTGCCGGCCATGCTCAACCCGTCGGGTGCTCA
ATTGCTGACCATGCCGCTGCTCGCCGCTGTCGGTGTCCTGGGCGGGGTTCTGCGCGACCTGGCGCCCAGTCCGGAGGAGA
TCTGGCGCTTCACGCCATTTTTCGATCTCAATGTCTACCGTTTTTTCAAGGAGAGCCGCAATCACCGGCGCACGGCTTTC
CACCTGGAATTTTCGGCGGGCATTCTGGCCGCGGAATTCCTGCGCCAGCGGCTCGACGGATTCTTCTCAGGCCGAATTTT
TTCCCTGACGCCCGAGGGCACTCATCCGCAGCCCTGGACGCTGGCCGCAATCTATGCATCCACGCTTTTCGCGGTGGCCA
TCCCGCTGAAGATTTGGAACAACACGCGGAATGAAAAGAAGCTCGAAGAGCAGGAGCGCCTGCTGGCAGAAGCACGGCTG
GCCGCGCTTACCAGCCAGATCAATCCGCACTTTCTGTTCAACACGCTGAACTCGGTCTCATCCCTGATTCGTACCGATCC
GAACCAGGCGCGGGTCATGGTAGTGCGGCTGAGTAAGGTACTGCGCCGTTTGCTACGCCAACACGAGCATTTCAGCCCAC
TGCGCGACGAATTGAGTTTCATCGAGGACTATCTTGCAATTGAGGTGGTTCGTTTTGGAGAGAAGCTGCGTTTCGAACGC
GATGTGGCCGAAGATACCCTCGACATGCTGGTACCCAGCATGCTATTGCAACCGCTGGTGGAAAATTCCATCAAGCACGG
TTTAAGTACAAAGGTGGAGGGCGGTACAATCCGGATTCGTACTTATCGCACTGAGAACAGACTCCACCTCATGGTGGAGG
ACGACGGGGTCGGTATCCCGGATGAAAAACTCGCGACCCTGCTGGACCGCGGAATCGGCGTCAACAACGTGCATGAGCGC
CTGAGGGTCCTGTTCGGCAACGAGTACCGGATGTGGATCGAGAGCCAGCCGGGGAACGGCGTTCGTATCCAGATCGAAGT
GCCGGAACTGCAGACGGCGGTAACGGTTTAA

Upstream 100 bases:

>100_bases
TTCCGCTTCAGCTACTTTTTTGAGCCGCGGAACGGCTGGTTTGTTCATGCGTTAACTATGTGAAGCTTAATGCTTTTATT
ATAATGGCTTCCGAGACCGA

Downstream 100 bases:

>100_bases
GGAGATTTTTTTGAACAGACTCGAAGAATCTGTGAGTGCCTGGCCGGTCAATGGCCTGCCGGCTACTTTGGCCGGGCGCA
CCCGCCGTGTCTATGACCGG

Product: signal transduction histidine kinase LytS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MLESYFPLLVKLGAMASIASVLARSNSFKSLLMQETRTLNQRVALSLWLSSAFAASVAVRVFSKSYPAADLGLEGALIAG
ILGGYVTGLFSGVLISVPAMLNPSGAQLLTMPLLAAVGVLGGVLRDLAPSPEEIWRFTPFFDLNVYRFFKESRNHRRTAF
HLEFSAGILAAEFLRQRLDGFFSGRIFSLTPEGTHPQPWTLAAIYASTLFAVAIPLKIWNNTRNEKKLEEQERLLAEARL
AALTSQINPHFLFNTLNSVSSLIRTDPNQARVMVVRLSKVLRRLLRQHEHFSPLRDELSFIEDYLAIEVVRFGEKLRFER
DVAEDTLDMLVPSMLLQPLVENSIKHGLSTKVEGGTIRIRTYRTENRLHLMVEDDGVGIPDEKLATLLDRGIGVNNVHER
LRVLFGNEYRMWIESQPGNGVRIQIEVPELQTAVTV

Sequences:

>Translated_436_residues
MLESYFPLLVKLGAMASIASVLARSNSFKSLLMQETRTLNQRVALSLWLSSAFAASVAVRVFSKSYPAADLGLEGALIAG
ILGGYVTGLFSGVLISVPAMLNPSGAQLLTMPLLAAVGVLGGVLRDLAPSPEEIWRFTPFFDLNVYRFFKESRNHRRTAF
HLEFSAGILAAEFLRQRLDGFFSGRIFSLTPEGTHPQPWTLAAIYASTLFAVAIPLKIWNNTRNEKKLEEQERLLAEARL
AALTSQINPHFLFNTLNSVSSLIRTDPNQARVMVVRLSKVLRRLLRQHEHFSPLRDELSFIEDYLAIEVVRFGEKLRFER
DVAEDTLDMLVPSMLLQPLVENSIKHGLSTKVEGGTIRIRTYRTENRLHLMVEDDGVGIPDEKLATLLDRGIGVNNVHER
LRVLFGNEYRMWIESQPGNGVRIQIEVPELQTAVTV
>Mature_436_residues
MLESYFPLLVKLGAMASIASVLARSNSFKSLLMQETRTLNQRVALSLWLSSAFAASVAVRVFSKSYPAADLGLEGALIAG
ILGGYVTGLFSGVLISVPAMLNPSGAQLLTMPLLAAVGVLGGVLRDLAPSPEEIWRFTPFFDLNVYRFFKESRNHRRTAF
HLEFSAGILAAEFLRQRLDGFFSGRIFSLTPEGTHPQPWTLAAIYASTLFAVAIPLKIWNNTRNEKKLEEQERLLAEARL
AALTSQINPHFLFNTLNSVSSLIRTDPNQARVMVVRLSKVLRRLLRQHEHFSPLRDELSFIEDYLAIEVVRFGEKLRFER
DVAEDTLDMLVPSMLLQPLVENSIKHGLSTKVEGGTIRIRTYRTENRLHLMVEDDGVGIPDEKLATLLDRGIGVNNVHER
LRVLFGNEYRMWIESQPGNGVRIQIEVPELQTAVTV

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=223, Percent_Identity=39.0134529147982, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1788446, Length=203, Percent_Identity=34.4827586206897, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48826; Mature: 48826

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLESYFPLLVKLGAMASIASVLARSNSFKSLLMQETRTLNQRVALSLWLSSAFAASVAVR
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFSKSYPAADLGLEGALIAGILGGYVTGLFSGVLISVPAMLNPSGAQLLTMPLLAAVGVL
HHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
GGVLRDLAPSPEEIWRFTPFFDLNVYRFFKESRNHRRTAFHLEFSAGILAAEFLRQRLDG
HHHHHHCCCCHHHHHEECCCEEHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHH
FFSGRIFSLTPEGTHPQPWTLAAIYASTLFAVAIPLKIWNNTRNEKKLEEQERLLAEARL
HHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AALTSQINPHFLFNTLNSVSSLIRTDPNQARVMVVRLSKVLRRLLRQHEHFSPLRDELSF
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IEDYLAIEVVRFGEKLRFERDVAEDTLDMLVPSMLLQPLVENSIKHGLSTKVEGGTIRIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
TYRTENRLHLMVEDDGVGIPDEKLATLLDRGIGVNNVHERLRVLFGNEYRMWIESQPGNG
EEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
VRIQIEVPELQTAVTV
EEEEEECCCCHHHCCC
>Mature Secondary Structure
MLESYFPLLVKLGAMASIASVLARSNSFKSLLMQETRTLNQRVALSLWLSSAFAASVAVR
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFSKSYPAADLGLEGALIAGILGGYVTGLFSGVLISVPAMLNPSGAQLLTMPLLAAVGVL
HHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
GGVLRDLAPSPEEIWRFTPFFDLNVYRFFKESRNHRRTAFHLEFSAGILAAEFLRQRLDG
HHHHHHCCCCHHHHHEECCCEEHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHH
FFSGRIFSLTPEGTHPQPWTLAAIYASTLFAVAIPLKIWNNTRNEKKLEEQERLLAEARL
HHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AALTSQINPHFLFNTLNSVSSLIRTDPNQARVMVVRLSKVLRRLLRQHEHFSPLRDELSF
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IEDYLAIEVVRFGEKLRFERDVAEDTLDMLVPSMLLQPLVENSIKHGLSTKVEGGTIRIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
TYRTENRLHLMVEDDGVGIPDEKLATLLDRGIGVNNVHERLRVLFGNEYRMWIESQPGNG
EEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
VRIQIEVPELQTAVTV
EEEEEECCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]