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The map label for this gene is merR1 [H]

Identifier: 116620876

GI number: 116620876

Start: 2186161

End: 2186583

Strand: Direct

Name: merR1 [H]

Synonym: Acid_1757

Alternate gene names: 116620876

Gene position: 2186161-2186583 (Clockwise)

Preceding gene: 116620875

Following gene: 116620877

Centisome position: 21.94

GC content: 68.32

Gene sequence:

>423_bases
ATGCTGCGCGCCGGGGAACTGGCGCAGGTCTGCGGGGTAAGCACGGACACGCTTCGGCACTACGAGCGGGTCGGAGTGCT
GGCGCGGCCCGAACGAACGCCGGCAGGATACAGGCAATATCCGGCGGAAGCGGTGGGGCGCGTCCGGATGGTGCGCCGTG
CGCTGGCGCTCGGGTTCTCGCTGGCGGAACTGGCGCGGATCTTCCGCGTGCGGGAACGAGGCGGCGCTCCGTGCCGCGAA
GTTCGGGCGATGGCGGCGGGCAAGCTCGAAGAGATCGAGCGGCAACTCGAAGAACTTCAAGAGTTGCGCGACTACTGGCG
CGGGCTCCTGGTGAAATGGGATGAGCGGCTGGGTTCGACTCCCGAGGGAGCGCGGGCCGGGCTGCTGGAGACGATCGGGG
ATCCTTCTTCCGGAAAGAGGTAG

Upstream 100 bases:

>100_bases
CTTGTAAATTCTTTGGCTCGGACTGCGATCGCGATTGACCCTGGAACGGTTCCGGGCCGGATACTGCGCTTGGAAGGTGG
ATCCCTCGTCTCAAGAATCG

Downstream 100 bases:

>100_bases
GTTTATGACGAGGATTCTTGCGACGGCTCTATTGATGGCTGCGACGGCATTCGCGCAGGACGCGCACGGGGTAGACCAGC
GCGGCGATCACGTGATGGGG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MLRAGELAQVCGVSTDTLRHYERVGVLARPERTPAGYRQYPAEAVGRVRMVRRALALGFSLAELARIFRVRERGGAPCRE
VRAMAAGKLEEIERQLEELQELRDYWRGLLVKWDERLGSTPEGARAGLLETIGDPSSGKR

Sequences:

>Translated_140_residues
MLRAGELAQVCGVSTDTLRHYERVGVLARPERTPAGYRQYPAEAVGRVRMVRRALALGFSLAELARIFRVRERGGAPCRE
VRAMAAGKLEEIERQLEELQELRDYWRGLLVKWDERLGSTPEGARAGLLETIGDPSSGKR
>Mature_140_residues
MLRAGELAQVCGVSTDTLRHYERVGVLARPERTPAGYRQYPAEAVGRVRMVRRALALGFSLAELARIFRVRERGGAPCRE
VRAMAAGKLEEIERQLEELQELRDYWRGLLVKWDERLGSTPEGARAGLLETIGDPSSGKR

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=139, Percent_Identity=30.2158273381295, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI1786695, Length=111, Percent_Identity=31.5315315315315, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15705; Mature: 15705

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRAGELAQVCGVSTDTLRHYERVGVLARPERTPAGYRQYPAEAVGRVRMVRRALALGFS
CCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCC
LAELARIFRVRERGGAPCREVRAMAAGKLEEIERQLEELQELRDYWRGLLVKWDERLGST
HHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEGARAGLLETIGDPSSGKR
CCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLRAGELAQVCGVSTDTLRHYERVGVLARPERTPAGYRQYPAEAVGRVRMVRRALALGFS
CCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCC
LAELARIFRVRERGGAPCREVRAMAAGKLEEIERQLEELQELRDYWRGLLVKWDERLGST
HHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEGARAGLLETIGDPSSGKR
CCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]