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The map label for this gene is serS [H]

Identifier: 116516325

GI number: 116516325

Start: 379740

End: 381014

Strand: Reverse

Name: serS [H]

Synonym: SPD_0375

Alternate gene names: 116516325

Gene position: 381014-379740 (Counterclockwise)

Preceding gene: 116516387

Following gene: 116516121

Centisome position: 18.62

GC content: 44.16

Gene sequence:

>1275_bases
ATGTTAGATATCAAACGTATTCGTACAGATTTTGAAGCTGTCGCAGAAAAATTAGCTACACGTGGTGTAGATGCTGCTGT
CTTGAATGAAATGAAAGAAATCGATGCTAAACGTCGTAACATCTTGGTCAAGGTTGAAACTCTCAAAGCAGAACGTAACA
CAGTTTCTGCTGAGATTGCCCAAGCTAAGCGCAACAAGGAAAATACAGATGACAAGATTGCTGCCATGCAAAATCTATCT
GCTGAGGTTAAAGCCTTGGATGCTGAATTGGCAGAAATCGATGCTAAATTGACAGAATTTACAACGACTCTTCCAAATAT
CCCAGCTGACAGCGTTCCTGTTGGGGCTGACGAAGACGACAATGTGGAAGTTCGCCGTTGGGGTACTCCACGCGAGTTTG
ACTTCGAACCTAAAGCTCACTGGGATCTCGGTGAAGACCTTGGTATCCTTGACTGGGAACGCGGTGGTAAGGTAACAGGC
GCTCGCTTCCTCTTCTATAAAGGCCTCGGTGCTCGTTTGGAACGTGCTATCTACAACTTTATGTTGGATGAACATGGAAA
AGAAGGCTATACTGAAGTCATCACACCTTACATAGTCAACCATGATTCTATGTTTGGTACTGGTCAGTATCCAAAATTTA
AGGAAGATACTTTTGAACTCAGCGATACCAACTTTGTCTTGATTCCAACTGCTGAAGTTCCTCTGACAAACTACTACCGT
GATGAAATCTTAGACGGCAAAGATCTTCCAATCTACTTCACTGCTATGAGTCCGTCATTCCGTTCTGAGGCTGGTTCTGC
CGGTCGTGATACGCGTGGCTTGATCCGTTTGCACCAATTCCACAAGGTTGAAATGGTCAAATTTGCCAAACCAGAAGAAT
CTTACGAAGAATTGGAAAAAATGACAGCCAACGCTGAAAACATTCTTCAAAAACTCAACCTTCCATACCGTGTCGTTGCT
CTCTCTACTGGAGATATGGGCTTCTCAGCTACGAAGACTTACGACTTGGAAGTGTGGATTCCAGCACAAAACAATTACCG
TGAAATCTCAAGCTGTTCAAACACAGAAGATTTCCAAGCCCGTCGTGCCCAAATCCGTTACCGTGATGAAGCAGATGGCA
AGGTGAAACTCCTTCATACCTTGAACGGTTCTGGACTTGCAGTTGGACGTACAGTGGCTGCAATTCTTGAAAATTACCAA
AATGAAGATGGTTCTGTGACCATCCCAGAAGCACTTCGTCCATACATGGGTGGAGCTGAAGTCATCAAACCATAA

Upstream 100 bases:

>100_bases
ATTACATACACAATCAAGTGCACACCTGTGAAGTTGGATGGAACCGTGGCCCTGCCACTCCAACGTTTTGTCAGGGTGCT
TTTTTCATAAAGGAGTTCTT

Downstream 100 bases:

>100_bases
AAAATAAGGTTTAGCTATTTCTAGCTAGACCTTTTTTCGTAACCAAATCAGATAAGCACCTAGTACAAAGAATAAAATAG
TTAGGCATATAATGGTTTCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLS
AEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLTNYYR
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVA
LSTGDMGFSATKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQ
NEDGSVTIPEALRPYMGGAEVIKP

Sequences:

>Translated_424_residues
MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLS
AEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLTNYYR
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVA
LSTGDMGFSATKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQ
NEDGSVTIPEALRPYMGGAEVIKP
>Mature_424_residues
MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLS
AEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLTNYYR
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVA
LSTGDMGFSATKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQ
NEDGSVTIPEALRPYMGGAEVIKP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=461, Percent_Identity=33.1887201735358, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI8923421, Length=441, Percent_Identity=30.8390022675737, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI225579074, Length=342, Percent_Identity=33.3333333333333, Blast_Score=198, Evalue=7e-51,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=55.5813953488372, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1786392, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=31.9742489270386, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=317, Percent_Identity=29.6529968454259, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=443, Percent_Identity=31.8284424379233, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6321799, Length=386, Percent_Identity=31.0880829015544, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24581334, Length=470, Percent_Identity=31.9148936170213, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI17737985, Length=374, Percent_Identity=30.7486631016043, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47724; Mature: 47724

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEEEEEECCCCHHHHHHHH
QAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDD
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTGARFLFYKGLGARLERAIYNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCHHHHHHHHHHHH
MLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLTNYYR
HHHHCCCCCCHHHCCCEEECCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCHHHHH
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEK
HHHCCCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCHHHHHHHHH
MTANAENILQKLNLPYRVVALSTGDMGFSATKTYDLEVWIPAQNNYREISSCSNTEDFQA
HHCCHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCHHHHCCCCCHHHHH
RRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEALRPYMGGAE
HHHHEEECCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHCCCCCCEECHHHHCCCCCCCC
VIKP
CCCC
>Mature Secondary Structure
MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEEEEEECCCCHHHHHHHH
QAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDD
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTGARFLFYKGLGARLERAIYNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCHHHHHHHHHHHH
MLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLTNYYR
HHHHCCCCCCHHHCCCEEECCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCHHHHH
DEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEK
HHHCCCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCHHHHHHHHH
MTANAENILQKLNLPYRVVALSTGDMGFSATKTYDLEVWIPAQNNYREISSCSNTEDFQA
HHCCHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCHHHHCCCCCHHHHH
RRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEALRPYMGGAE
HHHHEEECCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHCCCCCCEECHHHHCCCCCCCC
VIKP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA