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The map label for this gene is add

Identifier: 116495662

GI number: 116495662

Start: 2205131

End: 2206150

Strand: Direct

Name: add

Synonym: LSEI_2207

Alternate gene names: 116495662

Gene position: 2205131-2206150 (Clockwise)

Preceding gene: 116495656

Following gene: 116495663

Centisome position: 76.16

GC content: 48.73

Gene sequence:

>1020_bases
ATGGACTTTCAAACATTACATCAACTAAGCAAAACCGAACTACATTGTCATTTAGACGGCTCATTGTCGTTAAGTTGCAT
TCGTCAGCTCGCGAAAATGATCGACCGAAAATTACCGGCGACTGACGACGAGCTGCGGCGACTGGTTCAGGCCCCAGCAG
ATTCCGAGAATTTAGGTGATTATCTCAAAGCCTTCGACTTCGTGGCCCCCTTGCTGCAAACCAAAAAGGCCTTGCAACTC
GCGGCCTACGATGTCGTTGAACAAGCGGCTGAAGAAAACGTCCGCTATATCGAAATTCGCTTCGCGCCCGTATTTTCCCT
AGCAGGCGGATTATCGCTGGTCGAAGCAACGCAAGCCGTCATCGAAGGCTTGCACCAAGGCATGGCAACATATGACATCA
TGGCGAAGGCCTTAGTCTGTGGCATGCGACAGTTGCCCAACACCGATAACCAAACAATGTTTAAAACCACCGCCCCACTA
CTTGGTTCAACACTCGTCGGCGGTGACTTTGCCGGCAACGAAGCTGATTTTCCAACGAACGTGTGCGCGCCGGCCATTAA
AACTGCTCAATCTCTTGGCGTGCCGCTTACGTTTCATGCCGGCGAATGTCATTGCCCGCAAAACATTGGTGAAGCGGTAC
GACTCGGCATTCCGCGGATTGGCCATGCCACCGCTTGTTTTGATCAACCGGCACTCATTGAGAAAATTGTTGAAACTGGC
ACCACAGTTGAACTTTGCCTCACGAGCAACCTCCAAACGAAAGCCGCTCGGACACTTGCTGAGTTTCCGTATCAGGCGCT
TAAAAAAGCTGGTGCCAAAATCACCATTAACACTGATAATCGAACAGTCTCGAATACCACGTTAACCCAGGAATATCAGC
GTTATCAGCAAGCTTTTGGTACAACAGCAGCTGACTTTTTAGCATTCAATTTAAACGCCATTGATGCAGCTTTCATTCCT
GATGCCGATAAGAAATCATTACGCGACCAGTTACATCAAGATTACGCAACTTATTGTTAA

Upstream 100 bases:

>100_bases
TCTGCGCCAGTGAACGCGTTTAAAAAGACGCGAACCAATCACCCCTCGGTCATGCCGATCACTCTTTATTGCCTGCGAAC
TTGTTTAGGAGGAAAACTCG

Downstream 100 bases:

>100_bases
TTTTCCCCAATTAAAAGACAAGCCATGATCACGACTATTGCTTGTCTTTTTAATGCAGTTAACCAAGGCCTTGCTGATCA
GGCGCTTAATCATTGCTTAA

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MDFQTLHQLSKTELHCHLDGSLSLSCIRQLAKMIDRKLPATDDELRRLVQAPADSENLGDYLKAFDFVAPLLQTKKALQL
AAYDVVEQAAEENVRYIEIRFAPVFSLAGGLSLVEATQAVIEGLHQGMATYDIMAKALVCGMRQLPNTDNQTMFKTTAPL
LGSTLVGGDFAGNEADFPTNVCAPAIKTAQSLGVPLTFHAGECHCPQNIGEAVRLGIPRIGHATACFDQPALIEKIVETG
TTVELCLTSNLQTKAARTLAEFPYQALKKAGAKITINTDNRTVSNTTLTQEYQRYQQAFGTTAADFLAFNLNAIDAAFIP
DADKKSLRDQLHQDYATYC

Sequences:

>Translated_339_residues
MDFQTLHQLSKTELHCHLDGSLSLSCIRQLAKMIDRKLPATDDELRRLVQAPADSENLGDYLKAFDFVAPLLQTKKALQL
AAYDVVEQAAEENVRYIEIRFAPVFSLAGGLSLVEATQAVIEGLHQGMATYDIMAKALVCGMRQLPNTDNQTMFKTTAPL
LGSTLVGGDFAGNEADFPTNVCAPAIKTAQSLGVPLTFHAGECHCPQNIGEAVRLGIPRIGHATACFDQPALIEKIVETG
TTVELCLTSNLQTKAARTLAEFPYQALKKAGAKITINTDNRTVSNTTLTQEYQRYQQAFGTTAADFLAFNLNAIDAAFIP
DADKKSLRDQLHQDYATYC
>Mature_339_residues
MDFQTLHQLSKTELHCHLDGSLSLSCIRQLAKMIDRKLPATDDELRRLVQAPADSENLGDYLKAFDFVAPLLQTKKALQL
AAYDVVEQAAEENVRYIEIRFAPVFSLAGGLSLVEATQAVIEGLHQGMATYDIMAKALVCGMRQLPNTDNQTMFKTTAPL
LGSTLVGGDFAGNEADFPTNVCAPAIKTAQSLGVPLTFHAGECHCPQNIGEAVRLGIPRIGHATACFDQPALIEKIVETG
TTVELCLTSNLQTKAARTLAEFPYQALKKAGAKITINTDNRTVSNTTLTQEYQRYQQAFGTTAADFLAFNLNAIDAAFIP
DADKKSLRDQLHQDYATYC

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=344, Percent_Identity=29.0697674418605, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI226693318, Length=331, Percent_Identity=23.5649546827795, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1787910, Length=326, Percent_Identity=29.4478527607362, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17538512, Length=333, Percent_Identity=25.2252252252252, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32565969, Length=333, Percent_Identity=25.2252252252252, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324188, Length=341, Percent_Identity=20.8211143695015, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24645260, Length=333, Percent_Identity=27.3273273273273, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_LACC3 (Q036B8)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_807396.1
- ProteinModelPortal:   Q036B8
- SMR:   Q036B8
- STRING:   Q036B8
- GeneID:   4420754
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_2207
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   PYYMAMN
- PhylomeDB:   Q036B8
- ProtClustDB:   CLSK2318309
- BioCyc:   LCAS321967:LSEI_2207-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 36961; Mature: 36961

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 202-202 BINDING 17-17 BINDING 19-19 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFQTLHQLSKTELHCHLDGSLSLSCIRQLAKMIDRKLPATDDELRRLVQAPADSENLGD
CCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHH
YLKAFDFVAPLLQTKKALQLAAYDVVEQAAEENVRYIEIRFAPVFSLAGGLSLVEATQAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCHHHHHHHHHH
IEGLHQGMATYDIMAKALVCGMRQLPNTDNQTMFKTTAPLLGSTLVGGDFAGNEADFPTN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCHH
VCAPAIKTAQSLGVPLTFHAGECHCPQNIGEAVRLGIPRIGHATACFDQPALIEKIVETG
HHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHCC
TTVELCLTSNLQTKAARTLAEFPYQALKKAGAKITINTDNRTVSNTTLTQEYQRYQQAFG
CEEEEEECCCCHHHHHHHHHHCCHHHHHHCCCEEEEECCCCEECCHHHHHHHHHHHHHHC
TTAADFLAFNLNAIDAAFIPDADKKSLRDQLHQDYATYC
CHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFQTLHQLSKTELHCHLDGSLSLSCIRQLAKMIDRKLPATDDELRRLVQAPADSENLGD
CCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHH
YLKAFDFVAPLLQTKKALQLAAYDVVEQAAEENVRYIEIRFAPVFSLAGGLSLVEATQAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCHHHHHHHHHH
IEGLHQGMATYDIMAKALVCGMRQLPNTDNQTMFKTTAPLLGSTLVGGDFAGNEADFPTN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCHH
VCAPAIKTAQSLGVPLTFHAGECHCPQNIGEAVRLGIPRIGHATACFDQPALIEKIVETG
HHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHCC
TTVELCLTSNLQTKAARTLAEFPYQALKKAGAKITINTDNRTVSNTTLTQEYQRYQQAFG
CEEEEEECCCCHHHHHHHHHHCCHHHHHHCCCEEEEECCCCEECCHHHHHHHHHHHHHHC
TTAADFLAFNLNAIDAAFIPDADKKSLRDQLHQDYATYC
CHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA