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The map label for this gene is rnc

Identifier: 116620923

GI number: 116620923

Start: 2243092

End: 2243907

Strand: Reverse

Name: rnc

Synonym: Acid_1804

Alternate gene names: 116620923

Gene position: 2243907-2243092 (Counterclockwise)

Preceding gene: 116620924

Following gene: 116620922

Centisome position: 22.52

GC content: 63.85

Gene sequence:

>816_bases
ATGCGCGCGGAGCCCGCACTACTCGAGTTGAAACTCGACTATCGGTTCAACGACCCGGAGTTACTGCGCCGCGCGCTTAC
CCACAGTTCCCTGGCCAACGAAAACCGCCCCGGCGCGGGCGTGGGGTCGCCGCTCAACGACAACGAGCAACTGGAGTTTC
TCGGCGATTCGGTGCTCGGCTTTCTCATCGCCGAGGCACTGGTGCGCCGTTTCCCGGAATATCATGAGGGTGATCTCTCG
CGCCTGAAAGCTCACCTGGTAAGCGCGGCGCACTTGCACGGAGTTGCCCGGCGGCTCGACCTGGGAAGCTACCTGGAACT
CGGGCGCAGCGAGGAGATGAGCGGCGGACGGACCAAGAAGACGCTGCTGGTGGATGGCCTCGAAGCCATCATGGCGGCCA
TTTACCTGGATGGCGGCGTCGATGCGGCGCGCGCCTTCGTGGCGACTCATGTACTGGACGCTCCGTTCTTCGGAGACGAA
GAAGCCGGCACCGACATTCAACCCGCGATCACCAATTTCAAGAGCGCGCTGCAGGAACTGGCGCAAACGCGCAGGCTGCC
GCAACCGCGCTACTCGGTGGTGCGCGAGCGCGGCCCGGAGCACTCCAAAACCTTCACCGTGGAGGTCCGCGTCGGCAAGG
AATGGACCGCACAGGCGGAAGGACGCACCAAAAAGATTGCCGCGCAGCGCGCAGCGCGCGGACTCTACGAGCGACTGATG
GGGGACCCGATTGTGCCCCTGCCCGATGATTCCCCGGGTGATTCTCCCGATGATTCAGGTGACGCCGCTGAGAGCGGAGT
TATTTCCGCGACATGA

Upstream 100 bases:

>100_bases
AGATCAAGCAGGTGGCGCAGAACGTTCGCGCCGCCGCCGTGAAAGCCGGCGGCAAGGCACCGGGCGGCGCTCCGGCGCCG
GCGAAATAATCAGCCCCTAC

Downstream 100 bases:

>100_bases
ACGACTTCATGAACCCGGCGGAGTTCGCCAATATCCGGAACTCCGAGGAACATTTCTGGTGGTACCGCGGGATGCGGTCG
ATTCTCTTCTCCATGATGGA

Product: RNAse III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MRAEPALLELKLDYRFNDPELLRRALTHSSLANENRPGAGVGSPLNDNEQLEFLGDSVLGFLIAEALVRRFPEYHEGDLS
RLKAHLVSAAHLHGVARRLDLGSYLELGRSEEMSGGRTKKTLLVDGLEAIMAAIYLDGGVDAARAFVATHVLDAPFFGDE
EAGTDIQPAITNFKSALQELAQTRRLPQPRYSVVRERGPEHSKTFTVEVRVGKEWTAQAEGRTKKIAAQRAARGLYERLM
GDPIVPLPDDSPGDSPDDSGDAAESGVISAT

Sequences:

>Translated_271_residues
MRAEPALLELKLDYRFNDPELLRRALTHSSLANENRPGAGVGSPLNDNEQLEFLGDSVLGFLIAEALVRRFPEYHEGDLS
RLKAHLVSAAHLHGVARRLDLGSYLELGRSEEMSGGRTKKTLLVDGLEAIMAAIYLDGGVDAARAFVATHVLDAPFFGDE
EAGTDIQPAITNFKSALQELAQTRRLPQPRYSVVRERGPEHSKTFTVEVRVGKEWTAQAEGRTKKIAAQRAARGLYERLM
GDPIVPLPDDSPGDSPDDSGDAAESGVISAT
>Mature_271_residues
MRAEPALLELKLDYRFNDPELLRRALTHSSLANENRPGAGVGSPLNDNEQLEFLGDSVLGFLIAEALVRRFPEYHEGDLS
RLKAHLVSAAHLHGVARRLDLGSYLELGRSEEMSGGRTKKTLLVDGLEAIMAAIYLDGGVDAARAFVATHVLDAPFFGDE
EAGTDIQPAITNFKSALQELAQTRRLPQPRYSVVRERGPEHSKTFTVEVRVGKEWTAQAEGRTKKIAAQRAARGLYERLM
GDPIVPLPDDSPGDSPDDSGDAAESGVISAT

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=209, Percent_Identity=28.7081339712919, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI155030236, Length=209, Percent_Identity=28.7081339712919, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788920, Length=207, Percent_Identity=38.1642512077295, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17506883, Length=228, Percent_Identity=30.7017543859649, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193202651, Length=228, Percent_Identity=30.7017543859649, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137682, Length=241, Percent_Identity=29.8755186721992, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_SOLUE (Q027L3)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_823079.1
- ProteinModelPortal:   Q027L3
- SMR:   Q027L3
- STRING:   Q027L3
- GeneID:   4430002
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_1804
- NMPDR:   fig|234267.9.peg.1717
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q027L3
- ProtClustDB:   CLSK775050
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 29496; Mature: 29496

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAEPALLELKLDYRFNDPELLRRALTHSSLANENRPGAGVGSPLNDNEQLEFLGDSVLG
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FLIAEALVRRFPEYHEGDLSRLKAHLVSAAHLHGVARRLDLGSYLELGRSEEMSGGRTKK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHH
TLLVDGLEAIMAAIYLDGGVDAARAFVATHVLDAPFFGDEEAGTDIQPAITNFKSALQEL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AQTRRLPQPRYSVVRERGPEHSKTFTVEVRVGKEWTAQAEGRTKKIAAQRAARGLYERLM
HHHHCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GDPIVPLPDDSPGDSPDDSGDAAESGVISAT
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MRAEPALLELKLDYRFNDPELLRRALTHSSLANENRPGAGVGSPLNDNEQLEFLGDSVLG
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FLIAEALVRRFPEYHEGDLSRLKAHLVSAAHLHGVARRLDLGSYLELGRSEEMSGGRTKK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHH
TLLVDGLEAIMAAIYLDGGVDAARAFVATHVLDAPFFGDEEAGTDIQPAITNFKSALQEL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AQTRRLPQPRYSVVRERGPEHSKTFTVEVRVGKEWTAQAEGRTKKIAAQRAARGLYERLM
HHHHCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GDPIVPLPDDSPGDSPDDSGDAAESGVISAT
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA