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The map label for this gene is pcrA [H]

Identifier: 116620812

GI number: 116620812

Start: 2107542

End: 2109791

Strand: Direct

Name: pcrA [H]

Synonym: Acid_1693

Alternate gene names: 116620812

Gene position: 2107542-2109791 (Clockwise)

Preceding gene: 116620811

Following gene: 116620813

Centisome position: 21.15

GC content: 55.02

Gene sequence:

>2250_bases
GTGTCAATCCCAAGGGACTTTTCCATCGTTGACGGCAAGGGCGGAGAGGAAACGCTGCAGGCTTTGGAGCTTGTTTCGAA
GCTCGCCCTTAAGTTCAACTTCGAACAGTGGCTCATTGAGCACGCTCCCCAAGAATCACATCTTCAGGTCCAAGCTGGCG
CGGGCACCGGAAAGACTGCCGTCATGATCCGGAGGGTAGACTTCCTGCTGCACTCTGTAGACGGCTTGGCGTTGAACGAC
ATCGCAATGATAACGTTCACACGCGATGCGACTCACGAAATGCGCAGCCGTCTCATGGATCACCTCAAAACGCGGCACGG
AGTCAGCGGGAAGGCTTGGTACATTGACTGGCTTGAACAATTCCCAGCGCTGAACATCAGCACAATTCACTCGCTGGCAC
GACGTCTCTTGCAGTCGGTCTGTGCGGAGATAGGATTGGGTCGCTCGTTTCGCCTGAACGCATTCCGTCAAGAGAAAAAG
CGGATTATCGAAGACGTTCTCGCTGCGCAGATCTCCGCTCAAGAAACGATTTCAAAGGTACTGCGCCTCCCGCTATATAA
ATTCATCGAAAATGCGGTTAGTTTTTGGGAGGAGCTCAGCAGGAAGGGTCTGAGCCTAATTGATATCGAGGGTATCGACT
GGGGAAACTGCACAGACGCTGACGGCGCGCGACTGCAGACAATCTTCTCAACGCTTTTTGCTCAGGCGGAGGCGAAATTG
GAGTCTCTGAAGCTGAATCAGAACTCAGCGTCGCTTGACGACCTGACTCGTCAACTCGCGACTTTGGCGTCACGCCGAAG
CCTGCTTGGCACTGGTGGGCCTACCTTTAGATATCTTTTTGTCGACGAGTTTCAGGATAGCGACGAGAGCCAGATCCGCC
TGGTTGCAGCGTTGTGTCGTGACTTCGGTGCCGTTCTCTTCGTGGTAGGTGACATTAAACAGTCCATTTACCGTTTTCGC
GGCGCGACCTATACGGCTTTCAATGCTTTGGAAAAAGCCATTTCCTCGTTCGGTGGCACTCTGGCTGAGTATACTCTAGC
CAAGAATTATAGGACTGCCAGCGCAGTGCTCGATCGACTTCATCCCCGCTTTTCATCTTGGAACGCTAATGGCTGGCTAC
CTTATCGATCTCAAGATCGACTCGTTCCTACAGTGCAAGACCAAGGCTCGTTCCGTTCCAGTGGATATCGAAAGAAGGGT
GAACGTCATCAAGCTCAAGTGCTCGAGTGGATTAGGGAAGCCGCGGACACTTTACCAACATCGGGAAGTGACGGCAGGCG
GCCCCGAGCCGCGGTCCTCGTACGAACGCATCGCGAAGCGGAACTCGTCCACGAATGGTGTAGCGGCGCAGGCATAGCCT
GCGAAGTCAGGCGGGGTGGGGATTTGTTCGCGTCCGAAGCGACGTATGATCTGCTCGCACTTATAACCGCATTTCTCCAC
CCCGGAGATTCAGTGGCCCTTCTCAACCTCGCGGCTACGGCGTATTCTGAAGTCCACATTCCGTGGCCGTTGCTCCTCCG
TCACAAAGGGGACGGTGCCGCATTGCGATCTGCCATGGAGAACCATCAGCTCACTGAGCACTGGGCTGGGCTTGTGGAAA
CATCCCGATCCGAGCCAGTTCTATCGCTCCTGCGCTCGGCCATAGAGCATCTTGAGCCCTCGAGAAGAATCCGCGATCGC
GAGCGGGAGCGAATTGCGGCCGAACACTCGGACTGGAATGAAGCGGAAGTCCTACGCGAGGCAAATCAGGCAGGCATCCG
ATATCAGCTCGATCTCGACAGACTAGTTGAGCTGATGCACAAGACGTTTAACGAGAATTTCGCCTCTCTCTACTCCGTGC
AAGAGTGGCTTACTGTTCAGCGTTCAGTCAACCGTGAACAGGAGCGGCTAGACCTGCCGGATGAAGTCTTGCCAGCGGTC
CTGTGTACCACGGTGCACGCGAGTAAGGGCGCTGAGTTCCACACGGTTATCCTCCCGTTTACACACCGGCCGTTCCGATT
CGACAGAAGCGAGCTGTTGCTGACGCAAGTGGCGAATCGCTGGCGTGCCGCCTGGAGGCTTATGGTCGATGAAGATAGCG
TGATTACAAACAGCCTTTACGCTTCTTCAAACCAGGACGAAGCATTGGAGGTGCGCAGGGAAGAAACACGGCTGCTGTAC
GTCGCCATGACGCGCTGCCAGAGACGATTGTGGATCTGCGCTTTCGAAAACTCACTGGCTACCGAGAACTGGGGAGACCT
CCTTAGATGA

Upstream 100 bases:

>100_bases
ACGCGAGGACATTAGAGTCGTACTCTTCTCGGACCGCCCTCCGACAGGAACGGATGTGAACAGCCTGATCTCAAGTCGTG
TCATCGAGGTCCATCCTGTC

Downstream 100 bases:

>100_bases
CTGGAGGCGTTGAAGTGACGAGGGTCTTGACATACACGCACCCGAGCGAAATCCCGGTGCACACCGGGCAGAGCGATCTC
TTGGATTGGCTTCACATCTG

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MSIPRDFSIVDGKGGEETLQALELVSKLALKFNFEQWLIEHAPQESHLQVQAGAGTGKTAVMIRRVDFLLHSVDGLALND
IAMITFTRDATHEMRSRLMDHLKTRHGVSGKAWYIDWLEQFPALNISTIHSLARRLLQSVCAEIGLGRSFRLNAFRQEKK
RIIEDVLAAQISAQETISKVLRLPLYKFIENAVSFWEELSRKGLSLIDIEGIDWGNCTDADGARLQTIFSTLFAQAEAKL
ESLKLNQNSASLDDLTRQLATLASRRSLLGTGGPTFRYLFVDEFQDSDESQIRLVAALCRDFGAVLFVVGDIKQSIYRFR
GATYTAFNALEKAISSFGGTLAEYTLAKNYRTASAVLDRLHPRFSSWNANGWLPYRSQDRLVPTVQDQGSFRSSGYRKKG
ERHQAQVLEWIREAADTLPTSGSDGRRPRAAVLVRTHREAELVHEWCSGAGIACEVRRGGDLFASEATYDLLALITAFLH
PGDSVALLNLAATAYSEVHIPWPLLLRHKGDGAALRSAMENHQLTEHWAGLVETSRSEPVLSLLRSAIEHLEPSRRIRDR
ERERIAAEHSDWNEAEVLREANQAGIRYQLDLDRLVELMHKTFNENFASLYSVQEWLTVQRSVNREQERLDLPDEVLPAV
LCTTVHASKGAEFHTVILPFTHRPFRFDRSELLLTQVANRWRAAWRLMVDEDSVITNSLYASSNQDEALEVRREETRLLY
VAMTRCQRRLWICAFENSLATENWGDLLR

Sequences:

>Translated_749_residues
MSIPRDFSIVDGKGGEETLQALELVSKLALKFNFEQWLIEHAPQESHLQVQAGAGTGKTAVMIRRVDFLLHSVDGLALND
IAMITFTRDATHEMRSRLMDHLKTRHGVSGKAWYIDWLEQFPALNISTIHSLARRLLQSVCAEIGLGRSFRLNAFRQEKK
RIIEDVLAAQISAQETISKVLRLPLYKFIENAVSFWEELSRKGLSLIDIEGIDWGNCTDADGARLQTIFSTLFAQAEAKL
ESLKLNQNSASLDDLTRQLATLASRRSLLGTGGPTFRYLFVDEFQDSDESQIRLVAALCRDFGAVLFVVGDIKQSIYRFR
GATYTAFNALEKAISSFGGTLAEYTLAKNYRTASAVLDRLHPRFSSWNANGWLPYRSQDRLVPTVQDQGSFRSSGYRKKG
ERHQAQVLEWIREAADTLPTSGSDGRRPRAAVLVRTHREAELVHEWCSGAGIACEVRRGGDLFASEATYDLLALITAFLH
PGDSVALLNLAATAYSEVHIPWPLLLRHKGDGAALRSAMENHQLTEHWAGLVETSRSEPVLSLLRSAIEHLEPSRRIRDR
ERERIAAEHSDWNEAEVLREANQAGIRYQLDLDRLVELMHKTFNENFASLYSVQEWLTVQRSVNREQERLDLPDEVLPAV
LCTTVHASKGAEFHTVILPFTHRPFRFDRSELLLTQVANRWRAAWRLMVDEDSVITNSLYASSNQDEALEVRREETRLLY
VAMTRCQRRLWICAFENSLATENWGDLLR
>Mature_748_residues
SIPRDFSIVDGKGGEETLQALELVSKLALKFNFEQWLIEHAPQESHLQVQAGAGTGKTAVMIRRVDFLLHSVDGLALNDI
AMITFTRDATHEMRSRLMDHLKTRHGVSGKAWYIDWLEQFPALNISTIHSLARRLLQSVCAEIGLGRSFRLNAFRQEKKR
IIEDVLAAQISAQETISKVLRLPLYKFIENAVSFWEELSRKGLSLIDIEGIDWGNCTDADGARLQTIFSTLFAQAEAKLE
SLKLNQNSASLDDLTRQLATLASRRSLLGTGGPTFRYLFVDEFQDSDESQIRLVAALCRDFGAVLFVVGDIKQSIYRFRG
ATYTAFNALEKAISSFGGTLAEYTLAKNYRTASAVLDRLHPRFSSWNANGWLPYRSQDRLVPTVQDQGSFRSSGYRKKGE
RHQAQVLEWIREAADTLPTSGSDGRRPRAAVLVRTHREAELVHEWCSGAGIACEVRRGGDLFASEATYDLLALITAFLHP
GDSVALLNLAATAYSEVHIPWPLLLRHKGDGAALRSAMENHQLTEHWAGLVETSRSEPVLSLLRSAIEHLEPSRRIRDRE
RERIAAEHSDWNEAEVLREANQAGIRYQLDLDRLVELMHKTFNENFASLYSVQEWLTVQRSVNREQERLDLPDEVLPAVL
CTTVHASKGAEFHTVILPFTHRPFRFDRSELLLTQVANRWRAAWRLMVDEDSVITNSLYASSNQDEALEVRREETRLLYV
AMTRCQRRLWICAFENSLATENWGDLLR

Specific function: DNA helicase used for plasmid rolling-circle replication and also involved in UV repair [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 84888; Mature: 84757

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPRDFSIVDGKGGEETLQALELVSKLALKFNFEQWLIEHAPQESHLQVQAGAGTGKTA
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCCCHH
VMIRRVDFLLHSVDGLALNDIAMITFTRDATHEMRSRLMDHLKTRHGVSGKAWYIDWLEQ
HHHHHHHHHHHHCCCCEECCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FPALNISTIHSLARRLLQSVCAEIGLGRSFRLNAFRQEKKRIIEDVLAAQISAQETISKV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLPLYKFIENAVSFWEELSRKGLSLIDIEGIDWGNCTDADGARLQTIFSTLFAQAEAKL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ESLKLNQNSASLDDLTRQLATLASRRSLLGTGGPTFRYLFVDEFQDSDESQIRLVAALCR
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHH
DFGAVLFVVGDIKQSIYRFRGATYTAFNALEKAISSFGGTLAEYTLAKNYRTASAVLDRL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHH
HPRFSSWNANGWLPYRSQDRLVPTVQDQGSFRSSGYRKKGERHQAQVLEWIREAADTLPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
SGSDGRRPRAAVLVRTHREAELVHEWCSGAGIACEVRRGGDLFASEATYDLLALITAFLH
CCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
PGDSVALLNLAATAYSEVHIPWPLLLRHKGDGAALRSAMENHQLTEHWAGLVETSRSEPV
CCCCEEHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHCHHHHHHHHHHHCCCCCHH
LSLLRSAIEHLEPSRRIRDRERERIAAEHSDWNEAEVLREANQAGIRYQLDLDRLVELMH
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHH
KTFNENFASLYSVQEWLTVQRSVNREQERLDLPDEVLPAVLCTTVHASKGAEFHTVILPF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEC
THRPFRFDRSELLLTQVANRWRAAWRLMVDEDSVITNSLYASSNQDEALEVRREETRLLY
CCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
VAMTRCQRRLWICAFENSLATENWGDLLR
HHHHHHHHHEEEEEECCCCCCCCHHHHCC
>Mature Secondary Structure 
SIPRDFSIVDGKGGEETLQALELVSKLALKFNFEQWLIEHAPQESHLQVQAGAGTGKTA
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCCCHH
VMIRRVDFLLHSVDGLALNDIAMITFTRDATHEMRSRLMDHLKTRHGVSGKAWYIDWLEQ
HHHHHHHHHHHHCCCCEECCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FPALNISTIHSLARRLLQSVCAEIGLGRSFRLNAFRQEKKRIIEDVLAAQISAQETISKV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLPLYKFIENAVSFWEELSRKGLSLIDIEGIDWGNCTDADGARLQTIFSTLFAQAEAKL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ESLKLNQNSASLDDLTRQLATLASRRSLLGTGGPTFRYLFVDEFQDSDESQIRLVAALCR
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHH
DFGAVLFVVGDIKQSIYRFRGATYTAFNALEKAISSFGGTLAEYTLAKNYRTASAVLDRL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHH
HPRFSSWNANGWLPYRSQDRLVPTVQDQGSFRSSGYRKKGERHQAQVLEWIREAADTLPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
SGSDGRRPRAAVLVRTHREAELVHEWCSGAGIACEVRRGGDLFASEATYDLLALITAFLH
CCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
PGDSVALLNLAATAYSEVHIPWPLLLRHKGDGAALRSAMENHQLTEHWAGLVETSRSEPV
CCCCEEHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHCHHHHHHHHHHHCCCCCHH
LSLLRSAIEHLEPSRRIRDRERERIAAEHSDWNEAEVLREANQAGIRYQLDLDRLVELMH
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHH
KTFNENFASLYSVQEWLTVQRSVNREQERLDLPDEVLPAVLCTTVHASKGAEFHTVILPF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEC
THRPFRFDRSELLLTQVANRWRAAWRLMVDEDSVITNSLYASSNQDEALEVRREETRLLY
CCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
VAMTRCQRRLWICAFENSLATENWGDLLR
HHHHHHHHHEEEEEECCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9701819; 9384377 [H]