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The map label for this gene is yrbE [H]

Identifier: 116619317

GI number: 116619317

Start: 222407

End: 223828

Strand: Direct

Name: yrbE [H]

Synonym: Acid_0174

Alternate gene names: 116619317

Gene position: 222407-223828 (Clockwise)

Preceding gene: 116619315

Following gene: 116619318

Centisome position: 2.23

GC content: 60.13

Gene sequence:

>1422_bases
ATGGCCCAGGACAAAGACGTTTCCCGCCGCGATGTACTGAAAGTTGCAGGAGCCGTGACCGCCGTGGCGGCGGCCACCGT
GAATCGCGCTCCCGCGATTCAAAAGGTCAGAGCCGCGAACGACCAGGTGCAGTTCGGCATGATCGGCACCGGGAGCCGGG
GAAGCTATCTCCTGAAGCACCTCAAAGGGATCGATAACGGCCGCTGCGTAGCGCTCTGCGATATCAACGACGAGAACCTC
AAGCACGGCGTGGATACGATCGGGACCAATCCCAAGACCTTCAAGGATTATCGCGAACTGCTTTCGCAGAAGGATGTGGA
CGCGGTATTCGTTACCACGCCCCTGTTCGTTCATTTCCCGGTGACGAAGGACGCCCTCCAGGCCGGCAAGCACGTATTCT
GCGAAAAGTGCCTGGTGTTCAAGCCCGAGGAAGTGCACGCGCTTCGCGCGCTTGCGAACGAGCACTCCAAGCAGACGCTC
CAGACGGGATTGCAGCGGCGCTACAGCTACTTCTACCAGACCGTGAAGAGCATGGTCGATAAGGGAATTCTGGGCGACGT
GCACCACATCCACGCGCAGTGGCACCGCAATATGGTGAACAAGCCGAGCTCACTGTGGACGATGAAGCCGGGCGGGGAAA
GCAATATCGCCAACTGGCGCGTTTTCCGGTCGATGTCGGGCGGGCTGACCGCGGAGTTGACATCCCACCAGGTGGACGTG
GCCGATTGGATGTTCGGATCCTCGCCGGAGTTTGTCATGGGGTTGGGCAGCCTCGATACGTTGAAAGACGGCCGCGATGT
TTACGACAACATCCAGTTGATCTACAAATATCCGGGCGGGAAGAAGCTGACCTATTCCTCGGTCAGCACCAATAGCTTCC
TGCCATACTTCAATGCCAGCCGCGCCGAGATGGGCGAGATCATCATGGGCACGGACGGCACGGTGGAGATCACGGTAGGC
GCGGACGGCACGCCGCCGATCGCGTGGTGGTATCGCGAGCCCCCAAAGGCCGCCGCGGAGACCAGCAAAGCCGGTGAGAA
GAAGAAGGCATTCGTCGCGGGCGCCACGATGGTGGCATCGGGCGGACCGGCTACGCCGATTCCGATCATGACCGGTGATC
TGGATTTTACGGGCAAGGAAAGCTTCCTGGATAAGGAAGTGAAGTTTGCCAAGCGCTGGCTCACGACCAAAGGCGTGATC
CTGCAGGAAGAGCAGCGCAACCCGGTGGACACGGAACTCGAGAGCTTCTTCCAGAATTGCCGCGACGGGAAAAAGCCGAA
GGCCGATCTCGAAGTCGGGCTGGCCGACTCGGTGGCCGTGATGCTTTCCAACCAGGCGATGGACGAAGGGCGCAAGGTTT
ACTTCAACGAGATCGACAAGACGAAGCCCGGGGCGCCGGCGCCGGTCGTTAAAAAGGGCTAG

Upstream 100 bases:

>100_bases
TATTGTCCGTCACGAGTTCTCCCACTGCAATCGGGAAGGGGCGGGCGCCGGAAATTCCACATGTTACAATCGGGGAAAAT
ACAGGAAGAGGTGCCTACGT

Downstream 100 bases:

>100_bases
CAGCCCAACTACCGAGAGCGTGTACCAGTACTGTTCAGCCTTGTAAGGTAGATTTCCCCGGACTACGCTCTCCTCTGTGC
TGGCACGATGTCTCATGGCG

Product: oxidoreductase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MAQDKDVSRRDVLKVAGAVTAVAAATVNRAPAIQKVRAANDQVQFGMIGTGSRGSYLLKHLKGIDNGRCVALCDINDENL
KHGVDTIGTNPKTFKDYRELLSQKDVDAVFVTTPLFVHFPVTKDALQAGKHVFCEKCLVFKPEEVHALRALANEHSKQTL
QTGLQRRYSYFYQTVKSMVDKGILGDVHHIHAQWHRNMVNKPSSLWTMKPGGESNIANWRVFRSMSGGLTAELTSHQVDV
ADWMFGSSPEFVMGLGSLDTLKDGRDVYDNIQLIYKYPGGKKLTYSSVSTNSFLPYFNASRAEMGEIIMGTDGTVEITVG
ADGTPPIAWWYREPPKAAAETSKAGEKKKAFVAGATMVASGGPATPIPIMTGDLDFTGKESFLDKEVKFAKRWLTTKGVI
LQEEQRNPVDTELESFFQNCRDGKKPKADLEVGLADSVAVMLSNQAMDEGRKVYFNEIDKTKPGAPAPVVKKG

Sequences:

>Translated_473_residues
MAQDKDVSRRDVLKVAGAVTAVAAATVNRAPAIQKVRAANDQVQFGMIGTGSRGSYLLKHLKGIDNGRCVALCDINDENL
KHGVDTIGTNPKTFKDYRELLSQKDVDAVFVTTPLFVHFPVTKDALQAGKHVFCEKCLVFKPEEVHALRALANEHSKQTL
QTGLQRRYSYFYQTVKSMVDKGILGDVHHIHAQWHRNMVNKPSSLWTMKPGGESNIANWRVFRSMSGGLTAELTSHQVDV
ADWMFGSSPEFVMGLGSLDTLKDGRDVYDNIQLIYKYPGGKKLTYSSVSTNSFLPYFNASRAEMGEIIMGTDGTVEITVG
ADGTPPIAWWYREPPKAAAETSKAGEKKKAFVAGATMVASGGPATPIPIMTGDLDFTGKESFLDKEVKFAKRWLTTKGVI
LQEEQRNPVDTELESFFQNCRDGKKPKADLEVGLADSVAVMLSNQAMDEGRKVYFNEIDKTKPGAPAPVVKKG
>Mature_472_residues
AQDKDVSRRDVLKVAGAVTAVAAATVNRAPAIQKVRAANDQVQFGMIGTGSRGSYLLKHLKGIDNGRCVALCDINDENLK
HGVDTIGTNPKTFKDYRELLSQKDVDAVFVTTPLFVHFPVTKDALQAGKHVFCEKCLVFKPEEVHALRALANEHSKQTLQ
TGLQRRYSYFYQTVKSMVDKGILGDVHHIHAQWHRNMVNKPSSLWTMKPGGESNIANWRVFRSMSGGLTAELTSHQVDVA
DWMFGSSPEFVMGLGSLDTLKDGRDVYDNIQLIYKYPGGKKLTYSSVSTNSFLPYFNASRAEMGEIIMGTDGTVEITVGA
DGTPPIAWWYREPPKAAAETSKAGEKKKAFVAGATMVASGGPATPIPIMTGDLDFTGKESFLDKEVKFAKRWLTTKGVIL
QEEQRNPVDTELESFFQNCRDGKKPKADLEVGLADSVAVMLSNQAMDEGRKVYFNEIDKTKPGAPAPVVKKG

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI87081947, Length=253, Percent_Identity=24.5059288537549, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87082405, Length=279, Percent_Identity=24.3727598566308, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581117, Length=214, Percent_Identity=27.1028037383178, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 51959; Mature: 51828

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQDKDVSRRDVLKVAGAVTAVAAATVNRAPAIQKVRAANDQVQFGMIGTGSRGSYLLKH
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
LKGIDNGRCVALCDINDENLKHGVDTIGTNPKTFKDYRELLSQKDVDAVFVTTPLFVHFP
HCCCCCCCEEEEEECCHHHHHHCHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCEEEEEC
VTKDALQAGKHVFCEKCLVFKPEEVHALRALANEHSKQTLQTGLQRRYSYFYQTVKSMVD
CCHHHHHCCHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGILGDVHHIHAQWHRNMVNKPSSLWTMKPGGESNIANWRVFRSMSGGLTAELTSHQVDV
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHEEHHCCCCCEEEECCCEEEH
ADWMFGSSPEFVMGLGSLDTLKDGRDVYDNIQLIYKYPGGKKLTYSSVSTNSFLPYFNAS
HHHHCCCCCCCEEECCCCHHHCCCHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCCC
RAEMGEIIMGTDGTVEITVGADGTPPIAWWYREPPKAAAETSKAGEKKKAFVAGATMVAS
CCCCCCEEECCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHCCCHHHEEEECEEEEEC
GGPATPIPIMTGDLDFTGKESFLDKEVKFAKRWLTTKGVILQEEQRNPVDTELESFFQNC
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHH
RDGKKPKADLEVGLADSVAVMLSNQAMDEGRKVYFNEIDKTKPGAPAPVVKKG
HCCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AQDKDVSRRDVLKVAGAVTAVAAATVNRAPAIQKVRAANDQVQFGMIGTGSRGSYLLKH
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
LKGIDNGRCVALCDINDENLKHGVDTIGTNPKTFKDYRELLSQKDVDAVFVTTPLFVHFP
HCCCCCCCEEEEEECCHHHHHHCHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCEEEEEC
VTKDALQAGKHVFCEKCLVFKPEEVHALRALANEHSKQTLQTGLQRRYSYFYQTVKSMVD
CCHHHHHCCHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGILGDVHHIHAQWHRNMVNKPSSLWTMKPGGESNIANWRVFRSMSGGLTAELTSHQVDV
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHEEHHCCCCCEEEECCCEEEH
ADWMFGSSPEFVMGLGSLDTLKDGRDVYDNIQLIYKYPGGKKLTYSSVSTNSFLPYFNAS
HHHHCCCCCCCEEECCCCHHHCCCHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCCC
RAEMGEIIMGTDGTVEITVGADGTPPIAWWYREPPKAAAETSKAGEKKKAFVAGATMVAS
CCCCCCEEECCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHCCCHHHEEEECEEEEEC
GGPATPIPIMTGDLDFTGKESFLDKEVKFAKRWLTTKGVILQEEQRNPVDTELESFFQNC
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHH
RDGKKPKADLEVGLADSVAVMLSNQAMDEGRKVYFNEIDKTKPGAPAPVVKKG
HCCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]