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The map label for this gene is psaA [H]

Identifier: 116495871

GI number: 116495871

Start: 2416012

End: 2416929

Strand: Direct

Name: psaA [H]

Synonym: LSEI_2427

Alternate gene names: 116495871

Gene position: 2416012-2416929 (Clockwise)

Preceding gene: 116495864

Following gene: 116495872

Centisome position: 83.45

GC content: 44.77

Gene sequence:

>918_bases
ATGATGAAGCGATTACTTGCAGGTATCAGTGTCGCATTGCTGGCAATTTTTGCAGTCGCATGCGGTAGTAATGGTGCCGC
AAAGCAATCCAGCTCGAATGGCAGCAAGATTCAAGTTGTTGCCAGTCTTGATTTTTATGGTGAGGTTGCCAAAGCTGTGG
GTGGTAACAAGGTGTCGGTGCAGTCGATTATCAACAATCCGGCGGTTGATCCCCATGACTATGAGCCTACTACCAAAGTT
GGGAAATCAGTTGCGTCTGCCGATCTTGTTGTCGCCAGTGGCATTGGTTACGACGGCTGGATGGATAAGGTCGTGAAGTC
GGCGGACAAATCCAAAAATTACTTACGTGTCGCTGACGATTTGATGAATAAAAAGGAAGGCGACAACGAACATATCTGGT
ACGATCCGCGAACCATGTCAAAACTGGCCAATACCTTAGCTGATAAGTTTGCCAAGAAAGATCCAGCTGACAAAGCGACC
TTCAAGGCGAATGCAAAGAAATACATCGCTTCCCTGGACAATCTCAATACTTTGATCAACAAGTTGAAGTCGAAAGTAAA
TGGCCAACTCGTTGATGTCTCCGAACCTGTCTTTGGCTACGCGCTCGATTATCTGGGCTACAAAGTCAATGACGATCACT
TCTCGAAGTCAACCGAAGACGGCACAGACTACAGCGCAAAAGATATCCATGGTATCGAAACCGATATTAAGGAAAAGAAA
ATTGCCTTCTTTGTCAATAACATCCAAGCAAGCTCAAAGACTGTCAATCAACTCGTCAAATTAGCTGAACAAAATAATGT
GCCGGTTTTGAAAGTGACCGAGACATTACCTAAAGGCAAAAACTATCGGACTTGGATGACCAGCCAATACCAGCAACTTG
AAAAAATTCAGGATCAAGCAACGAACAGCGCAAAATAG

Upstream 100 bases:

>100_bases
CACTTTTCTCAATTTTTTTGAAAATTTTCCTTGCCAGACCGCTCACTTTGCTTTATGGTTTAAATCGTAATTATTACGTT
TTGGAAGGAAGCGGGAATTT

Downstream 100 bases:

>100_bases
CATCACTTCTGGTCACAGGGGTTTATCATTCCCCCAATGTTTCGGCAAAGCTCACCCTCTGTCGAAGTTTCGTTAATTGC
TTTGATGACAAGATAAACCA

Product: ABC-type metal ion transport system, periplasmic component/surface adhesin

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: Pneumococcal surface adhesin A [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MMKRLLAGISVALLAIFAVACGSNGAAKQSSSNGSKIQVVASLDFYGEVAKAVGGNKVSVQSIINNPAVDPHDYEPTTKV
GKSVASADLVVASGIGYDGWMDKVVKSADKSKNYLRVADDLMNKKEGDNEHIWYDPRTMSKLANTLADKFAKKDPADKAT
FKANAKKYIASLDNLNTLINKLKSKVNGQLVDVSEPVFGYALDYLGYKVNDDHFSKSTEDGTDYSAKDIHGIETDIKEKK
IAFFVNNIQASSKTVNQLVKLAEQNNVPVLKVTETLPKGKNYRTWMTSQYQQLEKIQDQATNSAK

Sequences:

>Translated_305_residues
MMKRLLAGISVALLAIFAVACGSNGAAKQSSSNGSKIQVVASLDFYGEVAKAVGGNKVSVQSIINNPAVDPHDYEPTTKV
GKSVASADLVVASGIGYDGWMDKVVKSADKSKNYLRVADDLMNKKEGDNEHIWYDPRTMSKLANTLADKFAKKDPADKAT
FKANAKKYIASLDNLNTLINKLKSKVNGQLVDVSEPVFGYALDYLGYKVNDDHFSKSTEDGTDYSAKDIHGIETDIKEKK
IAFFVNNIQASSKTVNQLVKLAEQNNVPVLKVTETLPKGKNYRTWMTSQYQQLEKIQDQATNSAK
>Mature_305_residues
MMKRLLAGISVALLAIFAVACGSNGAAKQSSSNGSKIQVVASLDFYGEVAKAVGGNKVSVQSIINNPAVDPHDYEPTTKV
GKSVASADLVVASGIGYDGWMDKVVKSADKSKNYLRVADDLMNKKEGDNEHIWYDPRTMSKLANTLADKFAKKDPADKAT
FKANAKKYIASLDNLNTLINKLKSKVNGQLVDVSEPVFGYALDYLGYKVNDDHFSKSTEDGTDYSAKDIHGIETDIKEKK
IAFFVNNIQASSKTVNQLVKLAEQNNVPVLKVTETLPKGKNYRTWMTSQYQQLEKIQDQATNSAK

Specific function: Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 33313; Mature: 33313

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKRLLAGISVALLAIFAVACGSNGAAKQSSSNGSKIQVVASLDFYGEVAKAVGGNKVSV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHCCCCCEEH
QSIINNPAVDPHDYEPTTKVGKSVASADLVVASGIGYDGWMDKVVKSADKSKNYLRVADD
HHHHCCCCCCCCCCCCHHHHHHHHHHHHEHEECCCCCHHHHHHHHHHHHCCCCHHHHHHH
LMNKKEGDNEHIWYDPRTMSKLANTLADKFAKKDPADKATFKANAKKYIASLDNLNTLIN
HHHCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KLKSKVNGQLVDVSEPVFGYALDYLGYKVNDDHFSKSTEDGTDYSAKDIHGIETDIKEKK
HHHHHHCCEEEECCCCHHHHHHHHHCCEECCHHCCCCCCCCCCCCHHHCCCCHHHHHHHH
IAFFVNNIQASSKTVNQLVKLAEQNNVPVLKVTETLPKGKNYRTWMTSQYQQLEKIQDQA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
TNSAK
CCCCC
>Mature Secondary Structure
MMKRLLAGISVALLAIFAVACGSNGAAKQSSSNGSKIQVVASLDFYGEVAKAVGGNKVSV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHCCCCCEEH
QSIINNPAVDPHDYEPTTKVGKSVASADLVVASGIGYDGWMDKVVKSADKSKNYLRVADD
HHHHCCCCCCCCCCCCHHHHHHHHHHHHEHEECCCCCHHHHHHHHHHHHCCCCHHHHHHH
LMNKKEGDNEHIWYDPRTMSKLANTLADKFAKKDPADKATFKANAKKYIASLDNLNTLIN
HHHCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KLKSKVNGQLVDVSEPVFGYALDYLGYKVNDDHFSKSTEDGTDYSAKDIHGIETDIKEKK
HHHHHHCCEEEECCCCHHHHHHHHHCCEECCHHCCCCCCCCCCCCHHHCCCCHHHHHHHH
IAFFVNNIQASSKTVNQLVKLAEQNNVPVLKVTETLPKGKNYRTWMTSQYQQLEKIQDQA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
TNSAK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8945574; 9767595; 11463916; 9379902 [H]