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The map label for this gene is ywcA [H]

Identifier: 116620053

GI number: 116620053

Start: 1159616

End: 1161181

Strand: Direct

Name: ywcA [H]

Synonym: Acid_0925

Alternate gene names: 116620053

Gene position: 1159616-1161181 (Clockwise)

Preceding gene: 116620052

Following gene: 116620056

Centisome position: 11.64

GC content: 63.67

Gene sequence:

>1566_bases
ATGTCGATGCCTCTGCTGATGTTCCTGTTCTTCATCCTGGCGACACTCGGCATTACGGCGTGGGCCGCGCGCCGATCCTC
CGGCGCCAGCGCCTACTTTGCCGCCGGACGGCGCATCACCGGATGGCAGAACGGCATCGCGGTCGCCGGCGACTACATGA
GCGCCGCGAGCTTCCTCGGGATTGCCGGCATCATCGCCTTCCAGGGCTACGACGGCTTTATGTACTCCGTGGGCTGGCTG
GTAGCGTACCTCACCGTTCTGCTCATCGTCGCCGAGCCCCTGCGCAACGCCGGCAAGTACACCATGGCGGATGTGCTCGC
CTATCGCCTTCATCCCAAGCCGGTCCGCGCCATGGCCGCGCTCTCTACCCTGACCGTCAGCACGTTCTACATGATCGCCC
AAATGGTGGGCGCCGGAACGCTCGTCGCCCTGCTGCTCAAGGATTCCGGAATCACCTTCAATTGGGCGGTCACCATGGTT
GGCATGCTGATGATCGCCTATGTCGTCTTCGGCGGAATGCTGGCCACCACCTGGGTGCAGATCGTCAAAGCCGTGCTCCT
GATGGGTGGGACCGTTCTGCTCAGCTTCCTGGTGCTCGCGCACTTCCACTTCTCGTTCGCGGAATTCTTCTACGCCATCG
CGCACGTGAACGATAACGGCAAGACCGTCAACTTCCTGACCCCCGGCCTTCGCTACAAACCGCCCTACGGCGCGCTCGAC
CTGATCTCGCTCGGCCTCGCCCTGATCTTCGGTACCGCCGGACTGCCCCACATCCTGGTCCGCTTCTACACCGTCCCCGA
CGCCCGCACCGCGCGTGTCAGCGTGGTCTGGGCGATGGGCATCATCGGCACTTTCTACATCATGACGACATTCCTCGGCT
TCGGCGCCGCGACCATCGTCGGCAAAGCCTATATCACGCAGAATGGCGGCATCAATATGAGCGCACCGCTCCTTGCGCAG
CGCCTGGCCGGCGACGTCTTCTTCGCCTTCATCAGCGCGATTGCGTTCGCCACCATCCTCGCTGTGGTCGCCGGGCTCAC
CATCAGCGCCTCCACCTCGTTCGCCCACGATTTCTACACCAACGTGCTGCGGCACGGCAAGGTTTACGACGCCTACCAGG
AAGTGCGTGTGGCGCGAATTACGGCCTTCGTCGTGGGCGCGGTCTCCATCGCGATCGCGATTTTACTAGGTCCCACGTTC
AATGTCGCCTTCCTCGTCGGGCTGGCCTTCGCCGTAGCGGCCTCGGCCAATCTTCCGGTGATTCTGCTTTCCATTTTCTG
GCGCAGGTTCACCACCGAGGGCGCGGTCTGCGGACTCGCCACCGGACTGCTCAGCTCCCTGGCCCTGATCGTCGCCGGCC
CCAGCATCATGGGGATGGGCGCCGGCCACCTGATTCACGCCGCGCCGATGTTCCCGCTGGAGAACCCCGGCATAGTCAGC
ATTCCGTTGGGCTTCCTGGGTGCCGTCCTCGCAACCCTGCTAGGCCCGCGCGACCAAGCGGCTGAGCACAAGTTCACCGA
ACTGGAAGTCCGCGCCAACACCGGCTTGGGAGCGGAGAAAGGCTAG

Upstream 100 bases:

>100_bases
TTGCTTTCCTCTACGTGCGCGCCGCCGAGCGTTTCGATCAACAGGGCCGCCGCGTCTTGGAGCACTTGGACCGGCACAAT
GCCGGCAAGGAGCCGCGCTG

Downstream 100 bases:

>100_bases
GCCTGTCATCAGCGACGCTCCCTTACTTGCTGTCGCGCCCCTGTTCCGATGCGCAGTGAGCTTCGCTCGACTGCCCGTCT
CCAGTTACCGCACCGTCGGA

Product: SSS family solute/sodium (Na+) symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MSMPLLMFLFFILATLGITAWAARRSSGASAYFAAGRRITGWQNGIAVAGDYMSAASFLGIAGIIAFQGYDGFMYSVGWL
VAYLTVLLIVAEPLRNAGKYTMADVLAYRLHPKPVRAMAALSTLTVSTFYMIAQMVGAGTLVALLLKDSGITFNWAVTMV
GMLMIAYVVFGGMLATTWVQIVKAVLLMGGTVLLSFLVLAHFHFSFAEFFYAIAHVNDNGKTVNFLTPGLRYKPPYGALD
LISLGLALIFGTAGLPHILVRFYTVPDARTARVSVVWAMGIIGTFYIMTTFLGFGAATIVGKAYITQNGGINMSAPLLAQ
RLAGDVFFAFISAIAFATILAVVAGLTISASTSFAHDFYTNVLRHGKVYDAYQEVRVARITAFVVGAVSIAIAILLGPTF
NVAFLVGLAFAVAASANLPVILLSIFWRRFTTEGAVCGLATGLLSSLALIVAGPSIMGMGAGHLIHAAPMFPLENPGIVS
IPLGFLGAVLATLLGPRDQAAEHKFTELEVRANTGLGAEKG

Sequences:

>Translated_521_residues
MSMPLLMFLFFILATLGITAWAARRSSGASAYFAAGRRITGWQNGIAVAGDYMSAASFLGIAGIIAFQGYDGFMYSVGWL
VAYLTVLLIVAEPLRNAGKYTMADVLAYRLHPKPVRAMAALSTLTVSTFYMIAQMVGAGTLVALLLKDSGITFNWAVTMV
GMLMIAYVVFGGMLATTWVQIVKAVLLMGGTVLLSFLVLAHFHFSFAEFFYAIAHVNDNGKTVNFLTPGLRYKPPYGALD
LISLGLALIFGTAGLPHILVRFYTVPDARTARVSVVWAMGIIGTFYIMTTFLGFGAATIVGKAYITQNGGINMSAPLLAQ
RLAGDVFFAFISAIAFATILAVVAGLTISASTSFAHDFYTNVLRHGKVYDAYQEVRVARITAFVVGAVSIAIAILLGPTF
NVAFLVGLAFAVAASANLPVILLSIFWRRFTTEGAVCGLATGLLSSLALIVAGPSIMGMGAGHLIHAAPMFPLENPGIVS
IPLGFLGAVLATLLGPRDQAAEHKFTELEVRANTGLGAEKG
>Mature_520_residues
SMPLLMFLFFILATLGITAWAARRSSGASAYFAAGRRITGWQNGIAVAGDYMSAASFLGIAGIIAFQGYDGFMYSVGWLV
AYLTVLLIVAEPLRNAGKYTMADVLAYRLHPKPVRAMAALSTLTVSTFYMIAQMVGAGTLVALLLKDSGITFNWAVTMVG
MLMIAYVVFGGMLATTWVQIVKAVLLMGGTVLLSFLVLAHFHFSFAEFFYAIAHVNDNGKTVNFLTPGLRYKPPYGALDL
ISLGLALIFGTAGLPHILVRFYTVPDARTARVSVVWAMGIIGTFYIMTTFLGFGAATIVGKAYITQNGGINMSAPLLAQR
LAGDVFFAFISAIAFATILAVVAGLTISASTSFAHDFYTNVLRHGKVYDAYQEVRVARITAFVVGAVSIAIAILLGPTFN
VAFLVGLAFAVAASANLPVILLSIFWRRFTTEGAVCGLATGLLSSLALIVAGPSIMGMGAGHLIHAAPMFPLENPGIVSI
PLGFLGAVLATLLGPRDQAAEHKFTELEVRANTGLGAEKG

Specific function: Unknown

COG id: COG4147

COG function: function code R; Predicted symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=454, Percent_Identity=21.8061674008811, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790503, Length=525, Percent_Identity=47.2380952380952, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI87082237, Length=461, Percent_Identity=23.2104121475054, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787251, Length=537, Percent_Identity=24.3947858472998, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 55198; Mature: 55067

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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ECHHHHHHHHHHHHCCCCHHHCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
SMPLLMFLFFILATLGITAWAARRSSGASAYFAAGRRITGWQNGIAVAGDYMSAASFLG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCEEEECHHHHHHHHHH
IAGIIAFQGYDGFMYSVGWLVAYLTVLLIVAEPLRNAGKYTMADVLAYRLHPKPVRAMAA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
LSTLTVSTFYMIAQMVGAGTLVALLLKDSGITFNWAVTMVGMLMIAYVVFGGMLATTWVQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKAVLLMGGTVLLSFLVLAHFHFSFAEFFYAIAHVNDNGKTVNFLTPGLRYKPPYGALD
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCCCCCHHH
LISLGLALIFGTAGLPHILVRFYTVPDARTARVSVVWAMGIIGTFYIMTTFLGFGAATIV
HHHHHHHHHHHCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
GKAYITQNGGINMSAPLLAQRLAGDVFFAFISAIAFATILAVVAGLTISASTSFAHDFYT
HHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHH
NVLRHGKVYDAYQEVRVARITAFVVGAVSIAIAILLGPTFNVAFLVGLAFAVAASANLPV
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
ILLSIFWRRFTTEGAVCGLATGLLSSLALIVAGPSIMGMGAGHLIHAAPMFPLENPGIVS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCEEE
IPLGFLGAVLATLLGPRDQAAEHKFTELEVRANTGLGAEKG
ECHHHHHHHHHHHHCCCCHHHCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]