Click here to switch to the map view.

The map label for this gene is nuoH1

Identifier: 116619259

GI number: 116619259

Start: 154475

End: 155668

Strand: Direct

Name: nuoH1

Synonym: Acid_0115

Alternate gene names: 116619259

Gene position: 154475-155668 (Clockwise)

Preceding gene: 116619258

Following gene: 116619260

Centisome position: 1.55

GC content: 60.05

Gene sequence:

>1194_bases
ATGGAGCTACTCGACTCGTTTATCTTTATCAGCCTGGTGAAGGCGGCAGTTATTTTCGGCGTGCTGATGACCACGCTGGC
CTACCTGCAGTGGGTGGAGCGCAAAGTGATCGCGCACATCCAGGTGCGCCCCGGACCCTATCGCGTGGGTCCGCACGGAC
TCCTGCAACCGCTCGCGGACGTCATCAAGCTCATCACCAAAGAAGACCTGGTGCCGCCGTACGTCAACAAGCCCCTGTAT
CTCGCGGCGCCATTCCTGGCGATCACGATGGCCCTGCTCTCGATTTCGGTAATTCCCTTCGGTCCCGTGATTCACATCGG
CCCGGTCACCACCGCGATGCAGATGACCGATCTCAACATCGGCGTCCTGTTCATCCTGGCCGTCTCCTCGATGGGCGTGT
ACGGCATCGCGCTCGCCGGATGGGCTTCCAACAACAAGTACTCGCTGATCGGCGGCCTGCGCAGTTCGGCGCAGATGATC
AGCTACGAGCTGCCCATGTCGCTCGCCATCGCCGCGCCGCTCTTGATTTCGAACACCCTGAGCCTGCGCGAGCTGGTGGA
GCGCCAGGCCGGCAGCATCTTGAACTGGAACCTTCTGAGCGGCCCGTTCCCGCAGGTCATCAGCTTCATCATCTTCATCA
TCGCGGCCTTCGCCGAAACCAATCGCGTGCCGTTCGATTTGCCGGAAGCCGAAAACGAGCTCGTCGCCGGCTTCCACACC
GAATACAGCAGCATGAAATTCGCCAGCTTCTTTATGGCCGAATACGCCAACATGATCACCGTGAGCGCCATGGCGACGCT
GCTCTTCCTGGGCGGCTGGATGGCTCCCTGGCCCGCAGCGTACGGATCCAGCCTGGTACCGAGCATCCTCTTCGGAATCT
CCGGCCTGGTGCTGCTCTATCACGGCGTAAACGCCGTGCGCAAGCGCGATAAGCTGACCTTCCCGGCCTTCGGCATCATT
TTCCTCGGCATCGCCGGCATCTTCCTGCTGCCGATGGTGCAAAGCTGGCTCTTACCGCTATTCTGGTTTTGCGCCAAAAC
CGGCGCGATTCTCTTCGCTTTTATGTGGATTCGCGGCACGCTGCCCCGCTTCCGCTACGACCAATTGATGGGCTTCACCT
GGAAATTCCTGTTCCCGGTGGCCATGTTGAACTTGTTGGTGACCGGTTTCCTGGTCGCCTGGACGACGAAGTAA

Upstream 100 bases:

>100_bases
CCTGGTGCGGAGTGACCATAATGGGCTCTTCGCCTCCGGTACCCTTGGGCGGTATTCTAAGGTTCTGAACTCCGTTATAG
AAAGTCGCTTGAGCCGCTAA

Downstream 100 bases:

>100_bases
ATGGACGTTATTCTCTTCCTCACATTCGCCGTGATCGCGGTGGTCTGCGCCATCAATGTCGTGGTGCAGACGCACCCCAT
CTCCAGCGCGCTTTCGCTGG

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 1; NDH-1 subunit H 1

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MELLDSFIFISLVKAAVIFGVLMTTLAYLQWVERKVIAHIQVRPGPYRVGPHGLLQPLADVIKLITKEDLVPPYVNKPLY
LAAPFLAITMALLSISVIPFGPVIHIGPVTTAMQMTDLNIGVLFILAVSSMGVYGIALAGWASNNKYSLIGGLRSSAQMI
SYELPMSLAIAAPLLISNTLSLRELVERQAGSILNWNLLSGPFPQVISFIIFIIAAFAETNRVPFDLPEAENELVAGFHT
EYSSMKFASFFMAEYANMITVSAMATLLFLGGWMAPWPAAYGSSLVPSILFGISGLVLLYHGVNAVRKRDKLTFPAFGII
FLGIAGIFLLPMVQSWLLPLFWFCAKTGAILFAFMWIRGTLPRFRYDQLMGFTWKFLFPVAMLNLLVTGFLVAWTTK

Sequences:

>Translated_397_residues
MELLDSFIFISLVKAAVIFGVLMTTLAYLQWVERKVIAHIQVRPGPYRVGPHGLLQPLADVIKLITKEDLVPPYVNKPLY
LAAPFLAITMALLSISVIPFGPVIHIGPVTTAMQMTDLNIGVLFILAVSSMGVYGIALAGWASNNKYSLIGGLRSSAQMI
SYELPMSLAIAAPLLISNTLSLRELVERQAGSILNWNLLSGPFPQVISFIIFIIAAFAETNRVPFDLPEAENELVAGFHT
EYSSMKFASFFMAEYANMITVSAMATLLFLGGWMAPWPAAYGSSLVPSILFGISGLVLLYHGVNAVRKRDKLTFPAFGII
FLGIAGIFLLPMVQSWLLPLFWFCAKTGAILFAFMWIRGTLPRFRYDQLMGFTWKFLFPVAMLNLLVTGFLVAWTTK
>Mature_397_residues
MELLDSFIFISLVKAAVIFGVLMTTLAYLQWVERKVIAHIQVRPGPYRVGPHGLLQPLADVIKLITKEDLVPPYVNKPLY
LAAPFLAITMALLSISVIPFGPVIHIGPVTTAMQMTDLNIGVLFILAVSSMGVYGIALAGWASNNKYSLIGGLRSSAQMI
SYELPMSLAIAAPLLISNTLSLRELVERQAGSILNWNLLSGPFPQVISFIIFIIAAFAETNRVPFDLPEAENELVAGFHT
EYSSMKFASFFMAEYANMITVSAMATLLFLGGWMAPWPAAYGSSLVPSILFGISGLVLLYHGVNAVRKRDKLTFPAFGII
FLGIAGIFLLPMVQSWLLPLFWFCAKTGAILFAFMWIRGTLPRFRYDQLMGFTWKFLFPVAMLNLLVTGFLVAWTTK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=247, Percent_Identity=44.1295546558704, Blast_Score=182, Evalue=6e-46,
Organism=Escherichia coli, GI1788618, Length=396, Percent_Identity=34.8484848484849, Blast_Score=224, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH1_SOLUE (Q02CT6)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_821415.1
- STRING:   Q02CT6
- GeneID:   4424097
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_0115
- NMPDR:   fig|234267.9.peg.109
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   QLMNLGW
- PhylomeDB:   Q02CT6
- ProtClustDB:   CLSK774513
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 43789; Mature: 43789

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13faef5c)-; HASH(0x13bfed74)-; HASH(0x1318543c)-; HASH(0x13187dc0)-; HASH(0x13534e8c)-; HASH(0x136c62f0)-; HASH(0x124e2954)-; HASH(0x124e2bf4)-; HASH(0x13182620)-; HASH(0x13dbe510)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLDSFIFISLVKAAVIFGVLMTTLAYLQWVERKVIAHIQVRPGPYRVGPHGLLQPLAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHH
VIKLITKEDLVPPYVNKPLYLAAPFLAITMALLSISVIPFGPVIHIGPVTTAMQMTDLNI
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCH
GVLFILAVSSMGVYGIALAGWASNNKYSLIGGLRSSAQMISYELPMSLAIAAPLLISNTL
HHHHHHHHHHCCHHHEEEEECCCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHCHH
SLRELVERQAGSILNWNLLSGPFPQVISFIIFIIAAFAETNRVPFDLPEAENELVAGFHT
HHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
EYSSMKFASFFMAEYANMITVSAMATLLFLGGWMAPWPAAYGSSLVPSILFGISGLVLLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHH
HGVNAVRKRDKLTFPAFGIIFLGIAGIFLLPMVQSWLLPLFWFCAKTGAILFAFMWIRGT
HCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPRFRYDQLMGFTWKFLFPVAMLNLLVTGFLVAWTTK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MELLDSFIFISLVKAAVIFGVLMTTLAYLQWVERKVIAHIQVRPGPYRVGPHGLLQPLAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHH
VIKLITKEDLVPPYVNKPLYLAAPFLAITMALLSISVIPFGPVIHIGPVTTAMQMTDLNI
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCH
GVLFILAVSSMGVYGIALAGWASNNKYSLIGGLRSSAQMISYELPMSLAIAAPLLISNTL
HHHHHHHHHHCCHHHEEEEECCCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHCHH
SLRELVERQAGSILNWNLLSGPFPQVISFIIFIIAAFAETNRVPFDLPEAENELVAGFHT
HHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
EYSSMKFASFFMAEYANMITVSAMATLLFLGGWMAPWPAAYGSSLVPSILFGISGLVLLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHH
HGVNAVRKRDKLTFPAFGIIFLGIAGIFLLPMVQSWLLPLFWFCAKTGAILFAFMWIRGT
HCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPRFRYDQLMGFTWKFLFPVAMLNLLVTGFLVAWTTK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA