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The map label for this gene is lexA [H]

Identifier: 116620617

GI number: 116620617

Start: 1835249

End: 1835872

Strand: Direct

Name: lexA [H]

Synonym: Acid_1496

Alternate gene names: 116620617

Gene position: 1835249-1835872 (Clockwise)

Preceding gene: 116620614

Following gene: 116620619

Centisome position: 18.42

GC content: 60.58

Gene sequence:

>624_bases
ATGGCACTGACGAAGCGGCAAAAGCAGGTGCTGGATTTCATCGGCAATTTCGTGGACGAGAACGGCTACTGTCCGAGTTA
CGAGGAGATCGCCCGCGGTTTGGAACTGGCATCGCTGGCTACCGTCCATAAGCACATTTCGGTACTGGAAGCGAAGAGCT
ATCTGAAGCGCGGATTCAACCAGAGCCGGTCGCTGGAGCTGACGCCGAAGTATGTGCAGGAACAGCGGCGCACACGGCCG
GCGATCGCGGAGATCCCGATGCTCGGGCGGATCGCGGCGGGTTTGCCGGTGGAGGCGGTGGAGCAGCGCGAGGTGCTGAA
CTTCGCCGATTTCGCGGGCGATGGCAACACGTTCGCGCTCGAAGTGCGCGGCAATTCGATGATCGATGACCACATCTGCG
ATGGCGACGTGATTCTGCTCGAGCGCGTCACGCAGGCGCGCGACGGCGATATCGTGGTGGCACTGGTGGCGGGGAGCGAT
ACCACGCTGAAGCGTTTTTATCGCGAGTCCGCGGACACAATCCGACTACAGCCAGCCAATGCCGCGCTCAAACCGATTTT
GGTTCCTGCCAGGGATGTACAGATTCAGGGCCGGCTGCTGGCCGTCCTGAGGAAGTATAAGTAA

Upstream 100 bases:

>100_bases
TGTTCGCTGATTATACGAGATTGGGAGGGTTTTGGTTCAGGCCGTTGATTTCGCTTGATTTTCCCTTTTTGTTCGCCCAC
AATGGAACGCAGGAGTCTGC

Downstream 100 bases:

>100_bases
GTAGAGTTACTTCGAGGTAACCGCGCGCAGTTCCTGCTCGGCACGCAGCCAATCTTCTTCGGGGGAGCCGCCCTGATAGC
CGCGCGCCACCCAATAGGAG

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MALTKRQKQVLDFIGNFVDENGYCPSYEEIARGLELASLATVHKHISVLEAKSYLKRGFNQSRSLELTPKYVQEQRRTRP
AIAEIPMLGRIAAGLPVEAVEQREVLNFADFAGDGNTFALEVRGNSMIDDHICDGDVILLERVTQARDGDIVVALVAGSD
TTLKRFYRESADTIRLQPANAALKPILVPARDVQIQGRLLAVLRKYK

Sequences:

>Translated_207_residues
MALTKRQKQVLDFIGNFVDENGYCPSYEEIARGLELASLATVHKHISVLEAKSYLKRGFNQSRSLELTPKYVQEQRRTRP
AIAEIPMLGRIAAGLPVEAVEQREVLNFADFAGDGNTFALEVRGNSMIDDHICDGDVILLERVTQARDGDIVVALVAGSD
TTLKRFYRESADTIRLQPANAALKPILVPARDVQIQGRLLAVLRKYK
>Mature_206_residues
ALTKRQKQVLDFIGNFVDENGYCPSYEEIARGLELASLATVHKHISVLEAKSYLKRGFNQSRSLELTPKYVQEQRRTRPA
IAEIPMLGRIAAGLPVEAVEQREVLNFADFAGDGNTFALEVRGNSMIDDHICDGDVILLERVTQARDGDIVVALVAGSDT
TLKRFYRESADTIRLQPANAALKPILVPARDVQIQGRLLAVLRKYK

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=208, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23051; Mature: 22920

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTKRQKQVLDFIGNFVDENGYCPSYEEIARGLELASLATVHKHISVLEAKSYLKRGFN
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QSRSLELTPKYVQEQRRTRPAIAEIPMLGRIAAGLPVEAVEQREVLNFADFAGDGNTFAL
CCCCEEECHHHHHHHHHCCCCHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEE
EVRGNSMIDDHICDGDVILLERVTQARDGDIVVALVAGSDTTLKRFYRESADTIRLQPAN
EECCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCEEEEECCC
AALKPILVPARDVQIQGRLLAVLRKYK
CCCCEEEECCCCCEEHHHHHHHHHHCC
>Mature Secondary Structure 
ALTKRQKQVLDFIGNFVDENGYCPSYEEIARGLELASLATVHKHISVLEAKSYLKRGFN
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QSRSLELTPKYVQEQRRTRPAIAEIPMLGRIAAGLPVEAVEQREVLNFADFAGDGNTFAL
CCCCEEECHHHHHHHHHCCCCHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEE
EVRGNSMIDDHICDGDVILLERVTQARDGDIVVALVAGSDTTLKRFYRESADTIRLQPAN
EECCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCEEEEECCC
AALKPILVPARDVQIQGRLLAVLRKYK
CCCCEEEECCCCCEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA