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The map label for this gene is gmhB [H]

Identifier: 116619560

GI number: 116619560

Start: 522602

End: 523150

Strand: Direct

Name: gmhB [H]

Synonym: Acid_0421

Alternate gene names: 116619560

Gene position: 522602-523150 (Clockwise)

Preceding gene: 116619559

Following gene: 116619561

Centisome position: 5.24

GC content: 65.21

Gene sequence:

>549_bases
GTGAGCAAAGCCGTATTCCTGGATCGCGACGGCGTGCTCAACGTGCCCGTGGTCCGCGACGGACGGCCCTATCCGCCTGC
CGGGCTCGACCAGTTGCAAATTTACCCCGATGCGCCGGGCGCCCTGGCGTGCCTGAAACGCGCAGGCTATCTGCTGATCG
TTGTCACCAATCAGCCGGACGTGGCGCGGGGCACTCAGAGTCGTGAGGCCGTGAACTCCATGAATGCCGCCGTCGGCGCG
GCACTGCCGGTGGACGAGTTCCTGGTCTGCTGGCATGACGATGGCGAGGACTGCGACTGCCGCAAACCCAAACCCGGGCT
GGTAATGGCCGCTGCCGAGCGGCACCAGATCGATCTGGCGCGGAGTTTCCTGGTTGGCGACCGCTGGCGCGACATCGATT
GCGGCGCGGCGGCGGGTGTACGCACAGTGTGGATCGATCGCCAATACCGCGAAAGGGCCCCATCGTCTTCACCGGACCAC
GTCGCCGATTCGCTGACTTCCGCAGCGTCATGGATCCTAGCGGTGTCGAAGATTACGCCAGGCGACTAG

Upstream 100 bases:

>100_bases
ACGTCACGCCGCACTCGGAAGCCTTTCAGGCCGTGATCTGGCACCTTTTGGTCACGCACCCGGCGCTGAAGCAGGCCGAA
ACCAAATGGGAATCAGTGAA

Downstream 100 bases:

>100_bases
CCCGCGTGCCATAATGGCAGGCGGAGGCTCGCCGTGCGAGTTTTATCACTAATTCTGGCGCTCTGGATCCCGGCGGCTGC
CCAGGTGGCACCCATGCTGA

Product: D-alpha,beta-D-heptose 1,7-bisphosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MSKAVFLDRDGVLNVPVVRDGRPYPPAGLDQLQIYPDAPGALACLKRAGYLLIVVTNQPDVARGTQSREAVNSMNAAVGA
ALPVDEFLVCWHDDGEDCDCRKPKPGLVMAAAERHQIDLARSFLVGDRWRDIDCGAAAGVRTVWIDRQYRERAPSSSPDH
VADSLTSAASWILAVSKITPGD

Sequences:

>Translated_182_residues
MSKAVFLDRDGVLNVPVVRDGRPYPPAGLDQLQIYPDAPGALACLKRAGYLLIVVTNQPDVARGTQSREAVNSMNAAVGA
ALPVDEFLVCWHDDGEDCDCRKPKPGLVMAAAERHQIDLARSFLVGDRWRDIDCGAAAGVRTVWIDRQYRERAPSSSPDH
VADSLTSAASWILAVSKITPGD
>Mature_181_residues
SKAVFLDRDGVLNVPVVRDGRPYPPAGLDQLQIYPDAPGALACLKRAGYLLIVVTNQPDVARGTQSREAVNSMNAAVGAA
LPVDEFLVCWHDDGEDCDCRKPKPGLVMAAAERHQIDLARSFLVGDRWRDIDCGAAAGVRTVWIDRQYRERAPSSSPDHV
ADSLTSAASWILAVSKITPGD

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Escherichia coli, GI1786399, Length=182, Percent_Identity=30.2197802197802, Blast_Score=81, Evalue=3e-17,
Organism=Escherichia coli, GI87082027, Length=154, Percent_Identity=31.8181818181818, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: NA

Molecular weight: Translated: 19666; Mature: 19535

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAVFLDRDGVLNVPVVRDGRPYPPAGLDQLQIYPDAPGALACLKRAGYLLIVVTNQPD
CCCEEEEECCCEEECCEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCEEEEEEECCCC
VARGTQSREAVNSMNAAVGAALPVDEFLVCWHDDGEDCDCRKPKPGLVMAAAERHQIDLA
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHH
RSFLVGDRWRDIDCGAAAGVRTVWIDRQYRERAPSSSPDHVADSLTSAASWILAVSKITP
HHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCC
GD
CC
>Mature Secondary Structure 
SKAVFLDRDGVLNVPVVRDGRPYPPAGLDQLQIYPDAPGALACLKRAGYLLIVVTNQPD
CCEEEEECCCEEECCEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCEEEEEEECCCC
VARGTQSREAVNSMNAAVGAALPVDEFLVCWHDDGEDCDCRKPKPGLVMAAAERHQIDLA
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHH
RSFLVGDRWRDIDCGAAAGVRTVWIDRQYRERAPSSSPDHVADSLTSAASWILAVSKITP
HHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCC
GD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]