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The map label for this gene is helD [H]

Identifier: 116496058

GI number: 116496058

Start: 2614786

End: 2617074

Strand: Direct

Name: helD [H]

Synonym: LSEI_2630

Alternate gene names: 116496058

Gene position: 2614786-2617074 (Clockwise)

Preceding gene: 116496048

Following gene: 116496059

Centisome position: 90.31

GC content: 47.92

Gene sequence:

>2289_bases
ATGGAAAATGCAACGAAGGCAGAAGAACAGGCTCGGGTCACGGCGGTCATTGAGAAGCTCAAGGCAAGGCTAGCGGCCAT
TCATGACCAGATCGAAGCGGCGCACAAAGAAACCAGCCGGATTGAACGATCTTACGGTGAAAATACCAAGGTCAACGTTA
CCGAAGTCGATGACCAAATGGAAACCAACGCTGCGGTTCAACAGCAGAAAGTCATGGTTGCCCGCGCCGTCGAAAATGAA
ACCATTCTCAAACACGAAGGTAATCGTCTCACCCTGCTAGCGGACAATCCTTATTTTGGCCGTATCGATATTGACGAAGA
TGGCGATCCCGACACGCTTTATATCGGCACTGCCACCTTCATTGACCAAGATGGCGAATTCTTGGTTTATGATTGGCGCG
CGCCGGTAAGTTCTATTTATTACAACGGTACCCTTGGCGATGTCAGCTACGATACACCAGCAGGCGAACAACACGCCACT
TTGAAAAACAAGCGTCAGTTCCAAATCGAACACGGCCACATCAAAACCATGTTCGACACCAATGAAACCGTTGGCGACGA
AATCCTTCAATCCGTTTTAGGCGATCAATCAGACGAATACATGAAAAATATTGTCGCGACCATTCAGCGCGAACAAAACG
ACATTATTCGTGATACCACCAGCGACTTGCTTGTGGTTCAAGGGGTCGCCGGCTCCGGGAAAACCAGTGCGGTCCTGCAA
CGCATTGCTTACTTGCTATATCACAGCCGTAGCGATCTGGATGCTGACCAAATGGTGCTTTTCTCGCCTAACCGCTTGTT
TGCCAATTACATCTCACAAGTTTTGCCGAGCTTAGGCGAAAAGAATATGCGGCAGGCAACCTTGTTTGAATTCTTGGCAA
ACCGTTTCACCGGCTTACATGTTGAAACATTATTTGAACGTTATGAACATGATGCAGCTGGATTGCCGCCAGCTGCTGAG
CATATCCGTCGCTTTAAAGAAGCGCCGCGCTATCTTGAAGCTATCTACGACTATGCTAAGCAACCGAAGCGGACACCGCA
TTTTATTGACGTTGAGTTCAACGGTGAGACTTTCTTCTCAGCCGCAACCATCGCAAAAATTTATCAAGCCCAGCCAGCAT
TGATGCAGCCAGTTGATAAGTTTACCGCCACTAAGAATGCTTTGATCAAACGTCTGAATACCCGAATTCATATGGAAGCC
AAACGAGACTGGGCGCAGTTGCGCGTTTCCGATCTGTCACAAACTGAATTGGAAACCTTGACCGCCGATCACGAATTCGA
AACCGGTGAAGATGAACAGCGATTTGTCTCGGAAGCTATTGTCTCAAAAGCATTTTCACCAATCTACGATGCACTGTACA
ACGATCATTTTTACGATGTGTTCCAAGACTATCAGCAATTCATGGCACAGGTGAAACCACCCGTTGCTCCGGCTATCTGG
CACACAATGGTCAACGCCTTTTCAGACGGAATCGAAGCGCATCAATTACGCTTAGAAGATGCCGCCCCGCTGCTTTATCT
TCGTGATCTCAGCACCGGCAGCGGTCAAAATAGCCTGATTCAGTATGTTTTCGTTGATGAGATGCAAGACTTCAGTATGG
CGCAGTTGTTGTACTTGAAACACGCCTTTCCTAAAGCCAAGTTGACTTTGTTGGGCGATGCCAAGCAAGACGTGTTTACC
AGTAATTATCAGCCTAGTGATTTCATTCATGAAATCGAGGACGTTTTTTCCGGCTATAAAATTCGACTCATTACGTTGAA
CAAAAGCTACCGATCCACGCAACCGATTACTAACTTTGCCAAAGCTTTATTACCAGAACACGACCATATTCAGGCGTTTA
ACCGTGCTGGTGATAAACCAGAAGTCTTGACGGTAGCGCGCACGGAAGCACCCGATGCTTTGTCAAAACTGGTGACGCAA
CTGCTGGCAACCGATACCACCGTGGCGATTCTAACCAAAGATGCCCAAACGGCTGATCAACTTTACGCCACTCTCAAACT
TGATGCACCAGTCACCTTGCTATCGGCTAATGACCATAGCCTTAAAAACGGTTGTGTCATTTTGCCAGTCTATCTCGCGA
AAGGTTTAGAGTTTGACGCAGTCATCGGTTGGGATATTTCTGCAACCACGTATCAAAATGAAGCCGACCGTGATATTCTC
TACACACTTTGCTCCCGAGCCTTGCACCATCTCACACTCGTTGCTTTGGACGCCCCAAGTCCATTGATCACGGCACTGCC
CGCTGATCTCTACACACATGCAGGGGATGCCTCTGAGGCGCGTGTCTAA

Upstream 100 bases:

>100_bases
CTCCGGTTTCTAACCGGGCCTGCTCACGCTCTTTACTTTTCCAAGTGCCCAGCGTACAATTATCGACACCATTTTAAACA
CCGAAAGGAGCGCCGTTTCT

Downstream 100 bases:

>100_bases
TGCCACCCATGCATCATCAACAAACGCCCGTGTCTTCGCTGACACGGGCGTTTGTTTGGCTTCTAGAATCATGATAAATT
ATCAATGGAACGATTTAATC

Product: superfamily I DNA/RNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 762; Mature: 762

Protein sequence:

>762_residues
MENATKAEEQARVTAVIEKLKARLAAIHDQIEAAHKETSRIERSYGENTKVNVTEVDDQMETNAAVQQQKVMVARAVENE
TILKHEGNRLTLLADNPYFGRIDIDEDGDPDTLYIGTATFIDQDGEFLVYDWRAPVSSIYYNGTLGDVSYDTPAGEQHAT
LKNKRQFQIEHGHIKTMFDTNETVGDEILQSVLGDQSDEYMKNIVATIQREQNDIIRDTTSDLLVVQGVAGSGKTSAVLQ
RIAYLLYHSRSDLDADQMVLFSPNRLFANYISQVLPSLGEKNMRQATLFEFLANRFTGLHVETLFERYEHDAAGLPPAAE
HIRRFKEAPRYLEAIYDYAKQPKRTPHFIDVEFNGETFFSAATIAKIYQAQPALMQPVDKFTATKNALIKRLNTRIHMEA
KRDWAQLRVSDLSQTELETLTADHEFETGEDEQRFVSEAIVSKAFSPIYDALYNDHFYDVFQDYQQFMAQVKPPVAPAIW
HTMVNAFSDGIEAHQLRLEDAAPLLYLRDLSTGSGQNSLIQYVFVDEMQDFSMAQLLYLKHAFPKAKLTLLGDAKQDVFT
SNYQPSDFIHEIEDVFSGYKIRLITLNKSYRSTQPITNFAKALLPEHDHIQAFNRAGDKPEVLTVARTEAPDALSKLVTQ
LLATDTTVAILTKDAQTADQLYATLKLDAPVTLLSANDHSLKNGCVILPVYLAKGLEFDAVIGWDISATTYQNEADRDIL
YTLCSRALHHLTLVALDAPSPLITALPADLYTHAGDASEARV

Sequences:

>Translated_762_residues
MENATKAEEQARVTAVIEKLKARLAAIHDQIEAAHKETSRIERSYGENTKVNVTEVDDQMETNAAVQQQKVMVARAVENE
TILKHEGNRLTLLADNPYFGRIDIDEDGDPDTLYIGTATFIDQDGEFLVYDWRAPVSSIYYNGTLGDVSYDTPAGEQHAT
LKNKRQFQIEHGHIKTMFDTNETVGDEILQSVLGDQSDEYMKNIVATIQREQNDIIRDTTSDLLVVQGVAGSGKTSAVLQ
RIAYLLYHSRSDLDADQMVLFSPNRLFANYISQVLPSLGEKNMRQATLFEFLANRFTGLHVETLFERYEHDAAGLPPAAE
HIRRFKEAPRYLEAIYDYAKQPKRTPHFIDVEFNGETFFSAATIAKIYQAQPALMQPVDKFTATKNALIKRLNTRIHMEA
KRDWAQLRVSDLSQTELETLTADHEFETGEDEQRFVSEAIVSKAFSPIYDALYNDHFYDVFQDYQQFMAQVKPPVAPAIW
HTMVNAFSDGIEAHQLRLEDAAPLLYLRDLSTGSGQNSLIQYVFVDEMQDFSMAQLLYLKHAFPKAKLTLLGDAKQDVFT
SNYQPSDFIHEIEDVFSGYKIRLITLNKSYRSTQPITNFAKALLPEHDHIQAFNRAGDKPEVLTVARTEAPDALSKLVTQ
LLATDTTVAILTKDAQTADQLYATLKLDAPVTLLSANDHSLKNGCVILPVYLAKGLEFDAVIGWDISATTYQNEADRDIL
YTLCSRALHHLTLVALDAPSPLITALPADLYTHAGDASEARV
>Mature_762_residues
MENATKAEEQARVTAVIEKLKARLAAIHDQIEAAHKETSRIERSYGENTKVNVTEVDDQMETNAAVQQQKVMVARAVENE
TILKHEGNRLTLLADNPYFGRIDIDEDGDPDTLYIGTATFIDQDGEFLVYDWRAPVSSIYYNGTLGDVSYDTPAGEQHAT
LKNKRQFQIEHGHIKTMFDTNETVGDEILQSVLGDQSDEYMKNIVATIQREQNDIIRDTTSDLLVVQGVAGSGKTSAVLQ
RIAYLLYHSRSDLDADQMVLFSPNRLFANYISQVLPSLGEKNMRQATLFEFLANRFTGLHVETLFERYEHDAAGLPPAAE
HIRRFKEAPRYLEAIYDYAKQPKRTPHFIDVEFNGETFFSAATIAKIYQAQPALMQPVDKFTATKNALIKRLNTRIHMEA
KRDWAQLRVSDLSQTELETLTADHEFETGEDEQRFVSEAIVSKAFSPIYDALYNDHFYDVFQDYQQFMAQVKPPVAPAIW
HTMVNAFSDGIEAHQLRLEDAAPLLYLRDLSTGSGQNSLIQYVFVDEMQDFSMAQLLYLKHAFPKAKLTLLGDAKQDVFT
SNYQPSDFIHEIEDVFSGYKIRLITLNKSYRSTQPITNFAKALLPEHDHIQAFNRAGDKPEVLTVARTEAPDALSKLVTQ
LLATDTTVAILTKDAQTADQLYATLKLDAPVTLLSANDHSLKNGCVILPVYLAKGLEFDAVIGWDISATTYQNEADRDIL
YTLCSRALHHLTLVALDAPSPLITALPADLYTHAGDASEARV

Specific function: Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP [H]

COG id: COG3973

COG function: function code R; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 85682; Mature: 85682

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENATKAEEQARVTAVIEKLKARLAAIHDQIEAAHKETSRIERSYGENTKVNVTEVDDQM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHH
ETNAAVQQQKVMVARAVENETILKHEGNRLTLLADNPYFGRIDIDEDGDPDTLYIGTATF
HHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCEEEEEEEEE
IDQDGEFLVYDWRAPVSSIYYNGTLGDVSYDTPAGEQHATLKNKRQFQIEHGHIKTMFDT
ECCCCCEEEEECCCCHHHEEECCEECCCCCCCCCCCCHHHHCCCCEEEEECCCEEEEECC
NETVGDEILQSVLGDQSDEYMKNIVATIQREQNDIIRDTTSDLLVVQGVAGSGKTSAVLQ
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
RIAYLLYHSRSDLDADQMVLFSPNRLFANYISQVLPSLGEKNMRQATLFEFLANRFTGLH
HHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCH
VETLFERYEHDAAGLPPAAEHIRRFKEAPRYLEAIYDYAKQPKRTPHFIDVEFNGETFFS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHH
AATIAKIYQAQPALMQPVDKFTATKNALIKRLNTRIHMEAKRDWAQLRVSDLSQTELETL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHCCHHHHHHH
TADHEFETGEDEQRFVSEAIVSKAFSPIYDALYNDHFYDVFQDYQQFMAQVKPPVAPAIW
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHH
HTMVNAFSDGIEAHQLRLEDAAPLLYLRDLSTGSGQNSLIQYVFVDEMQDFSMAQLLYLK
HHHHHHHHCCCHHHHEEECCCCCEEEEEECCCCCCCCHHEEEEEHHCCCCHHHHHHHHHH
HAFPKAKLTLLGDAKQDVFTSNYQPSDFIHEIEDVFSGYKIRLITLNKSYRSTQPITNFA
HCCCCCEEEEECCCHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHH
KALLPEHDHIQAFNRAGDKPEVLTVARTEAPDALSKLVTQLLATDTTVAILTKDAQTADQ
HHHCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHH
LYATLKLDAPVTLLSANDHSLKNGCVILPVYLAKGLEFDAVIGWDISATTYQNEADRDIL
HEEEEEECCCEEEEECCCCCCCCCEEEEEHHHHCCCCCCEEEECCCCCCCCCCCCHHHHH
YTLCSRALHHLTLVALDAPSPLITALPADLYTHAGDASEARV
HHHHHHHHHHEEEEEECCCCCHHHHCCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MENATKAEEQARVTAVIEKLKARLAAIHDQIEAAHKETSRIERSYGENTKVNVTEVDDQM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHH
ETNAAVQQQKVMVARAVENETILKHEGNRLTLLADNPYFGRIDIDEDGDPDTLYIGTATF
HHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCEEEEEEEEE
IDQDGEFLVYDWRAPVSSIYYNGTLGDVSYDTPAGEQHATLKNKRQFQIEHGHIKTMFDT
ECCCCCEEEEECCCCHHHEEECCEECCCCCCCCCCCCHHHHCCCCEEEEECCCEEEEECC
NETVGDEILQSVLGDQSDEYMKNIVATIQREQNDIIRDTTSDLLVVQGVAGSGKTSAVLQ
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
RIAYLLYHSRSDLDADQMVLFSPNRLFANYISQVLPSLGEKNMRQATLFEFLANRFTGLH
HHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCH
VETLFERYEHDAAGLPPAAEHIRRFKEAPRYLEAIYDYAKQPKRTPHFIDVEFNGETFFS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHH
AATIAKIYQAQPALMQPVDKFTATKNALIKRLNTRIHMEAKRDWAQLRVSDLSQTELETL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHCCHHHHHHH
TADHEFETGEDEQRFVSEAIVSKAFSPIYDALYNDHFYDVFQDYQQFMAQVKPPVAPAIW
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHH
HTMVNAFSDGIEAHQLRLEDAAPLLYLRDLSTGSGQNSLIQYVFVDEMQDFSMAQLLYLK
HHHHHHHHCCCHHHHEEECCCCCEEEEEECCCCCCCCHHEEEEEHHCCCCHHHHHHHHHH
HAFPKAKLTLLGDAKQDVFTSNYQPSDFIHEIEDVFSGYKIRLITLNKSYRSTQPITNFA
HCCCCCEEEEECCCHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHH
KALLPEHDHIQAFNRAGDKPEVLTVARTEAPDALSKLVTQLLATDTTVAILTKDAQTADQ
HHHCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHH
LYATLKLDAPVTLLSANDHSLKNGCVILPVYLAKGLEFDAVIGWDISATTYQNEADRDIL
HEEEEEECCCEEEEECCCCCCCCCEEEEEHHHHCCCCCCEEEECCCCCCCCCCCCHHHHH
YTLCSRALHHLTLVALDAPSPLITALPADLYTHAGDASEARV
HHHHHHHHHHEEEEEECCCCCHHHHCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]