BacMap

Definition	Streptococcus pneumoniae D39, complete genome.
Accession	NC_008533
Length	2,046,115

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The map label for this gene is lmrA [H]

Identifier: 116516505

GI number: 116516505

Start: 1369457

End: 1369909

Strand: Reverse

Name: lmrA [H]

Synonym: SPD_1355

Alternate gene names: 116516505

Gene position: 1369909-1369457 (Counterclockwise)

Preceding gene: 116516101

Following gene: 116515397

Centisome position: 66.95

GC content: 37.53

Gene sequence:

>453_bases
TTGAATTTTAACCATGTCTATTTTGGTTATGATGAAAATCGACCTGTCTTAAAGGATATTACTTGTTCAATTTTCAAGGG
GCAAAAAATTGCTTTTGTTGGACCATCTGGATCAGGAAAATCAACGATTGTGCGTTTGTTAGAGCAGTTTTATAAACCGC
TTTCAGGAGATATTCTAATGGAGCAATCAAGTATATATGATTTTAACTTAAAAGAATGGAGAAGTAAAATCGCTTGGGTT
TCACAAAATAATGCAGTCTTATCTGGCAGTATTCGTGACAATCTTTGTCTCGGTTTGAATCGCTTAGTAACTGATGATGA
ATTGATGAAAGTGCTAGACTTAGTATCACTAGGTGATGAGATTCGCTCCATGAAAGAGGGACTAGATACTGAAGTTGGTG
AACGCGGACGACTCTTGTCAGGGGGGGCAAAGCCAAAGACTTCAAATAGCTAG

Upstream 100 bases:

>100_bases
TGTTTATTCTAGGAGCAAGGGATCTTCAGTTGCACTGGAGAACTTGCTTGCAGTTCCTAAAGAAAAATTTGAGTGAGGAA
AATCGGTATCAGGACAAGGG

Downstream 100 bases:

>100_bases
AGCCTACTTAAAAGATGCTGAAATTCTTATATTTGATGAAGCCACTGCTAATCTTGATGCGGATTCTGAGTATGCGATTA
TCAGTAGCCTCTATTCTGTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MNFNHVYFGYDENRPVLKDITCSIFKGQKIAFVGPSGSGKSTIVRLLEQFYKPLSGDILMEQSSIYDFNLKEWRSKIAWV
SQNNAVLSGSIRDNLCLGLNRLVTDDELMKVLDLVSLGDEIRSMKEGLDTEVGERGRLLSGGAKPKTSNS

Sequences:

>Translated_150_residues
MNFNHVYFGYDENRPVLKDITCSIFKGQKIAFVGPSGSGKSTIVRLLEQFYKPLSGDILMEQSSIYDFNLKEWRSKIAWV
SQNNAVLSGSIRDNLCLGLNRLVTDDELMKVLDLVSLGDEIRSMKEGLDTEVGERGRLLSGGAKPKTSNS
>Mature_150_residues
MNFNHVYFGYDENRPVLKDITCSIFKGQKIAFVGPSGSGKSTIVRLLEQFYKPLSGDILMEQSSIYDFNLKEWRSKIAWV
SQNNAVLSGSIRDNLCLGLNRLVTDDELMKVLDLVSLGDEIRSMKEGLDTEVGERGRLLSGGAKPKTSNS

Specific function: Efflux transporter for a variety of amphiphilic cationic compounds, including antibiotics [H]

COG id: COG1132

COG function: function code V; ABC-type multidrug transport system, ATPase and permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI42490749, Length=146, Percent_Identity=41.7808219178082, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI9961252, Length=151, Percent_Identity=36.4238410596026, Blast_Score=103, Evalue=8e-23,
Organism=Homo sapiens, GI4505771, Length=151, Percent_Identity=36.4238410596026, Blast_Score=102, Evalue=8e-23,
Organism=Homo sapiens, GI73747917, Length=148, Percent_Identity=35.8108108108108, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI73747915, Length=148, Percent_Identity=35.8108108108108, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI9955963, Length=149, Percent_Identity=37.5838926174497, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI171184400, Length=152, Percent_Identity=38.8157894736842, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI42741659, Length=151, Percent_Identity=35.7615894039735, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI9961250, Length=158, Percent_Identity=34.8101265822785, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI148612844, Length=150, Percent_Identity=36, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI255708477, Length=150, Percent_Identity=36, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI9665248, Length=147, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI9955968, Length=151, Percent_Identity=34.4370860927152, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI9955966, Length=151, Percent_Identity=34.4370860927152, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI45243524, Length=151, Percent_Identity=34.4370860927152, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI21536378, Length=152, Percent_Identity=34.8684210526316, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI156105685, Length=150, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4557481, Length=148, Percent_Identity=33.7837837837838, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI89111135, Length=145, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI110832837, Length=139, Percent_Identity=33.0935251798561, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI110832839, Length=141, Percent_Identity=32.6241134751773, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI110832835, Length=139, Percent_Identity=33.0935251798561, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI157502201, Length=143, Percent_Identity=31.4685314685315, Blast_Score=63, Evalue=9e-11,
Organism=Escherichia coli, GI1786653, Length=149, Percent_Identity=35.5704697986577, Blast_Score=98, Evalue=2e-22,
Organism=Escherichia coli, GI1787143, Length=149, Percent_Identity=33.5570469798658, Blast_Score=91, Evalue=3e-20,
Organism=Escherichia coli, GI1786654, Length=141, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=9e-17,
Organism=Escherichia coli, GI1787112, Length=143, Percent_Identity=34.2657342657343, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787113, Length=122, Percent_Identity=29.5081967213115, Blast_Score=64, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17533971, Length=150, Percent_Identity=38, Blast_Score=113, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI193211015, Length=146, Percent_Identity=41.0958904109589, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71996809, Length=146, Percent_Identity=41.0958904109589, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193211017, Length=146, Percent_Identity=41.0958904109589, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17565938, Length=148, Percent_Identity=39.1891891891892, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI115535101, Length=148, Percent_Identity=38.5135135135135, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17541710, Length=150, Percent_Identity=41.3333333333333, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17543740, Length=150, Percent_Identity=36.6666666666667, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17567265, Length=148, Percent_Identity=35.8108108108108, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI25146777, Length=151, Percent_Identity=38.4105960264901, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17567269, Length=148, Percent_Identity=35.8108108108108, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193202349, Length=150, Percent_Identity=36.6666666666667, Blast_Score=99, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17558664, Length=150, Percent_Identity=38, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI212646699, Length=150, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17569143, Length=150, Percent_Identity=36.6666666666667, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI193208177, Length=150, Percent_Identity=36.6666666666667, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71996550, Length=148, Percent_Identity=37.1621621621622, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17511077, Length=151, Percent_Identity=32.4503311258278, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71992290, Length=150, Percent_Identity=32.6666666666667, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115534520, Length=150, Percent_Identity=34, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17569145, Length=145, Percent_Identity=35.1724137931034, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193209708, Length=151, Percent_Identity=37.0860927152318, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32563727, Length=144, Percent_Identity=32.6388888888889, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI115533592, Length=152, Percent_Identity=34.8684210526316, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71992285, Length=141, Percent_Identity=34.0425531914894, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71984940, Length=141, Percent_Identity=36.1702127659575, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17551702, Length=145, Percent_Identity=28.9655172413793, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17551700, Length=145, Percent_Identity=28.9655172413793, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=149, Percent_Identity=38.255033557047, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324985, Length=151, Percent_Identity=35.7615894039735, Blast_Score=93, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323217, Length=151, Percent_Identity=35.7615894039735, Blast_Score=88, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322640, Length=131, Percent_Identity=35.8778625954198, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320339, Length=130, Percent_Identity=30.7692307692308, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321720, Length=111, Percent_Identity=36.9369369369369, Blast_Score=60, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24659289, Length=150, Percent_Identity=34.6666666666667, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI85726357, Length=151, Percent_Identity=35.0993377483444, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI281363262, Length=151, Percent_Identity=32.4503311258278, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24653245, Length=151, Percent_Identity=32.4503311258278, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21357907, Length=151, Percent_Identity=33.112582781457, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136662, Length=151, Percent_Identity=34.4370860927152, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI23397593, Length=153, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24641565, Length=151, Percent_Identity=32.4503311258278, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551502, Length=148, Percent_Identity=35.8108108108108, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45551501, Length=148, Percent_Identity=35.8108108108108, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357851, Length=148, Percent_Identity=35.8108108108108, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45552335, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45552355, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45552345, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45552363, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552351, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552361, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552339, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552343, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552347, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552357, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552353, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552341, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552337, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583969, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552349, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552359, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550972, Length=129, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: =3.6.3.44 [H]

Molecular weight: Translated: 16723; Mature: 16723

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNHVYFGYDENRPVLKDITCSIFKGQKIAFVGPSGSGKSTIVRLLEQFYKPLSGDILM
CCCCEEEEEECCCCCHHHHHHHHEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
EQSSIYDFNLKEWRSKIAWVSQNNAVLSGSIRDNLCLGLNRLVTDDELMKVLDLVSLGDE
ECCCCCCCCHHHHHHHHEEEECCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHH
IRSMKEGLDTEVGERGRLLSGGAKPKTSNS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNFNHVYFGYDENRPVLKDITCSIFKGQKIAFVGPSGSGKSTIVRLLEQFYKPLSGDILM
CCCCEEEEEECCCCCHHHHHHHHEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
EQSSIYDFNLKEWRSKIAWVSQNNAVLSGSIRDNLCLGLNRLVTDDELMKVLDLVSLGDE
ECCCCCCCCHHHHHHHHEEEECCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHH
IRSMKEGLDTEVGERGRLLSGGAKPKTSNS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]