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The map label for this gene is kdgA [H]

Identifier: 116496100

GI number: 116496100

Start: 2658600

End: 2660276

Strand: Direct

Name: kdgA [H]

Synonym: LSEI_2673

Alternate gene names: 116496100

Gene position: 2658600-2660276 (Clockwise)

Preceding gene: 116496099

Following gene: 116496109

Centisome position: 91.83

GC content: 47.64

Gene sequence:

>1677_bases
ATGCAAAAATATGATTTTTTGAATCGGTTAATTGCCACTGGCTGTGTTGCCGTTGTTCGCGGTGATAACACCCAAACCGC
TATTAAGACTTGTGATGCCGTTATTGCTGGCGGGATTACCGGCATTGAACTAACTTTTACGGTGCCGCATGCCAATGAAG
CGCTTGAGACCTTAACCGAAAAATACGCCGGTCGTCAAGATGTCGTCATCGGTGCAGGAACCGTTCTTGACCCCGCTACT
GCCCGACTTGCCATCATCGCTGGTGCCAAGTTTATTGTGAGTCCCAGTTTTAATCCTGACGTTGCAAAAATATGTAACCT
TTACGCTATTCCATATACCCCTGGCGTTTTCACCCCAACCGAAATTCAAAGTGCCCTTGAAGTAGGCGTCGATCTTGTCA
AAATTTTTCCTGGCAGTGTCGCCGGGATCAATATGGTGAAAGCTTTACACGGCCCATTCCCAAACTTAGCCATGATGCCA
ACCGGTGGCGTTTCATTAGCAAACGTCACTGACTGGTTTGAAGCCGGCGTGATGCTGGTGGGTGCTGGTTCTAATCTCGT
AGATGACGCCAGTCAAGGCGACTACGAAAAAGTGACCGTCACCGCACAACAATATCGCGCCAAAATTGCCCAAATTAAGA
TACAAGGAGATGATGGCATGCCAACAGTACTGACACTCGGCGAAATGATGCTGCGATTAAAGCCCACCAATCAACAACGA
ATCCTCCAAACATCAGCATTCGCGGCTGATTATGGTGGCGCAGAGGCCAATGTTGCTGCGTCGCTGGCTTTACTTGGTGA
TCAAGTACAATATTTAACCAAACTCCCCGAAAATTCGCTGGGACACACCGCCCGCAACACGATTCGCGGCCTGGGTGTTG
ATACCCAGAAAATCCTTTGGGGTGGTCCTCGACTGGGCATCTATTTCTTTGAAAAAGGTGCAAGTGTACGGAATACAAAT
GTTGTCTATGATCGCGCGGGCAGTTCTTTTGCCACGATGAAAGCAGACGAATTTGACTGGCCAGTTTTGCTAAACGATAT
CAACTATTTTTATTTTTCCGGCATTACCCCAGCCATCGGGTCAGAACAACAAGCGGCCGTTTTTGCTGCCTGCCAGTATT
GTTCCGATCACAACATCACGGTTATTTGTGACATGAACTTTCGTGAAAAAATGTGGTCCCCTGAAGCAGCCCAAGCATTC
TTCAAAACTGTCATGCCGTTTATTGATGTCTGCATTGCTAACGATGAGGACTTTGAAGCAACCTTGGGCATCAAGGCGTT
TGATGGGAATATGGCAACCGGCATTGACCAACTTGCGGATTTTAAAGAAGGTATGCTTGAAGTTACCCGACGCTGGCCAA
ATGTCCACACAGTCGCCAGTGTCGTTCGTAACATTCATTCCGTCGAAGAAAGTCAATGGACCGCTCTCCTGGTTCAAAAT
GATAAAGTCTACCAAGGTCCTACGTTTGATATGCATATTTTTGAGGGCGTTGCGGCTGGCGATGCGTTTGGCGCCGGATT
AGTCCACGCTCTCATTCATCATTTTGAACCACAACGGACCATTAACTACGCCATTTCAGCGAGTGTCCTAAAGCTGACAA
TTGGCGGTGATCTCAACTTGGTGACAAATGCTGAAGTTGAGGCCAGCATGAAGACTAATAGCGGAGTCAATCGATAG

Upstream 100 bases:

>100_bases
AACCATTTTTTCGGTTAAGTGTATTGACTTCGATTATGACGTATCGTCCTGCTTGAAGCTCTTTTGCGAAAAAACCATCC
TCTGGAAAGAAGAATTCATC

Downstream 100 bases:

>100_bases
TGTTTTGCAGTCATTAAAGACCGGTTAGATTTCTGGCAGAAGTCTACCGGTCTTTTTTGGTGCCCAACGCACTTCTTCAA
GCAGCTTACCGATCAACGAG

Product: 2-keto-3-deoxy-6-phosphogluconate aldolase and 2-dehydro-3-deoxygluconokinase

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase; 2-keto-4-hydroxyglutarate aldolase; KHG-aldolase; 2-dehydro-3-deoxy-phosphogluconate aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MQKYDFLNRLIATGCVAVVRGDNTQTAIKTCDAVIAGGITGIELTFTVPHANEALETLTEKYAGRQDVVIGAGTVLDPAT
ARLAIIAGAKFIVSPSFNPDVAKICNLYAIPYTPGVFTPTEIQSALEVGVDLVKIFPGSVAGINMVKALHGPFPNLAMMP
TGGVSLANVTDWFEAGVMLVGAGSNLVDDASQGDYEKVTVTAQQYRAKIAQIKIQGDDGMPTVLTLGEMMLRLKPTNQQR
ILQTSAFAADYGGAEANVAASLALLGDQVQYLTKLPENSLGHTARNTIRGLGVDTQKILWGGPRLGIYFFEKGASVRNTN
VVYDRAGSSFATMKADEFDWPVLLNDINYFYFSGITPAIGSEQQAAVFAACQYCSDHNITVICDMNFREKMWSPEAAQAF
FKTVMPFIDVCIANDEDFEATLGIKAFDGNMATGIDQLADFKEGMLEVTRRWPNVHTVASVVRNIHSVEESQWTALLVQN
DKVYQGPTFDMHIFEGVAAGDAFGAGLVHALIHHFEPQRTINYAISASVLKLTIGGDLNLVTNAEVEASMKTNSGVNR

Sequences:

>Translated_558_residues
MQKYDFLNRLIATGCVAVVRGDNTQTAIKTCDAVIAGGITGIELTFTVPHANEALETLTEKYAGRQDVVIGAGTVLDPAT
ARLAIIAGAKFIVSPSFNPDVAKICNLYAIPYTPGVFTPTEIQSALEVGVDLVKIFPGSVAGINMVKALHGPFPNLAMMP
TGGVSLANVTDWFEAGVMLVGAGSNLVDDASQGDYEKVTVTAQQYRAKIAQIKIQGDDGMPTVLTLGEMMLRLKPTNQQR
ILQTSAFAADYGGAEANVAASLALLGDQVQYLTKLPENSLGHTARNTIRGLGVDTQKILWGGPRLGIYFFEKGASVRNTN
VVYDRAGSSFATMKADEFDWPVLLNDINYFYFSGITPAIGSEQQAAVFAACQYCSDHNITVICDMNFREKMWSPEAAQAF
FKTVMPFIDVCIANDEDFEATLGIKAFDGNMATGIDQLADFKEGMLEVTRRWPNVHTVASVVRNIHSVEESQWTALLVQN
DKVYQGPTFDMHIFEGVAAGDAFGAGLVHALIHHFEPQRTINYAISASVLKLTIGGDLNLVTNAEVEASMKTNSGVNR
>Mature_558_residues
MQKYDFLNRLIATGCVAVVRGDNTQTAIKTCDAVIAGGITGIELTFTVPHANEALETLTEKYAGRQDVVIGAGTVLDPAT
ARLAIIAGAKFIVSPSFNPDVAKICNLYAIPYTPGVFTPTEIQSALEVGVDLVKIFPGSVAGINMVKALHGPFPNLAMMP
TGGVSLANVTDWFEAGVMLVGAGSNLVDDASQGDYEKVTVTAQQYRAKIAQIKIQGDDGMPTVLTLGEMMLRLKPTNQQR
ILQTSAFAADYGGAEANVAASLALLGDQVQYLTKLPENSLGHTARNTIRGLGVDTQKILWGGPRLGIYFFEKGASVRNTN
VVYDRAGSSFATMKADEFDWPVLLNDINYFYFSGITPAIGSEQQAAVFAACQYCSDHNITVICDMNFREKMWSPEAAQAF
FKTVMPFIDVCIANDEDFEATLGIKAFDGNMATGIDQLADFKEGMLEVTRRWPNVHTVASVVRNIHSVEESQWTALLVQN
DKVYQGPTFDMHIFEGVAAGDAFGAGLVHALIHHFEPQRTINYAISASVLKLTIGGDLNLVTNAEVEASMKTNSGVNR

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. PARTICIPATES IN THE REGULATION OF THE INTRACELLULAR LEVEL OF GLYOXYLATE. [C]

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the KHG/KDPG aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1788156, Length=183, Percent_Identity=31.1475409836066, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI48994954, Length=193, Percent_Identity=32.1243523316062, Blast_Score=93, Evalue=4e-20,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000887
- InterPro:   IPR013785 [H]

Pfam domain/function: PF01081 Aldolase [H]

EC number: =4.1.3.16; =4.1.2.14 [H]

Molecular weight: Translated: 60148; Mature: 60148

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKYDFLNRLIATGCVAVVRGDNTQTAIKTCDAVIAGGITGIELTFTVPHANEALETLTE
CCHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHH
KYAGRQDVVIGAGTVLDPATARLAIIAGAKFIVSPSFNPDVAKICNLYAIPYTPGVFTPT
HHCCCCCEEEECCCEECCCHHEEEEEECCEEEECCCCCCCHHHHHCEEECCCCCCCCCHH
EIQSALEVGVDLVKIFPGSVAGINMVKALHGPFPNLAMMPTGGVSLANVTDWFEAGVMLV
HHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCEEEE
GAGSNLVDDASQGDYEKVTVTAQQYRAKIAQIKIQGDDGMPTVLTLGEMMLRLKPTNQQR
ECCCCCCCCCCCCCCEEEEEEHHHHHCEEEEEEEECCCCCCHHHHHHHHHHEECCCCHHH
ILQTSAFAADYGGAEANVAASLALLGDQVQYLTKLPENSLGHTARNTIRGLGVDTQKILW
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHEEE
GGPRLGIYFFEKGASVRNTNVVYDRAGSSFATMKADEFDWPVLLNDINYFYFSGITPAIG
CCCCEEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCCCEEEECCCEEEECCCCCCCC
SEQQAAVFAACQYCSDHNITVICDMNFREKMWSPEAAQAFFKTVMPFIDVCIANDEDFEA
CCCHHHHHHHHHHCCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCEE
TLGIKAFDGNMATGIDQLADFKEGMLEVTRRWPNVHTVASVVRNIHSVEESQWTALLVQN
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
DKVYQGPTFDMHIFEGVAAGDAFGAGLVHALIHHFEPQRTINYAISASVLKLTIGGDLNL
CEEECCCCCEEHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEEEEEEEEEEECCCEEE
VTNAEVEASMKTNSGVNR
EECCCEEEEECCCCCCCC
>Mature Secondary Structure
MQKYDFLNRLIATGCVAVVRGDNTQTAIKTCDAVIAGGITGIELTFTVPHANEALETLTE
CCHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHH
KYAGRQDVVIGAGTVLDPATARLAIIAGAKFIVSPSFNPDVAKICNLYAIPYTPGVFTPT
HHCCCCCEEEECCCEECCCHHEEEEEECCEEEECCCCCCCHHHHHCEEECCCCCCCCCHH
EIQSALEVGVDLVKIFPGSVAGINMVKALHGPFPNLAMMPTGGVSLANVTDWFEAGVMLV
HHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCEEEE
GAGSNLVDDASQGDYEKVTVTAQQYRAKIAQIKIQGDDGMPTVLTLGEMMLRLKPTNQQR
ECCCCCCCCCCCCCCEEEEEEHHHHHCEEEEEEEECCCCCCHHHHHHHHHHEECCCCHHH
ILQTSAFAADYGGAEANVAASLALLGDQVQYLTKLPENSLGHTARNTIRGLGVDTQKILW
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHEEE
GGPRLGIYFFEKGASVRNTNVVYDRAGSSFATMKADEFDWPVLLNDINYFYFSGITPAIG
CCCCEEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCCCEEEECCCEEEECCCCCCCC
SEQQAAVFAACQYCSDHNITVICDMNFREKMWSPEAAQAFFKTVMPFIDVCIANDEDFEA
CCCHHHHHHHHHHCCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCEE
TLGIKAFDGNMATGIDQLADFKEGMLEVTRRWPNVHTVASVVRNIHSVEESQWTALLVQN
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
DKVYQGPTFDMHIFEGVAAGDAFGAGLVHALIHHFEPQRTINYAISASVLKLTIGGDLNL
CEEECCCCCEEHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEEEEEEEEEEECCCEEE
VTNAEVEASMKTNSGVNR
EECCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]