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The map label for this gene is cysK [H]

Identifier: 116620988

GI number: 116620988

Start: 2326624

End: 2327694

Strand: Direct

Name: cysK [H]

Synonym: Acid_1869

Alternate gene names: 116620988

Gene position: 2326624-2327694 (Clockwise)

Preceding gene: 116620984

Following gene: 116620994

Centisome position: 23.35

GC content: 63.21

Gene sequence:

>1071_bases
ATGATGACAGTGGAAACGTCGAGCTTCTGCCACCTGGGACGGCTGGTGGGCAACACGCCGATGCTGGCCGTGGAATTCCG
GTTTCGCGGACGGCGGCGAGTGATTTACGCCAAGAGCGAGCAGTTGAACATGACGGGCAGCATCAAGGACCGGATGGCCT
TTCATATTCTCCGGCAGGGGTACGCTGACGGCACGCTGCGGCCGGACTGCACGATCGTGGAGGCGAGCAGCGGGAATTCA
GGGATCTCATTCGCGGCGCTGGGCCGGGCGCTGGGGCACAAAGTCACCATTCTGATGCCGGACTGGATGAGCCGCGAGCG
GATGGAACTGATCCATAGCTATGGCGCCACGATGATTCCGGTGTCGCGCGAGGAGGGCGGCTTTATGGGCTGCATGCGAC
GCGCGGAAGACATGGCACAGGGGCGCGCCGACGTGTTTCTGCCGAGGCAGTTCTCCAATCCGGCGGATGTGATGGCGCAC
GAGGTCTCGACGGGGCCGGAGATCTGGGCGCAACTGGCGCAGCACGGGCTGACGGCCGACGCGTTCGTGGCGGGGGTGGG
GACGGGCGGCACCGTGATGGGCGTCGGACGCTATCTGCGGCGGCGCAATCCAAAGGTGCGGGTACACGCGCTGCAACCGG
CGGAATCGCCGACACTGACCGCGGGACATAAGGTGGGGCGGCATCGAATGCAAGGGCTGACGGATGAATTCATTCCGGAG
ATCGTAAAGCTGGACGAACTGGACGAGGTCATCAGCGTGAGCGATGGCGATTCGATCTTGATGGCGCAGAGGCTGGCGAG
CGAGTTGGGGATCGCGGTGGGAATTTCATCAGGCGCGAATTTTCTGGGAGCGATCGAGGCGCAGAACCGGCTGGGCGCGG
ATGCTGTGGTGGCCACGGTCTTCAGCGACGACAACAAGAAGTACCTGACGACGGATTTGCTGCGCGAAGAGCCGGAGAAG
CCTGGCTATCTGTCGCCGGACGTGGAGTTGATCTCGTTCGATACCTACAAGCGAGTGTGCGATACGGCGTGCGAGTTCCC
GGGGTGCGAGGGTCACACACCCCAGAGGTAA

Upstream 100 bases:

>100_bases
GGGTTACGTTTGAATGGCTCAAAAGGTTACACTCCGGCGGGGGCCAATTCGAGCCTAATTAGGCCCATGCGGCAGTAAAG
GATGTTATTCTCCTGTTCGA

Downstream 100 bases:

>100_bases
TCGTCGGCTTGTGAGTTGCGAAGTTCTTCGCGGCCGCGGGCGAGGGCGGTGAGGTCGAGTTCGAAGAAGCGAGGGTTCTT
GACCAGCCGTCGGAGCGCGG

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MMTVETSSFCHLGRLVGNTPMLAVEFRFRGRRRVIYAKSEQLNMTGSIKDRMAFHILRQGYADGTLRPDCTIVEASSGNS
GISFAALGRALGHKVTILMPDWMSRERMELIHSYGATMIPVSREEGGFMGCMRRAEDMAQGRADVFLPRQFSNPADVMAH
EVSTGPEIWAQLAQHGLTADAFVAGVGTGGTVMGVGRYLRRRNPKVRVHALQPAESPTLTAGHKVGRHRMQGLTDEFIPE
IVKLDELDEVISVSDGDSILMAQRLASELGIAVGISSGANFLGAIEAQNRLGADAVVATVFSDDNKKYLTTDLLREEPEK
PGYLSPDVELISFDTYKRVCDTACEFPGCEGHTPQR

Sequences:

>Translated_356_residues
MMTVETSSFCHLGRLVGNTPMLAVEFRFRGRRRVIYAKSEQLNMTGSIKDRMAFHILRQGYADGTLRPDCTIVEASSGNS
GISFAALGRALGHKVTILMPDWMSRERMELIHSYGATMIPVSREEGGFMGCMRRAEDMAQGRADVFLPRQFSNPADVMAH
EVSTGPEIWAQLAQHGLTADAFVAGVGTGGTVMGVGRYLRRRNPKVRVHALQPAESPTLTAGHKVGRHRMQGLTDEFIPE
IVKLDELDEVISVSDGDSILMAQRLASELGIAVGISSGANFLGAIEAQNRLGADAVVATVFSDDNKKYLTTDLLREEPEK
PGYLSPDVELISFDTYKRVCDTACEFPGCEGHTPQR
>Mature_356_residues
MMTVETSSFCHLGRLVGNTPMLAVEFRFRGRRRVIYAKSEQLNMTGSIKDRMAFHILRQGYADGTLRPDCTIVEASSGNS
GISFAALGRALGHKVTILMPDWMSRERMELIHSYGATMIPVSREEGGFMGCMRRAEDMAQGRADVFLPRQFSNPADVMAH
EVSTGPEIWAQLAQHGLTADAFVAGVGTGGTVMGVGRYLRRRNPKVRVHALQPAESPTLTAGHKVGRHRMQGLTDEFIPE
IVKLDELDEVISVSDGDSILMAQRLASELGIAVGISSGANFLGAIEAQNRLGADAVVATVFSDDNKKYLTTDLLREEPEK
PGYLSPDVELISFDTYKRVCDTACEFPGCEGHTPQR

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=309, Percent_Identity=27.5080906148867, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI295821200, Length=309, Percent_Identity=27.5080906148867, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4557415, Length=309, Percent_Identity=27.5080906148867, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI2367138, Length=309, Percent_Identity=33.0097087378641, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788754, Length=308, Percent_Identity=34.7402597402597, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=36.6013071895425, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17562970, Length=303, Percent_Identity=36.963696369637, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32566674, Length=279, Percent_Identity=38.3512544802867, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI115535073, Length=301, Percent_Identity=37.2093023255814, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17561720, Length=303, Percent_Identity=37.2937293729373, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=216, Percent_Identity=37.037037037037, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25147552, Length=310, Percent_Identity=30, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17534315, Length=313, Percent_Identity=29.7124600638978, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6321594, Length=340, Percent_Identity=31.1764705882353, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=31.1926605504587, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24643623, Length=282, Percent_Identity=28.7234042553192, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI20129101, Length=282, Percent_Identity=28.7234042553192, Blast_Score=114, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38951; Mature: 38951

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTVETSSFCHLGRLVGNTPMLAVEFRFRGRRRVIYAKSEQLNMTGSIKDRMAFHILRQG
CEEECCCCHHHHHHHHCCCCEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHC
YADGTLRPDCTIVEASSGNSGISFAALGRALGHKVTILMPDWMSRERMELIHSYGATMIP
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCEEEE
VSREEGGFMGCMRRAEDMAQGRADVFLPRQFSNPADVMAHEVSTGPEIWAQLAQHGLTAD
ECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHH
AFVAGVGTGGTVMGVGRYLRRRNPKVRVHALQPAESPTLTAGHKVGRHRMQGLTDEFIPE
HHEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHH
IVKLDELDEVISVSDGDSILMAQRLASELGIAVGISSGANFLGAIEAQNRLGADAVVATV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEEEEHHCCCCCCCEEEEE
FSDDNKKYLTTDLLREEPEKPGYLSPDVELISFDTYKRVCDTACEFPGCEGHTPQR
EECCCCEEEHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MMTVETSSFCHLGRLVGNTPMLAVEFRFRGRRRVIYAKSEQLNMTGSIKDRMAFHILRQG
CEEECCCCHHHHHHHHCCCCEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHC
YADGTLRPDCTIVEASSGNSGISFAALGRALGHKVTILMPDWMSRERMELIHSYGATMIP
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCEEEE
VSREEGGFMGCMRRAEDMAQGRADVFLPRQFSNPADVMAHEVSTGPEIWAQLAQHGLTAD
ECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHH
AFVAGVGTGGTVMGVGRYLRRRNPKVRVHALQPAESPTLTAGHKVGRHRMQGLTDEFIPE
HHEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHH
IVKLDELDEVISVSDGDSILMAQRLASELGIAVGISSGANFLGAIEAQNRLGADAVVATV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEEEEHHCCCCCCCEEEEE
FSDDNKKYLTTDLLREEPEKPGYLSPDVELISFDTYKRVCDTACEFPGCEGHTPQR
EECCCCEEEHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA