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The map label for this gene is zraS [C]

Identifier: 116619595

GI number: 116619595

Start: 561127

End: 562686

Strand: Direct

Name: zraS [C]

Synonym: Acid_0456

Alternate gene names: 116619595

Gene position: 561127-562686 (Clockwise)

Preceding gene: 116619594

Following gene: 116619599

Centisome position: 5.63

GC content: 63.46

Gene sequence:

>1560_bases
ATGGTTCAACCATTGGAGCTTTTATTCATTGGTGAAAGTGGTGTGGACGCTGTCGTCGCGGAACTCCGGCGCGGCGGCTA
TTCCCCCTCTATTCGCTGCGCGAATACTCTTACGGAGCTTGAAAGCGCTCTCACGTCCCGTCCCGATATCGCCATTAGCG
ATTTCTCGATTGAACCCGGCTTCGGCGCACTGGAAGCCCTTCGCGTCATTCAGGACCAAGGCGTCGATCTGCCCGTGATT
GTCGTTTCCGGAAAAATCCGTGATTCCGATGTCCTGGCGGTTCTTAAGGCCGGCGCCGCCGATCACCTCACCCGCACTAA
CCTCATGCGCCTCAACGCTGCCGTCGAACGGGAACTTCGCAGCGCCCGCATGCGCACAGACCGCGTACGCCTTGAAGAGC
AATTCCGCCAGGCACAGAAAATGGAGGCCGTCGGCCGGCTCGCCGGCGGCGTTGCTCACGATTTCAATAATCTCCTGACC
GTGATCACCGGCTACAGCGACCTCCTGCTGGGAAGCCGGGACCTCAAGGAAGCCCAGCGTTCGGCGCTTGAGGAAATCCG
CCGCTCCGCCGAGCGCGGCGGCGCCCTCACTCACCAGTTGCTCGCCTTCAGCCGCCGTCAGCCCATGCAGGCTCGCCCCC
TGAAGATCGACGAGCTGGTACTCCACATGGAGCGCATGCTGCGCCGCCTGATCGGCGAAGATGTCGAGTTGGTGACCATC
GCCGCCTCCTCCGAAACTGTATTCGCCGACCCCGGCCGCCTCGAGCAGGTGATCATGAACCTTGTGGTCAATGCCCGCGA
CGCCATGCCCGGCGGCGGCAAGCTCACTATCGAAACCGGCAGCATCCGCCTGAACGACGGCCTCGCCGCCCGCCACCTCG
GCGTGCCCCCCGGGCAATACGTCACCATCTTCATCACCGATACCGGTGTCGGCATGGACCAGGAGACGCAGAGCCATCTG
TTCGAACCCTTCTTCACCACCAAGAACCCAGGCCGCGGCACCGGCCTTGGACTGGCCACCGTTTATGGCATCATCCGCCA
GAGCGGCGGTGCCATCGGCATCGCGAGTGAGCCCGGCAAAGGGACCTCCGCAAATATCTACCTTCCCCGCGCCAAGGAGA
AAGCCGAACCCGCGGTGGACCGTCCCCCTGCCCTGATGCCGCTCACCGGGCGCGAAACCATCCTGGTCGTGGAGGACGAA
GCCCGCGTCCGCAAATTGATCGTGGACGTACTCACCGGCCGCGGCTACCGCGTCCTCGAAGCCACCCGTGGCGAAGAGGC
CCTCCGCATCTGCAAGACCCACGCCGACGAGATCGATCTCGCCGTCGTGGACGTCGTCATGCCCGAAATGAACGGCCCGG
ACCTCATCCGCCAGATGCAGCCCATCTGCAAGGGAATCCGCGTTCTCTACATCTCCGGCTACACCGATGAAGCCATGATC
CACCACGGCATTCCGGAGTCCGGAGCCGCCTTCCTCCAGAAACCCTTCGTCCCCGATCAACTCGCCCGCAAAGTCCGCGA
AGTCCTGGACGCCCGCGCCAACGCCGCCGAAGGCCAGTAG

Upstream 100 bases:

>100_bases
CTGTGAGCCGTTTCACAGTTGTTGTAAATCTCACATCAGTAAATCGCTTAGTACCCCAATACTATTCCGCATCCATTACT
CTAGTGGGGAGCAGCAGGTG

Downstream 100 bases:

>100_bases
GACGGGCTCGCACGCCGCGAACCGCGACTGTCAGGGAGCGATCTCTTGATGCCCGCCAGAGAGCGATCTCTTATTTGCCC
TCATCTCGGGTGCGTAAACT

Product: histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MVQPLELLFIGESGVDAVVAELRRGGYSPSIRCANTLTELESALTSRPDIAISDFSIEPGFGALEALRVIQDQGVDLPVI
VVSGKIRDSDVLAVLKAGAADHLTRTNLMRLNAAVERELRSARMRTDRVRLEEQFRQAQKMEAVGRLAGGVAHDFNNLLT
VITGYSDLLLGSRDLKEAQRSALEEIRRSAERGGALTHQLLAFSRRQPMQARPLKIDELVLHMERMLRRLIGEDVELVTI
AASSETVFADPGRLEQVIMNLVVNARDAMPGGGKLTIETGSIRLNDGLAARHLGVPPGQYVTIFITDTGVGMDQETQSHL
FEPFFTTKNPGRGTGLGLATVYGIIRQSGGAIGIASEPGKGTSANIYLPRAKEKAEPAVDRPPALMPLTGRETILVVEDE
ARVRKLIVDVLTGRGYRVLEATRGEEALRICKTHADEIDLAVVDVVMPEMNGPDLIRQMQPICKGIRVLYISGYTDEAMI
HHGIPESGAAFLQKPFVPDQLARKVREVLDARANAAEGQ

Sequences:

>Translated_519_residues
MVQPLELLFIGESGVDAVVAELRRGGYSPSIRCANTLTELESALTSRPDIAISDFSIEPGFGALEALRVIQDQGVDLPVI
VVSGKIRDSDVLAVLKAGAADHLTRTNLMRLNAAVERELRSARMRTDRVRLEEQFRQAQKMEAVGRLAGGVAHDFNNLLT
VITGYSDLLLGSRDLKEAQRSALEEIRRSAERGGALTHQLLAFSRRQPMQARPLKIDELVLHMERMLRRLIGEDVELVTI
AASSETVFADPGRLEQVIMNLVVNARDAMPGGGKLTIETGSIRLNDGLAARHLGVPPGQYVTIFITDTGVGMDQETQSHL
FEPFFTTKNPGRGTGLGLATVYGIIRQSGGAIGIASEPGKGTSANIYLPRAKEKAEPAVDRPPALMPLTGRETILVVEDE
ARVRKLIVDVLTGRGYRVLEATRGEEALRICKTHADEIDLAVVDVVMPEMNGPDLIRQMQPICKGIRVLYISGYTDEAMI
HHGIPESGAAFLQKPFVPDQLARKVREVLDARANAAEGQ
>Mature_519_residues
MVQPLELLFIGESGVDAVVAELRRGGYSPSIRCANTLTELESALTSRPDIAISDFSIEPGFGALEALRVIQDQGVDLPVI
VVSGKIRDSDVLAVLKAGAADHLTRTNLMRLNAAVERELRSARMRTDRVRLEEQFRQAQKMEAVGRLAGGVAHDFNNLLT
VITGYSDLLLGSRDLKEAQRSALEEIRRSAERGGALTHQLLAFSRRQPMQARPLKIDELVLHMERMLRRLIGEDVELVTI
AASSETVFADPGRLEQVIMNLVVNARDAMPGGGKLTIETGSIRLNDGLAARHLGVPPGQYVTIFITDTGVGMDQETQSHL
FEPFFTTKNPGRGTGLGLATVYGIIRQSGGAIGIASEPGKGTSANIYLPRAKEKAEPAVDRPPALMPLTGRETILVVEDE
ARVRKLIVDVLTGRGYRVLEATRGEEALRICKTHADEIDLAVVDVVMPEMNGPDLIRQMQPICKGIRVLYISGYTDEAMI
HHGIPESGAAFLQKPFVPDQLARKVREVLDARANAAEGQ

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=263, Percent_Identity=27.7566539923954, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788549, Length=253, Percent_Identity=31.6205533596838, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788713, Length=338, Percent_Identity=27.2189349112426, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=353, Percent_Identity=25.7790368271955, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=416, Percent_Identity=24.2788461538462, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=262, Percent_Identity=26.3358778625954, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=263, Percent_Identity=26.9961977186312, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56521; Mature: 56521

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQPLELLFIGESGVDAVVAELRRGGYSPSIRCANTLTELESALTSRPDIAISDFSIEPG
CCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCC
FGALEALRVIQDQGVDLPVIVVSGKIRDSDVLAVLKAGAADHLTRTNLMRLNAAVERELR
CCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SARMRTDRVRLEEQFRQAQKMEAVGRLAGGVAHDFNNLLTVITGYSDLLLGSRDLKEAQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHH
SALEEIRRSAERGGALTHQLLAFSRRQPMQARPLKIDELVLHMERMLRRLIGEDVELVTI
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEE
AASSETVFADPGRLEQVIMNLVVNARDAMPGGGKLTIETGSIRLNDGLAARHLGVPPGQY
EECCCEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECEEEECCCCEEEECCCCCCCE
VTIFITDTGVGMDQETQSHLFEPFFTTKNPGRGTGLGLATVYGIIRQSGGAIGIASEPGK
EEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCC
GTSANIYLPRAKEKAEPAVDRPPALMPLTGRETILVVEDEARVRKLIVDVLTGRGYRVLE
CCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHCCCCEEEEE
ATRGEEALRICKTHADEIDLAVVDVVMPEMNGPDLIRQMQPICKGIRVLYISGYTDEAMI
CCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHH
HHGIPESGAAFLQKPFVPDQLARKVREVLDARANAAEGQ
HCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVQPLELLFIGESGVDAVVAELRRGGYSPSIRCANTLTELESALTSRPDIAISDFSIEPG
CCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCC
FGALEALRVIQDQGVDLPVIVVSGKIRDSDVLAVLKAGAADHLTRTNLMRLNAAVERELR
CCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SARMRTDRVRLEEQFRQAQKMEAVGRLAGGVAHDFNNLLTVITGYSDLLLGSRDLKEAQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHH
SALEEIRRSAERGGALTHQLLAFSRRQPMQARPLKIDELVLHMERMLRRLIGEDVELVTI
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEE
AASSETVFADPGRLEQVIMNLVVNARDAMPGGGKLTIETGSIRLNDGLAARHLGVPPGQY
EECCCEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECEEEECCCCEEEECCCCCCCE
VTIFITDTGVGMDQETQSHLFEPFFTTKNPGRGTGLGLATVYGIIRQSGGAIGIASEPGK
EEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCC
GTSANIYLPRAKEKAEPAVDRPPALMPLTGRETILVVEDEARVRKLIVDVLTGRGYRVLE
CCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHCCCCEEEEE
ATRGEEALRICKTHADEIDLAVVDVVMPEMNGPDLIRQMQPICKGIRVLYISGYTDEAMI
CCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHH
HHGIPESGAAFLQKPFVPDQLARKVREVLDARANAAEGQ
HCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA