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The map label for this gene is lldD [C]

Identifier: 116620760

GI number: 116620760

Start: 2027501

End: 2028679

Strand: Direct

Name: lldD [C]

Synonym: Acid_1641

Alternate gene names: 116620760

Gene position: 2027501-2028679 (Clockwise)

Preceding gene: 116620759

Following gene: 116620761

Centisome position: 20.34

GC content: 64.12

Gene sequence:

>1179_bases
ATGTACAACAGTTTGTCGGCTCGCCGCGAGTTTCTGCGGTTCCTCGCGGGTAGTCCGCTGGCGGCCACGGCCTTCGCGCA
GGAAACAGGGATCGTGAAGGATGCGCTGAACGTGATGGACTTCGAAGCTTGGGCTCGCAAGGCGCTTCCGCCGGCGCATT
TCGGTTACCTGGCGACGGGCGTGGATGGCGATGTGACGCTGCAAGCGAATCGCGAGGCAATGACGCACTACCAGTTGCGG
GCGCGGCGGCTAATGGGCGTGGAGCAGGCCGACCTGCGGACGGAGGTCTTCGGCGCCGAATGGGAGATGCCGATTTACGT
GAGTGCGGTGGGGAGCCAGAAGGCTTTTCATCCCGAGGGCGAGTTGGCAACGGCGCGCGCGGCGAAGAGTCGGAACGCGA
TGCAGATGCTCTCGACTGTCAGTTCCACGAGTGTGGAGGATGTGAGCATGGCGCTGGGCGCAGCCCCCTGGTACCAGCTC
TACATGCCGGTGCCGTGGGGCGATACGGAGAAGATGGTGAAACGGGCCGAAGCGGCCGGGTGTCCGGTGCTGGTTTGGAC
GATCGACATCCTGGGAGGGCGAAATACGGAGACTGCGACCCGGTCCGCGAGGAGCGATACGCGCCAGTGTTCATCCTGCC
ACTCGGTGAGCCCGATGGCCGGGATCACACCCGAACGGAACCGGACCAGGCCTATGTTCGCGGGACTCTCGGGATCGATC
AATCCGGCGGCCGCGGATTGGACTTACGTGGACCGGCTGAAGAAAATTACGAAGATGAAGGTGGTGCTTAAGGGAATCGA
TTGTGCAGAAGACGCGAAACTGGCTCGCGAACACGGGGCGGATGGCTTGATCGTGTCGAACCACGGCGGACGCGCGACCG
AGACAGGACGCGGCACGCTGGATATTCTGCCGGAGGTGGTGGAGGCAACCGCGGGACAGACGCCGGTATTCGTGGACGGA
GGCTTTCGTCGCGGCACGGACGTGCTGAAGGCCTTGGCGCTTGGCGCGCGCGCTGTGGGGATCGGTCGGCCTTATATCTG
GGGCCTCGCGGCATTCGGGCAGGAAGGCGTGGAGCGCGTGTTGGAGATTCTGCGCGCGGAACTGGCGTTGACGATGCGGC
AGTGCGGGATCGCTTCGACGGCGCAGATTACCCGGGCGGCGGTGTTGCGGAAGTTGTAG

Upstream 100 bases:

>100_bases
ATATCGCGCGCAAAGCTATCTGACCTTCAAGATGTTATTCAATGCATTGTTGTACCCATAGGAGCTGTACCCGTAGGACG
AATGGGTATAATGGCGGTCC

Downstream 100 bases:

>100_bases
GGTCAATACTGCGCGCGCCGGTGCGGAACCATGCGACCGGTGTTACGGCTCACCCTTAGCAATTGCAACATCTTCATTGA
AATCCGAATGTGACCCATCT

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MYNSLSARREFLRFLAGSPLAATAFAQETGIVKDALNVMDFEAWARKALPPAHFGYLATGVDGDVTLQANREAMTHYQLR
ARRLMGVEQADLRTEVFGAEWEMPIYVSAVGSQKAFHPEGELATARAAKSRNAMQMLSTVSSTSVEDVSMALGAAPWYQL
YMPVPWGDTEKMVKRAEAAGCPVLVWTIDILGGRNTETATRSARSDTRQCSSCHSVSPMAGITPERNRTRPMFAGLSGSI
NPAAADWTYVDRLKKITKMKVVLKGIDCAEDAKLAREHGADGLIVSNHGGRATETGRGTLDILPEVVEATAGQTPVFVDG
GFRRGTDVLKALALGARAVGIGRPYIWGLAAFGQEGVERVLEILRAELALTMRQCGIASTAQITRAAVLRKL

Sequences:

>Translated_392_residues
MYNSLSARREFLRFLAGSPLAATAFAQETGIVKDALNVMDFEAWARKALPPAHFGYLATGVDGDVTLQANREAMTHYQLR
ARRLMGVEQADLRTEVFGAEWEMPIYVSAVGSQKAFHPEGELATARAAKSRNAMQMLSTVSSTSVEDVSMALGAAPWYQL
YMPVPWGDTEKMVKRAEAAGCPVLVWTIDILGGRNTETATRSARSDTRQCSSCHSVSPMAGITPERNRTRPMFAGLSGSI
NPAAADWTYVDRLKKITKMKVVLKGIDCAEDAKLAREHGADGLIVSNHGGRATETGRGTLDILPEVVEATAGQTPVFVDG
GFRRGTDVLKALALGARAVGIGRPYIWGLAAFGQEGVERVLEILRAELALTMRQCGIASTAQITRAAVLRKL
>Mature_392_residues
MYNSLSARREFLRFLAGSPLAATAFAQETGIVKDALNVMDFEAWARKALPPAHFGYLATGVDGDVTLQANREAMTHYQLR
ARRLMGVEQADLRTEVFGAEWEMPIYVSAVGSQKAFHPEGELATARAAKSRNAMQMLSTVSSTSVEDVSMALGAAPWYQL
YMPVPWGDTEKMVKRAEAAGCPVLVWTIDILGGRNTETATRSARSDTRQCSSCHSVSPMAGITPERNRTRPMFAGLSGSI
NPAAADWTYVDRLKKITKMKVVLKGIDCAEDAKLAREHGADGLIVSNHGGRATETGRGTLDILPEVVEATAGQTPVFVDG
GFRRGTDVLKALALGARAVGIGRPYIWGLAAFGQEGVERVLEILRAELALTMRQCGIASTAQITRAAVLRKL

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=356, Percent_Identity=37.6404494382022, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI54234014, Length=359, Percent_Identity=35.3760445682451, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI7705393, Length=359, Percent_Identity=35.3760445682451, Blast_Score=207, Evalue=9e-54,
Organism=Escherichia coli, GI1790033, Length=373, Percent_Identity=29.4906166219839, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI193208036, Length=354, Percent_Identity=34.180790960452, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32566217, Length=273, Percent_Identity=30.7692307692308, Blast_Score=118, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323587, Length=366, Percent_Identity=33.6065573770492, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI78707188, Length=365, Percent_Identity=38.6301369863014, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI281363140, Length=365, Percent_Identity=38.6301369863014, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI78707190, Length=365, Percent_Identity=38.6301369863014, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 42330; Mature: 42330

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNSLSARREFLRFLAGSPLAATAFAQETGIVKDALNVMDFEAWARKALPPAHFGYLATG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHCEEEEC
VDGDVTLQANREAMTHYQLRARRLMGVEQADLRTEVFGAEWEMPIYVSAVGSQKAFHPEG
CCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
ELATARAAKSRNAMQMLSTVSSTSVEDVSMALGAAPWYQLYMPVPWGDTEKMVKRAEAAG
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCC
CPVLVWTIDILGGRNTETATRSARSDTRQCSSCHSVSPMAGITPERNRTRPMFAGLSGSI
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCC
NPAAADWTYVDRLKKITKMKVVLKGIDCAEDAKLAREHGADGLIVSNHGGRATETGRGTL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHH
DILPEVVEATAGQTPVFVDGGFRRGTDVLKALALGARAVGIGRPYIWGLAAFGQEGVERV
HHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHH
LEILRAELALTMRQCGIASTAQITRAAVLRKL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYNSLSARREFLRFLAGSPLAATAFAQETGIVKDALNVMDFEAWARKALPPAHFGYLATG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHCEEEEC
VDGDVTLQANREAMTHYQLRARRLMGVEQADLRTEVFGAEWEMPIYVSAVGSQKAFHPEG
CCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
ELATARAAKSRNAMQMLSTVSSTSVEDVSMALGAAPWYQLYMPVPWGDTEKMVKRAEAAG
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCC
CPVLVWTIDILGGRNTETATRSARSDTRQCSSCHSVSPMAGITPERNRTRPMFAGLSGSI
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCC
NPAAADWTYVDRLKKITKMKVVLKGIDCAEDAKLAREHGADGLIVSNHGGRATETGRGTL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHH
DILPEVVEATAGQTPVFVDGGFRRGTDVLKALALGARAVGIGRPYIWGLAAFGQEGVERV
HHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHH
LEILRAELALTMRQCGIASTAQITRAAVLRKL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]