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The map label for this gene is pknD [H]

Identifier: 116619658

GI number: 116619658

Start: 630869

End: 632626

Strand: Direct

Name: pknD [H]

Synonym: Acid_0520

Alternate gene names: 116619658

Gene position: 630869-632626 (Clockwise)

Preceding gene: 116619657

Following gene: 116619659

Centisome position: 6.33

GC content: 63.77

Gene sequence:

>1758_bases
ATGACGATCCGGGGTCTTTCGCTCGAAGTGTGTCTGTGTGCCTGTCTGTGCGCGTCCGCCTGGGGCCAGCAGTACACCAT
CACCACCATCGCCGGTAATGGCGCGGCCGGCTTTGCCGGAGACGGCGGCGACCCTAAAGTTGCCCAGTTCAGCTCTCCTA
CAGGCCTCGCGCTCGATCCCAAGACCGGCAATCTGTACATCGCCGATTCCGCCAATCATCGCATCCGCATGATCTCCGGC
AGCACCATCAGCACCGTTGCCGGCAACGGCACCGCGGGCTTTGCCGGCGACAAGGCCGCTGCCACCAGCGCCAATCTCAA
CACCCCCAGCGGCGTCGCCCTCGATTCTTCCGGCAACTTCTACATCGCCGACTCCCTCAACAGCGTCATCCGCAAGGTCA
CCGGCGGCACCATCACAACCGTCGCCGGCGATTACACCCAGTTTCCCGGAGACCAGGGCGATGGCGGCCAGGCTAACGTC
GCGGTCCTCAACAACCCCACCAGCGTGATGGTCGATCCCGCGGGCAACTACTACATCGCCGACAGCGGCAACAACCGCAT
CCGCAAGGTCGATACCACCGGGACCATCAACGCCTATCTCGGTACCCTGGCCACCGGCGGGAGATTGCGCAATCCCTACG
CTCTCGCTCTGTTTGGCAATGTACTTTATATCGCAGATACTTCGAACAATCGGATCGCGAAGTACGCGCCCTATACTGCC
AACAATGTCGCCGCCGACCTCACCAACTTCGCCGGCAACCTGACCGCGGGCTTCGCCGGCGATGGCAACACCGCCACTCT
CTCCCAGTTGAACAAGCCCGTCGGCATCGCGGTCGATTCCGCCGGCAACGTCTACATTGCCGATTCCAACAACGGGCGCA
TTCGCAAAGTCGGCACCGATGGCATCATCACCACCATCGCCGGCAAAGGCGGCTCCGGATATAGCGGCGATGGCGGCCCC
GCCACCTCCGCTGTCCTCAGCTTCCCGCGCGGCATCGCCGTCGCGGCCAACGGCACCGTGTACATCGCCGATACCAACAA
TCACGTAATCCGCGCCCTTGTCCCGACTGTTCCCACCATCAACTCCGGCGGCGTCGTCAACGCCGCCAGTTTCACCGCGC
GCATCTCGCCCGGCGAACTCGCCAGCGTCTTTGGCAACGGCTTCGGCATCTCTACCGTACAGCCTGACGTTCCCCTCCCC
ACCATCGCCGCCGGCGTCACCGTCAGCGTCAATGGCAAGGCCGCGCCCATCCTCTACCTCACGCCCGGCCAGATCAATTT
CCAGGTGCCGTGGTCCACTCCAACCACCGGCAGCGTCAACGTCGTCGTCAGCGCCGGCAGCATCAACAGCAATACCATCG
CCGTGCCCGTCGGCACCGCCGCCCCCGGCGTCTTCACGCTGCCCACCGGCGCCGCCATCGTGCAGAACTTCCCCGATTAC
TCGCTCAACGATCCCGGTAATCCTGCCAAGGCCGGCAGCACCATCATTGCCTATCTCACCGGCTCCGGGCCGGTTTCTCC
CGCTGCGAATGATGGTGTCCCCGCTCCGTCTTCTACAGTGACCACCGCCACCGCGGTCGCCACTGCGAAAATCGGCTCCG
CTGATGCCGTCGTTTCCTTCACCGGACTCACGCCCTCATTCGTCGGCCTCGCCCAGATGAACATCGTCGTGCCAGCCACG
CTCGCACCCGGCGTCTACCCCCTCGTCATCACCATCGACGGCCAGACTGCCAATTCGGCCACCATTGCCGTAAAATAG

Upstream 100 bases:

>100_bases
GCCGGAGCTATCGCGCTCGGGCTCTGTTGGATCATCGCCGCCACGCTTCACTGATTTCTTGTAACGCGTCCGGCGGCTCG
TGCGTTTAGACTGTATATAT

Downstream 100 bases:

>100_bases
ACCAATATGCTGTTTGAAGCCGACAAGGTGATGTTTGAGATCTATAAAGAGACGGAATATACCGGCAAGTACCGGGTCGT
CTACTTCACCGAACTGCAGG

Product: NHL repeat-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MTIRGLSLEVCLCACLCASAWGQQYTITTIAGNGAAGFAGDGGDPKVAQFSSPTGLALDPKTGNLYIADSANHRIRMISG
STISTVAGNGTAGFAGDKAAATSANLNTPSGVALDSSGNFYIADSLNSVIRKVTGGTITTVAGDYTQFPGDQGDGGQANV
AVLNNPTSVMVDPAGNYYIADSGNNRIRKVDTTGTINAYLGTLATGGRLRNPYALALFGNVLYIADTSNNRIAKYAPYTA
NNVAADLTNFAGNLTAGFAGDGNTATLSQLNKPVGIAVDSAGNVYIADSNNGRIRKVGTDGIITTIAGKGGSGYSGDGGP
ATSAVLSFPRGIAVAANGTVYIADTNNHVIRALVPTVPTINSGGVVNAASFTARISPGELASVFGNGFGISTVQPDVPLP
TIAAGVTVSVNGKAAPILYLTPGQINFQVPWSTPTTGSVNVVVSAGSINSNTIAVPVGTAAPGVFTLPTGAAIVQNFPDY
SLNDPGNPAKAGSTIIAYLTGSGPVSPAANDGVPAPSSTVTTATAVATAKIGSADAVVSFTGLTPSFVGLAQMNIVVPAT
LAPGVYPLVITIDGQTANSATIAVK

Sequences:

>Translated_585_residues
MTIRGLSLEVCLCACLCASAWGQQYTITTIAGNGAAGFAGDGGDPKVAQFSSPTGLALDPKTGNLYIADSANHRIRMISG
STISTVAGNGTAGFAGDKAAATSANLNTPSGVALDSSGNFYIADSLNSVIRKVTGGTITTVAGDYTQFPGDQGDGGQANV
AVLNNPTSVMVDPAGNYYIADSGNNRIRKVDTTGTINAYLGTLATGGRLRNPYALALFGNVLYIADTSNNRIAKYAPYTA
NNVAADLTNFAGNLTAGFAGDGNTATLSQLNKPVGIAVDSAGNVYIADSNNGRIRKVGTDGIITTIAGKGGSGYSGDGGP
ATSAVLSFPRGIAVAANGTVYIADTNNHVIRALVPTVPTINSGGVVNAASFTARISPGELASVFGNGFGISTVQPDVPLP
TIAAGVTVSVNGKAAPILYLTPGQINFQVPWSTPTTGSVNVVVSAGSINSNTIAVPVGTAAPGVFTLPTGAAIVQNFPDY
SLNDPGNPAKAGSTIIAYLTGSGPVSPAANDGVPAPSSTVTTATAVATAKIGSADAVVSFTGLTPSFVGLAQMNIVVPAT
LAPGVYPLVITIDGQTANSATIAVK
>Mature_584_residues
TIRGLSLEVCLCACLCASAWGQQYTITTIAGNGAAGFAGDGGDPKVAQFSSPTGLALDPKTGNLYIADSANHRIRMISGS
TISTVAGNGTAGFAGDKAAATSANLNTPSGVALDSSGNFYIADSLNSVIRKVTGGTITTVAGDYTQFPGDQGDGGQANVA
VLNNPTSVMVDPAGNYYIADSGNNRIRKVDTTGTINAYLGTLATGGRLRNPYALALFGNVLYIADTSNNRIAKYAPYTAN
NVAADLTNFAGNLTAGFAGDGNTATLSQLNKPVGIAVDSAGNVYIADSNNGRIRKVGTDGIITTIAGKGGSGYSGDGGPA
TSAVLSFPRGIAVAANGTVYIADTNNHVIRALVPTVPTINSGGVVNAASFTARISPGELASVFGNGFGISTVQPDVPLPT
IAAGVTVSVNGKAAPILYLTPGQINFQVPWSTPTTGSVNVVVSAGSINSNTIAVPVGTAAPGVFTLPTGAAIVQNFPDYS
LNDPGNPAKAGSTIIAYLTGSGPVSPAANDGVPAPSSTVTTATAVATAKIGSADAVVSFTGLTPSFVGLAQMNIVVPATL
APGVYPLVITIDGQTANSATIAVK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI170016091, Length=414, Percent_Identity=28.5024154589372, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI253970446, Length=508, Percent_Identity=25.7874015748031, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI253970444, Length=508, Percent_Identity=25.7874015748031, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI110347400, Length=508, Percent_Identity=25.7874015748031, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI84993742, Length=305, Percent_Identity=26.2295081967213, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI169790825, Length=284, Percent_Identity=28.5211267605634, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI122937400, Length=287, Percent_Identity=28.9198606271777, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17553622, Length=287, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71980713, Length=351, Percent_Identity=23.0769230769231, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71980716, Length=351, Percent_Identity=23.0769230769231, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221330419, Length=322, Percent_Identity=27.0186335403727, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24655386, Length=322, Percent_Identity=27.0186335403727, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI22024206, Length=322, Percent_Identity=27.0186335403727, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24668551, Length=345, Percent_Identity=26.9565217391304, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161085696, Length=244, Percent_Identity=29.5081967213115, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011009
- InterPro:   IPR001258
- InterPro:   IPR013017
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271 [H]

Pfam domain/function: PF01436 NHL; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 58264; Mature: 58132

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS51125 NHL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRGLSLEVCLCACLCASAWGQQYTITTIAGNGAAGFAGDGGDPKVAQFSSPTGLALDP
CEEECCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEECC
KTGNLYIADSANHRIRMISGSTISTVAGNGTAGFAGDKAAATSANLNTPSGVALDSSGNF
CCCCEEEEECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCE
YIADSLNSVIRKVTGGTITTVAGDYTQFPGDQGDGGQANVAVLNNPTSVMVDPAGNYYIA
EEECCHHHHHHHHCCCEEEEEECCHHCCCCCCCCCCCEEEEEEECCCEEEECCCCCEEEE
DSGNNRIRKVDTTGTINAYLGTLATGGRLRNPYALALFGNVLYIADTSNNRIAKYAPYTA
ECCCCEEEEEECCCEEHHHHHHHCCCCCCCCCEEEEEECCEEEEEECCCCEEEEECCCCC
NNVAADLTNFAGNLTAGFAGDGNTATLSQLNKPVGIAVDSAGNVYIADSNNGRIRKVGTD
CCHHHHHHHCCCCEEEEECCCCCEEEHHHCCCCEEEEEECCCCEEEEECCCCEEEEECCC
GIITTIAGKGGSGYSGDGGPATSAVLSFPRGIAVAANGTVYIADTNNHVIRALVPTVPTI
CEEEEEECCCCCCCCCCCCCHHHHHHHCCCCEEEEECCEEEEEECCCCEEEEEECCCCCC
NSGGVVNAASFTARISPGELASVFGNGFGISTVQPDVPLPTIAAGVTVSVNGKAAPILYL
CCCCEEEEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCEECCCEEEEECCCEEEEEEE
TPGQINFQVPWSTPTTGSVNVVVSAGSINSNTIAVPVGTAAPGVFTLPTGAAIVQNFPDY
CCCEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCEEECCCCHHHHHCCCCC
SLNDPGNPAKAGSTIIAYLTGSGPVSPAANDGVPAPSSTVTTATAVATAKIGSADAVVSF
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEEE
TGLTPSFVGLAQMNIVVPATLAPGVYPLVITIDGQTANSATIAVK
ECCCCHHHEEEEEEEEEEECCCCCCEEEEEEECCCCCCCEEEEEC
>Mature Secondary Structure 
TIRGLSLEVCLCACLCASAWGQQYTITTIAGNGAAGFAGDGGDPKVAQFSSPTGLALDP
EEECCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEECC
KTGNLYIADSANHRIRMISGSTISTVAGNGTAGFAGDKAAATSANLNTPSGVALDSSGNF
CCCCEEEEECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCE
YIADSLNSVIRKVTGGTITTVAGDYTQFPGDQGDGGQANVAVLNNPTSVMVDPAGNYYIA
EEECCHHHHHHHHCCCEEEEEECCHHCCCCCCCCCCCEEEEEEECCCEEEECCCCCEEEE
DSGNNRIRKVDTTGTINAYLGTLATGGRLRNPYALALFGNVLYIADTSNNRIAKYAPYTA
ECCCCEEEEEECCCEEHHHHHHHCCCCCCCCCEEEEEECCEEEEEECCCCEEEEECCCCC
NNVAADLTNFAGNLTAGFAGDGNTATLSQLNKPVGIAVDSAGNVYIADSNNGRIRKVGTD
CCHHHHHHHCCCCEEEEECCCCCEEEHHHCCCCEEEEEECCCCEEEEECCCCEEEEECCC
GIITTIAGKGGSGYSGDGGPATSAVLSFPRGIAVAANGTVYIADTNNHVIRALVPTVPTI
CEEEEEECCCCCCCCCCCCCHHHHHHHCCCCEEEEECCEEEEEECCCCEEEEEECCCCCC
NSGGVVNAASFTARISPGELASVFGNGFGISTVQPDVPLPTIAAGVTVSVNGKAAPILYL
CCCCEEEEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCEECCCEEEEECCCEEEEEEE
TPGQINFQVPWSTPTTGSVNVVVSAGSINSNTIAVPVGTAAPGVFTLPTGAAIVQNFPDY
CCCEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCEEECCCCHHHHHCCCCC
SLNDPGNPAKAGSTIIAYLTGSGPVSPAANDGVPAPSSTVTTATAVATAKIGSADAVVSF
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEEE
TGLTPSFVGLAQMNIVVPATLAPGVYPLVITIDGQTANSATIAVK
ECCCCHHHEEEEEEEEEEECCCCCCEEEEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9119030; 9634230; 12218036 [H]