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The map label for this gene is ddc [H]

Identifier: 116620305

GI number: 116620305

Start: 1455413

End: 1456825

Strand: Reverse

Name: ddc [H]

Synonym: Acid_1182

Alternate gene names: 116620305

Gene position: 1456825-1455413 (Counterclockwise)

Preceding gene: 116620306

Following gene: 116620303

Centisome position: 14.62

GC content: 65.75

Gene sequence:

>1413_bases
ATGAATCCTGAAGAATTTCGGCGCCGGGGGCATCAGATCATCGATCGGATTGCGGATTATCGAGCCAATGTGGCGCGGTA
TCCGGTGATGGCGCGGACGGCTCCCGGCGAAATCAAGGCGGCGCTGCCCGCCGAACCGCCGGAGAATCCGGAAAGCTTCG
ACGAGGTGCTGGCCGATCTCGACCGGGTGGTGATGCCCGGACTCTCGCACTGGCAGCACCCGCGGTTCTTCGGCTACTTC
CCTTCCAACGGCGAGCTCTCGAGCGTGCTGGGCGATTACCTCTCCACCGGATTGGGGGTGCTGGGACTCTCCTGGCAATC
CAGCCCGGCGCTGAGCGAAGTCGAAGAGGTGGTGACCGACTGGATGCGGCAGATGACCGGACTTTCGGCGGAATGGAGCG
GCGTGATTCAGGACACCGCCTCCACCTGTACGCTGGTGGCGCTGCTGTGCGCGCGCGAGCGCTCCACCGGCTACGGCCTG
GCGCGCGGCGGATTGCAGGCGGAAGCGCAGCCGCTAATCGTTTACACCTCCGGGCACAGTCACAGTTCGGTGGATAAAGC
GGCGCTGCTCGCGGGCTTCGGCCGAGAGAACGTGCGACATATCGCGAGTGATGAGAAGTTCGCGCTGCGACCGGAGGCGC
TGGAGGAGGCGATCCGCGAAGACCTGGCGGCGGGGCGAAAACCTTGCGCGATCGCCGGCACCACTGGGACTACGGCGACG
ACCGCGCTCGACCCCATTGCGGACATGGCGCGCATCGCACGAGAGTATGGACTCTGGCTGCACGTGGACGCGGCCATGGC
GGGTTCTGCCATGGTGCTGCCTGAGTGCCGCTGGATGTGGGACGGCATCGAAGGCGCGGATTCCGTGGTGCTCAATCCGC
ACAAGTGGCTCGGGGCGGCCTTCGATTGTTCGCTATATTACGTTCGGGGCCCCGAGCACCTGATTCGCGTCATGTCCACG
AGTCCCAGCTACCTAAGGACCGCGGCCGACGATCAGGTCAAGAACCTGCGCGATTGGGGACTGCCGCTGGGTCGCCGGTT
CCGCGCCCTGAAGCTCTGGTTTCTGATTCGCGAGCAAGGAGTTAAGGGATTGCAGGCCCGGCTGCGCCGGGATCTCGTCA
ACGCGCAGTGGCTTACCTCCGCAATCTGCGCGGAGCCAAACTGGCGAGTCCTGGCCCCGGTACCGCTGCAGACGCTGTGC
GTCCGGCACGAGCCGCCGGGGTTGGAGGGTGAAGCGCTGGACCGCCACACGCAGGCATGGGCGGACCGCATCAATCGCTC
GGGAGAGGCGTACCTGACGCCGGCGATTCTCGAGGGCCGGTGGATGGTGCGGGTGTCGGTCGGCGCGCTCCTGACCGAAC
GGGAGCACGTAGAGGCTTTGTGGCGGCTGATGCGAAAAGAAGCGGGCGGCTGA

Upstream 100 bases:

>100_bases
GATGGTGGAGAAGGGCGCGCAAGGGAGCGCGGGAGAGATCCGGGCTGTGATTGGGTACCTGGCGGAGAACTACGGGAAAT
AGTGTTTGAATCAGTAGTGT

Downstream 100 bases:

>100_bases
GAGTGCCACCGCCCGCGTAGCCCGTCTAGGGGATATCGATCATGTAGCCGGAGATCGAGGCCAACACGGAGAACGTGGAT
CCGGTGGCGACGAAGGTGTC

Product: aromatic-L-amino-acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MNPEEFRRRGHQIIDRIADYRANVARYPVMARTAPGEIKAALPAEPPENPESFDEVLADLDRVVMPGLSHWQHPRFFGYF
PSNGELSSVLGDYLSTGLGVLGLSWQSSPALSEVEEVVTDWMRQMTGLSAEWSGVIQDTASTCTLVALLCARERSTGYGL
ARGGLQAEAQPLIVYTSGHSHSSVDKAALLAGFGRENVRHIASDEKFALRPEALEEAIREDLAAGRKPCAIAGTTGTTAT
TALDPIADMARIAREYGLWLHVDAAMAGSAMVLPECRWMWDGIEGADSVVLNPHKWLGAAFDCSLYYVRGPEHLIRVMST
SPSYLRTAADDQVKNLRDWGLPLGRRFRALKLWFLIREQGVKGLQARLRRDLVNAQWLTSAICAEPNWRVLAPVPLQTLC
VRHEPPGLEGEALDRHTQAWADRINRSGEAYLTPAILEGRWMVRVSVGALLTEREHVEALWRLMRKEAGG

Sequences:

>Translated_470_residues
MNPEEFRRRGHQIIDRIADYRANVARYPVMARTAPGEIKAALPAEPPENPESFDEVLADLDRVVMPGLSHWQHPRFFGYF
PSNGELSSVLGDYLSTGLGVLGLSWQSSPALSEVEEVVTDWMRQMTGLSAEWSGVIQDTASTCTLVALLCARERSTGYGL
ARGGLQAEAQPLIVYTSGHSHSSVDKAALLAGFGRENVRHIASDEKFALRPEALEEAIREDLAAGRKPCAIAGTTGTTAT
TALDPIADMARIAREYGLWLHVDAAMAGSAMVLPECRWMWDGIEGADSVVLNPHKWLGAAFDCSLYYVRGPEHLIRVMST
SPSYLRTAADDQVKNLRDWGLPLGRRFRALKLWFLIREQGVKGLQARLRRDLVNAQWLTSAICAEPNWRVLAPVPLQTLC
VRHEPPGLEGEALDRHTQAWADRINRSGEAYLTPAILEGRWMVRVSVGALLTEREHVEALWRLMRKEAGG
>Mature_470_residues
MNPEEFRRRGHQIIDRIADYRANVARYPVMARTAPGEIKAALPAEPPENPESFDEVLADLDRVVMPGLSHWQHPRFFGYF
PSNGELSSVLGDYLSTGLGVLGLSWQSSPALSEVEEVVTDWMRQMTGLSAEWSGVIQDTASTCTLVALLCARERSTGYGL
ARGGLQAEAQPLIVYTSGHSHSSVDKAALLAGFGRENVRHIASDEKFALRPEALEEAIREDLAAGRKPCAIAGTTGTTAT
TALDPIADMARIAREYGLWLHVDAAMAGSAMVLPECRWMWDGIEGADSVVLNPHKWLGAAFDCSLYYVRGPEHLIRVMST
SPSYLRTAADDQVKNLRDWGLPLGRRFRALKLWFLIREQGVKGLQARLRRDLVNAQWLTSAICAEPNWRVLAPVPLQTLC
VRHEPPGLEGEALDRHTQAWADRINRSGEAYLTPAILEGRWMVRVSVGALLTEREHVEALWRLMRKEAGG

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=482, Percent_Identity=36.0995850622407, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI132814448, Length=482, Percent_Identity=36.0995850622407, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI92110055, Length=483, Percent_Identity=36.0248447204969, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI194294551, Length=412, Percent_Identity=29.126213592233, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI197383062, Length=367, Percent_Identity=29.9727520435967, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI58331246, Length=372, Percent_Identity=28.2258064516129, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI197276620, Length=379, Percent_Identity=27.7044854881267, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4503875, Length=379, Percent_Identity=27.7044854881267, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17534819, Length=478, Percent_Identity=37.0292887029289, Blast_Score=335, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI17534817, Length=478, Percent_Identity=37.0292887029289, Blast_Score=334, Evalue=6e-92,
Organism=Caenorhabditis elegans, GI71981211, Length=508, Percent_Identity=28.740157480315, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71981217, Length=517, Percent_Identity=28.0464216634429, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17551992, Length=509, Percent_Identity=28.2907662082515, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI133931025, Length=482, Percent_Identity=27.3858921161826, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17555682, Length=414, Percent_Identity=27.0531400966184, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71993058, Length=387, Percent_Identity=28.1653746770026, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71993062, Length=344, Percent_Identity=27.906976744186, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI193205882, Length=381, Percent_Identity=22.0472440944882, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24586044, Length=477, Percent_Identity=34.5911949685535, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI28573972, Length=472, Percent_Identity=36.864406779661, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24585139, Length=480, Percent_Identity=35.2083333333333, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI221476190, Length=480, Percent_Identity=35.2083333333333, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24585143, Length=480, Percent_Identity=35.2083333333333, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24652373, Length=481, Percent_Identity=35.1351351351351, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI17136190, Length=475, Percent_Identity=35.1578947368421, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24585135, Length=475, Percent_Identity=34.7368421052632, Blast_Score=281, Evalue=6e-76,
Organism=Drosophila melanogaster, GI17136594, Length=445, Percent_Identity=28.5393258426966, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24657193, Length=379, Percent_Identity=27.9683377308707, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24657185, Length=379, Percent_Identity=27.9683377308707, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24657188, Length=379, Percent_Identity=27.9683377308707, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21356415, Length=291, Percent_Identity=28.8659793814433, Blast_Score=118, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52037; Mature: 52037

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPEEFRRRGHQIIDRIADYRANVARYPVMARTAPGEIKAALPAEPPENPESFDEVLADL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCCHHHHHHHHHHH
DRVVMPGLSHWQHPRFFGYFPSNGELSSVLGDYLSTGLGVLGLSWQSSPALSEVEEVVTD
HHHHHCCCHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
WMRQMTGLSAEWSGVIQDTASTCTLVALLCARERSTGYGLARGGLQAEAQPLIVYTSGHS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEEEEECCCC
HSSVDKAALLAGFGRENVRHIASDEKFALRPEALEEAIREDLAAGRKPCAIAGTTGTTAT
CCHHHHHHHHHHCCHHHHHHHCCCCCEEECHHHHHHHHHHHHHCCCCCEEEECCCCCCHH
TALDPIADMARIAREYGLWLHVDAAMAGSAMVLPECRWMWDGIEGADSVVLNPHKWLGAA
HHHHHHHHHHHHHHHCCCEEEEEHHHCCCEEECCCHHHHHCCCCCCCCEEECCHHHHCCE
FDCSLYYVRGPEHLIRVMSTSPSYLRTAADDQVKNLRDWGLPLGRRFRALKLWFLIREQG
EEEEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
VKGLQARLRRDLVNAQWLTSAICAEPNWRVLAPVPLQTLCVRHEPPGLEGEALDRHTQAW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCHHHHHHHHHH
ADRINRSGEAYLTPAILEGRWMVRVSVGALLTEREHVEALWRLMRKEAGG
HHHHCCCCCEEECHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPEEFRRRGHQIIDRIADYRANVARYPVMARTAPGEIKAALPAEPPENPESFDEVLADL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCCHHHHHHHHHHH
DRVVMPGLSHWQHPRFFGYFPSNGELSSVLGDYLSTGLGVLGLSWQSSPALSEVEEVVTD
HHHHHCCCHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
WMRQMTGLSAEWSGVIQDTASTCTLVALLCARERSTGYGLARGGLQAEAQPLIVYTSGHS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEEEEECCCC
HSSVDKAALLAGFGRENVRHIASDEKFALRPEALEEAIREDLAAGRKPCAIAGTTGTTAT
CCHHHHHHHHHHCCHHHHHHHCCCCCEEECHHHHHHHHHHHHHCCCCCEEEECCCCCCHH
TALDPIADMARIAREYGLWLHVDAAMAGSAMVLPECRWMWDGIEGADSVVLNPHKWLGAA
HHHHHHHHHHHHHHHCCCEEEEEHHHCCCEEECCCHHHHHCCCCCCCCEEECCHHHHCCE
FDCSLYYVRGPEHLIRVMSTSPSYLRTAADDQVKNLRDWGLPLGRRFRALKLWFLIREQG
EEEEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
VKGLQARLRRDLVNAQWLTSAICAEPNWRVLAPVPLQTLCVRHEPPGLEGEALDRHTQAW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCHHHHHHHHHH
ADRINRSGEAYLTPAILEGRWMVRVSVGALLTEREHVEALWRLMRKEAGG
HHHHCCCCCEEECHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]