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The map label for this gene is prsA [H]

Identifier: 116620640

GI number: 116620640

Start: 1864286

End: 1865314

Strand: Direct

Name: prsA [H]

Synonym: Acid_1519

Alternate gene names: 116620640

Gene position: 1864286-1865314 (Clockwise)

Preceding gene: 116620638

Following gene: 116620643

Centisome position: 18.71

GC content: 56.75

Gene sequence:

>1029_bases
ATGAAGCGCATTTTTGTTGTCTTTGCAGCGGGCGTTGCCGCCCTCACTCTTGCGTCGTGCAAGCACTCGCCGCCAGCCAA
TGTCGCGGCGGAGGTGGACAACCACGCCATAACGAACTCTGACCTGGAAAAAACTTACCAGTCGCAGTACGCGCAGCAAT
CGGAAGGCGCGAGTGAAGACCAGATCCTGACGCAAAAGCTGGACCTGCTTTCGAGCATGATCACGCAGGAAATCATGCTG
CGCAAAGCGGAAAAGCTCGGACTGGCCGCGGTGGATGCGGACGTGGACGCCGAAATTTCCAAGATGCGCGCGCCGTACAC
CAAGGAAGAGTTCGAAAAGCAGCTTTCCGCGCAGCACATGACGCTGGACGATCTAAAGCTCAAGGTGCGCAGCAAGCTGA
CGGTGGATAAGCTGGTCAACAAAGAGATCACGTCGAAGATTACGATCACCGACGCCGACGTGAAGAACTTCTACAACAAT
AACAAAGCGGCCTTCAATCTTCCGGAGCCCGCCATTCACATGGCGCAGATCCTGGTGACCCCGTTTCCCGACCCCAACGT
GCGCAATCTGAAGAACAGCAAAGCACAGAACGATAAGGAAGCGCGCGCCAAAATCGAGGACATTCTGGGACGCCTGAAGC
GCGGCGATGATTTCGGCATGCTGGCGCAAAACTACTCGGAAGATGCCAATTCCGCGCCCAACGGCGGCGATATGGGTTTC
GTGCGCCAGTCTGATCTGGAGAAGGTCAACCCGGAGTTGCGCAAGATGGTGATCTCGCTGCCGCCCAACGGCGTCTCGCC
GATTATCCCCACGCCCGAGGGCTACCGCATCCTAAAGGTCATTAGCAAAGAGCCGGCCGGGCAGCGCGAGTTGAACGATC
CGCGCGTGCAGCAGAATATCCGGGATACGCTACTGAACAGTAAAGACCAGTTGCTGCGCGCCGCGTATTACGAGACCGCA
CGCAACGACGCCAAGATTCAGAATTACCTGGCGAAGAGCATTGTGGATAATGCCGGGAAGAGCAAGTAA

Upstream 100 bases:

>100_bases
CGTGCCGATCATTCCGACTCTCATGGGTACGACTATTCTAGCGAGCTTTATGTTGAGGCGGGTGCTACAGGATACAATAA
AGGGTTAGCCAACCATACAA

Downstream 100 bases:

>100_bases
GAGGACGCTCCCTGATGATCGCGGCTCAGTTCGTGTGGCCCATTTCGTAGACGTAGATGGTGTGCTCCATCTTGCCGATT
TTGACGTGGACCACTTCGGC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKRIFVVFAAGVAALTLASCKHSPPANVAAEVDNHAITNSDLEKTYQSQYAQQSEGASEDQILTQKLDLLSSMITQEIML
RKAEKLGLAAVDADVDAEISKMRAPYTKEEFEKQLSAQHMTLDDLKLKVRSKLTVDKLVNKEITSKITITDADVKNFYNN
NKAAFNLPEPAIHMAQILVTPFPDPNVRNLKNSKAQNDKEARAKIEDILGRLKRGDDFGMLAQNYSEDANSAPNGGDMGF
VRQSDLEKVNPELRKMVISLPPNGVSPIIPTPEGYRILKVISKEPAGQRELNDPRVQQNIRDTLLNSKDQLLRAAYYETA
RNDAKIQNYLAKSIVDNAGKSK

Sequences:

>Translated_342_residues
MKRIFVVFAAGVAALTLASCKHSPPANVAAEVDNHAITNSDLEKTYQSQYAQQSEGASEDQILTQKLDLLSSMITQEIML
RKAEKLGLAAVDADVDAEISKMRAPYTKEEFEKQLSAQHMTLDDLKLKVRSKLTVDKLVNKEITSKITITDADVKNFYNN
NKAAFNLPEPAIHMAQILVTPFPDPNVRNLKNSKAQNDKEARAKIEDILGRLKRGDDFGMLAQNYSEDANSAPNGGDMGF
VRQSDLEKVNPELRKMVISLPPNGVSPIIPTPEGYRILKVISKEPAGQRELNDPRVQQNIRDTLLNSKDQLLRAAYYETA
RNDAKIQNYLAKSIVDNAGKSK
>Mature_342_residues
MKRIFVVFAAGVAALTLASCKHSPPANVAAEVDNHAITNSDLEKTYQSQYAQQSEGASEDQILTQKLDLLSSMITQEIML
RKAEKLGLAAVDADVDAEISKMRAPYTKEEFEKQLSAQHMTLDDLKLKVRSKLTVDKLVNKEITSKITITDADVKNFYNN
NKAAFNLPEPAIHMAQILVTPFPDPNVRNLKNSKAQNDKEARAKIEDILGRLKRGDDFGMLAQNYSEDANSAPNGGDMGF
VRQSDLEKVNPELRKMVISLPPNGVSPIIPTPEGYRILKVISKEPAGQRELNDPRVQQNIRDTLLNSKDQLLRAAYYETA
RNDAKIQNYLAKSIVDNAGKSK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786238, Length=225, Percent_Identity=25.3333333333333, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 37967; Mature: 37967

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIFVVFAAGVAALTLASCKHSPPANVAAEVDNHAITNSDLEKTYQSQYAQQSEGASED
CCEEEEEHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
QILTQKLDLLSSMITQEIMLRKAEKLGLAAVDADVDAEISKMRAPYTKEEFEKQLSAQHM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCC
TLDDLKLKVRSKLTVDKLVNKEITSKITITDADVKNFYNNNKAAFNLPEPAIHMAQILVT
CHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHCCCCEEECCCCHHHHHHHHHCC
PFPDPNVRNLKNSKAQNDKEARAKIEDILGRLKRGDDFGMLAQNYSEDANSAPNGGDMGF
CCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCC
VRQSDLEKVNPELRKMVISLPPNGVSPIIPTPEGYRILKVISKEPAGQRELNDPRVQQNI
CCHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHH
RDTLLNSKDQLLRAAYYETARNDAKIQNYLAKSIVDNAGKSK
HHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRIFVVFAAGVAALTLASCKHSPPANVAAEVDNHAITNSDLEKTYQSQYAQQSEGASED
CCEEEEEHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
QILTQKLDLLSSMITQEIMLRKAEKLGLAAVDADVDAEISKMRAPYTKEEFEKQLSAQHM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCC
TLDDLKLKVRSKLTVDKLVNKEITSKITITDADVKNFYNNNKAAFNLPEPAIHMAQILVT
CHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHCCCCEEECCCCHHHHHHHHHCC
PFPDPNVRNLKNSKAQNDKEARAKIEDILGRLKRGDDFGMLAQNYSEDANSAPNGGDMGF
CCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCC
VRQSDLEKVNPELRKMVISLPPNGVSPIIPTPEGYRILKVISKEPAGQRELNDPRVQQNI
CCHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHH
RDTLLNSKDQLLRAAYYETARNDAKIQNYLAKSIVDNAGKSK
HHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA