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The map label for this gene is hom [H]

Identifier: 116495608

GI number: 116495608

Start: 2140792

End: 2141991

Strand: Direct

Name: hom [H]

Synonym: LSEI_2151

Alternate gene names: 116495608

Gene position: 2140792-2141991 (Clockwise)

Preceding gene: 116495599

Following gene: 116495609

Centisome position: 73.94

GC content: 49.25

Gene sequence:

>1200_bases
ATGAAAATTGCCATCTTAGGTTTTGGGACTGTCGGCAGCGGCGTTTACGATATTATTGCAAATGGTGATACCCGAATGCG
CGTCACCGCTATTTTCATTCGGCCAACGCACCCTGCGACCATGCCTGAGATGACAACAGACCTTGACGCCATCTTAAACG
ATCCTACTATTGATGTGATCGTTGAAACAATGGGCGGTCTTCATCCAGCACATGATTATATTTTACAGGCTTTGCAGCAC
GGTAAGCACGTGGTTACCGCTAATAAAGCCGTTGTCGCTAAATATTTGCCGGAGTTTACCGCTGTTGCTGCACAGCATCA
CGTGCAATTTTACTTCGAAGCCACTACTGGCGGCGGCATCCCGTGGATTCGCAACCTTGAACGCGCCGCACGCATTGATC
AGATCGATACCATCGAAGGCATTTTCAATGGCACTAGCAATTATATTCTCGATCAGATGCAACGCGCCCACCTCGATTTT
GACCCCGTTCTCCTAGCCGCTAAAGATATGGGCTATGCCGAAGCCGATCCCAGTGCTGATATTGATGGCGAGGATGTGGT
CAACAAGCTGAAAATTTCGGCAGCACTTGCCTACAACATGGCCCCACCACGTGATGTCCCAACTTTTGGTATTCGCAACG
TCAGCAAAGCCGACATTGACTTTTTCGCAAGTCAACATCAGGTTTTACGGTTGATTGGTAAAAGTAAACGTGACGGTGAC
CACTATAGTATGGTCGTGGAACCGCGCTTGTATTCAGAAACCGCCTTGGCGGCCAATACATTTGAAAACTTCAATCTAAT
TCGCCTGCATGGACAAACGATTGGCGACCTGCAATTTTATGGTCAAGGCGCCGGAAAATACCCGACAGCCAACGCTATCG
TGCAAGATCTGTACGATATCTTTGAAAATGCCCCGCATCTGGACCGTAGCTTCGATCAGCCGCTGCATTTTGACGCCAAC
CTGAATGTCACCGATTACGTTTTGCGCGCCGATCCCATGACCTTCGCGATGTTCAATGATCGCGAAACCGAGATCGTCAA
TGACCGGCTTGTGATCAAGCAAATACCAACTGGCGACATGCACAAACTCATGCGCGGCGTTTTGGCCATTGATGCCGATG
CTTTTATGGCAGCAATCGGAGACAGTGAGTTGGCTGCTAAAGACGTCCTTCACCAGCAAGATCAGGAGGTGATCGGATGA

Upstream 100 bases:

>100_bases
CTCCTATCTCATTCGGCTTGAATTAACGATATGGATATGATAATCTGTTCGCATTAGAAAAACAAGTGTCTATATTTTAT
AAACAAGGAGCTGAGAATTT

Downstream 100 bases:

>100_bases
AGGTCGTTAAATTTGGCGGTAGTTCCGTGGCCGATGCCGGTCAATTCCAGAAAGTTAAAGCCATAATCGATCAGGATGTG
AATCGGCAAATCGTCGTGAT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKIAILGFGTVGSGVYDIIANGDTRMRVTAIFIRPTHPATMPEMTTDLDAILNDPTIDVIVETMGGLHPAHDYILQALQH
GKHVVTANKAVVAKYLPEFTAVAAQHHVQFYFEATTGGGIPWIRNLERAARIDQIDTIEGIFNGTSNYILDQMQRAHLDF
DPVLLAAKDMGYAEADPSADIDGEDVVNKLKISAALAYNMAPPRDVPTFGIRNVSKADIDFFASQHQVLRLIGKSKRDGD
HYSMVVEPRLYSETALAANTFENFNLIRLHGQTIGDLQFYGQGAGKYPTANAIVQDLYDIFENAPHLDRSFDQPLHFDAN
LNVTDYVLRADPMTFAMFNDRETEIVNDRLVIKQIPTGDMHKLMRGVLAIDADAFMAAIGDSELAAKDVLHQQDQEVIG

Sequences:

>Translated_399_residues
MKIAILGFGTVGSGVYDIIANGDTRMRVTAIFIRPTHPATMPEMTTDLDAILNDPTIDVIVETMGGLHPAHDYILQALQH
GKHVVTANKAVVAKYLPEFTAVAAQHHVQFYFEATTGGGIPWIRNLERAARIDQIDTIEGIFNGTSNYILDQMQRAHLDF
DPVLLAAKDMGYAEADPSADIDGEDVVNKLKISAALAYNMAPPRDVPTFGIRNVSKADIDFFASQHQVLRLIGKSKRDGD
HYSMVVEPRLYSETALAANTFENFNLIRLHGQTIGDLQFYGQGAGKYPTANAIVQDLYDIFENAPHLDRSFDQPLHFDAN
LNVTDYVLRADPMTFAMFNDRETEIVNDRLVIKQIPTGDMHKLMRGVLAIDADAFMAAIGDSELAAKDVLHQQDQEVIG
>Mature_399_residues
MKIAILGFGTVGSGVYDIIANGDTRMRVTAIFIRPTHPATMPEMTTDLDAILNDPTIDVIVETMGGLHPAHDYILQALQH
GKHVVTANKAVVAKYLPEFTAVAAQHHVQFYFEATTGGGIPWIRNLERAARIDQIDTIEGIFNGTSNYILDQMQRAHLDF
DPVLLAAKDMGYAEADPSADIDGEDVVNKLKISAALAYNMAPPRDVPTFGIRNVSKADIDFFASQHQVLRLIGKSKRDGD
HYSMVVEPRLYSETALAANTFENFNLIRLHGQTIGDLQFYGQGAGKYPTANAIVQDLYDIFENAPHLDRSFDQPLHFDAN
LNVTDYVLRADPMTFAMFNDRETEIVNDRLVIKQIPTGDMHKLMRGVLAIDADAFMAAIGDSELAAKDVLHQQDQEVIG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=189, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=204, Percent_Identity=27.9411764705882, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44099; Mature: 44099

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAILGFGTVGSGVYDIIANGDTRMRVTAIFIRPTHPATMPEMTTDLDAILNDPTIDVI
CEEEEEECCCCCCCEEEEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHH
VETMGGLHPAHDYILQALQHGKHVVTANKAVVAKYLPEFTAVAAQHHVQFYFEATTGGGI
HHHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCC
PWIRNLERAARIDQIDTIEGIFNGTSNYILDQMQRAHLDFDPVLLAAKDMGYAEADPSAD
HHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCC
IDGEDVVNKLKISAALAYNMAPPRDVPTFGIRNVSKADIDFFASQHQVLRLIGKSKRDGD
CCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
HYSMVVEPRLYSETALAANTFENFNLIRLHGQTIGDLQFYGQGAGKYPTANAIVQDLYDI
CEEEEECCCHHCCHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHH
FENAPHLDRSFDQPLHFDANLNVTDYVLRADPMTFAMFNDRETEIVNDRLVIKQIPTGDM
HHCCCCCCCCCCCCEEECCCCCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCHH
HKLMRGVLAIDADAFMAAIGDSELAAKDVLHQQDQEVIG
HHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIAILGFGTVGSGVYDIIANGDTRMRVTAIFIRPTHPATMPEMTTDLDAILNDPTIDVI
CEEEEEECCCCCCCEEEEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHH
VETMGGLHPAHDYILQALQHGKHVVTANKAVVAKYLPEFTAVAAQHHVQFYFEATTGGGI
HHHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCC
PWIRNLERAARIDQIDTIEGIFNGTSNYILDQMQRAHLDFDPVLLAAKDMGYAEADPSAD
HHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCC
IDGEDVVNKLKISAALAYNMAPPRDVPTFGIRNVSKADIDFFASQHQVLRLIGKSKRDGD
CCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
HYSMVVEPRLYSETALAANTFENFNLIRLHGQTIGDLQFYGQGAGKYPTANAIVQDLYDI
CEEEEECCCHHCCHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHH
FENAPHLDRSFDQPLHFDANLNVTDYVLRADPMTFAMFNDRETEIVNDRLVIKQIPTGDM
HHCCCCCCCCCCCCEEECCCCCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCHH
HKLMRGVLAIDADAFMAAIGDSELAAKDVLHQQDQEVIG
HHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]