Click here to switch to the map view.

The map label for this gene is cysG [H]

Identifier: 116619324

GI number: 116619324

Start: 231379

End: 232128

Strand: Direct

Name: cysG [H]

Synonym: Acid_0181

Alternate gene names: 116619324

Gene position: 231379-232128 (Clockwise)

Preceding gene: 116619318

Following gene: 116619325

Centisome position: 2.32

GC content: 64.67

Gene sequence:

>750_bases
GTGGCAAGCATGGCGAAAGTGTATCTGGTCGGCGCCGGTCCCGGCGACCCCGATCTCCTCACCCGTAAGGCATTGCGCCT
GTTGGAACAAGCCGACGTCATCCTGCACGACCGTCTGGTTAGTGATGGAATCCTGGCGCTGGCAAGTCCACGGGCACGAC
TGATCGATGTTGGCAAGCAGCAGGGGCAGCAGGAAGAGATCCAGTCCGAAATCTACACGTGGATCCTGCGGCTGGGCCGC
TCCGCGCGCACCATCGTCCGCCTCAAAAGCGGCGACCCCATGGTCTTCGGTCGCGGCGGCGAAGAACTGGAGTTTCTCGC
CCGGCACGGCATTGACGCCGAAGTGGTTCCCGGGCTTTCCTCCGCGCTGGCCGCTCCCGCGCTGGCCGGAATTCCAGTGA
CCTACCGGGGTGTAGCCGCCTCCTTCTCCGTGATTGCCGGACACCGCCAGAGTCTCACCACCCTCGATTGGTCGGTGTAC
CAGGGAGTGGATACCCTCATCATCCTCATGGGCGTGGAGTACCGCGACATAATCGCGCACACGCTCATCGAACAAGGCCG
CCCGGCAAGCCAGCCCGTGGCATTCCTGGAGAACGCATCTACCAGCCGCGAGCGCGTCGTGGAATCCACGCTCGAACTCG
TGGCGCGCCGCCAGGTGGAGGTGAAGGCCCCGGCCGTAATGGTGATCGGCGAAGTGGTCCGCCACCGGACCGCGGTGCGT
AGAGCCATGCTGCAGGAGGCGGTCGCTTGA

Upstream 100 bases:

>100_bases
CTCAGGCTCATTGCCGAGCCGAATCCCAAACAGATAAACAGAACCGCGCACTCCGTCCGTTTGCGCGATTCCTGTTGGCG
ATTTTCTCGAAGGAGCCCGA

Downstream 100 bases:

>100_bases
CCGGGTTACCCCTGCTCGAAAGCGACTTGCTCTACCGGCCGGTGCCTACCGGACTCGTGCAGCTCCGCCGTGCGCCGGAA
CTGACTCCGCGCCGACCCCT

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MASMAKVYLVGAGPGDPDLLTRKALRLLEQADVILHDRLVSDGILALASPRARLIDVGKQQGQQEEIQSEIYTWILRLGR
SARTIVRLKSGDPMVFGRGGEELEFLARHGIDAEVVPGLSSALAAPALAGIPVTYRGVAASFSVIAGHRQSLTTLDWSVY
QGVDTLIILMGVEYRDIIAHTLIEQGRPASQPVAFLENASTSRERVVESTLELVARRQVEVKAPAVMVIGEVVRHRTAVR
RAMLQEAVA

Sequences:

>Translated_249_residues
MASMAKVYLVGAGPGDPDLLTRKALRLLEQADVILHDRLVSDGILALASPRARLIDVGKQQGQQEEIQSEIYTWILRLGR
SARTIVRLKSGDPMVFGRGGEELEFLARHGIDAEVVPGLSSALAAPALAGIPVTYRGVAASFSVIAGHRQSLTTLDWSVY
QGVDTLIILMGVEYRDIIAHTLIEQGRPASQPVAFLENASTSRERVVESTLELVARRQVEVKAPAVMVIGEVVRHRTAVR
RAMLQEAVA
>Mature_248_residues
ASMAKVYLVGAGPGDPDLLTRKALRLLEQADVILHDRLVSDGILALASPRARLIDVGKQQGQQEEIQSEIYTWILRLGRS
ARTIVRLKSGDPMVFGRGGEELEFLARHGIDAEVVPGLSSALAAPALAGIPVTYRGVAASFSVIAGHRQSLTTLDWSVYQ
GVDTLIILMGVEYRDIIAHTLIEQGRPASQPVAFLENASTSRERVVESTLELVARRQVEVKAPAVMVIGEVVRHRTAVRR
AMLQEAVA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=230, Percent_Identity=42.6086956521739, Blast_Score=180, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=33.4763948497854, Blast_Score=126, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 27020; Mature: 26888

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASMAKVYLVGAGPGDPDLLTRKALRLLEQADVILHDRLVSDGILALASPRARLIDVGKQ
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
QGQQEEIQSEIYTWILRLGRSARTIVRLKSGDPMVFGRGGEELEFLARHGIDAEVVPGLS
CCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCHHHHHHHHCCCCCHHCCCHH
SALAAPALAGIPVTYRGVAASFSVIAGHRQSLTTLDWSVYQGVDTLIILMGVEYRDIIAH
HHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TLIEQGRPASQPVAFLENASTSRERVVESTLELVARRQVEVKAPAVMVIGEVVRHRTAVR
HHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RAMLQEAVA
HHHHHHHCC
>Mature Secondary Structure 
ASMAKVYLVGAGPGDPDLLTRKALRLLEQADVILHDRLVSDGILALASPRARLIDVGKQ
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
QGQQEEIQSEIYTWILRLGRSARTIVRLKSGDPMVFGRGGEELEFLARHGIDAEVVPGLS
CCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCHHHHHHHHCCCCCHHCCCHH
SALAAPALAGIPVTYRGVAASFSVIAGHRQSLTTLDWSVYQGVDTLIILMGVEYRDIIAH
HHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TLIEQGRPASQPVAFLENASTSRERVVESTLELVARRQVEVKAPAVMVIGEVVRHRTAVR
HHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RAMLQEAVA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA