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The map label for this gene is yfnA [H]

Identifier: 116620298

GI number: 116620298

Start: 1445796

End: 1447289

Strand: Direct

Name: yfnA [H]

Synonym: Acid_1175

Alternate gene names: 116620298

Gene position: 1445796-1447289 (Clockwise)

Preceding gene: 116620297

Following gene: 116620299

Centisome position: 14.51

GC content: 60.71

Gene sequence:

>1494_bases
GTGAGTATTTTCCGGACGAAGAGTATCGATGCACTCATCGCCGCCTCCGAAGATCCGGAGAAGAAACTACGGCGCACCCT
AGGTCCATGGAGCCTCACCGCGTTCGGTATCGGCGCGGTGATCGGCTCCGGCATTTTCATTCTCACCGGCACGGCGGCGG
CCGGGGAGACCCTGAACTACAAATCGATTCTGCACGCCCCCGTGCTGGATCTGATCATGCACGGCACCCAGGCTCTCTCC
ATGACGGGCCGCCAGGGTGCCGGACCAGCCATCACACTTTCCTTCCTGCTGACGGCGATCGCCTGCAGTTTCGCGGCCTT
GTGCTACGCGGAACTTGCCTCGATGATCCCGATCGCGGGGAGCGCGTACACCTATGCCTACGCGACGCTGGGCGAGATTA
TCGCCTGGATCATCGGCTGGGACCTCATTCTGGAGTATGCGGTCAGTAATATGGCGGTGGCGGTGGGCTTCTCCGCCTAT
TTAAACGATGTGCTGGATAACGTCTTCGGCTGGCATATCCCGGCCAAATTCGCCAATCCACCAATCGCCGAAGGTCAGCT
GACCGGAGCCTGGTTCAATATTTCCGCGCTGCTGGTGCTGATGATTCTCACCTGGATTCTGGTCAAGGGAGTCAAGGAGA
GCGCGAGCACGAACAACGCTATGGTAGCGATCAAGATCGCCGCCATTCTAATCTTCGTGATCGGGGCGGCGAAGGCGGTG
GATACTTCGAACTGGAAGCCGTTCGCCCCTCATGGATTCCCCGGCGTCCTGACCGGTGCGGCCATCGTCTTTTTCACCTA
CATCGGGTTCGATTCGGTATCCACCGCGGCCGAGGAATGCAAGCGCCCGCAGCGCGATCTGCCGCTCGGGATTATCCTGA
CGCTGATCATCTGCGCGATTCTCTATATCCTGGTGGCCCTGGTGCTCACCGGCATCGCCCGCTACGACACCCTCAACAAC
GCGGCGCCCGTGGCCAATGCTCTGAAGGTGCTCGGGTATAACGGCATCCGGCAATGGGTCAGCCTGGGGGCCCTGGTTGG
AATGCTCTCCTCGCTGCTGGTCTTCCAGTATGGACAGGCGCGCATCTGGTTTGCGATGTCGCGCGACGGCCTGCTGCCCA
AGATGTTTTCCAAGGTGCACCCGGTCTACAAGACCCCGCACATCAGCACCTGGATCGCCGGCCTGGTGGTCGGGATCCCG
GCCGGAATCTGGGACATCGGCACTTTCGCGGACTTGGCGAACATCGGTACGCTCTTCGCCTTCATCATCGTCAGCGTAGG
GGTAATCGTGCTACGCAGGACCCAGCCCGACCGTCCGCGCGGATTCCGCGTGCCGGGTGGCGGCTTCCTGCCCGTGATCT
CGATCGTCTTCTGCCTGATCCTGATGATGGCTCTGCCGCTCGAAACATGGGTCCGGTTTTTCGTCTGGCTGCTGATCGGG
TTCGCGATCTATTTCCCGTTTGGAAGAAAGAACAGCGCGCTGGCCCGCCGATAG

Upstream 100 bases:

>100_bases
CCTCCGGCGTAGCACGCGGATCCGAAAAAAAGAAGATCCGCCACCAGGCGCAAGGTCAGCGTAAGCGCTAGAGCCAAAAC
CACATACAGGGGCCGCCACC

Downstream 100 bases:

>100_bases
CACGCGTCGATCTAACCTTAGTTAACCCTTACGAATTCTTACAGATCGCGCCTTTCCGTAAGAGATCTCACTTGTTATAA
TCGCGTGAAAGTAGTTACAA

Product: amino acid permease-associated protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSIFRTKSIDALIAASEDPEKKLRRTLGPWSLTAFGIGAVIGSGIFILTGTAAAGETLNYKSILHAPVLDLIMHGTQALS
MTGRQGAGPAITLSFLLTAIACSFAALCYAELASMIPIAGSAYTYAYATLGEIIAWIIGWDLILEYAVSNMAVAVGFSAY
LNDVLDNVFGWHIPAKFANPPIAEGQLTGAWFNISALLVLMILTWILVKGVKESASTNNAMVAIKIAAILIFVIGAAKAV
DTSNWKPFAPHGFPGVLTGAAIVFFTYIGFDSVSTAAEECKRPQRDLPLGIILTLIICAILYILVALVLTGIARYDTLNN
AAPVANALKVLGYNGIRQWVSLGALVGMLSSLLVFQYGQARIWFAMSRDGLLPKMFSKVHPVYKTPHISTWIAGLVVGIP
AGIWDIGTFADLANIGTLFAFIIVSVGVIVLRRTQPDRPRGFRVPGGGFLPVISIVFCLILMMALPLETWVRFFVWLLIG
FAIYFPFGRKNSALARR

Sequences:

>Translated_497_residues
MSIFRTKSIDALIAASEDPEKKLRRTLGPWSLTAFGIGAVIGSGIFILTGTAAAGETLNYKSILHAPVLDLIMHGTQALS
MTGRQGAGPAITLSFLLTAIACSFAALCYAELASMIPIAGSAYTYAYATLGEIIAWIIGWDLILEYAVSNMAVAVGFSAY
LNDVLDNVFGWHIPAKFANPPIAEGQLTGAWFNISALLVLMILTWILVKGVKESASTNNAMVAIKIAAILIFVIGAAKAV
DTSNWKPFAPHGFPGVLTGAAIVFFTYIGFDSVSTAAEECKRPQRDLPLGIILTLIICAILYILVALVLTGIARYDTLNN
AAPVANALKVLGYNGIRQWVSLGALVGMLSSLLVFQYGQARIWFAMSRDGLLPKMFSKVHPVYKTPHISTWIAGLVVGIP
AGIWDIGTFADLANIGTLFAFIIVSVGVIVLRRTQPDRPRGFRVPGGGFLPVISIVFCLILMMALPLETWVRFFVWLLIG
FAIYFPFGRKNSALARR
>Mature_496_residues
SIFRTKSIDALIAASEDPEKKLRRTLGPWSLTAFGIGAVIGSGIFILTGTAAAGETLNYKSILHAPVLDLIMHGTQALSM
TGRQGAGPAITLSFLLTAIACSFAALCYAELASMIPIAGSAYTYAYATLGEIIAWIIGWDLILEYAVSNMAVAVGFSAYL
NDVLDNVFGWHIPAKFANPPIAEGQLTGAWFNISALLVLMILTWILVKGVKESASTNNAMVAIKIAAILIFVIGAAKAVD
TSNWKPFAPHGFPGVLTGAAIVFFTYIGFDSVSTAAEECKRPQRDLPLGIILTLIICAILYILVALVLTGIARYDTLNNA
APVANALKVLGYNGIRQWVSLGALVGMLSSLLVFQYGQARIWFAMSRDGLLPKMFSKVHPVYKTPHISTWIAGLVVGIPA
GIWDIGTFADLANIGTLFAFIIVSVGVIVLRRTQPDRPRGFRVPGGGFLPVISIVFCLILMMALPLETWVRFFVWLLIGF
AIYFPFGRKNSALARR

Specific function: Probable Amino-Acid Or Metabolite Transport Protein. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=470, Percent_Identity=34.0425531914894, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI258614003, Length=455, Percent_Identity=30.3296703296703, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI258614005, Length=455, Percent_Identity=30.3296703296703, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI114326544, Length=469, Percent_Identity=28.7846481876333, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI114326550, Length=469, Percent_Identity=28.7846481876333, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI258645169, Length=455, Percent_Identity=30.3296703296703, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI181337167, Length=447, Percent_Identity=28.8590604026846, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI110347453, Length=419, Percent_Identity=32.4582338902148, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI186910308, Length=470, Percent_Identity=27.4468085106383, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI186910306, Length=470, Percent_Identity=27.4468085106383, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI186910304, Length=470, Percent_Identity=27.4468085106383, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI115648063, Length=392, Percent_Identity=25.765306122449, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI115648022, Length=392, Percent_Identity=25.765306122449, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI7657683, Length=381, Percent_Identity=24.9343832020997, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI71979932, Length=504, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI187423910, Length=519, Percent_Identity=22.5433526011561, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7657591, Length=519, Percent_Identity=22.5433526011561, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI33286428, Length=461, Percent_Identity=24.5119305856833, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081869, Length=353, Percent_Identity=26.9121813031161, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87082023, Length=349, Percent_Identity=27.7936962750716, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082250, Length=460, Percent_Identity=24.1304347826087, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790653, Length=492, Percent_Identity=20.7317073170732, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87081915, Length=459, Percent_Identity=23.9651416122004, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788480, Length=380, Percent_Identity=23.4210526315789, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786302, Length=311, Percent_Identity=24.1157556270096, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=464, Percent_Identity=33.1896551724138, Blast_Score=221, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17531343, Length=447, Percent_Identity=34.8993288590604, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17533459, Length=443, Percent_Identity=31.3769751693002, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17540018, Length=480, Percent_Identity=22.2916666666667, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32566699, Length=359, Percent_Identity=22.2841225626741, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17568033, Length=464, Percent_Identity=22.8448275862069, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666159, Length=450, Percent_Identity=34, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI221512776, Length=450, Percent_Identity=34, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24668806, Length=449, Percent_Identity=32.0712694877506, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI21356285, Length=449, Percent_Identity=32.0712694877506, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24668802, Length=449, Percent_Identity=32.0712694877506, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24667468, Length=452, Percent_Identity=31.4159292035398, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI281366235, Length=436, Percent_Identity=31.1926605504587, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI116007820, Length=436, Percent_Identity=31.1926605504587, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI116007818, Length=438, Percent_Identity=31.2785388127854, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI85725152, Length=438, Percent_Identity=31.2785388127854, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161077963, Length=444, Percent_Identity=29.5045045045045, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI221331183, Length=463, Percent_Identity=25.0539956803456, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17647653, Length=463, Percent_Identity=25.0539956803456, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24664379, Length=463, Percent_Identity=25.0539956803456, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24651635, Length=450, Percent_Identity=22.6666666666667, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24651633, Length=450, Percent_Identity=22.6666666666667, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45550968, Length=498, Percent_Identity=23.4939759036145, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921172, Length=498, Percent_Identity=23.4939759036145, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357367, Length=460, Percent_Identity=24.3478260869565, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53480; Mature: 53349

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFRTKSIDALIAASEDPEKKLRRTLGPWSLTAFGIGAVIGSGIFILTGTAAAGETLNY
CCCCCCCCCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCH
KSILHAPVLDLIMHGTQALSMTGRQGAGPAITLSFLLTAIACSFAALCYAELASMIPIAG
HHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SAYTYAYATLGEIIAWIIGWDLILEYAVSNMAVAVGFSAYLNDVLDNVFGWHIPAKFANP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC
PIAEGQLTGAWFNISALLVLMILTWILVKGVKESASTNNAMVAIKIAAILIFVIGAAKAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
DTSNWKPFAPHGFPGVLTGAAIVFFTYIGFDSVSTAAEECKRPQRDLPLGIILTLIICAI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LYILVALVLTGIARYDTLNNAAPVANALKVLGYNGIRQWVSLGALVGMLSSLLVFQYGQA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RIWFAMSRDGLLPKMFSKVHPVYKTPHISTWIAGLVVGIPAGIWDIGTFADLANIGTLFA
EEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FIIVSVGVIVLRRTQPDRPRGFRVPGGGFLPVISIVFCLILMMALPLETWVRFFVWLLIG
HHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FAIYFPFGRKNSALARR
HHHHCCCCCCCCHHCCC
>Mature Secondary Structure 
SIFRTKSIDALIAASEDPEKKLRRTLGPWSLTAFGIGAVIGSGIFILTGTAAAGETLNY
CCCCCCCCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCH
KSILHAPVLDLIMHGTQALSMTGRQGAGPAITLSFLLTAIACSFAALCYAELASMIPIAG
HHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SAYTYAYATLGEIIAWIIGWDLILEYAVSNMAVAVGFSAYLNDVLDNVFGWHIPAKFANP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC
PIAEGQLTGAWFNISALLVLMILTWILVKGVKESASTNNAMVAIKIAAILIFVIGAAKAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
DTSNWKPFAPHGFPGVLTGAAIVFFTYIGFDSVSTAAEECKRPQRDLPLGIILTLIICAI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LYILVALVLTGIARYDTLNNAAPVANALKVLGYNGIRQWVSLGALVGMLSSLLVFQYGQA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RIWFAMSRDGLLPKMFSKVHPVYKTPHISTWIAGLVVGIPAGIWDIGTFADLANIGTLFA
EEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FIIVSVGVIVLRRTQPDRPRGFRVPGGGFLPVISIVFCLILMMALPLETWVRFFVWLLIG
HHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FAIYFPFGRKNSALARR
HHHHCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]