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The map label for this gene is hipA [C]

Identifier: 116621180

GI number: 116621180

Start: 2618190

End: 2619452

Strand: Reverse

Name: hipA [C]

Synonym: Acid_2061

Alternate gene names: 116621180

Gene position: 2619452-2618190 (Counterclockwise)

Preceding gene: 116621181

Following gene: 116621175

Centisome position: 26.28

GC content: 62.47

Gene sequence:

>1263_bases
ATGGCCCGCATGCTTGACGTCTACCTGCACACCGACCTCGCCGGGCATCTTACTCAGGACGATGACGGCGACATGAGCTT
TCAGTACGCCGAAAGCTGGCTGCACAAGCCAGGCGCCGGCCCGCTGTCGCATTCCTTGCCGCTCCGCCCCGAGCGGTTCC
GCCGCAAGCAATGCCGCGGGTATTTCGCCGGAATCCTGCCGGAAGAGAGCAAGCGTGAAATGATCGCGCGCAACCTGGGA
ATTAGCGCGCGCAACGATTACGCCATGCTGGAGCGCATCGGCGGGGAATGCGCCGGTGCCGTAACCTTCCTGCCGCACGG
CGAACCGATGCCAGACCGGCACTATGGATATCGCCGGCTGTCCGAAGAAGAACTTGCAGCCATTCTGAAAGAGCTTCCCC
GCCGGCCGCTCCTGGCCGGAGACGAGGGCATCCGGCTCTCGCTCGCGGGCGCCCAGGACAAACTCGCCGTCCGCCTCGAA
GACAGAACCATCAGCCTGCCACTCGGCGGCGCTCCGAGCACTCACATCCTCAAGCCGAATGTGGAGCGGTTCGAAGGCGT
GGTGTTCAACGAAGCCTTTTGCATGCGGCTGGCGGCCGCCGCAGGCCTGCCGGCGGCCGCCATCGAGACACACGAGATCG
GCGGCATCAGTTTTCTGCTGGTCGAACGCTACGACCGTCATCATCGGCCCCTGCCAGACGGAGCACCGGCGATCGAGCGG
CTGCACCAGGAAGACTTCTGCCAAGCCCTTGGTATCGTCTCCGAGCAGAAGTACCAGAAGGAGGGCGGGCCGTCCCTGAA
GCAGTGCTTTGCCCTCTTGCGAGATGTGTCGAGTGTCCCGGCGATCGACGTCGCCCGCCTGCTCGATGATGTCCTTTTCA
ATTACATCGTCGGCAATAACGATGCCCACGGCAAGAACTTTTCGCTGGTCTATCGAGCCGGCGGCGCCGGCGAACTCGAG
ATACGACTTTCGCCGCTTTACGATGTGGTCGGTACCATCTATTACCCCGAACTGAGCCGCGACATGGCCATGCGCATCGG
CGACCAGTATTCCTCCGAAAAAGTCACGCGGCGCGATTTCGAGAAACTTGCCGAGGATGCCAAGCTTGGAAGACCGCTCG
TGAGAGACCGGTTGATAGAAGTGACAGAGCGCGTGCGGGCTGCTCTCCCGAACGTGCCCGCTACCAATCCCGTTGCGGAA
CAGATGCGAGATCTGATCCGAACCCGGTCGGAGAAGGCCCTCACCGAGTTTCGCGGTCGCTGA

Upstream 100 bases:

>100_bases
GAAACCTGTGAAGTCGGCAAGGTGCTGACCGTTCTCCACACGCTCGGCATCAAGATGACGCTCACGCCACCCGCAGCGAC
CGCGCAGGAAGGATCAGGCG

Downstream 100 bases:

>100_bases
CGCATATCGGTCTTTCGAACTCTTCAGAAGGTTGGACATCGGGTCGGCCCACACCCAGCTTCCCAGCAGCGGTTGAACGA
CTTCTCGCGGGCCGCGCACC

Product: HipA domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MARMLDVYLHTDLAGHLTQDDDGDMSFQYAESWLHKPGAGPLSHSLPLRPERFRRKQCRGYFAGILPEESKREMIARNLG
ISARNDYAMLERIGGECAGAVTFLPHGEPMPDRHYGYRRLSEEELAAILKELPRRPLLAGDEGIRLSLAGAQDKLAVRLE
DRTISLPLGGAPSTHILKPNVERFEGVVFNEAFCMRLAAAAGLPAAAIETHEIGGISFLLVERYDRHHRPLPDGAPAIER
LHQEDFCQALGIVSEQKYQKEGGPSLKQCFALLRDVSSVPAIDVARLLDDVLFNYIVGNNDAHGKNFSLVYRAGGAGELE
IRLSPLYDVVGTIYYPELSRDMAMRIGDQYSSEKVTRRDFEKLAEDAKLGRPLVRDRLIEVTERVRAALPNVPATNPVAE
QMRDLIRTRSEKALTEFRGR

Sequences:

>Translated_420_residues
MARMLDVYLHTDLAGHLTQDDDGDMSFQYAESWLHKPGAGPLSHSLPLRPERFRRKQCRGYFAGILPEESKREMIARNLG
ISARNDYAMLERIGGECAGAVTFLPHGEPMPDRHYGYRRLSEEELAAILKELPRRPLLAGDEGIRLSLAGAQDKLAVRLE
DRTISLPLGGAPSTHILKPNVERFEGVVFNEAFCMRLAAAAGLPAAAIETHEIGGISFLLVERYDRHHRPLPDGAPAIER
LHQEDFCQALGIVSEQKYQKEGGPSLKQCFALLRDVSSVPAIDVARLLDDVLFNYIVGNNDAHGKNFSLVYRAGGAGELE
IRLSPLYDVVGTIYYPELSRDMAMRIGDQYSSEKVTRRDFEKLAEDAKLGRPLVRDRLIEVTERVRAALPNVPATNPVAE
QMRDLIRTRSEKALTEFRGR
>Mature_419_residues
ARMLDVYLHTDLAGHLTQDDDGDMSFQYAESWLHKPGAGPLSHSLPLRPERFRRKQCRGYFAGILPEESKREMIARNLGI
SARNDYAMLERIGGECAGAVTFLPHGEPMPDRHYGYRRLSEEELAAILKELPRRPLLAGDEGIRLSLAGAQDKLAVRLED
RTISLPLGGAPSTHILKPNVERFEGVVFNEAFCMRLAAAAGLPAAAIETHEIGGISFLLVERYDRHHRPLPDGAPAIERL
HQEDFCQALGIVSEQKYQKEGGPSLKQCFALLRDVSSVPAIDVARLLDDVLFNYIVGNNDAHGKNFSLVYRAGGAGELEI
RLSPLYDVVGTIYYPELSRDMAMRIGDQYSSEKVTRRDFEKLAEDAKLGRPLVRDRLIEVTERVRAALPNVPATNPVAEQ
MRDLIRTRSEKALTEFRGR

Specific function: Unbalanced Or Excessive Expression Of Hipa Is Toxic To The Cell. [C]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli hipA, H.influenzae HI_0665 and y4dM [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=418, Percent_Identity=29.4258373205742, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 46936; Mature: 46805

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARMLDVYLHTDLAGHLTQDDDGDMSFQYAESWLHKPGAGPLSHSLPLRPERFRRKQCRG
CCCCEEEHHHHCHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
YFAGILPEESKREMIARNLGISARNDYAMLERIGGECAGAVTFLPHGEPMPDRHYGYRRL
HHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHC
SEEELAAILKELPRRPLLAGDEGIRLSLAGAQDKLAVRLEDRTISLPLGGAPSTHILKPN
CHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEEECCEEEEECCCCCCCCEECCC
VERFEGVVFNEAFCMRLAAAAGLPAAAIETHEIGGISFLLVERYDRHHRPLPDGAPAIER
HHHHCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHH
LHQEDFCQALGIVSEQKYQKEGGPSLKQCFALLRDVSSVPAIDVARLLDDVLFNYIVGNN
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
DAHGKNFSLVYRAGGAGELEIRLSPLYDVVGTIYYPELSRDMAMRIGDQYSSEKVTRRDF
CCCCCCEEEEEECCCCCEEEEEECHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHH
EKLAEDAKLGRPLVRDRLIEVTERVRAALPNVPATNPVAEQMRDLIRTRSEKALTEFRGR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARMLDVYLHTDLAGHLTQDDDGDMSFQYAESWLHKPGAGPLSHSLPLRPERFRRKQCRG
CCCEEEHHHHCHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
YFAGILPEESKREMIARNLGISARNDYAMLERIGGECAGAVTFLPHGEPMPDRHYGYRRL
HHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHC
SEEELAAILKELPRRPLLAGDEGIRLSLAGAQDKLAVRLEDRTISLPLGGAPSTHILKPN
CHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEEECCEEEEECCCCCCCCEECCC
VERFEGVVFNEAFCMRLAAAAGLPAAAIETHEIGGISFLLVERYDRHHRPLPDGAPAIER
HHHHCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHH
LHQEDFCQALGIVSEQKYQKEGGPSLKQCFALLRDVSSVPAIDVARLLDDVLFNYIVGNN
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
DAHGKNFSLVYRAGGAGELEIRLSPLYDVVGTIYYPELSRDMAMRIGDQYSSEKVTRRDF
CCCCCCEEEEEECCCCCEEEEEECHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHH
EKLAEDAKLGRPLVRDRLIEVTERVRAALPNVPATNPVAEQMRDLIRTRSEKALTEFRGR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]