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The map label for this gene is thiD [H]

Identifier: 116620349

GI number: 116620349

Start: 1512205

End: 1512993

Strand: Direct

Name: thiD [H]

Synonym: Acid_1226

Alternate gene names: 116620349

Gene position: 1512205-1512993 (Clockwise)

Preceding gene: 116620348

Following gene: 116620350

Centisome position: 15.17

GC content: 67.05

Gene sequence:

>789_bases
ATGAAGGCGGCGGCACTGACGATTGCGGGAAGCGATCCGAGCGGAGGGGCAGGGATACAGGCGGATCTGAAGACATTTCA
TCAGTTTGGGGTTTACGGCGAGGCCGTGATCACGCTGGTGACGGTGCAAAATACCGTACGGGTGTCGCGAGTGGAAGTGA
TGCCGGAGGCGCTGGTGCTGGAGCAGATTGCGGCGGTCGTCGAAGATATTCCTCCGGGGGCGGCGAAGACGGGGGCGCTG
GGGTCGGCGGGCATGGTGGCGGCCGTGGCGGGGGCGGCGGCCGGGTTCGGGTTTCCACTGGTGGTGGATCCGGTGATGGT
GAGTAAGCACGGGCTGCCGCTATTGCCGGGAGATGCGGTGGGGGCGATCCGCGAGCTGCTGTTGCCCCAGGCGGCGCTGA
TTACGCCGAACGTGCCGGAGGCGGAGGCGCTGACCGGGATCACGATCTCCGGAGTGGTCGAGATGCGGGCGGCGGCCTGC
CGCCTGCGGGAGATGGGGGCGCGGGCGGTGTTGATCAAGGGCGGGCATTTGGAGGGCGAGGCGATCGACCTGCTCTTGGA
TGGCGGGGAATGGTACGTGTTCGAGGGCAAGCGGGTGGACACGCGGCATACTCACGGGACCGGATGCACGTACTCGGCGG
CGATCACGGCGGGGCTCGCGCTCGGGCTCGGGATGGCGGAAGCGGTGGGAAAGGCGAAGCGATTCATCCAGGAAGCGATT
CGGACGAATCCGGGCCTGGGGAGCGGGTGTGGACCGGTGAATCATCACGCTCGAACGGAGGCGGAATGA

Upstream 100 bases:

>100_bases
GCGGCTCTGCGGCTCTGCGAGAGACTGAGAGTTTCTCGCGAAGCCGCCAAGCCGCAAAGTAACGCCAAGAAGAATAACAA
AGATATAAGCTGAGAGAACC

Downstream 100 bases:

>100_bases
AATTCCAGGAAATGTTGCTGGCGGCGATCGAGCGTGCGGAGATTCCGCTGCGGTTCGAACCGGGGGCGGGGGAAGCGGTG
GCGAAGCCGGTTACGGAGAT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MKAAALTIAGSDPSGGAGIQADLKTFHQFGVYGEAVITLVTVQNTVRVSRVEVMPEALVLEQIAAVVEDIPPGAAKTGAL
GSAGMVAAVAGAAAGFGFPLVVDPVMVSKHGLPLLPGDAVGAIRELLLPQAALITPNVPEAEALTGITISGVVEMRAAAC
RLREMGARAVLIKGGHLEGEAIDLLLDGGEWYVFEGKRVDTRHTHGTGCTYSAAITAGLALGLGMAEAVGKAKRFIQEAI
RTNPGLGSGCGPVNHHARTEAE

Sequences:

>Translated_262_residues
MKAAALTIAGSDPSGGAGIQADLKTFHQFGVYGEAVITLVTVQNTVRVSRVEVMPEALVLEQIAAVVEDIPPGAAKTGAL
GSAGMVAAVAGAAAGFGFPLVVDPVMVSKHGLPLLPGDAVGAIRELLLPQAALITPNVPEAEALTGITISGVVEMRAAAC
RLREMGARAVLIKGGHLEGEAIDLLLDGGEWYVFEGKRVDTRHTHGTGCTYSAAITAGLALGLGMAEAVGKAKRFIQEAI
RTNPGLGSGCGPVNHHARTEAE
>Mature_262_residues
MKAAALTIAGSDPSGGAGIQADLKTFHQFGVYGEAVITLVTVQNTVRVSRVEVMPEALVLEQIAAVVEDIPPGAAKTGAL
GSAGMVAAVAGAAAGFGFPLVVDPVMVSKHGLPLLPGDAVGAIRELLLPQAALITPNVPEAEALTGITISGVVEMRAAAC
RLREMGARAVLIKGGHLEGEAIDLLLDGGEWYVFEGKRVDTRHTHGTGCTYSAAITAGLALGLGMAEAVGKAKRFIQEAI
RTNPGLGSGCGPVNHHARTEAE

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=256, Percent_Identity=43.359375, Blast_Score=165, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325378, Length=274, Percent_Identity=31.3868613138686, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324517, Length=273, Percent_Identity=34.4322344322344, Blast_Score=109, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324997, Length=273, Percent_Identity=35.1648351648352, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 26684; Mature: 26684

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAALTIAGSDPSGGAGIQADLKTFHQFGVYGEAVITLVTVQNTVRVSRVEVMPEALVL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHH
EQIAAVVEDIPPGAAKTGALGSAGMVAAVAGAAAGFGFPLVVDPVMVSKHGLPLLPGDAV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCHHHHCCCCCCCCCCHHH
GAIRELLLPQAALITPNVPEAEALTGITISGVVEMRAAACRLREMGARAVLIKGGHLEGE
HHHHHHHCCCHHEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
AIDLLLDGGEWYVFEGKRVDTRHTHGTGCTYSAAITAGLALGLGMAEAVGKAKRFIQEAI
EEEEEEECCEEEEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTNPGLGSGCGPVNHHARTEAE
HCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKAAALTIAGSDPSGGAGIQADLKTFHQFGVYGEAVITLVTVQNTVRVSRVEVMPEALVL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHH
EQIAAVVEDIPPGAAKTGALGSAGMVAAVAGAAAGFGFPLVVDPVMVSKHGLPLLPGDAV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCHHHHCCCCCCCCCCHHH
GAIRELLLPQAALITPNVPEAEALTGITISGVVEMRAAACRLREMGARAVLIKGGHLEGE
HHHHHHHCCCHHEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
AIDLLLDGGEWYVFEGKRVDTRHTHGTGCTYSAAITAGLALGLGMAEAVGKAKRFIQEAI
EEEEEEECCEEEEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTNPGLGSGCGPVNHHARTEAE
HCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]