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The map label for this gene is exuT [H]

Identifier: 116621236

GI number: 116621236

Start: 2706765

End: 2707961

Strand: Direct

Name: exuT [H]

Synonym: Acid_2117

Alternate gene names: 116621236

Gene position: 2706765-2707961 (Clockwise)

Preceding gene: 116621235

Following gene: 116621237

Centisome position: 27.16

GC content: 66.25

Gene sequence:

>1197_bases
GTGAGCCATTCCACTGGCGCCACCCACTACCGATGGCTGGTGCTCGGGATCTTCGTCCTCTCCACCGCGATCAACATTCT
GGACCGAGCCACGCTCTCCGCGCTTGCGCCCGTGATCAAACAGGAATTTTCGCTCAACAATGAGCAGTTCGGTTGGATCA
CCAGCGCCTTCAGCCTCACCTATGCGGCTGCCGCCCCCTTCGCCGGCCTGCTCATCGATCGCCTGGGCTTGAATCGCGTG
ATCAGCTTCGCTGTCGGTCTATGGAGCTGCGCCGGGATCGCCACCGGCTTCACCAGCGGACTGGGAGGTCTCGTGGGTTG
CCGCGCCGTGCTCGGTGTCGCCGAAGCTGCGGGCATTCCGGCTGCCGGCAAGGCCATCCATAAATACCTGCTGCCGGGTG
AACGCGCCCTCGGCAACGGTGTCAATCAGGGCGGCGTCAGCCTCGGGCAAATCGTCGCTCCCGTGTTGGCTACCTTCATG
GCCGTGCACTATGGCTGGAGGCAGGCCTTCATCGTCACCGGCGCGCTCGGCCTCGCCTGGATCCCGCTGTGGAATTGGGC
CGCCCGCCGTGCCCCCGCGGCCGATCCGCCGAAGCAACAGGCCGGCGCATCCGCCGCCATGCTGCGCGATCGCCGCCTCT
GGATTTTCGTGGTGGCCAATGCGCTAAGCATGGTGGGCTACTACCTATGGTTCAGCTGGACTACGCTCTACATGGTGGAC
GCGCGCGGCCTCACGCTTCAGCAGGCCGTCCGGTACGTGTGGATTCCGCCGGTGTTTGCCGCTGTCGGAGGCTTCGTCGG
CGGCTGGCTCTCGCTCCGCTCCATCGCGCGCGGACTGCCTGCGCCCGCGGCGCGCTTCCGCGTTTGCCTGGCCGCCAGCG
TTATCGCGGTTGCCACGGCGGCGATTCCGTGGCTGCCTTCCCCCGCCTGGGCCTCGGCCGGAATCTCGCTCAGCATTCTC
GCCGTCGCCGCCTTCAGCGTCAACATGTATACCCTGCCGCTCGACGTCTTCGGCGCCGCGCCTGCCGGCTTCGCCATCGC
TGCCCTGGTCTCGAGTTACGGCTTCATTGCTGCCATCGTCGCCCCCATCATCGGCAAAATCATTGACCATCAGGGCTACA
CGCCCGTGATCGTCGCCGTCGCCTTCACTCCCCTGGCGGCATCCGCCGTGCTCTGGTTCTCGAGGTCCACGCGATGA

Upstream 100 bases:

>100_bases
GTTGTGGCGTGCAGAAGGCACGCAAAATCACGGTCGAGTATTTCGCGAAGGTGAATTCCAAACTGGCCACCGCTGGTGAA
GTGGCAACCATCGATTTCCA

Downstream 100 bases:

>100_bases
AGGAGTGGATCTTCCGCCTGCTCGGAAAAGGGCCCGAAGCAGTGGTGGTGGTCTTCTGCACCGGCGACCCGGATCTCTGC
GCCCGCATGGTGGAAGAGGT

Product: major facilitator transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSHSTGATHYRWLVLGIFVLSTAINILDRATLSALAPVIKQEFSLNNEQFGWITSAFSLTYAAAAPFAGLLIDRLGLNRV
ISFAVGLWSCAGIATGFTSGLGGLVGCRAVLGVAEAAGIPAAGKAIHKYLLPGERALGNGVNQGGVSLGQIVAPVLATFM
AVHYGWRQAFIVTGALGLAWIPLWNWAARRAPAADPPKQQAGASAAMLRDRRLWIFVVANALSMVGYYLWFSWTTLYMVD
ARGLTLQQAVRYVWIPPVFAAVGGFVGGWLSLRSIARGLPAPAARFRVCLAASVIAVATAAIPWLPSPAWASAGISLSIL
AVAAFSVNMYTLPLDVFGAAPAGFAIAALVSSYGFIAAIVAPIIGKIIDHQGYTPVIVAVAFTPLAASAVLWFSRSTR

Sequences:

>Translated_398_residues
MSHSTGATHYRWLVLGIFVLSTAINILDRATLSALAPVIKQEFSLNNEQFGWITSAFSLTYAAAAPFAGLLIDRLGLNRV
ISFAVGLWSCAGIATGFTSGLGGLVGCRAVLGVAEAAGIPAAGKAIHKYLLPGERALGNGVNQGGVSLGQIVAPVLATFM
AVHYGWRQAFIVTGALGLAWIPLWNWAARRAPAADPPKQQAGASAAMLRDRRLWIFVVANALSMVGYYLWFSWTTLYMVD
ARGLTLQQAVRYVWIPPVFAAVGGFVGGWLSLRSIARGLPAPAARFRVCLAASVIAVATAAIPWLPSPAWASAGISLSIL
AVAAFSVNMYTLPLDVFGAAPAGFAIAALVSSYGFIAAIVAPIIGKIIDHQGYTPVIVAVAFTPLAASAVLWFSRSTR
>Mature_397_residues
SHSTGATHYRWLVLGIFVLSTAINILDRATLSALAPVIKQEFSLNNEQFGWITSAFSLTYAAAAPFAGLLIDRLGLNRVI
SFAVGLWSCAGIATGFTSGLGGLVGCRAVLGVAEAAGIPAAGKAIHKYLLPGERALGNGVNQGGVSLGQIVAPVLATFMA
VHYGWRQAFIVTGALGLAWIPLWNWAARRAPAADPPKQQAGASAAMLRDRRLWIFVVANALSMVGYYLWFSWTTLYMVDA
RGLTLQQAVRYVWIPPVFAAVGGFVGGWLSLRSIARGLPAPAARFRVCLAASVIAVATAAIPWLPSPAWASAGISLSILA
VAAFSVNMYTLPLDVFGAAPAGFAIAALVSSYGFIAAIVAPIIGKIIDHQGYTPVIVAVAFTPLAASAVLWFSRSTR

Specific function: Aldohexuronate transport system [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI256219543, Length=286, Percent_Identity=22.3776223776224, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI256219598, Length=286, Percent_Identity=22.3776223776224, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4503847, Length=286, Percent_Identity=22.3776223776224, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI256219483, Length=286, Percent_Identity=22.3776223776224, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI2367193, Length=402, Percent_Identity=26.865671641791, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI87082320, Length=310, Percent_Identity=27.4193548387097, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI2367379, Length=420, Percent_Identity=24.7619047619048, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789515, Length=320, Percent_Identity=23.125, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789152, Length=404, Percent_Identity=23.5148514851485, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560030, Length=258, Percent_Identity=21.7054263565891, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41798; Mature: 41667

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SHSTGATHYRWLVLGIFVLSTAINILDRATLSALAPVIKQEFSLNNEQFGWITSAFSLT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH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HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]