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The map label for this gene is hemH [H]

Identifier: 116620156

GI number: 116620156

Start: 1273221

End: 1274180

Strand: Direct

Name: hemH [H]

Synonym: Acid_1029

Alternate gene names: 116620156

Gene position: 1273221-1274180 (Clockwise)

Preceding gene: 116620155

Following gene: 116620158

Centisome position: 12.78

GC content: 68.23

Gene sequence:

>960_bases
ATGCATTACGATGCCATTCTGTTCGTGTCCTTCGGCGGCCCCGAAAAGGTCGCCGATGTCATCCCCTTCCTGGAGAACGT
CCTCCGCGGGCGCAACGTGCCCCGCGAGCGCATGCTCCAGGTTGCCGAGCACTACTACCACTTCGGCGGCCGCAGCCCCA
TAAACGACCAGTGCCGCGACCTGATTGCCGCCCTGCGCCCCGCCATCGACCTTCCCATCTACTGGGGCAATCGCAACTGG
CATCCCCTGCTCGCCGATACCATGCGCCAGATGGCCGCCGACGGAGTCCGCCGCGCCCTCGCCATCGCCACCTCGGCGTA
TTCCTCTTACTCCGGATGCCGCCAGTACATCGAGAACCTCGCTTGCGCGAGCGCGGCCGCCGGCCCCAACGCTCCCGCGA
TCGACAAGCTCCCGCCATTCTGGAATCAACCTGGTTTCGTCGAGGCGAATGCGGATCGCGTGTCCGACGCCCTCGCCCGC
CTCCCGCATGATCGCCGCGACGCAGCGCGCCTGGTCTTTACCGCGCACAGCATCCCGCTCGCCATGGCCACCACCTGCCG
CTACGAGGAGCAACTCGTCGAAACCGCCCGGGCCGTCGCCGCCCGCATCGCCCACGACGAGTGGGATCTCGTCTGGCAGA
GCCGCAGCGGTCCTCCGACGCAGCCCTGGCTCGAGCCCGACATCCTGGACCACCTCCGCGCGCTGGCCGAAAACGGCGTC
CGCGACGTGATCGTTTCCCCCATCGGCTTCCTCAGCGACCACATGGAAGTCCTGTACGATCTCGACGAAGAGGCCGCCGC
TCTCGCTCGCGAACTCGGCCTCAATTTCATCCGCGCCGCCACCGCCGGCACACACGCCGCCGTGATCGCGATGCTCGCCG
ACCTGATCGCGCGGCGTCAGGCCTCGCCCGAAACTCCGCTCTGCGCGCCCGATTGCTGCCCCGCGCTGCGCCGGCCCTGA

Upstream 100 bases:

>100_bases
CGAGGCGCCCTCCTGCCCCAGCGGACGCTGCGGCAATCCGGGCATGTGCGGAATGAATTTTAACTAGCCGCGACACGCCG
GCTGGCATCCAATTTCTTCC

Downstream 100 bases:

>100_bases
GCCTCACGTACCGGCCAGAACCTGGTGGACGAACTGCACCGCCATCGATCCTTCTCCCACTGCCGAGGCCACGCGCTTGA
TGCTGTTCGCCCGTATATCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MHYDAILFVSFGGPEKVADVIPFLENVLRGRNVPRERMLQVAEHYYHFGGRSPINDQCRDLIAALRPAIDLPIYWGNRNW
HPLLADTMRQMAADGVRRALAIATSAYSSYSGCRQYIENLACASAAAGPNAPAIDKLPPFWNQPGFVEANADRVSDALAR
LPHDRRDAARLVFTAHSIPLAMATTCRYEEQLVETARAVAARIAHDEWDLVWQSRSGPPTQPWLEPDILDHLRALAENGV
RDVIVSPIGFLSDHMEVLYDLDEEAAALARELGLNFIRAATAGTHAAVIAMLADLIARRQASPETPLCAPDCCPALRRP

Sequences:

>Translated_319_residues
MHYDAILFVSFGGPEKVADVIPFLENVLRGRNVPRERMLQVAEHYYHFGGRSPINDQCRDLIAALRPAIDLPIYWGNRNW
HPLLADTMRQMAADGVRRALAIATSAYSSYSGCRQYIENLACASAAAGPNAPAIDKLPPFWNQPGFVEANADRVSDALAR
LPHDRRDAARLVFTAHSIPLAMATTCRYEEQLVETARAVAARIAHDEWDLVWQSRSGPPTQPWLEPDILDHLRALAENGV
RDVIVSPIGFLSDHMEVLYDLDEEAAALARELGLNFIRAATAGTHAAVIAMLADLIARRQASPETPLCAPDCCPALRRP
>Mature_319_residues
MHYDAILFVSFGGPEKVADVIPFLENVLRGRNVPRERMLQVAEHYYHFGGRSPINDQCRDLIAALRPAIDLPIYWGNRNW
HPLLADTMRQMAADGVRRALAIATSAYSSYSGCRQYIENLACASAAAGPNAPAIDKLPPFWNQPGFVEANADRVSDALAR
LPHDRRDAARLVFTAHSIPLAMATTCRYEEQLVETARAVAARIAHDEWDLVWQSRSGPPTQPWLEPDILDHLRALAENGV
RDVIVSPIGFLSDHMEVLYDLDEEAAALARELGLNFIRAATAGTHAAVIAMLADLIARRQASPETPLCAPDCCPALRRP

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=363, Percent_Identity=27.5482093663912, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI60499021, Length=363, Percent_Identity=27.5482093663912, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324750, Length=321, Percent_Identity=25.2336448598131, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17864156, Length=346, Percent_Identity=26.3005780346821, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45552018, Length=184, Percent_Identity=30.9782608695652, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35232; Mature: 35232

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYDAILFVSFGGPEKVADVIPFLENVLRGRNVPRERMLQVAEHYYHFGGRSPINDQCRD
CCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
LIAALRPAIDLPIYWGNRNWHPLLADTMRQMAADGVRRALAIATSAYSSYSGCRQYIENL
HHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACASAAAGPNAPAIDKLPPFWNQPGFVEANADRVSDALARLPHDRRDAARLVFTAHSIPL
HHHHHCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCH
AMATTCRYEEQLVETARAVAARIAHDEWDLVWQSRSGPPTQPWLEPDILDHLRALAENGV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCH
RDVIVSPIGFLSDHMEVLYDLDEEAAALARELGLNFIRAATAGTHAAVIAMLADLIARRQ
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
ASPETPLCAPDCCPALRRP
CCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MHYDAILFVSFGGPEKVADVIPFLENVLRGRNVPRERMLQVAEHYYHFGGRSPINDQCRD
CCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
LIAALRPAIDLPIYWGNRNWHPLLADTMRQMAADGVRRALAIATSAYSSYSGCRQYIENL
HHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACASAAAGPNAPAIDKLPPFWNQPGFVEANADRVSDALARLPHDRRDAARLVFTAHSIPL
HHHHHCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCH
AMATTCRYEEQLVETARAVAARIAHDEWDLVWQSRSGPPTQPWLEPDILDHLRALAENGV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCH
RDVIVSPIGFLSDHMEVLYDLDEEAAALARELGLNFIRAATAGTHAAVIAMLADLIARRQ
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
ASPETPLCAPDCCPALRRP
CCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]