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The map label for this gene is aphA [H]

Identifier: 116620666

GI number: 116620666

Start: 1898494

End: 1899957

Strand: Direct

Name: aphA [H]

Synonym: Acid_1546

Alternate gene names: 116620666

Gene position: 1898494-1899957 (Clockwise)

Preceding gene: 116620665

Following gene: 116620667

Centisome position: 19.05

GC content: 62.3

Gene sequence:

>1464_bases
ATGATGCGTCCGCTGCGCGATCTACCGATCCGGCAGAAGCTCGTGGTCATCATGATGCTGACCACGGCCGCGGCGCTGTT
GTTGTCGGGCTTCGGGATCGTGGCGCTGGATTCCTACCTGTTCCGCGCCTCCATGCAGCGGGATCTCTCGGCGCTGGCGC
GGATCGTCGCCGACGCGAGCACCGCGGCTGTGGCCTTCGATGATGCCCAGGCCGCCGCGCAGACTCTGGCGGCATTGCGG
GCGCGGCCTCACATGGTGGCTGCCTGTATCTACCGCGGGAATGGCACGATCCTCGCCGAGTATGTGCGCGCCGGCGAATC
GCCGCAGTGCCCGCATCCCCTCCCCGAAGACGAGGTCCGATTCACGAGCCTGGGCCTGACGGTGTCAGATCCGATCCTGC
TTCAGCACCGGCGGATCGGGAGTCTGGTGTTGCTGTACGATCTGGGCGAAATACCCGAGCGGATCACGCTCTACGGCGAA
ATCGTGCAGGCGATCCTGCTGGCTTCGAGTGTGATCGCGCTGCTGATTTCGTCGCGGCTGCGCGCGCTCATCGCCACGCC
GATATCACGCCTCGCGCAGGCTGCGACCTCGGTGTCGGCCACCAGCGACTACAGCATTCGGGCGCAGAAGCTCTCGGGCG
ACGAACTTGGCGTCCTTGTAGATGAGTTCAACCAAATGTTGGAGCGAGTTCAGCTGCGCGACCAGGAATTGAAGCAGGCG
CTGGATTCGTTGAAGAGCACCAATGAAAGTCTCGCGCGCTCGAATGAAGACCTGGAGCGTTTCGCCTTCGTCGCCAGCCA
CGACCTGCAGGAGCCCTTGCGTATGATCACGACGTACGCGCAACTGCTGGTGAAGACCCACCGCGGCGAACTCGATCCGG
ACGCATCGATGTTTGTGGAGAACATCGTTGAGGGCACGAAGCGCATGCGCGAATTGCTGATCGACCTGCTGGCGTATACG
GAGATACGAACGCGATCGGGCGAGCCGCTGGCCGCTGTCGATCTCAACGTTGTCTTGGACAAGGTCAAGGAGAATCTGAA
AGCGGCCATCGACGGCAGTGGCGCCACCATCGTTGCCGAGCGCTTGCCCACGGTACCCGGATACGAAGGCCACTTCATCC
CACTGCTCCAAAACCTGATCGGGAATGCCATTAAATACCGCGGCGACCAGCCGCCGGTGATTGCCATTTCCGTGGAGAAA
GTCGCGGGTAATTTCCAGTTCGCCGTGGTCGATAACGGCATCGGCATCGACCCGGAGTACCATGAAAGAATCTTCGAGGT
GTTTCGGCGGCTGCATGGAAAGAAAATTCCGGGCACGGGCATTGGCCTCTCCATATGCCAGCGTGTCGTGGAGCGGTATG
GCGGCCGCATTTGGGTCGAATCGCGCGAAGGCCGGGGCTCGAAGTTCCTCTTCACCTTGCCGCGCGGGGATGCGGCGATC
GCCGCGTCCGGGGAGGGACGTTGA

Upstream 100 bases:

>100_bases
AGAACCACCGGGTGCGCTTCGATATCAACCAGGGCGCGGCCTCCAATGCCGAGCTCAGCCTGAGCTCCCGGCTGTTGAGC
GTGGCGAAAACGGTGGCAAA

Downstream 100 bases:

>100_bases
ATGCTTGAGAAATCGGATGCTGGAAAAACTCTCATACTGTTGGTCGAAGATAATCCCGCCGACGTCGGATTGTTCCGGCT
GGCGTTGAAGGACGCGGAAC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MMRPLRDLPIRQKLVVIMMLTTAAALLLSGFGIVALDSYLFRASMQRDLSALARIVADASTAAVAFDDAQAAAQTLAALR
ARPHMVAACIYRGNGTILAEYVRAGESPQCPHPLPEDEVRFTSLGLTVSDPILLQHRRIGSLVLLYDLGEIPERITLYGE
IVQAILLASSVIALLISSRLRALIATPISRLAQAATSVSATSDYSIRAQKLSGDELGVLVDEFNQMLERVQLRDQELKQA
LDSLKSTNESLARSNEDLERFAFVASHDLQEPLRMITTYAQLLVKTHRGELDPDASMFVENIVEGTKRMRELLIDLLAYT
EIRTRSGEPLAAVDLNVVLDKVKENLKAAIDGSGATIVAERLPTVPGYEGHFIPLLQNLIGNAIKYRGDQPPVIAISVEK
VAGNFQFAVVDNGIGIDPEYHERIFEVFRRLHGKKIPGTGIGLSICQRVVERYGGRIWVESREGRGSKFLFTLPRGDAAI
AASGEGR

Sequences:

>Translated_487_residues
MMRPLRDLPIRQKLVVIMMLTTAAALLLSGFGIVALDSYLFRASMQRDLSALARIVADASTAAVAFDDAQAAAQTLAALR
ARPHMVAACIYRGNGTILAEYVRAGESPQCPHPLPEDEVRFTSLGLTVSDPILLQHRRIGSLVLLYDLGEIPERITLYGE
IVQAILLASSVIALLISSRLRALIATPISRLAQAATSVSATSDYSIRAQKLSGDELGVLVDEFNQMLERVQLRDQELKQA
LDSLKSTNESLARSNEDLERFAFVASHDLQEPLRMITTYAQLLVKTHRGELDPDASMFVENIVEGTKRMRELLIDLLAYT
EIRTRSGEPLAAVDLNVVLDKVKENLKAAIDGSGATIVAERLPTVPGYEGHFIPLLQNLIGNAIKYRGDQPPVIAISVEK
VAGNFQFAVVDNGIGIDPEYHERIFEVFRRLHGKKIPGTGIGLSICQRVVERYGGRIWVESREGRGSKFLFTLPRGDAAI
AASGEGR
>Mature_487_residues
MMRPLRDLPIRQKLVVIMMLTTAAALLLSGFGIVALDSYLFRASMQRDLSALARIVADASTAAVAFDDAQAAAQTLAALR
ARPHMVAACIYRGNGTILAEYVRAGESPQCPHPLPEDEVRFTSLGLTVSDPILLQHRRIGSLVLLYDLGEIPERITLYGE
IVQAILLASSVIALLISSRLRALIATPISRLAQAATSVSATSDYSIRAQKLSGDELGVLVDEFNQMLERVQLRDQELKQA
LDSLKSTNESLARSNEDLERFAFVASHDLQEPLRMITTYAQLLVKTHRGELDPDASMFVENIVEGTKRMRELLIDLLAYT
EIRTRSGEPLAAVDLNVVLDKVKENLKAAIDGSGATIVAERLPTVPGYEGHFIPLLQNLIGNAIKYRGDQPPVIAISVEK
VAGNFQFAVVDNGIGIDPEYHERIFEVFRRLHGKKIPGTGIGLSICQRVVERYGGRIWVESREGRGSKFLFTLPRGDAAI
AASGEGR

Specific function: Photoreceptor which exists in two forms that are reversibly interconvertible by light:the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=372, Percent_Identity=26.0752688172043, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=274, Percent_Identity=30.6569343065693, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI48994928, Length=244, Percent_Identity=27.8688524590164, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=27.0916334661355, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=28.5067873303167, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=301, Percent_Identity=26.9102990033223, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87081816, Length=282, Percent_Identity=24.822695035461, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR013654
- InterPro:   IPR016132
- InterPro:   IPR001294
- InterPro:   IPR013515
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF00512 HisKA; PF08446 PAS_2; PF00360 Phytochrome [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53332; Mature: 53332

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN ; PS01333 PYRASE_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRPLRDLPIRQKLVVIMMLTTAAALLLSGFGIVALDSYLFRASMQRDLSALARIVADAS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TAAVAFDDAQAAAQTLAALRARPHMVAACIYRGNGTILAEYVRAGESPQCPHPLPEDEVR
HHEEEECHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCE
FTSLGLTVSDPILLQHRRIGSLVLLYDLGEIPERITLYGEIVQAILLASSVIALLISSRL
EEEECCEECCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALIATPISRLAQAATSVSATSDYSIRAQKLSGDELGVLVDEFNQMLERVQLRDQELKQA
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LDSLKSTNESLARSNEDLERFAFVASHDLQEPLRMITTYAQLLVKTHRGELDPDASMFVE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
NIVEGTKRMRELLIDLLAYTEIRTRSGEPLAAVDLNVVLDKVKENLKAAIDGSGATIVAE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEEHH
RLPTVPGYEGHFIPLLQNLIGNAIKYRGDQPPVIAISVEKVAGNFQFAVVDNGIGIDPEY
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCEEEEEEECCCCCCHHH
HERIFEVFRRLHGKKIPGTGIGLSICQRVVERYGGRIWVESREGRGSKFLFTLPRGDAAI
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCEEE
AASGEGR
ECCCCCC
>Mature Secondary Structure
MMRPLRDLPIRQKLVVIMMLTTAAALLLSGFGIVALDSYLFRASMQRDLSALARIVADAS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TAAVAFDDAQAAAQTLAALRARPHMVAACIYRGNGTILAEYVRAGESPQCPHPLPEDEVR
HHEEEECHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCE
FTSLGLTVSDPILLQHRRIGSLVLLYDLGEIPERITLYGEIVQAILLASSVIALLISSRL
EEEECCEECCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALIATPISRLAQAATSVSATSDYSIRAQKLSGDELGVLVDEFNQMLERVQLRDQELKQA
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LDSLKSTNESLARSNEDLERFAFVASHDLQEPLRMITTYAQLLVKTHRGELDPDASMFVE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
NIVEGTKRMRELLIDLLAYTEIRTRSGEPLAAVDLNVVLDKVKENLKAAIDGSGATIVAE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEEHH
RLPTVPGYEGHFIPLLQNLIGNAIKYRGDQPPVIAISVEKVAGNFQFAVVDNGIGIDPEY
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCEEEEEEECCCCCCHHH
HERIFEVFRRLHGKKIPGTGIGLSICQRVVERYGGRIWVESREGRGSKFLFTLPRGDAAI
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCEEE
AASGEGR
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]