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The map label for this gene is fabF [H]

Identifier: 116620290

GI number: 116620290

Start: 1436646

End: 1437887

Strand: Reverse

Name: fabF [H]

Synonym: Acid_1167

Alternate gene names: 116620290

Gene position: 1437887-1436646 (Counterclockwise)

Preceding gene: 116620291

Following gene: 116620289

Centisome position: 14.43

GC content: 59.9

Gene sequence:

>1242_bases
TTGTCACGAAGAGTGGTAGTGACCGGCGTCGGACTTCTGACGCCGTTGGGGATTGGAACACAGACGACCTGGGACGCCCT
GCTTGCGTCGAAATCGGGCATCGCCGGTATCACCCAGTTTGATGCGACCGCCTTTTCCTGCAGGATTGCAGGGGAAGTCA
AAGGCTTCGATCCCTCCAATTACATCGAGAAAAAAGAAATTAAGAAGATGGGGCGCTTCATCCAGTTCGCCATTGCGGCG
GCGGATTTTGCCCTCAAGGATTCCGGACTCGTGGTCACGCCGGAGATCGCCGAGGAAGTCGGCGTCTATATCGGCAGTGG
AATCGGCGGCTTCGAAGTGATCGAGCGCGAGCACCAGACGCTGCTGGAACACGGGCCGCGCCGCATCTCACCCTTCTTTA
TTCCGGCCACAATTATTAACCTGGCGTCCGGCTATGTTTCGATAAAAAGCGGTGCGAAGGGTCCGAATTCGGCTACCGCG
ACGGCCTGCACCACCAGCGCACATTCGATCGGCGATTCGTTCCGGATGATTCAGCGCGGTGACGCTGTCGCCATGATTTG
CGGCGGCACCGAGGCCGCCGTTACGCCGATGGGAATCGGGGGGTTCGCTGCCATGCGAGCTCTTTCCACGCGCAATGACG
ATCCGGAACGGGCTTCGCGTCCCTGGGATAAGGACCGCGACGGTTTCGTGGTGGGCGAAGGCGCCGGAATCATCGTATTG
GAAGCGCTGGAACATGCCACTGCCCGCGGCGCGAAGATCCTCGCCGAGATTGTGGGGTATGGCATGAGCGCCGACGCGTT
CCACGTGACGGCTCCCCCGGACGACGGCGACGGGGCATTCCGGGTGATGCGGAACGCCATAAAGGACGCCGGCTTGAGTC
CTGAACAGATCGATTACATCAACGCGCACGGCACCTCTACCGATGTGGGCGATAAGGCAGAGACGATGGCGATCAAGCGC
GCTTTTGGCGAGCATGCTTACAAGGTCGCAGTCAGCTCCACCAAGTCCATGACCGGACACCTGCTGGGCGGCGCCGGCGG
TCTGGAGGCCGGCATCACAGTGATGGCGATTCACGACCAGGTGGCGCCGCCGACTATCAATCATGAGTGTCCCGACCCGG
CATGCGATCTGGATTACGTGCCGAATCACGCGCGCAAAATGCCGATCGAATATGCCTTGTCGAACAGTTTCGGGTTCGGC
GGCACTAACGGCTGCCTTATTTTCAAGCGATACTCTGAGTAG

Upstream 100 bases:

>100_bases
TGAGGACGCCGAGAAAATCACTACGGTGAAAGACGCGGTGGATTACATCGAAGGCAAGACCACCAAGAAATAGCGGCTGG
CCTGCCCGGGGAGAAGAGTT

Downstream 100 bases:

>100_bases
TATCCGGCATTAACTCCCAAAAATTTTATGAAAATCGTGGTTGCGATCAAGCAGGTTCCGGCTCGCGATTCTCAATTGCG
AATCGCCTCTTCGGGCAAGT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSRRVVVTGVGLLTPLGIGTQTTWDALLASKSGIAGITQFDATAFSCRIAGEVKGFDPSNYIEKKEIKKMGRFIQFAIAA
ADFALKDSGLVVTPEIAEEVGVYIGSGIGGFEVIEREHQTLLEHGPRRISPFFIPATIINLASGYVSIKSGAKGPNSATA
TACTTSAHSIGDSFRMIQRGDAVAMICGGTEAAVTPMGIGGFAAMRALSTRNDDPERASRPWDKDRDGFVVGEGAGIIVL
EALEHATARGAKILAEIVGYGMSADAFHVTAPPDDGDGAFRVMRNAIKDAGLSPEQIDYINAHGTSTDVGDKAETMAIKR
AFGEHAYKVAVSSTKSMTGHLLGGAGGLEAGITVMAIHDQVAPPTINHECPDPACDLDYVPNHARKMPIEYALSNSFGFG
GTNGCLIFKRYSE

Sequences:

>Translated_413_residues
MSRRVVVTGVGLLTPLGIGTQTTWDALLASKSGIAGITQFDATAFSCRIAGEVKGFDPSNYIEKKEIKKMGRFIQFAIAA
ADFALKDSGLVVTPEIAEEVGVYIGSGIGGFEVIEREHQTLLEHGPRRISPFFIPATIINLASGYVSIKSGAKGPNSATA
TACTTSAHSIGDSFRMIQRGDAVAMICGGTEAAVTPMGIGGFAAMRALSTRNDDPERASRPWDKDRDGFVVGEGAGIIVL
EALEHATARGAKILAEIVGYGMSADAFHVTAPPDDGDGAFRVMRNAIKDAGLSPEQIDYINAHGTSTDVGDKAETMAIKR
AFGEHAYKVAVSSTKSMTGHLLGGAGGLEAGITVMAIHDQVAPPTINHECPDPACDLDYVPNHARKMPIEYALSNSFGFG
GTNGCLIFKRYSE
>Mature_412_residues
SRRVVVTGVGLLTPLGIGTQTTWDALLASKSGIAGITQFDATAFSCRIAGEVKGFDPSNYIEKKEIKKMGRFIQFAIAAA
DFALKDSGLVVTPEIAEEVGVYIGSGIGGFEVIEREHQTLLEHGPRRISPFFIPATIINLASGYVSIKSGAKGPNSATAT
ACTTSAHSIGDSFRMIQRGDAVAMICGGTEAAVTPMGIGGFAAMRALSTRNDDPERASRPWDKDRDGFVVGEGAGIIVLE
ALEHATARGAKILAEIVGYGMSADAFHVTAPPDDGDGAFRVMRNAIKDAGLSPEQIDYINAHGTSTDVGDKAETMAIKRA
FGEHAYKVAVSSTKSMTGHLLGGAGGLEAGITVMAIHDQVAPPTINHECPDPACDLDYVPNHARKMPIEYALSNSFGFGG
TNGCLIFKRYSE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=48.9208633093525, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI223972627, Length=169, Percent_Identity=50.2958579881657, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI41872631, Length=438, Percent_Identity=25.7990867579909, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=56.7237163814181, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1788663, Length=421, Percent_Identity=36.5795724465558, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=38.3132530120482, Blast_Score=268, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=43.9393939393939, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI212642053, Length=359, Percent_Identity=23.3983286908078, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=269, Percent_Identity=23.7918215613383, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=451, Percent_Identity=37.4722838137472, Blast_Score=281, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=44.8931116389549, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI19920632, Length=377, Percent_Identity=23.8726790450928, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI221330659, Length=377, Percent_Identity=23.8726790450928, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24581345, Length=376, Percent_Identity=21.2765957446809, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43444; Mature: 43313

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRVVVTGVGLLTPLGIGTQTTWDALLASKSGIAGITQFDATAFSCRIAGEVKGFDPSN
CCCEEEEECCHHHCCCCCCCCHHHHHHHHCCCCCCCEEECCCEEEEEEEECCCCCCCCHH
YIEKKEIKKMGRFIQFAIAAADFALKDSGLVVTPEIAEEVGVYIGSGIGGFEVIEREHQT
HHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECHHHHHHHCCEEECCCCHHHHHHHHHHH
LLEHGPRRISPFFIPATIINLASGYVSIKSGAKGPNSATATACTTSAHSIGDSFRMIQRG
HHHCCCCCCCCEEHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCHHHHCHHHHHHHCC
DAVAMICGGTEAAVTPMGIGGFAAMRALSTRNDDPERASRPWDKDRDGFVVGEGAGIIVL
CEEEEEECCCCCEECCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCCCEEEE
EALEHATARGAKILAEIVGYGMSADAFHVTAPPDDGDGAFRVMRNAIKDAGLSPEQIDYI
EHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEEE
NAHGTSTDVGDKAETMAIKRAFGEHAYKVAVSSTKSMTGHLLGGAGGLEAGITVMAIHDQ
ECCCCCCCCCCHHHHHHHHHHHCCHHEEEEECCCCCCCCEEECCCCCCCCCEEEEEEECC
VAPPTINHECPDPACDLDYVPNHARKMPIEYALSNSFGFGGTNGCLIFKRYSE
CCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SRRVVVTGVGLLTPLGIGTQTTWDALLASKSGIAGITQFDATAFSCRIAGEVKGFDPSN
CCEEEEECCHHHCCCCCCCCHHHHHHHHCCCCCCCEEECCCEEEEEEEECCCCCCCCHH
YIEKKEIKKMGRFIQFAIAAADFALKDSGLVVTPEIAEEVGVYIGSGIGGFEVIEREHQT
HHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECHHHHHHHCCEEECCCCHHHHHHHHHHH
LLEHGPRRISPFFIPATIINLASGYVSIKSGAKGPNSATATACTTSAHSIGDSFRMIQRG
HHHCCCCCCCCEEHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCHHHHCHHHHHHHCC
DAVAMICGGTEAAVTPMGIGGFAAMRALSTRNDDPERASRPWDKDRDGFVVGEGAGIIVL
CEEEEEECCCCCEECCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCCCEEEE
EALEHATARGAKILAEIVGYGMSADAFHVTAPPDDGDGAFRVMRNAIKDAGLSPEQIDYI
EHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEEE
NAHGTSTDVGDKAETMAIKRAFGEHAYKVAVSSTKSMTGHLLGGAGGLEAGITVMAIHDQ
ECCCCCCCCCCHHHHHHHHHHHCCHHEEEEECCCCCCCCEEECCCCCCCCCEEEEEEECC
VAPPTINHECPDPACDLDYVPNHARKMPIEYALSNSFGFGGTNGCLIFKRYSE
CCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]