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The map label for this gene is pepQ [H]

Identifier: 116516123

GI number: 116516123

Start: 1438174

End: 1439256

Strand: Direct

Name: pepQ [H]

Synonym: SPD_1418

Alternate gene names: 116516123

Gene position: 1438174-1439256 (Clockwise)

Preceding gene: 116515943

Following gene: 116517192

Centisome position: 70.29

GC content: 43.95

Gene sequence:

>1083_bases
ATGTCTAAATTACAACAAATCCTAACATATCTTGAATCAGAAAAACTAGACGTCGCTGTCGTATCTGACCCCGTCACAAT
CAATTACCTCACTGGTTTTTACAGTGATCCCCATGAACGCCAAATGTTCCTCTTTGTCCTAGCGGATCAGGAACCTCTCC
TCTTTGTCCCAGCTCTTGAAGTAGAACGTGCAAGTAGCACCGTTTCCTTCCCAGTAGTGGGCTATGTCGATTCTGAAAAT
CCATGGCAAAAAATCAAACATGCTCTTCCACAACTTGACTTCAAACGTGTCGCTGTTGAGTTTGACAATCTCATCTTGAC
CAAATACCATGGTTTGAAAACAGTTTTTGAGACTGCTGAGTTTGACAACCTCACTCCTCGTATCCAACGCATGCGCCTCA
TCAAATCAGCTGATGAAGTGCAAAAAATGATGATTGCAGGTCTTTATGCTGACAAGGCTGTTCATGTTGGTTTTGACAAT
ATTTCTCTTGATAAGACTGAGACAGATATCATCGCACAAATCGACTTTGCCATGAAACGTGAAGGTTATGAAATGAGCTT
TGATACCATGGTCTTGACTGGTGATAATGCTGCGAATCCACACGGCATTCCAGCAGCTAATAAGGTTGAAAATGATGCTC
TTCTCCTCTTTGACCTGGGTGTTCTGGTCAATGGCTATGCGTCAGATATGACTCGTACAGTCGCTGTCGGCAAACCAGAC
CAATTCAAGAAAGATATTTACAACTTGACTCTTGAAGCCCAACAAGCTGCTCTTGACTTTATCAAGCCAGGTGTGACTGC
TCATGAAGTGGACCGCGCTGCCCGTGAGGTCATCGAAAAAGCTGGTTATGGTGAGTACTTCAACCACCGTCTCGGGCATG
GTATCGGTATGGATGTCCATGAATTCCCATCTATCATGGAAGGAAACGACATGGTCATCGAAGAAGGCATGTGCTTCTCT
GCTGAACCAGGTATCTATATCCCTGGTAAAGTCGGTGTTCGTATTGAAGACTGCGGTGTTGTTACCAAGGATGGCTTCGA
CCTCTTTACAAGCACCAGCAAAGATTTGCTTTATTTTGATTAA

Upstream 100 bases:

>100_bases
TCCGTTATCTTGTCGGAGTTTTTTGTCTTTTCTTTTACCCTTCTCCCTTGCATTTTCTCTCATTTTTTGCCAAAATAGAG
GGGTAGAAAGAAGGTAGCAT

Downstream 100 bases:

>100_bases
ACTATATAGCCCCTATGCTTTCCTTTCAAAATATCTAGGGGCTATTTTATTGTCATTTTTCTGCTATTATGCTAAAGAAA
TTGGCTGCAATAATCTAACC

Product: proline dipeptidase PepQ

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALEVERASSTVSFPVVGYVDSEN
PWQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMIAGLYADKAVHVGFDN
ISLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPD
QFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFS
AEPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD

Sequences:

>Translated_360_residues
MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALEVERASSTVSFPVVGYVDSEN
PWQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMIAGLYADKAVHVGFDN
ISLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPD
QFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFS
AEPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD
>Mature_359_residues
SKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALEVERASSTVSFPVVGYVDSENP
WQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMIAGLYADKAVHVGFDNI
SLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPDQ
FKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFSA
EPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD

Specific function: Strict dipeptidase active on Xaa-Pro dipeptides, except Gly-Pro and Pro-Pro [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=293, Percent_Identity=26.6211604095563, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI93141226, Length=164, Percent_Identity=34.7560975609756, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI264681563, Length=187, Percent_Identity=32.0855614973262, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI40385867, Length=204, Percent_Identity=25.4901960784314, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788728, Length=245, Percent_Identity=38.3673469387755, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1789275, Length=259, Percent_Identity=28.1853281853282, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786364, Length=233, Percent_Identity=27.0386266094421, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=239, Percent_Identity=29.2887029288703, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320922, Length=254, Percent_Identity=23.2283464566929, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322999, Length=174, Percent_Identity=32.7586206896552, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19920384, Length=252, Percent_Identity=26.5873015873016, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 40259; Mature: 40128

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALE
CHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEEEECCCCEEEEECCC
VERASSTVSFPVVGYVDSENPWQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAE
HHCCCCEEEEEEEEEECCCCHHHHHHHHCCCCCHHHHHEECCCEEEEECCCHHHHHHHHC
FDNLTPRIQRMRLIKSADEVQKMMIAGLYADKAVHVGFDNISLDKTETDIIAQIDFAMKR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEHHHHHC
EGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPD
CCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCHHHHCEEEEECCCCH
QFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVH
HHHHHHHHEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHH
EFPSIMEGNDMVIEEGMCFSAEPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD
HCCHHHCCCCEEEECCEEECCCCCEEECCCCCEEEECCCEEECCCCHHCCCCCCCEEEEC
>Mature Secondary Structure 
SKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALE
HHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEEEECCCCEEEEECCC
VERASSTVSFPVVGYVDSENPWQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAE
HHCCCCEEEEEEEEEECCCCHHHHHHHHCCCCCHHHHHEECCCEEEEECCCHHHHHHHHC
FDNLTPRIQRMRLIKSADEVQKMMIAGLYADKAVHVGFDNISLDKTETDIIAQIDFAMKR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEHHHHHC
EGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPD
CCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCHHHHCEEEEECCCCH
QFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVH
HHHHHHHHEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHH
EFPSIMEGNDMVIEEGMCFSAEPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD
HCCHHHCCCCEEEECCEEECCCCCEEECCCCCEEEECCCEEECCCCHHCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10075426 [H]