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The map label for this gene is iclR [H]

Identifier: 116621060

GI number: 116621060

Start: 2420756

End: 2421571

Strand: Reverse

Name: iclR [H]

Synonym: Acid_1941

Alternate gene names: 116621060

Gene position: 2421571-2420756 (Counterclockwise)

Preceding gene: 116621061

Following gene: 116621057

Centisome position: 24.3

GC content: 62.5

Gene sequence:

>816_bases
ATGCCGCTAACAAGTGTGAAGAAAAATGGGAAGCGGAGGGCGGGCGCTCCGGACACCCCCGCCATACAAAGTCTCGATCG
CGGCCTGCAGATTTTGGAGGCGGTGGGCAAGTCGCCCGAACCCGTCTCTCTGGGTCAGTTGGCGGCGATGCTCGGCATCG
ACCGCAGCAGCGCGTTCCGTTTGGCGAAAACCCTCAAGCGGCGCGGCTTCCTTACTACTCCCAGCGCGGGCCGGGACTAC
GTGCTCGGCTCTTCCGTCTGGCGGCTTTCGCGCCAGTACGATTGGAGCAAAATGCTGGCGCGAGTTGCCCATGAACCTCT
CAAGACACTTGCCGCGCAGACCCATGAGACGGCGCACCTGGCGGTACGCGAGGGACGAAAGGCGCTGTTCATAGACCACG
TCACCACCAGCCACGTGATCTCCATTTCCGGCCAGACCGGCGAGTTGGTGCCGCTCTATTGCACGTCCCACGGCAAGGCT
CTCTTGATCGATTTCGAGGAACAGGACCTGGTGGACCTGCTGGGTCCAAAACCGCTGAAGGTGTACACGAAGAACACGAT
CCAGAGCATCCGGTCTCTGGCCGCGGAGTGCACGAGCCTGCGCGAAAAAGGGTTTGCTACGGATGAATCGGAGTATCTGG
AGGGGGTGCGGTGCCTGGCTGCGCCGATCCGGGACCGCGACGGCCAAGTAATCGCTTCAATTGGAATATCCGCGCCAGCC
GCGAGGTTCCCCCGGGAACGCGAACGGGAGTTCGCCGGCCTGGTCGTCGCGGTCGCTGCGGAAATCGGCGAGTTGGTCGG
ATCGCTCGAGGACTAA

Upstream 100 bases:

>100_bases
GAAGCGGTGCGGGAATCCGTGTTGTGGCTGGTGGCAAACCTCATCATCCGAGGCGCAAGTGTCTGAAGCCGGGGCCGGAA
TGGAATAATCTAGTACAGGA

Downstream 100 bases:

>100_bases
ACCAGGAGTCGGGATCAGTATGGCCGCCGGGTCACGCTTAGTTTCCCGCGGCACGGCGGTCGTTCCAGTGGACCATCGGC
AGCCCGGGAACGGGCGCGCG

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPLTSVKKNGKRRAGAPDTPAIQSLDRGLQILEAVGKSPEPVSLGQLAAMLGIDRSSAFRLAKTLKRRGFLTTPSAGRDY
VLGSSVWRLSRQYDWSKMLARVAHEPLKTLAAQTHETAHLAVREGRKALFIDHVTTSHVISISGQTGELVPLYCTSHGKA
LLIDFEEQDLVDLLGPKPLKVYTKNTIQSIRSLAAECTSLREKGFATDESEYLEGVRCLAAPIRDRDGQVIASIGISAPA
ARFPREREREFAGLVVAVAAEIGELVGSLED

Sequences:

>Translated_271_residues
MPLTSVKKNGKRRAGAPDTPAIQSLDRGLQILEAVGKSPEPVSLGQLAAMLGIDRSSAFRLAKTLKRRGFLTTPSAGRDY
VLGSSVWRLSRQYDWSKMLARVAHEPLKTLAAQTHETAHLAVREGRKALFIDHVTTSHVISISGQTGELVPLYCTSHGKA
LLIDFEEQDLVDLLGPKPLKVYTKNTIQSIRSLAAECTSLREKGFATDESEYLEGVRCLAAPIRDRDGQVIASIGISAPA
ARFPREREREFAGLVVAVAAEIGELVGSLED
>Mature_270_residues
PLTSVKKNGKRRAGAPDTPAIQSLDRGLQILEAVGKSPEPVSLGQLAAMLGIDRSSAFRLAKTLKRRGFLTTPSAGRDYV
LGSSVWRLSRQYDWSKMLARVAHEPLKTLAAQTHETAHLAVREGRKALFIDHVTTSHVISISGQTGELVPLYCTSHGKAL
LIDFEEQDLVDLLGPKPLKVYTKNTIQSIRSLAAECTSLREKGFATDESEYLEGVRCLAAPIRDRDGQVIASIGISAPAA
RFPREREREFAGLVVAVAAEIGELVGSLED

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=251, Percent_Identity=31.8725099601594, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1786715, Length=266, Percent_Identity=27.4436090225564, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788131, Length=251, Percent_Identity=28.2868525896414, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786468, Length=223, Percent_Identity=27.3542600896861, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789999, Length=233, Percent_Identity=28.3261802575107, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788581, Length=254, Percent_Identity=27.1653543307087, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29440; Mature: 29309

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTSVKKNGKRRAGAPDTPAIQSLDRGLQILEAVGKSPEPVSLGQLAAMLGIDRSSAFR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHH
LAKTLKRRGFLTTPSAGRDYVLGSSVWRLSRQYDWSKMLARVAHEPLKTLAAQTHETAHL
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
AVREGRKALFIDHVTTSHVISISGQTGELVPLYCTSHGKALLIDFEEQDLVDLLGPKPLK
HHHCCCEEEEEEECCCCEEEEECCCCCCEEEEEECCCCCEEEEECCHHHHHHHHCCCCEE
VYTKNTIQSIRSLAAECTSLREKGFATDESEYLEGVRCLAAPIRDRDGQVIASIGISAPA
EHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCH
ARFPREREREFAGLVVAVAAEIGELVGSLED
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLTSVKKNGKRRAGAPDTPAIQSLDRGLQILEAVGKSPEPVSLGQLAAMLGIDRSSAFR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHH
LAKTLKRRGFLTTPSAGRDYVLGSSVWRLSRQYDWSKMLARVAHEPLKTLAAQTHETAHL
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
AVREGRKALFIDHVTTSHVISISGQTGELVPLYCTSHGKALLIDFEEQDLVDLLGPKPLK
HHHCCCEEEEEEECCCCEEEEECCCCCCEEEEEECCCCCEEEEECCHHHHHHHHCCCCEE
VYTKNTIQSIRSLAAECTSLREKGFATDESEYLEGVRCLAAPIRDRDGQVIASIGISAPA
EHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCH
ARFPREREREFAGLVVAVAAEIGELVGSLED
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]