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The map label for this gene is iolS [H]

Identifier: 116620628

GI number: 116620628

Start: 1847488

End: 1848474

Strand: Reverse

Name: iolS [H]

Synonym: Acid_1507

Alternate gene names: 116620628

Gene position: 1848474-1847488 (Counterclockwise)

Preceding gene: 116620629

Following gene: 116620627

Centisome position: 18.55

GC content: 66.77

Gene sequence:

>987_bases
ATGATCTCCCAACGCTCGCTCGGCCAACAGGGACTCCGCGTCTCCGCCCTTGGACTCGGCTGCCTCGGCATGAGCGCCTC
CTACGGCGTTCCCGACGACCAGGAATCGCTGGCCACCCTTGACCGCGCCGTCGAATTGGGCGTCACCCTCTTTGACACCG
CCGAAGCCTATGGCCCCTTCGTCAACGAAGAACTCGTCGGACGCGCTCTCAAGAACGTCCGCAGCCGCGTTACTATCGCC
ACCAAATTCGGCTGGCGCTTCGAGAATGGCCGCTTCACCGGCACCGATAGCCGCCCCGAGCACGTGAAAGAGGTCGCCGA
CGCCTCTCTCCGCCGCCTCGGCACCGACTACATCGATATCTTCTACCAGCACCGCGTCGATCCCGACGTTCCCATCGAAG
ATACCGTCGGTGCCATGGCCGACCTCGTCCGACAAGGCAAGGTGCGCTATCTCGGCCTCTCCGAAGCCGGCGAGTCCACC
ATCCGCCGCGCTCACGCCGTTCATCCCATCTCGGTGCTGCAAAGCGAGTACTCACTGTGGGAGCGCAACCTCGAACCGCG
CATCATTCCCACCCTGCGCGAACTCGGCATTGGCCTCGTCCCGTTCGCGCCGCTGGGCCGCGGCTTTCTGACCGGCACCG
CCAAACCGGCCGCCGAATATCCGGAGACCGATTGGCGCCGCACGGACCCGCGCTTTGAAGGCGAGCACTACGACCGCAAT
ATGCAGGCCGCCGGCGCCGTCCGCCAGATCGCTGCGCAGCACAACGCGACGCCCGCCCAGGTCTCGCTCGCCTGGCTGCT
CCATCAGGGCCCCGACATCGTCCCCATCCCCGGCACCAAACGCCGCCTCTACCTCGAGGAGAATCTCCAGGCCGCCGCAC
TCCAGCTCGGCGCCGCGGACCTGGAGCGCCTGGACGCGGCACTCGCGCCCGATATCGTCGCCGGCCCCCGCTACCATCCG
CGCCTGATGGCCTTCATCGATCGCTAA

Upstream 100 bases:

>100_bases
CGGTGGGGGTTTTCGACCGTGCAGCCGCCTTTCAGGCGGCTTCTGCGGTGACCGGCTTCGCGTCCAATCTAAATACCCAC
CCGTCTGCTAGCATACCGGC

Downstream 100 bases:

>100_bases
GTCACGTATCGCACTTCGCAGTAAAATTAAGATCAGTTCGGGTGCGCATGAAGGCCAGCCTCCAAGTCGCCGCTGCGGTG
GTGCTCGCCGTTCCAGGTTT

Product: aldo/keto reductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MISQRSLGQQGLRVSALGLGCLGMSASYGVPDDQESLATLDRAVELGVTLFDTAEAYGPFVNEELVGRALKNVRSRVTIA
TKFGWRFENGRFTGTDSRPEHVKEVADASLRRLGTDYIDIFYQHRVDPDVPIEDTVGAMADLVRQGKVRYLGLSEAGEST
IRRAHAVHPISVLQSEYSLWERNLEPRIIPTLRELGIGLVPFAPLGRGFLTGTAKPAAEYPETDWRRTDPRFEGEHYDRN
MQAAGAVRQIAAQHNATPAQVSLAWLLHQGPDIVPIPGTKRRLYLEENLQAAALQLGAADLERLDAALAPDIVAGPRYHP
RLMAFIDR

Sequences:

>Translated_328_residues
MISQRSLGQQGLRVSALGLGCLGMSASYGVPDDQESLATLDRAVELGVTLFDTAEAYGPFVNEELVGRALKNVRSRVTIA
TKFGWRFENGRFTGTDSRPEHVKEVADASLRRLGTDYIDIFYQHRVDPDVPIEDTVGAMADLVRQGKVRYLGLSEAGEST
IRRAHAVHPISVLQSEYSLWERNLEPRIIPTLRELGIGLVPFAPLGRGFLTGTAKPAAEYPETDWRRTDPRFEGEHYDRN
MQAAGAVRQIAAQHNATPAQVSLAWLLHQGPDIVPIPGTKRRLYLEENLQAAALQLGAADLERLDAALAPDIVAGPRYHP
RLMAFIDR
>Mature_328_residues
MISQRSLGQQGLRVSALGLGCLGMSASYGVPDDQESLATLDRAVELGVTLFDTAEAYGPFVNEELVGRALKNVRSRVTIA
TKFGWRFENGRFTGTDSRPEHVKEVADASLRRLGTDYIDIFYQHRVDPDVPIEDTVGAMADLVRQGKVRYLGLSEAGEST
IRRAHAVHPISVLQSEYSLWERNLEPRIIPTLRELGIGLVPFAPLGRGFLTGTAKPAAEYPETDWRRTDPRFEGEHYDRN
MQAAGAVRQIAAQHNATPAQVSLAWLLHQGPDIVPIPGTKRRLYLEENLQAAALQLGAADLERLDAALAPDIVAGPRYHP
RLMAFIDR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=321, Percent_Identity=28.3489096573209, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4504825, Length=321, Percent_Identity=28.3489096573209, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI27436971, Length=279, Percent_Identity=31.5412186379928, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI27436962, Length=306, Percent_Identity=29.7385620915033, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI27436966, Length=304, Percent_Identity=29.9342105263158, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI27436964, Length=303, Percent_Identity=30.03300330033, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI223718702, Length=294, Percent_Identity=29.5918367346939, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI41327764, Length=288, Percent_Identity=29.1666666666667, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI41152114, Length=294, Percent_Identity=29.2517006802721, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87081735, Length=335, Percent_Identity=33.7313432835821, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789375, Length=327, Percent_Identity=32.4159021406728, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1788070, Length=310, Percent_Identity=30.6451612903226, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787674, Length=302, Percent_Identity=31.4569536423841, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788081, Length=278, Percent_Identity=28.0575539568345, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789199, Length=341, Percent_Identity=28.4457478005865, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI48994888, Length=127, Percent_Identity=34.6456692913386, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17564128, Length=319, Percent_Identity=24.4514106583072, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323998, Length=325, Percent_Identity=28, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325169, Length=345, Percent_Identity=27.8260869565217, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6319958, Length=301, Percent_Identity=26.2458471760797, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6325384, Length=319, Percent_Identity=27.8996865203762, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322615, Length=261, Percent_Identity=28.3524904214559, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6319951, Length=296, Percent_Identity=28.3783783783784, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24640980, Length=329, Percent_Identity=30.6990881458967, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45549126, Length=329, Percent_Identity=30.6990881458967, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646155, Length=251, Percent_Identity=29.8804780876494, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646159, Length=230, Percent_Identity=30.4347826086957, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36216; Mature: 36216

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISQRSLGQQGLRVSALGLGCLGMSASYGVPDDQESLATLDRAVELGVTLFDTAEAYGPF
CCCCHHCCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHCCC
VNEELVGRALKNVRSRVTIATKFGWRFENGRFTGTDSRPEHVKEVADASLRRLGTDYIDI
CCHHHHHHHHHHHHHHEEEEEEECEEECCCEECCCCCCHHHHHHHHHHHHHHHCCHHHHH
FYQHRVDPDVPIEDTVGAMADLVRQGKVRYLGLSEAGESTIRRAHAVHPISVLQSEYSLW
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
ERNLEPRIIPTLRELGIGLVPFAPLGRGFLTGTAKPAAEYPETDWRRTDPRFEGEHYDRN
HHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCC
MQAAGAVRQIAAQHNATPAQVSLAWLLHQGPDIVPIPGTKRRLYLEENLQAAALQLGAAD
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEHHCHHHHHHHHHHHH
LERLDAALAPDIVAGPRYHPRLMAFIDR
HHHHHHHHCCCHHCCCCCCCHHHHEECC
>Mature Secondary Structure
MISQRSLGQQGLRVSALGLGCLGMSASYGVPDDQESLATLDRAVELGVTLFDTAEAYGPF
CCCCHHCCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHCCC
VNEELVGRALKNVRSRVTIATKFGWRFENGRFTGTDSRPEHVKEVADASLRRLGTDYIDI
CCHHHHHHHHHHHHHHEEEEEEECEEECCCEECCCCCCHHHHHHHHHHHHHHHCCHHHHH
FYQHRVDPDVPIEDTVGAMADLVRQGKVRYLGLSEAGESTIRRAHAVHPISVLQSEYSLW
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
ERNLEPRIIPTLRELGIGLVPFAPLGRGFLTGTAKPAAEYPETDWRRTDPRFEGEHYDRN
HHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCC
MQAAGAVRQIAAQHNATPAQVSLAWLLHQGPDIVPIPGTKRRLYLEENLQAAALQLGAAD
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEHHCHHHHHHHHHHHH
LERLDAALAPDIVAGPRYHPRLMAFIDR
HHHHHHHHCCCHHCCCCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]