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The map label for this gene is dtxR [H]

Identifier: 116621297

GI number: 116621297

Start: 2791043

End: 2791699

Strand: Reverse

Name: dtxR [H]

Synonym: Acid_2178

Alternate gene names: 116621297

Gene position: 2791699-2791043 (Counterclockwise)

Preceding gene: 116621298

Following gene: 116621292

Centisome position: 28.01

GC content: 66.06

Gene sequence:

>657_bases
TTGCCTCCGCGAATCACAATTTCCAAGGAAAACTACCTGAAGGCCATCGCCGAGGCCGAGAGCGAAGGCGAGACGGTCAA
AGCGGTGACGCTGGCGCGGTGGCTGCATGTTTCCGCGCCCGCGGTCACGATGGCGATCAAACGGCTGCGCCGCGACGCGC
TGATCCACGTGGCGGCCGAAGGCCAACTGAGCCTGACGGCGCCAGGCCGCGAGATCGCCAACCGGCTGCTCAACCGTCAC
CACCTGATCGAGCGCATGCTGACCGAGATATTTGGGCTCGAATGGTACAAGGTGCACGACGAGGCAGAGCAATTGGAACA
CGCCGTCTCGGCTGATTTCGAGCGCAAGCTGATCGAACGGCTGGGCGTGGAATCGGAGTGTCCGCACGGCAACCGGGTGG
GCATGGACTCTCCGGGCGACCGGCGGCGTCGCGGGCTTAAGACGCTGGATGAGACCGCACCGGGCGAGCGCGTGGCTGTG
GTCAGCGTGTTCGAGCGCGATCGGGAGCTACTGGAGCACCTGGACAGCGTCGGTATTCGGCCGGGCGTTGAGCTCGAGGT
ACTGGCGGACGGGGCGGAACTGGAGTTGTCGGCGGCGGGGGAGCGGTTCACGCTGGATCGTACTTCGGCGGCGCGGGTGT
GGGTCGCGCGGGGATGA

Upstream 100 bases:

>100_bases
ACGCTGGAAGGTGAAAGCTCCACCGCCGAACTGCAGAAAATCGATGAACGCACGTTCTGGTTCGACGGCAGAGTGTTCGA
GGAAATGTAGGTTTCTGCGA

Downstream 100 bases:

>100_bases
GGAGATCGTGTTGGTGCGGGGCAAGCCGGCTGAAAGCCGGCTGCAGCCAGGATTGGCTGCCCCACGGTGCGGCGAACCGC
AAATTGAAATCGTGGTTTAC

Product: DtxR family iron dependent repressor

Products: NA

Alternate protein names: Iron-dependent diphtheria tox regulatory element; Tox regulatory factor [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MPPRITISKENYLKAIAEAESEGETVKAVTLARWLHVSAPAVTMAIKRLRRDALIHVAAEGQLSLTAPGREIANRLLNRH
HLIERMLTEIFGLEWYKVHDEAEQLEHAVSADFERKLIERLGVESECPHGNRVGMDSPGDRRRRGLKTLDETAPGERVAV
VSVFERDRELLEHLDSVGIRPGVELEVLADGAELELSAAGERFTLDRTSAARVWVARG

Sequences:

>Translated_218_residues
MPPRITISKENYLKAIAEAESEGETVKAVTLARWLHVSAPAVTMAIKRLRRDALIHVAAEGQLSLTAPGREIANRLLNRH
HLIERMLTEIFGLEWYKVHDEAEQLEHAVSADFERKLIERLGVESECPHGNRVGMDSPGDRRRRGLKTLDETAPGERVAV
VSVFERDRELLEHLDSVGIRPGVELEVLADGAELELSAAGERFTLDRTSAARVWVARG
>Mature_217_residues
PPRITISKENYLKAIAEAESEGETVKAVTLARWLHVSAPAVTMAIKRLRRDALIHVAAEGQLSLTAPGREIANRLLNRHH
LIERMLTEIFGLEWYKVHDEAEQLEHAVSADFERKLIERLGVESECPHGNRVGMDSPGDRRRRGLKTLDETAPGERVAVV
SVFERDRELLEHLDSVGIRPGVELEVLADGAELELSAAGERFTLDRTSAARVWVARG

Specific function: Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess [H]

COG id: COG1321

COG function: function code K; Mn-dependent transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH dtxR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007167
- InterPro:   IPR001367
- InterPro:   IPR022689
- InterPro:   IPR022687
- InterPro:   IPR008988
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02742 Fe_dep_repr_C; PF01325 Fe_dep_repress; PF04023 FeoA [H]

EC number: NA

Molecular weight: Translated: 24336; Mature: 24205

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50944 HTH_DTXR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPRITISKENYLKAIAEAESEGETVKAVTLARWLHVSAPAVTMAIKRLRRDALIHVAAE
CCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECC
GQLSLTAPGREIANRLLNRHHLIERMLTEIFGLEWYKVHDEAEQLEHAVSADFERKLIER
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHCCHHHHHHHHH
LGVESECPHGNRVGMDSPGDRRRRGLKTLDETAPGERVAVVSVFERDRELLEHLDSVGIR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCC
PGVELEVLADGAELELSAAGERFTLDRTSAARVWVARG
CCCEEEEEECCCEEEEECCCCEEEEECCCCCEEEEECC
>Mature Secondary Structure 
PPRITISKENYLKAIAEAESEGETVKAVTLARWLHVSAPAVTMAIKRLRRDALIHVAAE
CCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECC
GQLSLTAPGREIANRLLNRHHLIERMLTEIFGLEWYKVHDEAEQLEHAVSADFERKLIER
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHCCHHHHHHHHH
LGVESECPHGNRVGMDSPGDRRRRGLKTLDETAPGERVAVVSVFERDRELLEHLDSVGIR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCC
PGVELEVLADGAELELSAAGERFTLDRTSAARVWVARG
CCCEEEEEECCCEEEEECCCCEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]