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The map label for this gene is ppiA [H]

Identifier: 116620112

GI number: 116620112

Start: 1227272

End: 1227838

Strand: Reverse

Name: ppiA [H]

Synonym: Acid_0985

Alternate gene names: 116620112

Gene position: 1227838-1227272 (Counterclockwise)

Preceding gene: 116620113

Following gene: 116620111

Centisome position: 12.32

GC content: 62.61

Gene sequence:

>567_bases
ATGAAGACTCTGTCATGCGCACTGTTTGCCTTCGCGATTGCGAGCGCGCAATCCACCGTGCCGGTCATTATCGAAACCGA
ACTGGGCTCGATCGAAGTCGAGCTCGCCGCCGGCAATGCGCCCGTATCGAGCGCCAACTTCCTCCGCTACGTGGACGCGG
GCCTGTATGACAACGGACTCTTCCACCGCACCGTGACGCCCGGCAATCAGCCAAACAACACCGTCAGGATCGAGGTCATC
CAGGCCGGTGCGGCGCCGGGCGTGAAGCCCTTTCCTCCGATCCCGCTGGAACGTACGTCCCTCACCGGGCTCAAACATCT
CGACGGTACGATCTCAATGGCGCGTGCCGCACCCGACACCGCCGACACGGACTTTTTCATCTGTGTGGGCGATCAGCCCG
CGCTCGATTTCGGCGGCAAGCGCAATCCCGACGGGCAGGGCTTCGCCGCCTTCGGGCGCGTCACCAAAGGCATGGAAATC
GTGCGCAAGATTCAGGGCGCTCCGGCGAAGGGCCAGCAATTAACCCCTCCGGTGCGGATTGTGCGCATCATTCGCAAACC
GGCATAA

Upstream 100 bases:

>100_bases
AGGTCTTCAATCATCCGGGCTGGGTCGGCGATCGTCAGCCGCAGTTCCGGATCGGCAAGACACATTGGGCCTGGTACTTC
CCGCCGGGCAGCGAGGCGAA

Downstream 100 bases:

>100_bases
CGTTGTAGCGGGAAGGCGCGTCTATCTGCCTATGAGCACGGTCCTACAGAACGCCCGATTTGGGCTGCGGGTGTTTCGAC
GCGCGCCCGGGTTCGCGGCC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MKTLSCALFAFAIASAQSTVPVIIETELGSIEVELAAGNAPVSSANFLRYVDAGLYDNGLFHRTVTPGNQPNNTVRIEVI
QAGAAPGVKPFPPIPLERTSLTGLKHLDGTISMARAAPDTADTDFFICVGDQPALDFGGKRNPDGQGFAAFGRVTKGMEI
VRKIQGAPAKGQQLTPPVRIVRIIRKPA

Sequences:

>Translated_188_residues
MKTLSCALFAFAIASAQSTVPVIIETELGSIEVELAAGNAPVSSANFLRYVDAGLYDNGLFHRTVTPGNQPNNTVRIEVI
QAGAAPGVKPFPPIPLERTSLTGLKHLDGTISMARAAPDTADTDFFICVGDQPALDFGGKRNPDGQGFAAFGRVTKGMEI
VRKIQGAPAKGQQLTPPVRIVRIIRKPA
>Mature_188_residues
MKTLSCALFAFAIASAQSTVPVIIETELGSIEVELAAGNAPVSSANFLRYVDAGLYDNGLFHRTVTPGNQPNNTVRIEVI
QAGAAPGVKPFPPIPLERTSLTGLKHLDGTISMARAAPDTADTDFFICVGDQPALDFGGKRNPDGQGFAAFGRVTKGMEI
VRKIQGAPAKGQQLTPPVRIVRIIRKPA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789763, Length=148, Percent_Identity=41.8918918918919, Blast_Score=94, Evalue=4e-21,
Organism=Escherichia coli, GI1786736, Length=148, Percent_Identity=35.1351351351351, Blast_Score=78, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19867; Mature: 19867

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLSCALFAFAIASAQSTVPVIIETELGSIEVELAAGNAPVSSANFLRYVDAGLYDNGL
CCCHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCE
FHRTVTPGNQPNNTVRIEVIQAGAAPGVKPFPPIPLERTSLTGLKHLDGTISMARAAPDT
EEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCEEHHHCCCCC
ADTDFFICVGDQPALDFGGKRNPDGQGFAAFGRVTKGMEIVRKIQGAPAKGQQLTPPVRI
CCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
VRIIRKPA
HHHHHCCC
>Mature Secondary Structure
MKTLSCALFAFAIASAQSTVPVIIETELGSIEVELAAGNAPVSSANFLRYVDAGLYDNGL
CCCHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCE
FHRTVTPGNQPNNTVRIEVIQAGAAPGVKPFPPIPLERTSLTGLKHLDGTISMARAAPDT
EEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCEEHHHCCCCC
ADTDFFICVGDQPALDFGGKRNPDGQGFAAFGRVTKGMEIVRKIQGAPAKGQQLTPPVRI
CCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
VRIIRKPA
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]