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The map label for this gene is fabB [H]

Identifier: 116514998

GI number: 116514998

Start: 61084

End: 62307

Strand: Direct

Name: fabB [H]

Synonym: BCc_056

Alternate gene names: 116514998

Gene position: 61084-62307 (Clockwise)

Preceding gene: 116514993

Following gene: 116514999

Centisome position: 14.67

GC content: 25.74

Gene sequence:

>1224_bases
TTGAAAAGAATAGTTATTACGGGATTTGGTATTTTATCAAGTTTAGGTAGTTCTGAAAAAAATATTTTTAAATCATTAAA
ATATGGTCTTTCTGGAATAGAATTTTCTCAAGAAATGAAAAATTATGGTTTATATAGTACAGTTTGGGGAAATATATCAA
AAAAAAAAATTAGTAAAATACCTAGAAAATATTTGAGATTTATGAATTTAGCATCGATATATTCATATCTTTCTATGAAA
GATGCTATTACAAGTAGTAATTTAGATACTGAAATATTTATGAAAAATCCTAGAGTGGGAATTATTATTGGATCAGGAAG
TGGATCTACTCAATTCTATAAATCAATTTTTAAAAGAATACATAATAATTCTAATTATTTAAGTCCTTATGCTGCAATTC
AAAATATGTCATCTTCTATTTCTGCTTGTTTAGGATCTTTTTTTAAAATTTATGGAATGAGTTATTCTGTAAGTTCAGCT
TGTGCAACTTCAGCCCACTGCATTGCTCATGCTTATGAACTTTTAACTACTGGAAAACAGGATATAATTTTTGCAGGTGG
TGCGGAAGAATTAAGTGTAGAATTAGCATGTCAATTTGATGCAATGAAAATATTATCCTCTAAATTTAATAATACACCCG
AATTATCTTCTAGAGCATTTGATAAATATAGAGATGGATTTGTGATTTCAGGTGGTAGTGGAATTTTAGTATTAGAAGAA
TTAAATTTTGCATTATCACGAAATGCTAATATATATGCAGAAATTATTGGATATGGTACATCTTGTGATGGAAATAGTAT
TACTTTACCATCTGGTGATGGTTTTATACGCTGCATGAGAAATGCATTAAAAAATATTACAGAATCAGTAGATTATATAA
ATGCTCATAGCACATCAACACAAATTGGTGATATTAAAGAATTAATGGCTATTAAAAAAGTTTTTAAAAAATATGATTAT
CTTCCATATATATCCTCTACTAAATCTATTACAGGTCATTCTTTAGGAGCATCAGGTGTACAAGAAATTATTTATACTAT
TTTAATGTTAAAATATGGTTTTATTGCTCCTAGTATTAATATAGAATGTTTAGATGAAAGAATTTATAATATGAATATTG
TAAAGAATAGAATTAACAAAATTATTAATATTGCAATTTCAAATAGTTTTGGTTTTGGTGGTACAAATGTTTGTTTAGTG
ATTAAAAGATTTAATAGATATTAA

Upstream 100 bases:

>100_bases
TTTAATATAAAAATTTTAAATTTAATTTCATATATTATTTTATAAAATGAATATTGTTTGTTTTATAAAAATTATGTATT
AGTAAATAGGAAAATAATTT

Downstream 100 bases:

>100_bases
AATAACTTTTATATTAAAAAAATTTTTTTTAAAAATATAAATAGTTTTTATTAAAAATTTTTTATTATAAAATTATATTT
ATAATATATAAATTATTTTA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKRIVITGFGILSSLGSSEKNIFKSLKYGLSGIEFSQEMKNYGLYSTVWGNISKKKISKIPRKYLRFMNLASIYSYLSMK
DAITSSNLDTEIFMKNPRVGIIIGSGSGSTQFYKSIFKRIHNNSNYLSPYAAIQNMSSSISACLGSFFKIYGMSYSVSSA
CATSAHCIAHAYELLTTGKQDIIFAGGAEELSVELACQFDAMKILSSKFNNTPELSSRAFDKYRDGFVISGGSGILVLEE
LNFALSRNANIYAEIIGYGTSCDGNSITLPSGDGFIRCMRNALKNITESVDYINAHSTSTQIGDIKELMAIKKVFKKYDY
LPYISSTKSITGHSLGASGVQEIIYTILMLKYGFIAPSINIECLDERIYNMNIVKNRINKIINIAISNSFGFGGTNVCLV
IKRFNRY

Sequences:

>Translated_407_residues
MKRIVITGFGILSSLGSSEKNIFKSLKYGLSGIEFSQEMKNYGLYSTVWGNISKKKISKIPRKYLRFMNLASIYSYLSMK
DAITSSNLDTEIFMKNPRVGIIIGSGSGSTQFYKSIFKRIHNNSNYLSPYAAIQNMSSSISACLGSFFKIYGMSYSVSSA
CATSAHCIAHAYELLTTGKQDIIFAGGAEELSVELACQFDAMKILSSKFNNTPELSSRAFDKYRDGFVISGGSGILVLEE
LNFALSRNANIYAEIIGYGTSCDGNSITLPSGDGFIRCMRNALKNITESVDYINAHSTSTQIGDIKELMAIKKVFKKYDY
LPYISSTKSITGHSLGASGVQEIIYTILMLKYGFIAPSINIECLDERIYNMNIVKNRINKIINIAISNSFGFGGTNVCLV
IKRFNRY
>Mature_407_residues
MKRIVITGFGILSSLGSSEKNIFKSLKYGLSGIEFSQEMKNYGLYSTVWGNISKKKISKIPRKYLRFMNLASIYSYLSMK
DAITSSNLDTEIFMKNPRVGIIIGSGSGSTQFYKSIFKRIHNNSNYLSPYAAIQNMSSSISACLGSFFKIYGMSYSVSSA
CATSAHCIAHAYELLTTGKQDIIFAGGAEELSVELACQFDAMKILSSKFNNTPELSSRAFDKYRDGFVISGGSGILVLEE
LNFALSRNANIYAEIIGYGTSCDGNSITLPSGDGFIRCMRNALKNITESVDYINAHSTSTQIGDIKELMAIKKVFKKYDY
LPYISSTKSITGHSLGASGVQEIIYTILMLKYGFIAPSINIECLDERIYNMNIVKNRINKIINIAISNSFGFGGTNVCLV
IKRFNRY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=32.3809523809524, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=42.5675675675676, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI41872631, Length=326, Percent_Identity=27.9141104294479, Blast_Score=109, Evalue=6e-24,
Organism=Escherichia coli, GI1788663, Length=406, Percent_Identity=53.2019704433498, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=34.4578313253012, Blast_Score=201, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=30.0715990453461, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71983535, Length=268, Percent_Identity=36.5671641791045, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17550940, Length=282, Percent_Identity=29.7872340425532, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=326, Percent_Identity=26.0736196319018, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=30.8558558558559, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=33.175355450237, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI221330659, Length=327, Percent_Identity=29.3577981651376, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19920632, Length=327, Percent_Identity=29.3577981651376, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24581345, Length=280, Percent_Identity=27.1428571428571, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 44991; Mature: 44991

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIVITGFGILSSLGSSEKNIFKSLKYGLSGIEFSQEMKNYGLYSTVWGNISKKKISKI
CCEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCHHHHHHHH
PRKYLRFMNLASIYSYLSMKDAITSSNLDTEIFMKNPRVGIIIGSGSGSTQFYKSIFKRI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHH
HNNSNYLSPYAAIQNMSSSISACLGSFFKIYGMSYSVSSACATSAHCIAHAYELLTTGKQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DIIFAGGAEELSVELACQFDAMKILSSKFNNTPELSSRAFDKYRDGFVISGGSGILVLEE
CEEEECCCHHEEEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEE
LNFALSRNANIYAEIIGYGTSCDGNSITLPSGDGFIRCMRNALKNITESVDYINAHSTST
HHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
QIGDIKELMAIKKVFKKYDYLPYISSTKSITGHSLGASGVQEIIYTILMLKYGFIAPSIN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
IECLDERIYNMNIVKNRINKIINIAISNSFGFGGTNVCLVIKRFNRY
CEEHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEEHHCCC
>Mature Secondary Structure
MKRIVITGFGILSSLGSSEKNIFKSLKYGLSGIEFSQEMKNYGLYSTVWGNISKKKISKI
CCEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCHHHHHHHH
PRKYLRFMNLASIYSYLSMKDAITSSNLDTEIFMKNPRVGIIIGSGSGSTQFYKSIFKRI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHH
HNNSNYLSPYAAIQNMSSSISACLGSFFKIYGMSYSVSSACATSAHCIAHAYELLTTGKQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DIIFAGGAEELSVELACQFDAMKILSSKFNNTPELSSRAFDKYRDGFVISGGSGILVLEE
CEEEECCCHHEEEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEE
LNFALSRNANIYAEIIGYGTSCDGNSITLPSGDGFIRCMRNALKNITESVDYINAHSTST
HHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
QIGDIKELMAIKKVFKKYDYLPYISSTKSITGHSLGASGVQEIIYTILMLKYGFIAPSIN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
IECLDERIYNMNIVKNRINKIINIAISNSFGFGGTNVCLVIKRFNRY
CEEHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]