Click here to switch to the map view.

The map label for this gene is prsA [H]

Identifier: 116620335

GI number: 116620335

Start: 1496832

End: 1497815

Strand: Reverse

Name: prsA [H]

Synonym: Acid_1212

Alternate gene names: 116620335

Gene position: 1497815-1496832 (Counterclockwise)

Preceding gene: 116620336

Following gene: 116620334

Centisome position: 15.03

GC content: 61.38

Gene sequence:

>984_bases
ATGAGGTTTCCCTCCGTAGTTTTCCTGGCCGCCCTCAGTGTGTCCGCGATCGGTGTGCCCGTGATGGCGCAGGAAGCGCC
CAAGGCACAGCCACCGGTAATGACCCGGCCCGACGGCGCCACCGTGCCGCTCGAGGTGACGCCGCCGCCAGCGCCGCTGC
CGCCTAACCGCGTCATTCTCCAGGTAGGCGAAATCGCTCTCACCGCCGGACAGCTGGAGCAGATTCTGGAAGCCTATTCA
GAGGCCCAGCGTGTCTACGTGAACGGCCCCGGCCGCCCTCAGTTCATCCAGCAACTCATCCGCGTGCTGATGCTGTCGCA
GGAAGGCAAGCGGCGCAAGCTGGATGAGACCGATCGCTACCGCAATCAGCTGACCTACTCGGCCGCCGGCATTCTTTCCA
ATCACACCGAGGAAGACATTCGCAAGAAGATCAAGATCGACGATGCCATGCTGGAGGATTACCTGAAGGCGCATCCGCTC
GACTATATGCAGGTCCGCGCCCGGCACATCCTGATCCGCACCCCGGGATCCTCCCTGCCGCTCGAGCCCGGGCAGAAGGA
GTTGACTGATGCCGAAGCGCTCACCAAGGCGCAGGAACTCCGCGCGAAAATCGTGGCAGGCGCCGATTTCGCGGACGTGG
CCAAAATCGAATCGAACGACATTTCCACCAACACCAAGGGCGGCGACCTCGGATTCTTCAAGCGCGGCCAGATGGCGCCG
TCAATCGAAGAGGCAGCCTTCGCCCTCAAGCCCGGCGAAATCAGCCAACCCGTGAAAACCTCCATGGGCTACACCGTGAT
CAAAGTGGAGGAGATCAAGCCGGTGAAGAGCTTTGAGGAGCTGCGTCCCGACCTGGAACGGAACTTGCGCAACGAGTTGA
CCCGCAAATACGTGGATGATCTGAAGGCGTTGACGAAAATCGAAATCGACCCAGAATTCGCCGCGCCGCGCAAGGGAAGT
TTCCCGGTGAAGCCGGCCCAATGA

Upstream 100 bases:

>100_bases
GATTCAGGCATACGGTCCGGACTGGCGCCTGCCGCGATCCAAAGGTTCCATGAGCGCCGTGGTGGAACCCGCGCAGTAGA
GGTTGGTTATCATAACGAAT

Downstream 100 bases:

>100_bases
AGACTCGCAAGCTGGAGATCGCCTGCCCGCAGTGCGGCTCGAAGGAAGTCTTCTATAGCTGCACCCCAGGCTGCTGCTTC
AACCACGTGTGCAGCGACTG

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MRFPSVVFLAALSVSAIGVPVMAQEAPKAQPPVMTRPDGATVPLEVTPPPAPLPPNRVILQVGEIALTAGQLEQILEAYS
EAQRVYVNGPGRPQFIQQLIRVLMLSQEGKRRKLDETDRYRNQLTYSAAGILSNHTEEDIRKKIKIDDAMLEDYLKAHPL
DYMQVRARHILIRTPGSSLPLEPGQKELTDAEALTKAQELRAKIVAGADFADVAKIESNDISTNTKGGDLGFFKRGQMAP
SIEEAAFALKPGEISQPVKTSMGYTVIKVEEIKPVKSFEELRPDLERNLRNELTRKYVDDLKALTKIEIDPEFAAPRKGS
FPVKPAQ

Sequences:

>Translated_327_residues
MRFPSVVFLAALSVSAIGVPVMAQEAPKAQPPVMTRPDGATVPLEVTPPPAPLPPNRVILQVGEIALTAGQLEQILEAYS
EAQRVYVNGPGRPQFIQQLIRVLMLSQEGKRRKLDETDRYRNQLTYSAAGILSNHTEEDIRKKIKIDDAMLEDYLKAHPL
DYMQVRARHILIRTPGSSLPLEPGQKELTDAEALTKAQELRAKIVAGADFADVAKIESNDISTNTKGGDLGFFKRGQMAP
SIEEAAFALKPGEISQPVKTSMGYTVIKVEEIKPVKSFEELRPDLERNLRNELTRKYVDDLKALTKIEIDPEFAAPRKGS
FPVKPAQ
>Mature_327_residues
MRFPSVVFLAALSVSAIGVPVMAQEAPKAQPPVMTRPDGATVPLEVTPPPAPLPPNRVILQVGEIALTAGQLEQILEAYS
EAQRVYVNGPGRPQFIQQLIRVLMLSQEGKRRKLDETDRYRNQLTYSAAGILSNHTEEDIRKKIKIDDAMLEDYLKAHPL
DYMQVRARHILIRTPGSSLPLEPGQKELTDAEALTKAQELRAKIVAGADFADVAKIESNDISTNTKGGDLGFFKRGQMAP
SIEEAAFALKPGEISQPVKTSMGYTVIKVEEIKPVKSFEELRPDLERNLRNELTRKYVDDLKALTKIEIDPEFAAPRKGS
FPVKPAQ

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=150, Percent_Identity=28.6666666666667, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322478, Length=124, Percent_Identity=38.7096774193548, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 36186; Mature: 36186

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFPSVVFLAALSVSAIGVPVMAQEAPKAQPPVMTRPDGATVPLEVTPPPAPLPPNRVIL
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCCCCEEE
QVGEIALTAGQLEQILEAYSEAQRVYVNGPGRPQFIQQLIRVLMLSQEGKRRKLDETDRY
EHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
RNQLTYSAAGILSNHTEEDIRKKIKIDDAMLEDYLKAHPLDYMQVRARHILIRTPGSSLP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEECCCCCCC
LEPGQKELTDAEALTKAQELRAKIVAGADFADVAKIESNDISTNTKGGDLGFFKRGQMAP
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SIEEAAFALKPGEISQPVKTSMGYTVIKVEEIKPVKSFEELRPDLERNLRNELTRKYVDD
CHHHHHHEECCCCCCCCHHHHCCEEEEEEECCCCHHHHHHHCHHHHHHHHHHHHHHHHHH
LKALTKIEIDPEFAAPRKGSFPVKPAQ
HHHHHEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFPSVVFLAALSVSAIGVPVMAQEAPKAQPPVMTRPDGATVPLEVTPPPAPLPPNRVIL
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCCCCEEE
QVGEIALTAGQLEQILEAYSEAQRVYVNGPGRPQFIQQLIRVLMLSQEGKRRKLDETDRY
EHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
RNQLTYSAAGILSNHTEEDIRKKIKIDDAMLEDYLKAHPLDYMQVRARHILIRTPGSSLP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEECCCCCCC
LEPGQKELTDAEALTKAQELRAKIVAGADFADVAKIESNDISTNTKGGDLGFFKRGQMAP
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SIEEAAFALKPGEISQPVKTSMGYTVIKVEEIKPVKSFEELRPDLERNLRNELTRKYVDD
CHHHHHHEECCCCCCCCHHHHCCEEEEEEECCCCHHHHHHHCHHHHHHHHHHHHHHHHHH
LKALTKIEIDPEFAAPRKGSFPVKPAQ
HHHHHEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]