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The map label for this gene is mhpC [C]

Identifier: 116621095

GI number: 116621095

Start: 2496221

End: 2497084

Strand: Direct

Name: mhpC [C]

Synonym: Acid_1976

Alternate gene names: 116621095

Gene position: 2496221-2497084 (Clockwise)

Preceding gene: 116621094

Following gene: 116621096

Centisome position: 25.05

GC content: 58.91

Gene sequence:

>864_bases
ATGGATAAAGCACAGGCTAACGGAGTTCAATTGCACTACCAACAGTTCGGCGAGGGGCCGCCCGTCGTAATGGTCCACGG
CATCACCGGAAACCTCGCCATCTGGCATTTGGAAATCGTGCCCGGACTGATGTCCGACTTTCGCATTACCACTTATGATT
TACGCGGGCATGGCTATAGCGACGTCCCGCCCACCGGCTATACCACCGCCGACCATGCGATGGACCTGAAGCATCTGTTG
GAGACGCTGGGCATTGAACGCGCGCATGTCATGGGACATAGTTTCGGCGCGGATATCGCCCTGCATTTCACCATTCTTTT
CCCCGAGCGGGTGGACCGCCTGGTGCTGGTGGAACCCGGCATCGCCGCCTTAACACCCTTGCGGGAAAGCGAGGACTGGG
TCGGCTGGAAGTATTGGCGCGACAAACTAGCCCTGGGCGGTGTGGTCATACCGCCCGAGAAGTGGTACGACGCGGAATAC
CTGGTGCGCGCAAGCGTCGGTCTTCCGATGCTCTTCGGCTTCCGCAGGGGCCGGGCGCGCCGCGCCGCCCCCCTGGTGAG
GCTCATGGATACCACCACGGCAGCAAAGGATTACTGCGACCTGGCAGGCATGACGCTGGACAAAATAGACCAGATCCGCC
ATCAGACACTCGTCTTGTATGGCGAGGACTCGGTCTTTCTCGGGACTTACGAATACCTGCGAGACCACTTAGTCAACTCT
GTGTGTTTCCTTATGCCGGATAGTGAGCATTTCGGACCCATAGAGCGCCCCGAAATTTTACTTCAGCATGTGCGCACGTT
CCTGAGCGAGGCGGAGAAGCCGGCCCAGGCTAGGACCGCCGCATCTTCCGGTTATTCGACATGA

Upstream 100 bases:

>100_bases
ATGCGCCCATGGCGGCGCAGTCTCCCGTGGACGCGCCAATGGAAGCCGAATTAATTGGTCAGTTGCGCGCACTTGGATAT
ATGGAATAGGGACGTAGACC

Downstream 100 bases:

>100_bases
GTATCTTCCAGGGCAAGGTCGCGTTCGTAACCGGCGGCGGGTCGGGCCTTGGCCGCGCGCTTAGCGAAGAACTAGCGCGA
AGAGGCGCTGTGATTGCCGT

Product: alpha/beta hydrolase fold protein

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MDKAQANGVQLHYQQFGEGPPVVMVHGITGNLAIWHLEIVPGLMSDFRITTYDLRGHGYSDVPPTGYTTADHAMDLKHLL
ETLGIERAHVMGHSFGADIALHFTILFPERVDRLVLVEPGIAALTPLRESEDWVGWKYWRDKLALGGVVIPPEKWYDAEY
LVRASVGLPMLFGFRRGRARRAAPLVRLMDTTTAAKDYCDLAGMTLDKIDQIRHQTLVLYGEDSVFLGTYEYLRDHLVNS
VCFLMPDSEHFGPIERPEILLQHVRTFLSEAEKPAQARTAASSGYST

Sequences:

>Translated_287_residues
MDKAQANGVQLHYQQFGEGPPVVMVHGITGNLAIWHLEIVPGLMSDFRITTYDLRGHGYSDVPPTGYTTADHAMDLKHLL
ETLGIERAHVMGHSFGADIALHFTILFPERVDRLVLVEPGIAALTPLRESEDWVGWKYWRDKLALGGVVIPPEKWYDAEY
LVRASVGLPMLFGFRRGRARRAAPLVRLMDTTTAAKDYCDLAGMTLDKIDQIRHQTLVLYGEDSVFLGTYEYLRDHLVNS
VCFLMPDSEHFGPIERPEILLQHVRTFLSEAEKPAQARTAASSGYST
>Mature_287_residues
MDKAQANGVQLHYQQFGEGPPVVMVHGITGNLAIWHLEIVPGLMSDFRITTYDLRGHGYSDVPPTGYTTADHAMDLKHLL
ETLGIERAHVMGHSFGADIALHFTILFPERVDRLVLVEPGIAALTPLRESEDWVGWKYWRDKLALGGVVIPPEKWYDAEY
LVRASVGLPMLFGFRRGRARRAAPLVRLMDTTTAAKDYCDLAGMTLDKIDQIRHQTLVLYGEDSVFLGTYEYLRDHLVNS
VCFLMPDSEHFGPIERPEILLQHVRTFLSEAEKPAQARTAASSGYST

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=118, Percent_Identity=33.0508474576271, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI13376164, Length=118, Percent_Identity=33.0508474576271, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 32219; Mature: 32219

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKAQANGVQLHYQQFGEGPPVVMVHGITGNLAIWHLEIVPGLMSDFRITTYDLRGHGYS
CCCCCCCCEEEEHHHHCCCCCEEEEECCCCCEEEEEEEEHHHHHCCCEEEEEEECCCCCC
DVPPTGYTTADHAMDLKHLLETLGIERAHVMGHSFGADIALHFTILFPERVDRLVLVEPG
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEEEEHHHCCEEEEECCC
IAALTPLRESEDWVGWKYWRDKLALGGVVIPPEKWYDAEYLVRASVGLPMLFGFRRGRAR
HHHHCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCHHHEEEECCCCHHHHHHHCCCCH
RAAPLVRLMDTTTAAKDYCDLAGMTLDKIDQIRHQTLVLYGEDSVFLGTYEYLRDHLVNS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEEECCCCEEEHHHHHHHHHHHHH
VCFLMPDSEHFGPIERPEILLQHVRTFLSEAEKPAQARTAASSGYST
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MDKAQANGVQLHYQQFGEGPPVVMVHGITGNLAIWHLEIVPGLMSDFRITTYDLRGHGYS
CCCCCCCCEEEEHHHHCCCCCEEEEECCCCCEEEEEEEEHHHHHCCCEEEEEEECCCCCC
DVPPTGYTTADHAMDLKHLLETLGIERAHVMGHSFGADIALHFTILFPERVDRLVLVEPG
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEEEEHHHCCEEEEECCC
IAALTPLRESEDWVGWKYWRDKLALGGVVIPPEKWYDAEYLVRASVGLPMLFGFRRGRAR
HHHHCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCHHHEEEECCCCHHHHHHHCCCCH
RAAPLVRLMDTTTAAKDYCDLAGMTLDKIDQIRHQTLVLYGEDSVFLGTYEYLRDHLVNS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEEECCCCEEEHHHHHHHHHHHHH
VCFLMPDSEHFGPIERPEILLQHVRTFLSEAEKPAQARTAASSGYST
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]