Click here to switch to the map view.

The map label for this gene is tktB [C]

Identifier: 116619786

GI number: 116619786

Start: 820228

End: 820995

Strand: Direct

Name: tktB [C]

Synonym: Acid_0656

Alternate gene names: 116619786

Gene position: 820228-820995 (Clockwise)

Preceding gene: 116619785

Following gene: 116619787

Centisome position: 8.23

GC content: 56.38

Gene sequence:

>768_bases
ATGCGCCCGCTACTTAAACGTGCAAGAAAACGGCTGCTTCAGATGCATTTTGAAAGCCATGTAGGCCACATCGGAGGCAA
TCTTTCTGCTCTGGACGCGATGATGGTCCTCTACCACCAGGTTCTTCGTGACGATGATGTCTTCATTCTGTCCAAAGGGC
ATGCAGCCGGAGCCCTGTATGTCACACTGTGGACTGCCGGAAAGCTGACCGAAGACGATCTGAGGACATTTCACGGCGAG
GGTACGCTGCTCTCGGCACATCCGGCACCGGGTTGGTCACGGGATATTCCGTTCGCAACCGGCAGTCTGGGCCATGGGCT
GCCGGACGCAGCCGGAATCGCCTTGGGACATCGGTTTCGGGGACGGTCTGGACGTGTGTTTTGCTTGACCTCCGACGCAG
AGTGGCAAGAAGGGTCAAACTGGGAGGCCTTGATATTCGCTCGTCACCATCAGCTTCAAAATCTCATCATTGTGATCGAC
GAAAACCGCCTTCAGGGATTTGGCACCACTCGAGGGGTAGCGTCCATGGATCCAATCGGCGAGAAACTCTCCGGATTTGG
TCTGAACACCACGCACGCCGACGGCCACGACGTAGAGGCATTGCGTTGTGCATTCTCGGAAGCCGCGGGAGAGGGTCCGC
GAATCGTGATTCTGAAAACAACCAAAGGGCACGGAGTGTCGTTTATGGAGAACAGGATGGAGTGGCACTACCTGCCGATT
GACGCCGACCAGTACCGCATGGCTTTGGCAGAGGTAGACGCCGAATGA

Upstream 100 bases:

>100_bases
CGCGATCCATGAGATAGTTCGATGCCGGCCATGCCCAAACTAGTCCATTTGACCCGATCCAATACTATTTTCCCTGTCCC
CTTGCTATCCTTGTTGTTCC

Downstream 100 bases:

>100_bases
GGAAGGCGTTTGCCGAGGCGGTCGTCAAGCATGTGAAAACCGAGACCTCGGTATTCATGACGGGAGATCTAGGCTTCATG
GCGCTCGAACCTGTCCGTGA

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MRPLLKRARKRLLQMHFESHVGHIGGNLSALDAMMVLYHQVLRDDDVFILSKGHAAGALYVTLWTAGKLTEDDLRTFHGE
GTLLSAHPAPGWSRDIPFATGSLGHGLPDAAGIALGHRFRGRSGRVFCLTSDAEWQEGSNWEALIFARHHQLQNLIIVID
ENRLQGFGTTRGVASMDPIGEKLSGFGLNTTHADGHDVEALRCAFSEAAGEGPRIVILKTTKGHGVSFMENRMEWHYLPI
DADQYRMALAEVDAE

Sequences:

>Translated_255_residues
MRPLLKRARKRLLQMHFESHVGHIGGNLSALDAMMVLYHQVLRDDDVFILSKGHAAGALYVTLWTAGKLTEDDLRTFHGE
GTLLSAHPAPGWSRDIPFATGSLGHGLPDAAGIALGHRFRGRSGRVFCLTSDAEWQEGSNWEALIFARHHQLQNLIIVID
ENRLQGFGTTRGVASMDPIGEKLSGFGLNTTHADGHDVEALRCAFSEAAGEGPRIVILKTTKGHGVSFMENRMEWHYLPI
DADQYRMALAEVDAE
>Mature_255_residues
MRPLLKRARKRLLQMHFESHVGHIGGNLSALDAMMVLYHQVLRDDDVFILSKGHAAGALYVTLWTAGKLTEDDLRTFHGE
GTLLSAHPAPGWSRDIPFATGSLGHGLPDAAGIALGHRFRGRSGRVFCLTSDAEWQEGSNWEALIFARHHQLQNLIIVID
ENRLQGFGTTRGVASMDPIGEKLSGFGLNTTHADGHDVEALRCAFSEAAGEGPRIVILKTTKGHGVSFMENRMEWHYLPI
DADQYRMALAEVDAE

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=259, Percent_Identity=36.2934362934363, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI205277463, Length=263, Percent_Identity=34.9809885931559, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4507521, Length=263, Percent_Identity=34.9809885931559, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI225637461, Length=148, Percent_Identity=41.2162162162162, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI225637459, Length=148, Percent_Identity=41.2162162162162, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI225637463, Length=148, Percent_Identity=41.2162162162162, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1788808, Length=254, Percent_Identity=27.1653543307087, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994911, Length=266, Percent_Identity=23.3082706766917, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17539652, Length=247, Percent_Identity=35.2226720647773, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6325331, Length=255, Percent_Identity=26.2745098039216, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319593, Length=228, Percent_Identity=27.6315789473684, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45551847, Length=252, Percent_Identity=35.7142857142857, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45550715, Length=252, Percent_Identity=35.7142857142857, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645119, Length=219, Percent_Identity=38.3561643835616, Blast_Score=120, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24666278, Length=231, Percent_Identity=34.1991341991342, Blast_Score=111, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 28100; Mature: 28100

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLLKRARKRLLQMHFESHVGHIGGNLSALDAMMVLYHQVLRDDDVFILSKGHAAGALY
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEE
VTLWTAGKLTEDDLRTFHGEGTLLSAHPAPGWSRDIPFATGSLGHGLPDAAGIALGHRFR
EEEEECCCCCHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEC
GRSGRVFCLTSDAEWQEGSNWEALIFARHHQLQNLIIVIDENRLQGFGTTRGVASMDPIG
CCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHH
EKLSGFGLNTTHADGHDVEALRCAFSEAAGEGPRIVILKTTKGHGVSFMENRMEWHYLPI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCEEEEECC
DADQYRMALAEVDAE
CCHHHHHHHHHCCCC
>Mature Secondary Structure
MRPLLKRARKRLLQMHFESHVGHIGGNLSALDAMMVLYHQVLRDDDVFILSKGHAAGALY
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEE
VTLWTAGKLTEDDLRTFHGEGTLLSAHPAPGWSRDIPFATGSLGHGLPDAAGIALGHRFR
EEEEECCCCCHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEC
GRSGRVFCLTSDAEWQEGSNWEALIFARHHQLQNLIIVIDENRLQGFGTTRGVASMDPIG
CCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHH
EKLSGFGLNTTHADGHDVEALRCAFSEAAGEGPRIVILKTTKGHGVSFMENRMEWHYLPI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCEEEEECC
DADQYRMALAEVDAE
CCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]