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The map label for this gene is malR

Identifier: 116516891

GI number: 116516891

Start: 1912200

End: 1913186

Strand: Direct

Name: malR

Synonym: SPD_1938

Alternate gene names: 116516891

Gene position: 1912200-1913186 (Clockwise)

Preceding gene: 116516009

Following gene: 116515796

Centisome position: 93.46

GC content: 42.55

Gene sequence:

>987_bases
ATGCCCGTTACGATTAAAGACGTGGCCAAGGCTGCTGGTGTTTCGCCTTCAACCGTAACCCGTGTTATTCAAAATAAATC
AACCATTAGCGACGAAACAAAAAAACGCGTTCGCAAAGCTATGAAGGAACTCAACTACCACCCAAACCTCAACGCTCGTA
GCTTGGTAAGCAGCTATACTCAGGTTATCGGATTAGTTCTTCCTGATGACTCAGACGCCTTCTACCAGAATCCTTTCTTT
CCATCGGTTCTACGTGGCATCTCTCAAGTCGCATCTGAAAACCACTATGCCATTCAGATAGCAACAGGGAAAGATGAGAA
GGAGCGTCTCAACGCTATTTCACAAATGGTCTACGGCAAGCGTGTAGATGGGCTAATCTTTCTCTATGCCCAAGAAGAAG
ACCCTCTCGTAAAACTCGTCGCAGAAGAACAGTTCCCCTTCCTTATCCTAGGTAAATCTCTATCTCCTTTCATCCCACTT
GTCGACAACGACAATGTTCAAGCTGGTTTTGATGCGACTGAATATTTCATCAAAAAAGGCTGCAAACGCATTGCCTTTAT
CGGAGGAAGTAAAAAGCTCTTCGTGACCAAAGACCGTTTAACAGGCTATGAACAGGCGCTTAAACATTACAAACTTACCA
CTGACAACAATCGCATCTACTTTGCCGACGAGTTTCTGGAAGAAAAGGGCTATAAATTTAGCAAGCGATTATTCAAGCAC
GATCCACAAATTGATGCTATCATCACAACCGATAGCCTCCTAGCTGAAGGTGTTTGTAACTATATTGCCAAACACCAGCT
GGATGTCCCTGTTCTCAGCTTTGACTCGGTTAATCCCAAGCTCAACTTGGCAGCCTATGTCGATATCAATAGTTTAGAGC
TTGGTCGTGTTTCCCTTGAAACTATTCTCCAGATTATTAATGATAATAAAAACAATAAACAAATTTGTTACCGTCAATTG
ATCGCCCACAAAATTATCGAAAAATAA

Upstream 100 bases:

>100_bases
CCTGATTACTGTACAAAATATTCTTTTTGTTCTGTATCTGGTCACTATCTTTTATAAAACACATTTCCGTGATCCAAATT
ACCATAAATAGGAGATTTTT

Downstream 100 bases:

>100_bases
GAGACTGGGCAAAAAGTCGTTAAAAGCAAAAACGCATAGTATCAGGTATTGAAAAAACTTGATACTATGCGTTTTAATGT
GGGAAGATTTACTTCCTTTT

Product: maltose operon transcriptional repressor

Products: NA

Alternate protein names: Maltose operon transcriptional repressor

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFF
PSVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPL
VDNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKH
DPQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDSVNPKLNLAAYVDINSLELGRVSLETILQIINDNKNNKQICYRQL
IAHKIIEK

Sequences:

>Translated_328_residues
MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFF
PSVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPL
VDNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKH
DPQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDSVNPKLNLAAYVDINSLELGRVSLETILQIINDNKNNKQICYRQL
IAHKIIEK
>Mature_327_residues
PVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFFP
SVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPLV
DNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKHD
PQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDSVNPKLNLAAYVDINSLELGRVSLETILQIINDNKNNKQICYRQLI
AHKIIEK

Specific function: Transcriptional repressor of the maltosaccharide utilization operons malxCD and malMP

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787580, Length=330, Percent_Identity=27.2727272727273, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790369, Length=282, Percent_Identity=28.7234042553192, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790194, Length=282, Percent_Identity=30.1418439716312, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1789202, Length=300, Percent_Identity=29.3333333333333, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787948, Length=324, Percent_Identity=27.1604938271605, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1789068, Length=286, Percent_Identity=29.020979020979, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787906, Length=265, Percent_Identity=29.0566037735849, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788474, Length=297, Percent_Identity=25.9259259259259, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790715, Length=326, Percent_Identity=25.4601226993865, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI48994940, Length=272, Percent_Identity=26.8382352941176, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786268, Length=276, Percent_Identity=25.3623188405797, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786540, Length=285, Percent_Identity=24.2105263157895, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): MALR_STRPN (P0A4T1)

Other databases:

- EMBL:   AE005672
- PIR:   B49543
- PIR:   B95247
- RefSeq:   NP_346531.1
- ProteinModelPortal:   P0A4T1
- IntAct:   P0A4T1
- EnsemblBacteria:   EBSTRT00000026242
- GeneID:   930235
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_2112
- TIGR:   SP_2112
- GeneTree:   EBGT00050000026983
- HOGENOM:   HBG753640
- OMA:   YIDINAL
- ProtClustDB:   CLSK884199
- BioCyc:   SPNE170187-1:SP_2112-MONOMER
- GO:   GO:0005622
- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761
- PRINTS:   PR00036
- SMART:   SM00354

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1; SSF47413 Lambda_like_DNA

EC number: NA

Molecular weight: Translated: 37044; Mature: 36913

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS00356 HTH_LACI_1; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYT
CCCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QVIGLVLPDDSDAFYQNPFFPSVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGK
HHHEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCC
RVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPLVDNDNVQAGFDATEYFIKKG
CCCCEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHC
CKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKH
CCEEEEECCCCEEEEEHHHHCCHHHHHHHEEEECCCCEEEEHHHHHHHCCCHHHHHHHHC
DPQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDSVNPKLNLAAYVDINSLELGRVSLE
CCCCEEEEECHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCCCCHHHHH
TILQIINDNKNNKQICYRQLIAHKIIEK
HHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYT
CCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QVIGLVLPDDSDAFYQNPFFPSVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGK
HHHEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCC
RVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPLVDNDNVQAGFDATEYFIKKG
CCCCEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHC
CKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKH
CCEEEEECCCCEEEEEHHHHCCHHHHHHHEEEECCCCEEEEHHHHHHHCCCHHHHHHHHC
DPQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDSVNPKLNLAAYVDINSLELGRVSLE
CCCCEEEEECHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCCCCHHHHH
TILQIINDNKNNKQICYRQLIAHKIIEK
HHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916