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The map label for this gene is dnaA [H]

Identifier: 116619146

GI number: 116619146

Start: 89

End: 1402

Strand: Direct

Name: dnaA [H]

Synonym: Acid_0001

Alternate gene names: 116619146

Gene position: 89-1402 (Clockwise)

Preceding gene: NA

Following gene: 116619147

Centisome position: 0.0

GC content: 56.47

Gene sequence:

>1314_bases
ATGAATTATTGGGATCAAATCCGCCATTACCTACAAAGCAAAGTGAGCGCGGATGGTTACGACAACTGGCTGAAATCAAC
GGCATTTGTCGGCCAAAACGGCGACACTTTGTACGTTTCCGTGCCCGACCGCGAGACTCGCGCCTGGTTGGAAACGGAAT
ATACACAGCTCATTCAGGGCGGAATCCAGGCCTTGGGCCTGCCAGTGCGACACGTGAGCTTCGAGGCCGAGCAGTCACGC
CCGGCCGCACCCGCGGCGACGATAGCCGTCAACGCAAATACGGAGCCGGATGCGGCGGCCACCGTGCTCAATCCGAAATT
TACATTCAATTCCTTCGTGGTGGGCGCGTGCAACCAGTTCGCCCACGCCGCTGCGAAATCCGTGGCTACCAACCCCTCGC
GTAGCTACAACCCACTGTTTTTATATGGCGGGGTCGGGATGGGCAAGACGCACCTGATGCATGCCATCGGACGCCAATTG
ATCGATCAATTTGGCAGCATGCGGATCATCTACACCTCGAGCGAGCGCTTCATGAACGAGATGATCTCCTGCATCCGCAC
CGAGCGCATGCAGCAGTTTCACCAGCGTTACCGCGAAGCCGACGTGCTCCTGATCGACGACATCCAACTGCTGGGAAACA
AAGAACGTACTCAGGAGGAGTTCTTTCACACCTTCAACGAGCTCCACGACCACCAGAAGCAAATCGTGATCTCCAGCGAT
TCGCCCCCCAAGGATATTCCGGGCCTCTTGGAGCGCCTGCGTTCACGTTTCGAGTGGGGATTGATGGCCGACATCCAGCC
GCCCGATCTGGAGACCAAAATGGCCATTCTCGACAAGAAGGCGGAGATCGAAGGCGTCGAGTTGCCCGACGATGTTCGGA
CCTTCATGGCTTCCAAAACCAAGTCGAACGTCCGCGAACTCGAAGGCGCCCTGGTTAAATTGATCGCGTACTCCTCCCTC
ACCGGAACGCCGATCCACCTGCAGATGGCGCAACAGGTCCTGAAGCACCTGGTCCACGTGCAGGACCGCCGCGTCACCAT
GGATTCCATCCAAAAGGCCGTCGCGGAGAAATTCAGCATTAAGCAGTCCCAGCTCAAGGAAAAGAGCAATACCAAGAAGG
TGGTCTATCCGCGGCAGGTGGCAATGTACCTGGTCAAGGAGCTCACCAACGCGTCGCTACCTGAGATCGGGCGCGCTTTC
GGCGGAAAGCATCACACCACCGTGATCCACTCGATCAACAAAATCGAGAAGGATCGCCAGAGCGACCCTGAATTGAACAG
GTTACTACACAGCCTAATGGACTCATTACAATGA

Upstream 100 bases:

>100_bases
GAGCCTCGCTGGCAAATCTACCTGAACATCAGCACCTACCGGCTAATTGCTTCTCTTGTTCTCCCTGTGGAAATCGTGTG
GGATACGTGTGTAAAAGCTG

Downstream 100 bases:

>100_bases
CCTTCCACCGTTTTCCACAATTGCCCTTGCACCGGGCATGGGGAAATCTGTGTATATCGCATGACAGCGTTGGTTTTGCG
CAATTTTCCGCGCCGCAATC

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MNYWDQIRHYLQSKVSADGYDNWLKSTAFVGQNGDTLYVSVPDRETRAWLETEYTQLIQGGIQALGLPVRHVSFEAEQSR
PAAPAATIAVNANTEPDAAATVLNPKFTFNSFVVGACNQFAHAAAKSVATNPSRSYNPLFLYGGVGMGKTHLMHAIGRQL
IDQFGSMRIIYTSSERFMNEMISCIRTERMQQFHQRYREADVLLIDDIQLLGNKERTQEEFFHTFNELHDHQKQIVISSD
SPPKDIPGLLERLRSRFEWGLMADIQPPDLETKMAILDKKAEIEGVELPDDVRTFMASKTKSNVRELEGALVKLIAYSSL
TGTPIHLQMAQQVLKHLVHVQDRRVTMDSIQKAVAEKFSIKQSQLKEKSNTKKVVYPRQVAMYLVKELTNASLPEIGRAF
GGKHHTTVIHSINKIEKDRQSDPELNRLLHSLMDSLQ

Sequences:

>Translated_437_residues
MNYWDQIRHYLQSKVSADGYDNWLKSTAFVGQNGDTLYVSVPDRETRAWLETEYTQLIQGGIQALGLPVRHVSFEAEQSR
PAAPAATIAVNANTEPDAAATVLNPKFTFNSFVVGACNQFAHAAAKSVATNPSRSYNPLFLYGGVGMGKTHLMHAIGRQL
IDQFGSMRIIYTSSERFMNEMISCIRTERMQQFHQRYREADVLLIDDIQLLGNKERTQEEFFHTFNELHDHQKQIVISSD
SPPKDIPGLLERLRSRFEWGLMADIQPPDLETKMAILDKKAEIEGVELPDDVRTFMASKTKSNVRELEGALVKLIAYSSL
TGTPIHLQMAQQVLKHLVHVQDRRVTMDSIQKAVAEKFSIKQSQLKEKSNTKKVVYPRQVAMYLVKELTNASLPEIGRAF
GGKHHTTVIHSINKIEKDRQSDPELNRLLHSLMDSLQ
>Mature_437_residues
MNYWDQIRHYLQSKVSADGYDNWLKSTAFVGQNGDTLYVSVPDRETRAWLETEYTQLIQGGIQALGLPVRHVSFEAEQSR
PAAPAATIAVNANTEPDAAATVLNPKFTFNSFVVGACNQFAHAAAKSVATNPSRSYNPLFLYGGVGMGKTHLMHAIGRQL
IDQFGSMRIIYTSSERFMNEMISCIRTERMQQFHQRYREADVLLIDDIQLLGNKERTQEEFFHTFNELHDHQKQIVISSD
SPPKDIPGLLERLRSRFEWGLMADIQPPDLETKMAILDKKAEIEGVELPDDVRTFMASKTKSNVRELEGALVKLIAYSSL
TGTPIHLQMAQQVLKHLVHVQDRRVTMDSIQKAVAEKFSIKQSQLKEKSNTKKVVYPRQVAMYLVKELTNASLPEIGRAF
GGKHHTTVIHSINKIEKDRQSDPELNRLLHSLMDSLQ

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=468, Percent_Identity=41.2393162393162, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI226510964, Length=229, Percent_Identity=26.2008733624454, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 49493; Mature: 49493

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYWDQIRHYLQSKVSADGYDNWLKSTAFVGQNGDTLYVSVPDRETRAWLETEYTQLIQG
CCHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCEEEEECCCHHHHHHHHHHHHHHHHH
GIQALGLPVRHVSFEAEQSRPAAPAATIAVNANTEPDAAATVLNPKFTFNSFVVGACNQF
HHHHHCCCHHHEECCCCCCCCCCCCEEEEEECCCCCCCHHEEECCCCCHHHHHHHHHHHH
AHAAAKSVATNPSRSYNPLFLYGGVGMGKTHLMHAIGRQLIDQFGSMRIIYTSSERFMNE
HHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHH
MISCIRTERMQQFHQRYREADVLLIDDIQLLGNKERTQEEFFHTFNELHDHQKQIVISSD
HHHHHHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCC
SPPKDIPGLLERLRSRFEWGLMADIQPPDLETKMAILDKKAEIEGVELPDDVRTFMASKT
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHCCCCCCCCHHHHHHHHHHH
KSNVRELEGALVKLIAYSSLTGTPIHLQMAQQVLKHLVHVQDRRVTMDSIQKAVAEKFSI
HHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KQSQLKEKSNTKKVVYPRQVAMYLVKELTNASLPEIGRAFGGKHHTTVIHSINKIEKDRQ
HHHHHHHHCCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCC
SDPELNRLLHSLMDSLQ
CCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYWDQIRHYLQSKVSADGYDNWLKSTAFVGQNGDTLYVSVPDRETRAWLETEYTQLIQG
CCHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCEEEEECCCHHHHHHHHHHHHHHHHH
GIQALGLPVRHVSFEAEQSRPAAPAATIAVNANTEPDAAATVLNPKFTFNSFVVGACNQF
HHHHHCCCHHHEECCCCCCCCCCCCEEEEEECCCCCCCHHEEECCCCCHHHHHHHHHHHH
AHAAAKSVATNPSRSYNPLFLYGGVGMGKTHLMHAIGRQLIDQFGSMRIIYTSSERFMNE
HHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHH
MISCIRTERMQQFHQRYREADVLLIDDIQLLGNKERTQEEFFHTFNELHDHQKQIVISSD
HHHHHHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCC
SPPKDIPGLLERLRSRFEWGLMADIQPPDLETKMAILDKKAEIEGVELPDDVRTFMASKT
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHCCCCCCCCHHHHHHHHHHH
KSNVRELEGALVKLIAYSSLTGTPIHLQMAQQVLKHLVHVQDRRVTMDSIQKAVAEKFSI
HHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KQSQLKEKSNTKKVVYPRQVAMYLVKELTNASLPEIGRAFGGKHHTTVIHSINKIEKDRQ
HHHHHHHHCCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCC
SDPELNRLLHSLMDSLQ
CCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA