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The map label for this gene is murC

Identifier: 116515384

GI number: 116515384

Start: 1361559

End: 1362893

Strand: Reverse

Name: murC

Synonym: SPD_1349

Alternate gene names: 116515384

Gene position: 1362893-1361559 (Counterclockwise)

Preceding gene: 116516012

Following gene: 116516267

Centisome position: 66.61

GC content: 41.5

Gene sequence:

>1335_bases
ATGTCAAAGACATATCATTTTATCGGAATTAAGGGATCAGGGATGAGTGCCTTGGCCTTGATGTTGCACCAGATGGGGCA
CAAGGTTCAGGGATCAGATGTTGAAAAGTACTACTTTACCCAACGCGGTCTTGAGCAGGCAGGAATTACCATTCTTCCTT
TTGATGAAAAGAATCTAGACGGTGATATGGAAATTATCGCTGGAAATGCCTTTCGTCCAGATAACAACGTCGAAATTGCC
TATGCGGACCAAAATGGTATCAGCTACAAACGTTACCATGAGTTTCTAGGTAGCTTTATGCGTGACTTTGTTAGCATGGG
AGTAGCAGGAGCACATGGAAAAACTTCAACGACAGGTATGTTGTCTCATGTCTTGTCTCACATTACAGATACCAGTTTCT
TGATTGGAGATGGGACAGGTCGTGGTTCGGCTAATGCCAAATATTTTGTCTTTGAATCTGACGAATATGAGCGTCACTTC
ATGCCTTACCACCCAGAATACTCTATTATCACCAACATTGACTTTGACCATCCAGATTATTTCACAAGTCTCGAGGATGT
TTTTAATGCCTTTAACGACTATGCCAAACAAATTACCAAGGGTCTTTTTGTCTATGGTGAAGATGCTGAATTGCGTAAGA
TTACGTCTGATGCACCAATTTATTATTATGGTTTTGAAGCTGAAGGCAATGACTTTGTAGCTAGTGATCTTCTTCGTTCA
ACAACTGGTTCAACCTTCACCGTTCATTTCCGTGGACAAAACTTGGGGCAATTCCACATTCCAACCTTTGGTCGTCACAA
TATCATGAATGCGACAGCCGTTATTGGTCTTCTTTACACAGCAGGATTTGATTTGAACTTGGTGCGTGAGCACTTGAAAA
CATTTGCCGGTGTTAAACGTCGTTTCACTGAGAAAATTGTCAATGATACAGTGATTATTGATGACTTTGCCCATCATCCA
ACAGAAATTATTGCGACCTTGGATGCGGCTCGTCAGAAATACCCAAGCAAGGAAATTGTAGCAGTCTTTCAACCGCATAC
CTTTACAAGAACCATTGCCTTGTTGGACGACTTTGCCCATGCTTTAAACCAAGCAGATGCTGTTTATCTAGCGCAAATTT
ATGGCTCGGCTCGTGAAGTAGATCATGGTGACGTTAAGGTAGAAGACCTAGCCAACAAAATCAACAAAAAACACCAAGTG
ATTACTGTTGAAAATGTTTCTCCACTCCTAGACCATGACAATGCTGTTTACGTCTTTATGGGAGCAGGAGACATCCAAAC
CTATGAATACTCATTTGAGCGTCTCTTGTCTAACTTGACAAGCAATGTTCAATAG

Upstream 100 bases:

>100_bases
AAGAGCCAAATCTACAATAAAAAAAGTAAACAAACAGAACAAGAACGTCGGGTTGCCCAAGAGTTGAATCTGACCAGAAT
GACAGAATAGGGGAGAAAAC

Downstream 100 bases:

>100_bases
GATGTTCCCATGGAAATTCCAATTAAGATCATTCAGGCAAGCAAGTCTGATTTGCCTGAGATAGGGGCACTTCAGACCTC
GTCTTTTCCAGCTGAAAAGC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIA
YADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHF
MPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRS
TTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHP
TEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQV
ITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ

Sequences:

>Translated_444_residues
MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIA
YADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHF
MPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRS
TTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHP
TEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQV
ITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ
>Mature_443_residues
SKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIAY
ADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHFM
PYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRST
TGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHPT
EIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQVI
TVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1790680, Length=388, Percent_Identity=30.9278350515464, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1786279, Length=455, Percent_Identity=29.6703296703297, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_STRP2 (Q04HS5)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816811.1
- ProteinModelPortal:   Q04HS5
- SMR:   Q04HS5
- STRING:   Q04HS5
- EnsemblBacteria:   EBSTRT00000020368
- GeneID:   4441620
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1349
- eggNOG:   COG0773
- GeneTree:   EBGT00050000027198
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49874; Mature: 49743

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLD
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHCCCEEEECCCCCCC
GDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGM
CCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHFMPYHPEYSIITNIDFDHPDY
HHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHH
FTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRS
HHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
TTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKR
CCCCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAH
HHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH
ALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQVITVENVSPLLDHDNAVYVFM
HHCCCCHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCCEEEEEECCCCHHHCCCCEEEEEE
GAGDIQTYEYSFERLLSNLTSNVQ
ECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLD
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHCCCEEEECCCCCCC
GDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGM
CCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHFMPYHPEYSIITNIDFDHPDY
HHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHH
FTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRS
HHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
TTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKR
CCCCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAH
HHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH
ALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQVITVENVSPLLDHDNAVYVFM
HHCCCCHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCCEEEEEECCCCHHHCCCCEEEEEE
GAGDIQTYEYSFERLLSNLTSNVQ
ECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA